Simultaneous determination of rhynchophylline, isorhynchophylline, and their eight metabolites in rats

Journal of Traditional Medicines

Volumn 27, Issue 1, 2010, Pages 15-29

  Wang, Wei ^a   Chaomei, Ma ^a   Hattori, Masao ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

chotosan; isorhynchophylline; metabolism; rhynchophylline; yokukansan

Indexed keywords

EID: 84983041703     PISSN: 18801447     EISSN: 18813747     Source Type: Journal    
DOI: 10.11339/jtm.27.15     Document Type: Article

References (14)

1. “Illustration of the Chinese Medicine Prescriptions” (in Japanese) (Ed. by Kobe Chuigaku Kenkyukai), pp. 396, 399, 1982. Ishiyaku Publisher, Tokyo.
2. Obi, R., Tohda, M., Zhao, Q., Obi, N., Hori, H., Murakami, Y., Goto, H., Shimada, Y., Ochiai, H. and Matsumoto, K.: Chotosan enhances macrophage colony-stimulating factor mRNA expression in the ischemic rat brain and C6Bu-1 glimo cells. Biol. Pharm. Bull., 30, 2250-2256, 2007.
3. Zhao, Q., Murakami, Y., Tohda, M., Obi, R., Shimada, Y. and Matsumoto, K.: Chotosan, a Kampo formula, ameliorates chronic cerebral hypoperfusion-induced deficits in object recognition behaviors and central cholinergic systems in mice. J. Pharmacol. Sci., 103, 360-373, 2007.
4. Uchida, N., Egashira, N., Iwasaki, K., Ishibashi, A., Tashiro, R., Nogami, A., Manome, N., Abe, M., Takasaki, K., Mishima, K., Takata, J., Oishi, R., Nishimura, R. and Fujiwara, M.: Yokukansan inhibits social isolation-induced aggression and methamphetamine-induced hyperlocomotion in rodents. Biol. Pharm. Bull., 32, 372-375, 2009.
5. Jiang, J., Yamaguchi, T., Funakushi, N., Kuhara, T., Fan, P.-S., Ueki, R., Suto, H., Kase, Y., Ikeda, S. and Ogawa, H.: Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice. J. Dermatol. Sci., 56, 37-42, 2009.
6. Takeda, A., Tamano, H., Itoh, H. and Oku, N.: Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan. Neurochem. Int., 53, 230-235, 2008.
7. Watanabe, H., Zhao, Q., Matsumoto, K., Tohda, M., Murakami, Y., Zhang, S.-H., Kang, T.-H., Mahakunakorn, P., Maruyama, Y., Sakakibara, I., Aimi, N. and Takayama, H.: Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine. Pharmacol. Biochem. Behav., 75, 635-643, 2003.
8. Hsieh, C.-L., Ho, T.-Y., Su, S.-Y., Lo, W.-Y., Liu, C.-H. and Tang, N.-Y.: Uncaria rhynchophylla and rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor- B activity in kainic acid-treated rats. Am. J. Chin. Med., 37, 351-360, 2009.
9. Wang, W., Ma, C. M. and Hattori, M.: Metabolism and pharmacokinetics of rhynchophylline in rats. Biol. Pharm. Bull., (Accepted).
10. Wang, W., Ma, C. M. and Hattori, M.: Metabolism of isorhynchophylline in rats detected by LC-MS. J. Pharm. Pharmaceut. Sci., 13 (1), 27-37, 2010.
11. Reichen, J. and Le, M.: Influence of common bile duct cannula size on maximal secretory rate of taurocholate in the rat. Experientia, 40, 535-537, 1984.
12. Xu, L., Adams, B., Jeliazkova-Mecheva, V. V., Trimble, L., Kwei, G. and Harsch, A.: Identification of novel metabolites of colchicine in rat bile facilitated by enhanced online radiometric detection. Drug Metab. Dispos., 36, 731-739, 2008.
13. Shaffer, C. L., Ryder, T. F., Venkatakrishnan, K., Henne, I. K. and O'Connell, T. N.: Biotransformation of an α4β2 nicotinic acetylcholine receptor partial agonist in Sprague-Dawley rats and the dispositional characterization of its N-carbamoyl glucuronide metabolite. Drug Metab. Dispos., 37, 1480-1489, 2009.
14. Kang, T.-H., Murakami, Y., Takayama, H., Kitajima, M, Aimi, N., Watanabe, H. and Matsumoto K.: Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action. Life Sci., 76, 331-343, 2004.