Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723

Biochemical Pharmacology

Volumn 86, Issue 12, 2013, Pages 1699-1707

  Kaul, Malvika ^a   Mark, Lilly ^b,c   Zhang, Yongzheng ^b   Parhi, Ajit K ^b   Lavoie, Edmond J ^c   Pilch, Daniel S ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b TAXIS Pharmaceuticals Inc   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Antibiotics; Drug solubility; FtsZ; MRSA; Systemic infection

Indexed keywords

ANTIINFECTIVE AGENT; BENZAMIDE DERIVATIVE; ERYTHROMYCIN; OXACILLIN; TXY 541; UNCLASSIFIED DRUG; VANCOMYCIN; FUSED HETEROCYCLIC RINGS; IMIDE; N-(3-((6-CHLOROTHIAZOLO(5,4-B)PYRIDIN-2-YL)METHOXY)-2,6-DIFLUOROBENZOYL)-1-METHYLPIPERIDINE-4-CARBOXAMIDE; PC190723; PRODRUG; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; FEMALE; IC 50; IN VIVO STUDY; MAMMAL CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; STAPHYLOCOCCUS;

ANIMALS; ANTI-BACTERIAL AGENTS; FEMALE; HETEROCYCLIC COMPOUNDS, 2-RING; IMIDES; MICE; MICROBIAL SENSITIVITY TESTS; PRODRUGS; PYRIDINES; STAPHYLOCOCCUS; THIAZOLES;

EID: 84888872920     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.10.010     Document Type: Article

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