Comparative pharmacokinetics of senkyunolide I in a rat model of migraine versus normal controls

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 37, Issue 2, 2012, Pages 91-97

  Wang, Yi Han ^a   Hong, Yan Long ^a,b   Feng, Yi ^a,b   Xu, De Sheng ^a   Liang, Shuang ^a,b   Lin, Xiao ^a,c   Shen, Lan ^a,c  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai Zhangjiang Engineering Research Center of Modern Preparation Technology of TCM   (China)

^c SHANGHAI UNIVERSITY   (China)

Author keywords

HPLC; Migraine; Pharmacokinetic; Rats; Senkyunolide I

Indexed keywords

ALCOHOL; ANTIMIGRAINE AGENT; LIGUSTICUM CHUANXIONG EXTRACT; PLANT MEDICINAL PRODUCT; SENKYUNOLIDE I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG STRUCTURE; MALE; MAXIMUM PLASMA CONCENTRATION; MIGRAINE; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BENZOFURANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; MIGRAINE DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 84863725671     PISSN: 03787966     EISSN: 21070180     Source Type: Journal    
DOI: 10.1007/s13318-011-0073-6     Document Type: Article

References (21)

1. Arregui A, Cabrera J, Leon-Velarde F, Paredes S, Viscarra D, Arbaiza D (1991) High prevalence of migraine in a high-Altitude population. Neurology 41:1668
2. Balbisi EA (2006) Frovatriptan: A review of pharmacology, pharmacokinetics and clinical potential in treatment of menstrual migraine. Ther Clin Risk Manag 2:303-308
3. Cao J, Wang Z, Yang X, Kou H (2005) Determination of lactone components in Chuanxiong by reversed-phase high performance liquid chromatography. Se Pu Chin J Chrom 23:531-533
4. Chang XL, Ma YB, Zhang XM, Jiang ZY, Chen JJ (2007) Studies on chemical constituents of rhizomes of Ligusticum chuanxiong. Zhongguo Zhong Yao Za Zhi 32:1533-1536
5. Chen Z, Foster MW, Zhang J, Mao L, Rockman HA, Kawamoto T, Kitagawa K, Nakayama KI, Hess DT, Stamler JS (2005) An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. Proc Natl Acad Sci USA 102:12159-12164
6. Chen L, Qi J, Chang YX, Zhu D, Yu B (2009) Identification and determination of the major constituents in Traditional Chinese Medicinal formula Danggui-Shaoyao-San by HPLC-DAD-ESIMS/MS. J Pharm Biomed Anal 50:127-137
7. Hibbs JBJ, Taintora RR, Vavrin Z, Rachlin EM (1988) Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 157:87-94
8. Lao SC, Li SP, Kelvin K.W. Kan, Li P, Wan JB, Wang YT, Dong TX, Tsim KWK (2004) Identification and quantification of 13 components in Angelica sinensis (Danggui) by gas chromatography-mass spectrometry coupled with pressurized liquid extraction. Analytica Chimica Acta 526:131-137
9. Li HZ (2008) Pharmaceutical analysis in biological sample, 1st edn. People's Medical Publishing House, USA, pp 15-17
10. Lipinski CA, Lombardo F, Dominy BW, Feeny PJ (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 23:3-26
11. Masaru K, Miyuki F, Hiroshi M (1987) Studies on the constituents of Umbelliferae plants. XV. Constituents of Cnidium officinale: Occurrence of pregnenolone, Coniferyl ferulate and Hydroxyphthalides. Chem Pharm Bull 35:1427-1437
12. Peng C, Xie XF, Wang L, Guo L, Hu T (2009) Pharmacodynamic action and mechanism of volatile oil from Rhizoma Ligustica chuanxiong Hort on treating headache. Phytomedicine 16:25-34
13. Pini LA, Bertolotti M, Bergonzini G, Casalgrandi L, Giroldi L, Sternieri E (1990) Pharmacokinetics of tiaprofenic acid after oral administration in fasting patients during and between migraine attacks. Headache 30:672-675
14. Read SJ, Manning P, McNeil CJ, Hunter AJ, Parsons A (1999) Effects of sumatriptan on nitric oxide and superoxide balance during glyceryl trinitrate infusion in the rat. Implications for antimigraine mechanisms. Brain Res 847:1-8
15. Rose-Lee LM, Eadie MJ, Heazlewood V, Bochner F, Tyrer JH (1983) Aspirin pharmacokinetics in migraine. The effect of metoclopramide. Eur J Clin Pharmacol 24:777-785
16. Ru Y, Ge L, Nga LK, Yun KT (2007) Low oral bioavailability and pharmacokinetics of senkyunolide A, a major bioactive component in Rhizoma Chuanxiong, in the rat. Ther Drug Monit 29:49-56
17. Ru Y, Nga LK, Song LL, Yun KT, Ge L (2008) Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat. Drug Metab Dispos 36:400-408
18. Tommaso M, Libroa G, Guidoa M, Difruscolo O, Losito L, Sardaro M, Cerbo R (2004) Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: A study of laser evoked potentials. Neurosci Lett 363:272-275
19. Tudor IO, Andrew MD, Simon JT, Paul DL (2001) Is there a difference between leads and drugs? A historical perspective. J Chem Inf Comput Sci 41:1308-1315
20. Wang YH, Liang S, Xu DS, Lin X, He CY, Feng Y, Hong YL (2011) Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. J Pharm Pharmacol 63:261-266
21. Yuan Y, Lin X, Feng Y, Xu DS, Wang YH (2010) In vivo transmigration of Anti-Migrainous Compounds from Ligusticum chuanxiong Hort. Chin Pharm J 45:694-696