Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons

Journal of Proteome Research

Volumn 6, Issue 7, 2007, Pages 2435-2446

  Fu, Hongjun ^a   Li, Wenming ^a,b   Liu, Yulin ^b   Lao, Yuanzhi ^a   Liu, Wei ^b   Chen, Cheng ^a   Yu, Hua ^a   Lee, Nelson T K ^a   Chang, Donald C ^a   Li, Peng ^c   Pang, Yuanping ^d   Tsim, Karl W K ^a   Li, Mingtao ^b   Han, Yifan ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b SUN YAT SEN UNIVERSITY   (China)

^c TSINGHUA UNIVERSITY   (China)

^d MAYO CLINIC   (United States)

Author keywords

Bis(7) tacrine; Cerebellar granule neurons; Glutamate; MALDI TOF MS; Mitochondria; Two dimensional differential in gel electrophoresis

Indexed keywords

ACETYLCHOLINESTERASE; BIS(7)TACRINE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; ENERGY METABOLISM; EXCITOTOXICITY; GEL ELECTROPHORESIS; GRANULE CELL; MEMBRANE POTENTIAL; MITOCHONDRION; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; RAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; CEREBELLUM; ENERGY METABOLISM; GLUTAMIC ACID; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; N-METHYLASPARTATE; NEURONS; OXIDATIVE STRESS; PROTEOME; PROTEOMICS; RATS; TACRINE;

EID: 34547197906     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr060615g     Document Type: Article

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