Biosynthetic studies and genetic engineering of pactamycin analogs with improved selectivity toward malarial parasites

Chemistry and Biology

Volumn 18, Issue 4, 2011, Pages 425-431

  Lu, Wanli ^a   Roongsawang, Niran ^a   Mahmud, Taifo ^a  

^a OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYLUREA; 1,1-DIMETHYLUREA; ANTIINFECTIVE AGENT; ANTIMALARIAL AGENT; DRUG DERIVATIVE; METHYLUREA; PACTAMYCIN; TRANSFERASE;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CELL STRAIN HCT116; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; GENE INACTIVATION; GENE SILENCING; GENETIC ENGINEERING; GENETICS; HUMAN; MALARIA; METABOLISM; METHODOLOGY; PARASITOLOGY; PLASMODIUM FALCIPARUM; STREPTOMYCES;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTIMALARIALS; GENE KNOCKOUT TECHNIQUES; GENE SILENCING; GENETIC ENGINEERING; HCT116 CELLS; HUMANS; MALARIA; METHYLUREA COMPOUNDS; PACTAMYCIN; PLASMODIUM FALCIPARUM; STREPTOMYCES; TRANSFERASES;

MAMMALIA;

EID: 79955380502     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.01.016     Document Type: Article

References (15)

1. B.K. Bhuyan Pactamycin production by Streptomyces pactum Appl. Microbiol. 10 1962 302 304
2. D.E. Brodersen, W.M. Clemons Jr., A.P. Carter, R.J. Morgan-Warren, B.T. Wimberly, and V. Ramakrishnan The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit Cell 103 2000 1143 1154 (Pubitemid 32037400)
3. G. Dinos, D.N. Wilson, Y. Teraoka, W. Szaflarski, P. Fucini, D. Kalpaxis, and K.H. Nierhaus Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding Mol. Cell 13 2004 113 124 (Pubitemid 38117120)
4. L.J. Higgins, F. Yan, P. Liu, H.W. Liu, and C.L. Drennan Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme Nature 437 2005 838 844 (Pubitemid 41486753)
5. T. Ito, N. Roongsawang, N. Shirasaka, W. Lu, P.M. Flatt, N. Kasanah, C. Miranda, and T. Mahmud Deciphering pactamycin biosynthesis and engineered production of new pactamycin analogues ChemBioChem 10 2009 2253 2265
6. F. Kudo, Y. Kasama, T. Hirayama, and T. Eguchi Cloning of the pactamycin biosynthetic gene cluster and characterization of a crucial glycosyltransferase prior to a unique cyclopentane ring formation J. Antibiot. (Tokyo) 60 2007 492 503
7. T. Kuzuyama, T. Seki, T. Dairi, T. Hidaka, and H. Seto Nucleotide sequence of fortimicin KL1 methyltransferase gene isolated from Micromonospora olivasterospora, and comparison of its deduced amino acid sequence with those of methyltransferases involved in the biosynthesis of bialaphos and fosfomycin J. Antibiot. (Tokyo) 48 1995 1191 1193
8. Y. Mao, M. Varoglu, and D.H. Sherman Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564 Chem. Biol. 6 1999 251 263 (Pubitemid 29368412)
9. K. Otoguro, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tukashima, S. Shibahara, S. Kondo, H. Yamada, and S. Omura Promising lead compounds for novel antiprotozoals J. Antibiot. (Tokyo) 63 2010 381 384
10. 7N) unit of pactamycin J. Am. Chem. Soc. 103 1981 2099 2101 (Pubitemid 11037332)
11. H.J. Sofia, G. Chen, B.G. Hetzler, J.F. Reyes-Spindola, and N.E. Miller Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods Nucleic Acids Res. 29 2001 1097 1106 (Pubitemid 32186195)
12. R. Taber, D. Rekosh, and D. Baltimore Effect of pactamycin on synthesis of poliovirus proteins: a method for genetic mapping J. Virol. 8 1971 395 401
13. 7N unit J. Am. Chem. Soc. 100 1978 6757 6760 (Pubitemid 9101151)
14. L. Westrich, L. Heide, and S.M. Li CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin ChemBioChem 4 2003 768 773 (Pubitemid 37010602)
15. F.R. White Pactamycin Cancer Chemother. Rep. 24 1962 75 78