Benzodioxane-benzamides as new bacterial cell division inhibitors

European Journal of Medicinal Chemistry

Volumn 89, Issue , 2015, Pages 252-265

  Chiodini, Giuseppe ^a   Pallavicini, Marco ^a   Zanotto, Carlo ^a   Bissa, Massimiliano ^a   Radaelli, Antonia ^a   Straniero, Valentina ^a   Bolchi, Cristiano ^a   Fumagalli, Laura ^a   Ruggeri, Paola ^a   De Morghen, Carlo Giuli ^a   Valoti, Ermanno ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

2,6 Difluorobenzamide; Antibacterial activity; Benzodioxane; FtsZ; Staphylococcus aureus

Indexed keywords

1 (4 CHLOROBUTYL) 2,3 ISOPROPYLIDENEGLYCEROL; 1,4 BENZODIOXAN DERIVATIVE; 2 (2,6 DIFLUORO 3 NONYLOXYPHENYL) 4,5 DIHYDRO 1H IMIDAZOLE; 2 (2,6 DIFLUORO 3 NONYLOXYPHENYL) 4,5 DIHYDROOXAZOLE; 2 BENZYLOXY 5 CHLOROPHENOL; 2 BENZYLOXY 5 CHLOROPHENYL FORMATE; 2 [2 HYDROXY 3 (4 HYDROXYBUTOXY)PROPYL]ISOINDOLINE 1,3 DIONE; 2 [2 TOSYLOXY 3 (4 HYDROXYBUTOXY)PROPYL]ISOINDOLINE 1,3 DIONE; 2,4 DIFLUORO 1 NONYLOXYBENZENE; 2,6 DIFLUORO 3 NONYLOXYBENZALDEHYDE; 2,6 DIFLUORO 3 NONYLOXYBENZAMIDE; 2,6 DIFLUORO 3 NONYLOXYBENZOIC ACID; 2,6 DIFLUORO 3 NONYLOXYBENZONITRILE; 2,6 DIFLUORO 3 NONYLOXYBENZOYL CHLORIDE; 2,6 DIFLUORO N (2 AMINOETHYL) 3 NONYLOXYBENZAMIDE; 2,6 DIFLUORO N (2 AZIDOETHYL) 3 NONYLOXYBENZAMIDE; 2,6 DIFLUORO N (2 HYDROXYETHYL) 3 NONYLOXYBENZAMIDE; 3 (1,4 BENZODIOXAN 2 YLMETHOXY) 2,6 DIFLUOROBENZAMIDE; 3 [4 (2,3 DIHYDROXYPROPOXY)BUTOXY] 2,6 DIFLUOROBENZAMIDE; 3 [4 (3 AMINO 2 HYDROXYPROPOXY)BUTOXY] 2,6 DIFLUOROBENZAMIDE HYDROCHLORIDE; 3 [4 [(2,2 DIMETHYL 1,3 DIOXOLAN 4 YL)METHOXY]BUTOXY] 2,6 DIFLUOROBENZAMIDE; 3 [4 [3 (1,3 DIOXOISOINDOLIN 2 YL) 2 HYDROXYPROPOXY]BUTOXY] 2,6 DIFLUOROBENZAMIDE; 5 (2,6 DIFLUORO 3 NONYLOXYPHENYL) 1H TETRAZOLE; 6 FLUORO 7 NONYLOXY 1,2,3,4 TETRAHYDRO 5H 1,4 BENZODIAZEPIN 5 ONE; AGENTS AFFECTING CELL DIVISION; BENZAMIDE DERIVATIVE; FTSZ PROTEIN; METHYL 2,4 DIFLUORO 3 NONYLOXYBENZOATE; N,N' 1,2 ETHANEDIYLBIS(2,6 DIFLUORO 3 NONLOXY)BENZAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 1,4-BENZODIOXAN; 2,6-DIFLUOROBENZAMIDE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CYTOSKELETON PROTEIN; DIOXANE DERIVATIVE; FTSZ PROTEIN, BACTERIA; PC190723; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL GROWTH; CELL DIVISION; CELL GROWTH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SYNTHESIS; ENANTIOMER; ESCHERICHIA COLI; HUMAN; HUMAN CELL; KIDNEY CELL; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VERO CELL LINE;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BENZAMIDES; CELL DIVISION; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CYTOSKELETAL PROTEINS; DIOXANES; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRIDINES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; VERO CELLS;

EID: 84908537766     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.09.100     Document Type: Article

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