Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors

International Journal of Pharmaceutics

Volumn 477, Issue 1-2, 2014, Pages 442-453

  Qian, Shuai ^a,b   He, Lisi ^c   Mak, Marvin ^d   Han, Yifan ^d   Ho, Chun Yu ^c,e   Zuo, Zhong ^a  

^a Prince of Wales Hospital   (Hong Kong)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^e SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Acetylcholinesterase; Cytotoxicity; Dimers; Permeability; Tacrine

Indexed keywords

DIMER; TACRINE; ZOLPIDEM;

ARTICLE; CACO 2 CELL LINE; CHOLINESTERASE INHIBITION; COMPUTER MODEL; CONTROLLED STUDY; DIMERIZATION; DRUG ABSORPTION; DRUG CYTOTOXICITY; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; PHYSICAL CHEMISTRY;

EID: 84908584201     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.10.058     Document Type: Article

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