Mechanism of action of the cell-division inhibitor PC190723: Modulation of FtsZ assembly cooperativity

Journal of the American Chemical Society

Volumn 134, Issue 30, 2012, Pages 12342-12345

  Elsen, Nathaniel L ^a   Lu, Jun ^a   Parthasarathy, Gopal ^a   Reid, John C ^a   Sharma, Sujata ^a   Soisson, Stephen M ^a   Lumb, Kevin J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBACTERIAL AGENT; C-TERMINAL DOMAINS; CELL CYCLE; CELL DIVISIONS; CO-OPERATIVE ASSEMBLY; CONFORMATIONAL CHANGE; CONFORMATIONAL SWITCHES; COOPERATIVITY; CRITICAL CONCENTRATION; DOMAIN MOVEMENT; MECHANISM OF ACTION; MOLECULAR MECHANISM; POLYMER ASSEMBLIES; POTENTIAL DRUG; PROTOFILAMENTS; S. AUREUS; SMALL MOLECULES; STAPHYLOCOCCUS AUREUS;

BACTERIA; CELL PROLIFERATION; ENZYME INHIBITION; POLYMERIZATION;

CONFORMATIONS;

ANTIINFECTIVE AGENT; BINDING PROTEIN; FTSZ PROTEIN; PC 190723; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIVISION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG TARGETING; MICROFILAMENT; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN POLYMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTOFILAMENT; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CYTOSKELETAL PROTEINS; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; THIAZOLES;

EID: 84864494657     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja303564a     Document Type: Article

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