Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 13, 2014, Pages 2924-2927

  Straniero, Valentina ^a   Pallavicini, Marco ^a   Chiodini, Giuseppe ^a   Ruggeri, Paola ^a   Fumagalli, Laura ^a   Bolchi, Cristiano ^a   Corsini, Alberto ^a   Ferri, Nicola ^a,b   Ricci, Chiara ^a   Valoti, Ermanno ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b IRCCS MULTIMEDICA   (Italy)

Author keywords

2 Aminothiazole; Benzodioxane; FTase inhibitor; Mimetic; RAS protein

Indexed keywords

1,4 BENZODIOXAN DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; TETRAPEPTIDE; THIAZOLE DERIVATIVE; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; OLIGOPEPTIDE;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; ENZYME INHIBITION; NONHUMAN; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTA; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULAR MIMICRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; MUSCLE, SMOOTH, VASCULAR; OLIGOPEPTIDES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84901782838     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.078     Document Type: Article

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