Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn® H40, poly(l-lactide) and poly(ethylene glycol) for tumor-targeted drug delivery

Biomaterials

Volumn 30, Issue 16, 2009, Pages 3009-3019

  Prabaharan, Mani ^a   Grailer, Jamison J ^b   Pilla, Srikanth ^a   Steeber, Douglas A ^b   Gong, Shaoqin ^a  

^a University of Wisconsin Milwaukee   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

Cellular uptake; Cytotoxicity; Drug delivery; In vitro degradation; Unimolecular micelles

Indexed keywords

AMPHIPHILIC; ANTI-CANCER DRUGS; AQUEOUS SOLUTIONS; BLOCK POLYMERS; BURST RELEASE; CELLULAR UPTAKE; CORE-SHELL STRUCTURES; DOXORUBICIN; FREE BASE; GEL-PERMEATION-CHROMATOGRAPHY; HYPERBRANCHED; IN VITRO DEGRADATION; INNER SHELLS; MAMMARY CARCINOMA CELLS; METHOXY POLIES (ETHYLENE GLYCOL); MICELLAR PROPERTIES; NANOCARRIERS; OUTER SHELLS; POLY (PLA); POLY(ETHYLENE GLYCOL); POLY(L LACTIDE); POLYMER FRAGMENTS; RECEPTOR-MEDIATED ENDOCYTOSIS; SUSTAINED RELEASE; TARGETED DRUG DELIVERIES; TEM; UNIMOLECULAR MICELLES;

BIODEGRADATION; BLOCK COPOLYMERS; CELL CULTURE; CHROMATOGRAPHIC ANALYSIS; CONTROLLED DRUG DELIVERY; COPOLYMERIZATION; DEGRADATION; DENDRIMERS; DYNAMIC LIGHT SCATTERING; ETHYLENE; ETHYLENE GLYCOL; GELATION; MICELLES; MOTION PICTURE EXPERTS GROUP STANDARDS; ORGANIC POLYMERS; PLASTIC PRODUCTS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYMER BLENDS; TRANSMISSION ELECTRON MICROSCOPY; TUMORS;

POLYMERS;

BOLTORN; COPOLYMER; DOXORUBICIN; FOLATE RECEPTOR; FOLIC ACID; MACROGOL; METHOXYPOLYETHYLENE GLYCOL; NANOCARRIER; POLYLACTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BREAST CARCINOMA; BREAST CELL; CANCER CELL DESTRUCTION; CARCINOMA CELL; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG STRUCTURE; ENCAPSULATION; ENDOCYTOSIS; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; LIGHT SCATTERING; MICELLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SUSTAINED DRUG RELEASE; TRANSMISSION ELECTRON MICROSCOPY;

ANTINEOPLASTIC AGENTS; DENDRIMERS; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FOLIC ACID; MATERIALS TESTING; MICELLES; MOLECULAR STRUCTURE; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; SOLUTIONS; TIME FACTORS; WATER;

EID: 63649134641     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.02.011     Document Type: Article

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