Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 43, 2014, Pages E4658-E4667

  Roulis, Manolis ^a   Nikolaou, Christoforos ^a   Kotsaki, Elena ^a   Kaffe, Eleanna ^a   Karagianni, Niki ^b   Koliaraki, Vasiliki ^a   Salpea, Klelia ^a   Ragoussis, Jiannis ^a,c   Aidinis, Vassilis ^a   Martini, Eva ^d   Becker, Christoph ^d   Herschman, Harvey R ^e   Vetrano, Stefania ^f   Danese, Silvio ^f   Kollias, George ^a  

^a BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING   (Greece)

^b Biomedcode Hellas SA   (Greece)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

Crohn's disease; Cyclooxygenase 2; MAP kinases; Mesenchymal cells; Ulcerative colitis

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1 RECEPTOR TYPE I; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHOTRANSFERASE; PROSTAGLANDIN E2; TUMOR PROGRESSION LOCUS 2 KINASE; UNCLASSIFIED DRUG; DEXTRAN SULFATE; MAP3K8 PROTEIN, HUMAN; MAP3K8 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; ONCOPROTEIN; PTGS2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; EXPERIMENTAL COLITIS; FEMALE; HOMEOSTASIS; ILEUM; INNATE IMMUNITY; INTESTINE EPITHELIUM CELL; MOUSE; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ULCERATIVE COLITIS; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL LINEAGE; CELL PROLIFERATION; COLITIS; DEFICIENCY; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; EPITHELIUM; EPITHELIUM CELL; HUMAN; IMMUNOLOGY; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; INTESTINE; METABOLISM; PATHOLOGY; PHENOTYPE;

ANIMALS; CELL LINEAGE; CELL PROLIFERATION; COLITIS; CYCLOOXYGENASE 2; DEXTRAN SULFATE; DINOPROSTONE; DISEASE SUSCEPTIBILITY; ENZYME ACTIVATION; EPITHELIAL CELLS; EPITHELIUM; HOMEOSTASIS; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; INTESTINES; MAP KINASE KINASE KINASES; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MYOFIBROBLASTS; PHENOTYPE; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION;

EID: 84908519207     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415762111     Document Type: Article

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