Inhibition of RND-type efflux pumps confers the FtsZ-directed prodrug TXY436 with activity against Gram-negative bacteria

Biochemical Pharmacology

Volumn 89, Issue 3, 2014, Pages 321-328

  Kaul, Malvika ^a   Zhang, Yongzheng ^b   Parhi, Ajit K ^b   Lavoie, Edmond J ^c   Pilch, Daniel S ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b TAXIS Pharmaceuticals Inc   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRAB PROTEIN; AMPICILLIN; ANTIBIOTIC AGENT; BACTERIAL PROTEIN; FTSZ PROTEIN; MINOCYCLINE; PC 190723; PRODRUG; TXY 436; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ANISOTROPY; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; CELL DIVISION; CONTROLLED STUDY; DRUG PROTEIN BINDING; ESCHERICHIA COLI; FLUORESCENCE MICROSCOPY; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHASE CONTRAST MICROSCOPY; POLYMERIZATION; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; WILD TYPE;

ACINETOBACTER BAUMANNII; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BENZAMIDES; CYTOSKELETAL PROTEINS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PRODRUGS; PYRIDINES; RHO GTP-BINDING PROTEINS; THIAZOLES;

EID: 84899900046     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.03.002     Document Type: Article

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