Changes in actin dynamics and F-actin structure both in synaptoneurosomes of LRRK2(R1441G) mutant mice and in primary human fibroblasts of LRRK2(G2019S) mutation carriers

Neuroscience

Volumn 284, Issue , 2015, Pages 311-324

  Caesar, M ^a   Felk, S ^a   Aasly, J O ^b   Gillardon, F ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

F actin; Fibroblasts; Filopodia; LRRK2; Parkinson's disease; Synaptoneurosomes

Indexed keywords

ACTIN; ARGININE; F ACTIN; GLYCINE; LATRUNCULIN A; LEUCINE RICH REPEAT KINASE 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SERINE; CENTRAL NERVOUS SYSTEM AGENTS; FUSED HETEROCYCLIC RINGS; LRRK2 PROTEIN, HUMAN; LRRK2 PROTEIN, MOUSE; N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2A; PHOSPHATIDYLSERINE; PROTEIN SERINE THREONINE KINASE; THIAZOLIDINE DERIVATIVE;

ADULT; ARTICLE; BRAIN NERVE CELL; BRAIN SYNAPTOSOME; CONTROLLED STUDY; CYTOSKELETON; FILOPODIUM; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOUSE; MOUSE MUTANT; MUTATIONAL ANALYSIS; NONHUMAN; POSTSYNAPTIC MEMBRANE; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SKIN FIBROBLAST; TRANSGENIC MOUSE; AGING; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; FIBROBLAST; GENETICS; KNOCKOUT MOUSE; METABOLISM; PSEUDOPODIUM; SYNAPTOSOME; ULTRASTRUCTURE;

ACTINS; AGING; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM AGENTS; FIBROBLASTS; HUMANS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PHOSPHATIDYLSERINES; PRESYNAPTIC TERMINALS; PROTEIN-SERINE-THREONINE KINASES; PSEUDOPODIA; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTOSOMES; THIAZOLIDINES;

EID: 84908582402     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.09.070     Document Type: Article

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