Betacellulin inhibits amylase and glucagon production and promotes beta cell differentiation in mouse embryonic pancreas

Diabetologia

Volumn 50, Issue 8, 2007, Pages 1688-1697

  Thowfeequ, S ^a   Ralphs, K L ^a   Yu, W Y ^a   Slack, J M W ^a   Tosh, D ^a  

^a University of Bath   (United Kingdom)

Author keywords

Amylase; Beta cell; Betacellulin; Cytokeratin; Ductal morphogenesis; Glucagon; Insulin; Islets; Pancreas

Indexed keywords

AMYLASE; BETACELLULIN; GLUCAGON; INSULIN; TRANSCRIPTION FACTOR PDX 1;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; EMBRYO DEVELOPMENT; ENZYME INHIBITION; EXOCRINE SECRETION; HORMONE SYNTHESIS; IN VITRO STUDY; INSULIN SYNTHESIS; MESENCHYME CELL; MORPHOGENESIS; MOUSE; NONHUMAN; PANCREAS; PANCREAS DUCT; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TISSUE CULTURE;

AMYLASES; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; GHRELIN; GLUCAGON; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PANCREAS; PANCREATIC POLYPEPTIDE; SOMATOSTATIN;

EID: 34447129761     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0724-y     Document Type: Article

References (41)

1. Shapiro AM, Geng Hao E, Lakey JR, Finegood DT, Rajotte RV, Kneteman NM (2002) Defining optimal immunosuppression for islet transplantation based on reduced diabetogenicity in canine islet autografts. Transplantation 74:1522-1528
2. Naftanel MA, Harlan DM (2004) Pancreatic islet transplantation. PLoS Med 1:e58 (quiz e75)
3. Bonner-Weir S, Weir GC (2005) New sources of pancreatic beta-cells. Nat Biotechnol 23:857-861
4. Zalzman M, Anker-Kitai L, Efrat S (2005) Differentiation of human liver-derived, insulin-producing cells toward the beta-cell phenotype. Diabetes 54:2568-2575
5. Huotari MA, Miettinen PJ, Palgi J et al (2002) ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture. Endocrinology 143:4437-4446
6. Dunbar AJ, Goddard C (2000) Structure-function and biological role of betacellulin. Int J Biochem Cell Biol 32:805-815
7. Sasada R, Ono Y, Taniyama Y, Shing Y, Folkman J, Igarashi K (1993) Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family. Biochem Biophys Res Commun 190:1173-1179
8. Miyagawa J, Hanafusa O, Sasada R et al (1999) Immunohistochemical localization of betacellulin, a new member of the EGF family, in normal human pancreas and islet tumor cells. Endocr J 46:755-764
9. Jackson LF, Qiu TH, Sunnarborg SW et al (2003) Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J 22:2704-2716
10. Mashima H, Ohnishi H, Wakabayashi K et al (1996) Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. J Clin Invest 97:1647-1654
11. Demeterco C, Beattie GM, Dib SA, Lopez AD, Hayek A (2000) A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth. J Clin Endocrinol Metab 85:3892-3897
12. Li L, Seno M, Yamada H, Kojima I (2003) Betacellulin improves glucose metabolism by promoting conversion of intraislet precursor cells to beta-cells in streptozotocin-treated mice. Am J Physiol Endocrinol Metab 285:E577-E583
13. Kojima H, Fujimiya M, Matsumura K et al (2003) NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 9:596-603
14. Li L, Seno M, Yamada H, Kojima I (2001) Promotion of beta-cell regeneration by betacellulin in ninety percent-pancreatectomized rats. Endocrinology 142:5379-5385
15. Sakurai H, Tsukamoto T, Kjelsberg CA, Cantley LG, Nigam SK (1997) EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney. Am J Physiol 273:F463-F472
16. Kim SK, Hebrok M (2001) Intercellular signals regulating pancreas development and function. Genes Dev 15:111-127
17. Percival AC, Slack JM (1999) Analysis of pancreatic development using a cell lineage label. Exp Cell Res 247:123-132
18. Shen CN, Seckl JR, Slack JM, Tosh D (2003) Glucocorticoids suppress beta-cell development and induce hepatic metaplasia in embryonic pancreas. Biochem J 375:41-50
19. Li WC, Horb ME, Tosh D, Slack JM (2005) In vitro transdifferentiation of hepatoma cells into functional pancreatic cells. Mech Dev 122:835-847
20. Jiang FX, Harrison LC (2005) Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation. Differentiation 73:45-49
21. Miettinen PJ, Huotari M, Koivisto T et al (2000) Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors. Development 127:2617-2627
22. Bouwens L, Braet F, Heimberg H (1995) Identification of rat pancreatic duct cells by their expression of cytokeratins 7, 19, and 20 in vivo and after isolation and culture. J Histochem Cytochem 43:245-253
23. Stoffers DA, Heller RS, Miller CP, Habener JF (1999) Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology 140:5374-5381
24. Miyatsuka T, Kaneto H, Shiraiwa T et al (2006) Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev 20:1435-1440
25. Greten FR, Weber CK, Greten TF et al (2002) Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis. Gastroenterology 123:2052-2063
26. Scholz A, Heinze S, Detjen KM et al (2003) Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. Gastroenterology 125:891-905
27. Rescan C, Le Bras S, Lefebvre VH et al (2005) EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade. Lab Invest 85:65-74
28. Cras-Méneur C, Elghazi L, Czernichow P, Scharfmann R (2001) Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: a balance between proliferation and differentiation. Diabetes 50:1571-1579
29. Jones JT, Akita RW, Sliwkowski MX (1999) Binding specificities and affinities of EGF domains for ErbB receptors. FEBS Lett 447:227-231
30. Saito T, Okada S, Ohshima K et al (2004) Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF. Endocrinology 145:4232-4243
31. Schneider MR, Dahlhoff M, Herbach N et al (2005) Betacellulin overexpression in transgenic mice causes disproportionate growth, pulmonary hemorrhage syndrome, and complex eye pathology. Endocrinology 146:5237-5246
32. Rooman I, Heremans Y, Heimberg H, Bouwens L (2000) Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia 43:907-914
33. Miralles F, Czernichow P, Scharfmann R (1998) Follistatin regulates the relative proportions of endocrine vs exocrine tissue during pancreatic development. Development 125:1017-1024
34. Heller RS, Stoffers DA, Bock T et al (2001) Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas. Diabetes 50:1553-1561
35. Abe K, Watanabe S (1995) Apoptosis of mouse pancreatic acinar cells after duct ligation. Arch Histol Cytol 58:221-229
36. Jensen J (2004) Gene regulatory factors in pancreatic development. Dev Dyn 229:176-200
37. Ogata T, Li L, Yamada S et al (2004) Promotion of beta-cell differentiation by conophylline in fetal and neonatal rat pancreas. Diabetes 53:2596-2602
38. Ogata T, Park KY, Seno M, Kojima I (2004) Reversal of streptozotocin-induced hyperglycemia by transplantation of pseudoislets consisting of beta cells derived from ductal cells. Endocr J 51:381-386
39. Laguesse E (1893) Sur la formation des îlots de Langerhans dans le pancréas. Comptes Rendus Séances Soc Biol Fil 45:819-820
40. Kerr-Conte J, Pattou F, Lecomte-Houcke M et al (1996) Ductal cyst formation in collagen-embedded adult human islet preparations. A means to the reproduction of nesidioblastosis in vitro. Diabetes 45:1108-1114
41. Bonner-Weir S, Taneja M, Weir GC et al (2000) In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci U S A 97:7999-8004