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Volumn 10, Issue 11, 2014, Pages 654-661

Improving cardiovascular and renal outcomes in gout: What should we target?

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; ATORVASTATIN; BENZBROMARONE; C REACTIVE PROTEIN; COLCHICINE; FEBUXOSTAT; INTERLEUKIN 1; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; LESINURAD; LOSARTAN; PLACEBO; PROBENECID; TUMOR NECROSIS FACTOR; URIC ACID; XANTHINE OXIDASE; ANTIGOUT AGENT; URICOSURIC AGENT;

EID: 84908503998     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2014.124     Document Type: Review
Times cited : (180)

References (99)
  • 1
    • 54949100735 scopus 로고    scopus 로고
    • Uric acid and cardiovascular risk
    • Feig, D. I., Kang, D. H. & Johnson, R. J. Uric acid and cardiovascular risk. N. Engl. J. Med. 359, 1811-1821 (2008).
    • (2008) N. Engl. J. Med , vol.359 , pp. 1811-1821
    • Feig, D.I.1    Kang, D.H.2    Johnson, R.J.3
  • 3
    • 84894038623 scopus 로고    scopus 로고
    • Definition of hyperuricemia and gouty conditions
    • Bardin, T. & Richette, P. Definition of hyperuricemia and gouty conditions. Curr. Opin. Rheumatol. 26, 186-191 (2014).
    • (2014) Curr. Opin. Rheumatol , vol.26 , pp. 186-191
    • Bardin, T.1    Richette, P.2
  • 4
    • 84871174888 scopus 로고    scopus 로고
    • Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality
    • Kuo, C. F. et al. Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality. Rheumatology (Oxford) 52, 127-134 (2013).
    • (2013) Rheumatology (Oxford) , vol.52 , pp. 127-134
    • Kuo, C.F.1
  • 7
    • 34548142983 scopus 로고    scopus 로고
    • Independent impact of gout on mortality and risk for coronary heart disease
    • Choi, H. K. & Curhan, G. Independent impact of gout on mortality and risk for coronary heart disease. Circulation 116, 894-900 (2007).
    • (2007) Circulation , vol.116 , pp. 894-900
    • Choi, H.K.1    Curhan, G.2
  • 8
    • 77953690414 scopus 로고    scopus 로고
    • Independent impact of gout on the risk of acute myocardial infarction among elderly women: A population-based study
    • De Vera, M. A., Rahman, M. M., Bhole, V., Kopec, J. A. & Choi, H. K. Independent impact of gout on the risk of acute myocardial infarction among elderly women: A population-based study. Ann. Rheum. Dis. 69, 1162-1164 (2010).
    • (2010) Ann. Rheum. Dis , vol.69 , pp. 1162-1164
    • De Vera, M.A.1    Rahman, M.M.2    Bhole, V.3    Kopec, J.A.4    Choi, H.K.5
  • 9
    • 34548132096 scopus 로고    scopus 로고
    • Serum uric acid level and risk for peripheral arterial disease: Analysis of data from the multiple risk factor intervention trial
    • Baker, J. F., Schumacher, H. R. & Krishnan, E. Serum uric acid level and risk for peripheral arterial disease: Analysis of data from the multiple risk factor intervention trial. Angiology 58, 450-457 (2007).
    • (2007) Angiology , vol.58 , pp. 450-457
    • Baker, J.F.1    Schumacher, H.R.2    Krishnan, E.3
  • 10
    • 84859098332 scopus 로고    scopus 로고
    • Gout and the risk for incident heart failure and systolic dysfunction
    • Krishnan, E. Gout and the risk for incident heart failure and systolic dysfunction. BMJ Open 15, e000282 (2012).
    • (2012) BMJ Open , vol.15 , pp. e000282
    • Krishnan, E.1
  • 11
    • 84887794673 scopus 로고    scopus 로고
    • Gout as a risk factor for myocardial infarction and stroke in England: Evidence from record linkage studies
    • Seminog, O. O. & Goldacre, M. J. Gout as a risk factor for myocardial infarction and stroke in England: evidence from record linkage studies. Rheumatology (Oxford) 52, 2251-2259 (2013).
    • (2013) Rheumatology (Oxford) , vol.52 , pp. 2251-2259
    • Seminog, O.O.1    Goldacre, M.J.2
  • 12
    • 84862822542 scopus 로고    scopus 로고
    • Association between gout and all-cause as well as cardiovascular mortality: A systematic review
    • Lottmann, K., Chen, X. & Schadlich, P. K. Association between gout and all-cause as well as cardiovascular mortality: A systematic review. Curr. Rheumatol. Rep. 14, 195-203 (2012).
    • (2012) Curr. Rheumatol. Rep , vol.14 , pp. 195-203
    • Lottmann, K.1    Chen, X.2    Schadlich, P.K.3
  • 13
    • 84880323787 scopus 로고    scopus 로고
    • Independent and conjoint associations of gout and hyperuricaemia with total and cardiovascular mortality
    • Stack, A. G. et al. Independent and conjoint associations of gout and hyperuricaemia with total and cardiovascular mortality. QJM 106, 647-658 (2013).
    • (2013) QJM , vol.106 , pp. 647-658
    • Stack, A.G.1
  • 14
    • 84860918911 scopus 로고    scopus 로고
    • Mortality due to coronary heart disease and kidney disease among middle-aged and elderly men and women with gout in the Singapore Chinese Health Study
    • Teng, G. G. et al. Mortality due to coronary heart disease and kidney disease among middle-aged and elderly men and women with gout in the Singapore Chinese Health Study. Ann. Rheum. Dis. 71, 924-928 (2012).
    • (2012) Ann. Rheum. Dis , vol.71 , pp. 924-928
    • Teng, G.G.1
  • 15
    • 84889682611 scopus 로고    scopus 로고
    • Tophaceous gout and high level of hyperuricaemia are both associated with increased risk of mortality in patients with gout
    • Perez-Ruiz, F. et al. Tophaceous gout and high level of hyperuricaemia are both associated with increased risk of mortality in patients with gout. Ann. Rheum. Dis. 73, 177-182 (2014).
    • (2014) Ann. Rheum. Dis , vol.73 , pp. 177-182
    • Perez-Ruiz, F.1
  • 16
    • 75749130719 scopus 로고    scopus 로고
    • Hyperuricemia and coronary heart disease: A systematic review and meta-analysis
    • Kim, S. Y. et al. Hyperuricemia and coronary heart disease: A systematic review and meta-analysis. Arthritis Care Res. (Hoboken) 62, 170-180 (2010).
    • (2010) Arthritis Care Res. (Hoboken) , vol.62 , pp. 170-180
    • Kim, S.Y.1
  • 17
    • 33947615191 scopus 로고    scopus 로고
    • Severity of gouty arthritis is associated with Q-wave myocardial infarction: A large-scale, cross-sectional study
    • Chen, S. Y., Chen, C. L. & Shen, M. L. Severity of gouty arthritis is associated with Q-wave myocardial infarction: A large-scale, cross-sectional study. Clin. Rheumatol. 26, 308-313 (2007).
    • (2007) Clin. Rheumatol , vol.26 , pp. 308-313
    • Chen, S.Y.1    Chen, C.L.2    Shen, M.L.3
  • 18
    • 0033529386 scopus 로고    scopus 로고
    • Serum uric acid and risk for cardiovascular disease and death: The Framingham Heart Study
    • Culleton, B. F., Larson, M. G., Kannel, W. B. & Levy, D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann. Intern. Med. 131, 7-13 (1999).
    • (1999) Ann. Intern. Med , vol.131 , pp. 7-13
    • Culleton, B.F.1    Larson, M.G.2    Kannel, W.B.3    Levy, D.4
  • 19
    • 67650486326 scopus 로고    scopus 로고
    • Hyperuricemia and risk of stroke: A systematic review and meta-analysis
    • Kim, S. Y. et al. Hyperuricemia and risk of stroke: A systematic review and meta-analysis. Arthritis Rheum. 61, 885-892 (2009).
    • (2009) Arthritis Rheum , vol.61 , pp. 885-892
    • Kim, S.Y.1
  • 20
    • 79952232932 scopus 로고    scopus 로고
    • Hyperuricemia and incident hypertension: A systematic review and meta-analysis
    • Grayson, P. C., Kim, S. Y., LaValley, M. & Choi, H. K. Hyperuricemia and incident hypertension: A systematic review and meta-analysis. Arthritis Care Res. (Hoboken) 63, 102-110 (2010).
    • (2010) Arthritis Care Res. (Hoboken) , vol.63 , pp. 102-110
    • Grayson, P.C.1    Kim, S.Y.2    Lavalley, M.3    Choi, H.K.4
  • 21
    • 70449727922 scopus 로고    scopus 로고
    • Plasma uric acid and hypertension in a Chinese community: Prospective study and metaanalysis
    • Zhang, W. et al. Plasma uric acid and hypertension in a Chinese community: prospective study and metaanalysis. Clin. Chem. 55, 2026-2034 (2009).
    • (2009) Clin. Chem , vol.55 , pp. 2026-2034
    • Zhang, W.1
  • 22
    • 84880232785 scopus 로고    scopus 로고
    • Serum urate association with hypertension in young adults: Analysis from the Coronary Artery Risk Development in Young Adults cohort
    • Gaffo, A. L. et al. Serum urate association with hypertension in young adults: Analysis from the Coronary Artery Risk Development in Young Adults cohort. Ann. Rheum. Dis. 72, 1321-1327 (2013).
    • (2013) Ann. Rheum. Dis , vol.72 , pp. 1321-1327
    • Gaffo, A.L.1
  • 23
    • 84858698191 scopus 로고    scopus 로고
    • Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey 1999-2006
    • Loeffler, L. F., Navas-Acien, A., Brady, T. M., Miller, E. R. 3rd & Fadrowski, J. J. Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey, 1999-2006. Hypertension 59, 811-817 (2012).
    • (2012) Hypertension , vol.59 , pp. 811-817
    • Loeffler, L.F.1    Navas-Acien, A.2    Brady, T.M.3    Miller, E.R.4    Fadrowski, J.J.5
  • 24
    • 0036083844 scopus 로고    scopus 로고
    • Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism
    • Mazzali, M. et al. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am. J. Physiol. Renal Physiol. 282, F991-F997 (2002).
    • (2002) Am. J. Physiol. Renal Physiol , vol.282 , pp. F991-F997
    • Mazzali, M.1
  • 25
    • 0036839067 scopus 로고    scopus 로고
    • Mild hyperuricemia induces glomerular hypertension in normal rats
    • Sanchez-Lozada, L. G. et al. Mild hyperuricemia induces glomerular hypertension in normal rats. Am. J. Physiol. Renal Physiol. 283, F1105-F1110 (2002).
    • (2002) Am. J. Physiol. Renal Physiol , vol.283 , pp. F1105-F1110
    • Sanchez-Lozada, L.G.1
  • 26
    • 33846998296 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome in patients with gout: The Third National Health and Nutrition Examination Survey
    • Choi, H. K., Ford, E. S., Li, C. & Curhan, G. Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 57, 109-115 (2007).
    • (2007) Arthritis Rheum , vol.57 , pp. 109-115
    • Choi, H.K.1    Ford, E.S.2    Li, C.3    Curhan, G.4
  • 27
    • 84874263529 scopus 로고    scopus 로고
    • High serum uric acid and increased risk of type 2 diabetes: A systemic review and meta-analysis of prospective cohort studies
    • Lv, Q. et al. High serum uric acid and increased risk of type 2 diabetes: A systemic review and meta-analysis of prospective cohort studies. PLoS ONE 8, e56864 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e56864
    • Lv, Q.1
  • 28
    • 0029104069 scopus 로고
    • Effect of insulin on uric acid excretion in humans
    • Quinones Galvan, A. et al. Effect of insulin on uric acid excretion in humans. Am. J. Physiol. 268, E1-E5 (1995).
    • (1995) Am. J. Physiol , vol.268 , pp. E1-E5
    • Quinones Galvan, A.1
  • 29
    • 69549133582 scopus 로고    scopus 로고
    • Association between serum uric acid and development of type 2 diabetes
    • Kodama, S. et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care 32, 1737-1742 (2009).
    • (2009) Diabetes Care , vol.32 , pp. 1737-1742
    • Kodama, S.1
  • 30
    • 79951697681 scopus 로고    scopus 로고
    • Serum uric acid levels predict new-onset type 2 diabetes in hospitalized patients with primary hypertension: The MAGIC study
    • Viazzi, F., Leoncini, G., Vercelli, M., Deferrari, G. & Pontremoli, R. Serum uric acid levels predict new-onset type 2 diabetes in hospitalized patients with primary hypertension: the MAGIC study. Diabetes Care 34, 126-128 (2011).
    • (2011) Diabetes Care , vol.34 , pp. 126-128
    • Viazzi, F.1    Leoncini, G.2    Vercelli, M.3    Deferrari, G.4    Pontremoli, R.5
  • 31
    • 77957804998 scopus 로고    scopus 로고
    • Serum uric acid levels and the risk of type 2 diabetes: A prospective study
    • Bhole, V., Choi, J. W., Kim, S. W, de Vera, M. & Choi, H. Serum uric acid levels and the risk of type 2 diabetes: A prospective study. Am. J. Med. 123, 957-961 (2010).
    • (2010) Am. J. Med , vol.123 , pp. 957-961
    • Bhole, V.1    Choi, J.W.2    Kim, S.W.3    De Vera, M.4    Choi, H.5
  • 32
    • 33749260511 scopus 로고    scopus 로고
    • Serum uric acid is a determinant of metabolic syndrome in a population-based study
    • Onat, A. et al. Serum uric acid is a determinant of metabolic syndrome in a population-based study. Am. J. Hypertens. 19, 1055-1062 (2006).
    • (2006) Am. J. Hypertens , vol.19 , pp. 1055-1062
    • Onat, A.1
  • 33
    • 84866732607 scopus 로고    scopus 로고
    • Predictive value of serum uric acid levels for the diagnosis of metabolic syndrome in adolescents
    • Wang, J. Y. et al. Predictive value of serum uric acid levels for the diagnosis of metabolic syndrome in adolescents. J. Pediatr. 161, 753-756.e2 (2012).
    • (2012) J. Pediatr , vol.161 , pp. 753-753e2
    • Wang, J.Y.1
  • 34
    • 58149346039 scopus 로고    scopus 로고
    • Do thiazides worsen metabolic syndrome and renal disease? the pivotal roles for hyperuricemia and hypokalemia
    • Reungjui, S., Pratipanawatr, T., Johnson, R. & Nakagawa, T. Do thiazides worsen metabolic syndrome and renal disease? The pivotal roles for hyperuricemia and hypokalemia. Curr. Opin. Nephrol. Hypertens. 17, 470-476 (2008).
    • (2008) Curr. Opin. Nephrol Hypertens , vol.17 , pp. 470-476
    • Reungjui, S.1    Pratipanawatr, T.2    Johnson, R.3    Nakagawa, T.4
  • 35
    • 84867076729 scopus 로고    scopus 로고
    • Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans
    • Cox, C. L. et al. Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans. Nutr. Metab. (Lond.) 9, 68 (2012).
    • (2012) Nutr. Metab. (Lond.) , vol.9 , pp. 68
    • Cox, C.L.1
  • 36
    • 33846211514 scopus 로고    scopus 로고
    • Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats
    • Sanchez-Lozada, L. G. et al. Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am. J. Physiol. Renal Physiol. 292, F423-F429 (2007).
    • (2007) Am. J. Physiol. Renal Physiol , vol.292 , pp. F423-F429
    • Sanchez-Lozada, L.G.1
  • 37
    • 77949541626 scopus 로고    scopus 로고
    • Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: Role of uric acid in the hypertensive response
    • Perez-Pozo, S. E. et al. Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int. J. Obes. (Lond.) 34, 454-461 (2010).
    • (2010) Int. J. Obes. (Lond.) , vol.34 , pp. 454-461
    • Perez-Pozo, S.E.1
  • 38
    • 39549085729 scopus 로고    scopus 로고
    • Soft drinks, fructose consumption, and the risk of gout in men: Prospective cohort study
    • Choi, H. K. & Curhan, G. Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study. BMJ 336, 309-312 (2008).
    • (2008) BMJ , vol.336 , pp. 309-312
    • Choi, H.K.1    Curhan, G.2
  • 39
    • 78649424888 scopus 로고    scopus 로고
    • Fructose-rich beverages and risk of gout in women
    • Choi, H. K., Willett, W. & Curhan, G. Fructose-rich beverages and risk of gout in women. JAMA 304, 2270-2278 (2010).
    • (2010) JAMA , vol.304 , pp. 2270-2278
    • Choi, H.K.1    Willett, W.2    Curhan, G.3
  • 40
    • 77953187009 scopus 로고    scopus 로고
    • Uric acid transport and disease
    • So, A. & Thorens, B. Uric acid transport and disease. J. Clin. Invest. 120, 1791-1799 (2010).
    • (2010) J. Clin. Invest , vol.120 , pp. 1791-1799
    • So, A.1    Thorens, B.2
  • 41
    • 84862687850 scopus 로고    scopus 로고
    • Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007-2008
    • Zhu, Y., Pandya, B. J. & Choi, H. K. Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007-2008. Am. J. Med. 125, 679-687.e1 (2011).
    • (2011) Am. J. Med , vol.125 , pp. 679-679e1
    • Zhu, Y.1    Pandya, B.J.2    Choi, H.K.3
  • 43
    • 84882925526 scopus 로고    scopus 로고
    • Uric acid and chronic kidney disease: Which is chasing which?
    • Johnson, R. J. et al. Uric acid and chronic kidney disease: which is chasing which? Nephrol. Dial. Transplant. 28, 2221-2228 (2013).
    • (2013) Nephrol. Dial. Transplant , vol.28 , pp. 2221-2228
    • Johnson, R.J.1
  • 44
    • 0037383766 scopus 로고    scopus 로고
    • Increased expression of monocyte chemoattractant protein-1 (MCP-1) by renal epithelial cells in culture on exposure to calcium oxalate, phosphate and uric acid crystals
    • Umekawa, T., Chegini, N. & Khan, S. R. Increased expression of monocyte chemoattractant protein-1 (MCP-1) by renal epithelial cells in culture on exposure to calcium oxalate, phosphate and uric acid crystals. Nephrol. Dial. Transplant. 18, 664-669 (2003).
    • (2003) Nephrol. Dial. Transplant , vol.18 , pp. 664-669
    • Umekawa, T.1    Chegini, N.2    Khan, S.R.3
  • 45
    • 84865143534 scopus 로고    scopus 로고
    • Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy
    • Omori, H. et al. Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy. Clin. Exp. Nephrol. 16, 549-556 (2012).
    • (2012) Clin. Exp. Nephrol , vol.16 , pp. 549-556
    • Omori, H.1
  • 46
    • 44949242595 scopus 로고    scopus 로고
    • Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome
    • Sanchez-Lozada, L. G. et al. Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome. Am. J. Physiol. Renal Physiol. 294, F710-F718 (2008).
    • (2008) Am. J. Physiol. Renal Physiol , vol.294 , pp. F710-F718
    • Sanchez-Lozada, L.G.1
  • 47
    • 68049101366 scopus 로고    scopus 로고
    • Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice
    • Kosugi, T. et al. Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am. J. Physiol. Renal Physiol. 297, F481-F488 (2009).
    • (2009) Am. J. Physiol. Renal Physiol , vol.297 , pp. F481-F488
    • Kosugi, T.1
  • 48
    • 0025971753 scopus 로고
    • Persistence of monosodium urate crystals and low-grade inflammation in the synovial fluid of patients with untreated gout
    • Pascual, E. Persistence of monosodium urate crystals and low-grade inflammation in the synovial fluid of patients with untreated gout. Arthritis Rheum. 34, 141-145 (1991).
    • (1991) Arthritis Rheum , vol.34 , pp. 141-145
    • Pascual, E.1
  • 49
    • 65849231192 scopus 로고    scopus 로고
    • Treating to target: A strategy to cure gout
    • Perez-Ruiz, F. Treating to target: A strategy to cure gout. Rheumatology (Oxford) 48 (Suppl. 2), ii9-ii14 (2009).
    • (2009) Rheumatology (Oxford) , vol.48 , pp. ii9-ii14
    • Perez-Ruiz, F.1
  • 50
    • 77951759092 scopus 로고    scopus 로고
    • Cellular characterization of the gouty tophus: A quantitative analysis
    • Dalbeth, N. et al. Cellular characterization of the gouty tophus: A quantitative analysis. Arthritis Rheum. 62, 1549-1556 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 1549-1556
    • Dalbeth, N.1
  • 51
    • 84867405545 scopus 로고    scopus 로고
    • Canakinumab for acute gouty arthritis in patients with limited treatment options: Results from two randomised, multicentre, active-controlled, double-blind trials and their initial extensions
    • Schlesinger, N. et al. Canakinumab for acute gouty arthritis in patients with limited treatment options: results from two randomised, multicentre, active-controlled, double-blind trials and their initial extensions. Ann. Rheum. Dis. 71, 1839-1848 (2012).
    • (2012) Ann. Rheum. Dis , vol.71 , pp. 1839-1848
    • Schlesinger, N.1
  • 52
    • 84875957784 scopus 로고    scopus 로고
    • A systematic review of ultrasonography in gout and asymptomatic hyperuricaemia
    • Chowalloor, P. V. & Keen, H. I. A systematic review of ultrasonography in gout and asymptomatic hyperuricaemia. Ann. Rheum. Dis. 72, 638-645 (2013).
    • (2013) Ann. Rheum. Dis , vol.72 , pp. 638-645
    • Chowalloor, P.V.1    Keen, H.I.2
  • 53
    • 78651380618 scopus 로고    scopus 로고
    • Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: An ultrasound controlled study
    • Pineda, C. et al. Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: An ultrasound controlled study. Arthritis Res. Ther. 13, R4 (2011).
    • (2011) Arthritis Res. Ther , vol.13 , pp. R4
    • Pineda, C.1
  • 54
    • 46749111817 scopus 로고    scopus 로고
    • Asymptomatic hyperuricemia: Impact of ultrasonography
    • Puig, J. G. et al. Asymptomatic hyperuricemia: impact of ultrasonography. Nucleosides Nucleotides Nucleic Acids 27, 592-595 (2008).
    • (2008) Nucleosides Nucleotides Nucleic Acids , vol.27 , pp. 592-595
    • Puig, J.G.1
  • 55
    • 27544474476 scopus 로고    scopus 로고
    • Effect on serum uric acid levels of drugs prescribed for indications other than treating hyperuricaemia
    • Daskalopoulou, S. S., Tzovaras, V., Mikhailidis, D. P. & Elisaf, M. Effect on serum uric acid levels of drugs prescribed for indications other than treating hyperuricaemia. Curr. Pharm. Des. 11, 4161-4175 (2005).
    • (2005) Curr. Pharm. des , vol.11 , pp. 4161-4175
    • Daskalopoulou, S.S.1    Tzovaras, V.2    Mikhailidis, D.P.3    Elisaf, M.4
  • 56
    • 80054021686 scopus 로고    scopus 로고
    • Allopurinol as a cardiovascular drug
    • Kelkar, A., Kuo, A. & Frishman, W. H. Allopurinol as a cardiovascular drug. Cardiol. Rev. 19, 265-271 (2011).
    • (2011) Cardiol. Rev , vol.19 , pp. 265-271
    • Kelkar, A.1    Kuo, A.2    Frishman, W.H.3
  • 58
    • 77956269930 scopus 로고    scopus 로고
    • Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo
    • Hershfield, M. S. et al. Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo. Proc. Natl Acad. Sci. USA 107, 14351-14356 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 14351-14356
    • Hershfield, M.S.1
  • 59
    • 33644631485 scopus 로고    scopus 로고
    • Therapeutic effects of xanthine oxidase inhibitors: Renaissance half a century after the discovery of allopurinol
    • Pacher, P., Nivorozhkin, A. & Szabo, C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol. Rev. 58, 87-114 (2006).
    • (2006) Pharmacol. Rev , vol.58 , pp. 87-114
    • Pacher, P.1    Nivorozhkin, A.2    Szabo, C.3
  • 60
    • 77952899115 scopus 로고    scopus 로고
    • Urate-lowering therapy for gout: Focus on febuxostat
    • Love, B. L., Barrons, R., Veverka, A. & Snider, K. M. Urate-lowering therapy for gout: focus on febuxostat. Pharmacotherapy 30, 594-608 (2010).
    • (2010) Pharmacotherapy , vol.30 , pp. 594-608
    • Love, B.L.1    Barrons, R.2    Veverka, A.3    Snider, K.M.4
  • 61
    • 79957951218 scopus 로고    scopus 로고
    • Febuxostat inhibition of endothelial-bound XO: Implications for targeting vascular ROS production
    • Malik, U. Z. et al. Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production. Free Radic. Biol. Med. 51, 179-184 (2011).
    • (2011) Free Radic. Biol. Med , vol.51 , pp. 179-184
    • Malik, U.Z.1
  • 62
    • 73449130797 scopus 로고    scopus 로고
    • C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta-analysis
    • Kaptoge, S. et al. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta-analysis. Lancet 375, 132-140 (2010).
    • (2010) Lancet , vol.375 , pp. 132-140
    • Kaptoge, S.1
  • 63
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241 (2006).
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 64
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • Duewell, P. et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357-1361 (2010).
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1
  • 65
    • 84878129203 scopus 로고    scopus 로고
    • What can asymptomatic hyperuricaemia and systemic inflammation in the absence of gout tell us?
    • Inaba, S., Sautin, Y., Garcia, G. E. & Johnson, R. J. What can asymptomatic hyperuricaemia and systemic inflammation in the absence of gout tell us? Rheumatology (Oxford) 52, 963-965 (2013).
    • (2013) Rheumatology (Oxford) , vol.52 , pp. 963-965
    • Inaba, S.1    Sautin, Y.2    Garcia, G.E.3    Johnson, R.J.4
  • 66
    • 84866668703 scopus 로고    scopus 로고
    • Relationship between inflammatory cytokines and uric acid levels with adverse cardiovascular outcomes in patients with stable coronary heart disease
    • Rothenbacher, D. et al. Relationship between inflammatory cytokines and uric acid levels with adverse cardiovascular outcomes in patients with stable coronary heart disease. PLoS ONE 7, e45907 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e45907
    • Rothenbacher, D.1
  • 67
    • 0038579374 scopus 로고    scopus 로고
    • Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2
    • Kanellis, J. et al. Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension 41, 1287-1293 (2003).
    • (2003) Hypertension , vol.41 , pp. 1287-1293
    • Kanellis, J.1
  • 68
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • Shi, Y., Evans, J. E. & Rock, K. L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425, 516-521 (2003).
    • (2003) Nature , vol.425 , pp. 516-521
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 69
    • 84864545087 scopus 로고    scopus 로고
    • Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
    • Dinarello, C. A., Simon, A. & van der Meer, J. W. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat. Rev. Drug Discov. 11, 633-652 (2012).
    • (2012) Nat. Rev. Drug Discov , vol.11 , pp. 633-652
    • Dinarello, C.A.1    Simon, A.2    Van Der Meer, J.W.3
  • 70
    • 84863479133 scopus 로고    scopus 로고
    • Xanthine oxidase inhibition for the treatment of cardiovascular disease: A systematic review and meta-analysis
    • Higgins, P. et al. Xanthine oxidase inhibition for the treatment of cardiovascular disease: A systematic review and meta-analysis. Cardiovasc. Ther. 30, 217-226 (2012).
    • (2012) Cardiovasc. Ther , vol.30 , pp. 217-226
    • Higgins, P.1
  • 71
    • 80051616824 scopus 로고    scopus 로고
    • Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris
    • Rajendra, N. S. et al. Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris. J. Am. Coll. Cardiol. 58, 820-828 (2011).
    • (2011) J. Am. Coll. Cardiol , vol.58 , pp. 820-828
    • Rajendra, N.S.1
  • 72
    • 77953615298 scopus 로고    scopus 로고
    • Effect of high-dose allopurinol on exercise in patients with chronic stable angina: A randomised, placebo controlled crossover trial
    • Noman, A., Ang, D. S., Ogston, S., Lang, C. C. & Struthers, A. D. Effect of high-dose allopurinol on exercise in patients with chronic stable angina: A randomised, placebo controlled crossover trial. Lancet 375, 2161-2167 (2010).
    • (2010) Lancet , vol.375 , pp. 2161-2167
    • Noman, A.1    Ang, D.S.2    Ogston, S.3    Lang, C.C.4    Struthers, A.D.5
  • 74
    • 84926685553 scopus 로고    scopus 로고
    • Impact of allopurinol on risk of myocardial infarction
    • Grimaldi-Bensouda, L. et al. Impact of allopurinol on risk of myocardial infarction. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2012-202972 (2014).
    • (2014) Ann. Rheum. Dis
    • Grimaldi-Bensouda, L.1
  • 75
    • 1542268611 scopus 로고    scopus 로고
    • Effect of statins versus untreated dyslipidemia on serum uric acid levels in patients with coronary heart disease: A subgroup analysis of the GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) study
    • Athyros, V. G. et al. Effect of statins versus untreated dyslipidemia on serum uric acid levels in patients with coronary heart disease: A subgroup analysis of the GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) study. Am. J. Kidney Dis. 43, 589-599 (2004).
    • (2004) Am. J. Kidney Dis , vol.43 , pp. 589-599
    • Athyros, V.G.1
  • 76
    • 10744221128 scopus 로고    scopus 로고
    • The impact of serum uric acid on cardiovascular outcomes in the LIFE study
    • Hoieggen, A. et al. The impact of serum uric acid on cardiovascular outcomes in the LIFE study. Kidney Int. 65, 1041-1049 (2004).
    • (2004) Kidney Int , vol.65 , pp. 1041-1049
    • Hoieggen, A.1
  • 77
    • 33845447368 scopus 로고    scopus 로고
    • High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid
    • George, J., Carr, E., Davies, J., Belch, J. J. & Struthers, A. High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation 114, 2508-2516 (2006).
    • (2006) Circulation , vol.114 , pp. 2508-2516
    • George, J.1    Carr, E.2    Davies, J.3    Belch, J.J.4    Struthers, A.5
  • 78
    • 76549098607 scopus 로고    scopus 로고
    • Uric acid-lowering treatment with benzbromarone in patients with heart failure: A double-blind placebo-controlled crossover preliminary study
    • Ogino, K. et al. Uric acid-lowering treatment with benzbromarone in patients with heart failure: A double-blind placebo-controlled crossover preliminary study. Circ. Heart Fail. 3, 73-81 (2010).
    • (2010) Circ. Heart Fail , vol.3 , pp. 73-81
    • Ogino, K.1
  • 79
    • 84861189813 scopus 로고    scopus 로고
    • Uric acid, heart failure survival, and the impact of xanthine oxidase inhibition
    • Harzand, A., Tamariz, L. & Hare, J. M. Uric acid, heart failure survival, and the impact of xanthine oxidase inhibition. Congest. Heart Fail. 18, 179-182 (2012).
    • (2012) Congest. Heart Fail , vol.18 , pp. 179-182
    • Harzand, A.1    Tamariz, L.2    Hare, J.M.3
  • 80
    • 84874791323 scopus 로고    scopus 로고
    • Pharmacotherapy for hyperuricemia in hypertensive patients
    • Art. No.: CD008652
    • Gois, P. H. & Souza, E. R. Pharmacotherapy for hyperuricemia in hypertensive patients. Cochrane Database of Systematic Reviews, Issue 1. Art. No.: CD008652. http://dx.doi.org/10.1002/14651858.CD008652.pub2.
    • Cochrane Database of Systematic Reviews , pp. 1
    • Gois, P.H.1    Souza, E.R.2
  • 81
    • 84878784568 scopus 로고    scopus 로고
    • Effect of allopurinol on blood pressure: A systematic review and meta-analysis
    • Agarwal, V., Hans, N. & Messerli, F. H. Effect of allopurinol on blood pressure: A systematic review and meta-analysis. J. Clin. Hypertens. (Greenwich) 15, 435-442 (2013).
    • (2013) J. Clin. Hypertens. (Greenwich) , vol.15 , pp. 435-442
    • Agarwal, V.1    Hans, N.2    Messerli, F.H.3
  • 82
    • 50449095362 scopus 로고    scopus 로고
    • Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: A randomized trial
    • Feig, D. I., Soletsky, B. & Johnson, R. J. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: A randomized trial. JAMA 300, 924-932 (2008).
    • (2008) JAMA , vol.300 , pp. 924-932
    • Feig, D.I.1    Soletsky, B.2    Johnson, R.J.3
  • 83
    • 84868202490 scopus 로고    scopus 로고
    • Uric acid reduction rectifies prehypertension in obese adolescents
    • Soletsky, B. & Feig, D. I. Uric acid reduction rectifies prehypertension in obese adolescents. Hypertension 60, 1148-1156 (2012).
    • (2012) Hypertension , vol.60 , pp. 1148-1156
    • Soletsky, B.1    Feig, D.I.2
  • 84
    • 84880778263 scopus 로고    scopus 로고
    • Comparison of febuxostat and allopurinol for hyperuricemia in cardiac surgery patients (NU-FLASH Trial)
    • Sezai, A. et al. Comparison of febuxostat and allopurinol for hyperuricemia in cardiac surgery patients (NU-FLASH Trial). Circ. J. 77, 2043-2049 (2013).
    • (2013) Circ. J , vol.77 , pp. 2043-2049
    • Sezai, A.1
  • 85
    • 79952750479 scopus 로고    scopus 로고
    • Effect of allopurinol on blood pressure and aortic compliance in hypertensive patients
    • Kostka-Jeziorny, K., Uruski, P. & Tykarski, A. Effect of allopurinol on blood pressure and aortic compliance in hypertensive patients. Blood Press. 20, 104-110 (2011).
    • (2011) Blood Press , vol.20 , pp. 104-110
    • Kostka-Jeziorny, K.1    Uruski, P.2    Tykarski, A.3
  • 86
    • 29244447160 scopus 로고    scopus 로고
    • Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level
    • Siu, Y. P., Leung, K. T., Tong, M. K. & Kwan, T. H. Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am. J. Kidney Dis. 47, 51-59 (2006).
    • (2006) Am. J. Kidney Dis , vol.47 , pp. 51-59
    • Siu, Y.P.1    Leung, K.T.2    Tong, M.K.3    Kwan, T.H.4
  • 87
    • 77955729725 scopus 로고    scopus 로고
    • Effect of allopurinol in chronic kidney disease progression and cardiovascular risk
    • Goicoechea, M. et al. Effect of allopurinol in chronic kidney disease progression and cardiovascular risk. Clin. J. Am. Soc. Nephrol. 5, 1388-1393 (2010).
    • (2010) Clin. J. Am. Soc. Nephrol , vol.5 , pp. 1388-1393
    • Goicoechea, M.1
  • 88
    • 79959709376 scopus 로고    scopus 로고
    • Effect of a reduction in uric acid on renal outcomes during losartan treatment: A post hoc analysis of the reduction of endpoints in non-insulin-dependent diabetes mellitus with the Angiotensin II Antagonist Losartan Trial
    • Miao, Y. et al. Effect of a reduction in uric acid on renal outcomes during losartan treatment: A post hoc analysis of the reduction of endpoints in non-insulin-dependent diabetes mellitus with the Angiotensin II Antagonist Losartan Trial. Hypertension 58, 2-7 (2011).
    • (2011) Hypertension , vol.58 , pp. 2-7
    • Miao, Y.1
  • 90
    • 84873368355 scopus 로고    scopus 로고
    • Hypertension its treatment, hyperuricaemia and gout
    • Gibson, T. J. Hypertension, its treatment, hyperuricaemia and gout. Curr. Opin. Rheumatol. 25, 217-222 (2013).
    • (2013) Curr. Opin. Rheumatol , vol.25 , pp. 217-222
    • Gibson, T.J.1
  • 91
    • 0020037872 scopus 로고
    • Allopurinol treatment and its effect on renal function in gout: A controlled study
    • Gibson, T., Rodgers, V., Potter, C. & Simmonds, H. A. Allopurinol treatment and its effect on renal function in gout: A controlled study. Ann. Rheum. Dis. 41, 59-65 (1982).
    • (1982) Ann. Rheum. Dis , vol.41 , pp. 59-65
    • Gibson, T.1    Rodgers, V.2    Potter, C.3    Simmonds, H.A.4
  • 92
  • 93
    • 0026558206 scopus 로고
    • Treatment with colchicine decreases white cell counts in synovial fluid of asymptomatic knees that contain monosodium urate crystals
    • Pascual, E. & Castellano, J. A. Treatment with colchicine decreases white cell counts in synovial fluid of asymptomatic knees that contain monosodium urate crystals. J. Rheumatol. 19, 600-603 (1992).
    • (1992) J. Rheumatol , vol.19 , pp. 600-603
    • Pascual, E.1    Castellano, J.A.2
  • 94
    • 84863513850 scopus 로고    scopus 로고
    • Colchicine use is associated with decreased prevalence of myocardial infarction in patients with gout
    • Crittenden, D. B. et al. Colchicine use is associated with decreased prevalence of myocardial infarction in patients with gout. J. Rheumatol. 39, 1458-1464 (2012).
    • (2012) J. Rheumatol , vol.39 , pp. 1458-1464
    • Crittenden, D.B.1
  • 95
    • 33847716675 scopus 로고    scopus 로고
    • Effect of colchicine (0.5 mg twice daily) on high-sensitivity C-reactive protein independent of aspirin and atorvastatin in patients with stable coronary artery disease
    • Nidorf, M. & Thompson, P. L. Effect of colchicine (0.5 mg twice daily) on high-sensitivity C-reactive protein independent of aspirin and atorvastatin in patients with stable coronary artery disease. Am. J. Cardiol. 99, 805-807 (2007).
    • (2007) Am. J. Cardiol , vol.99 , pp. 805-807
    • Nidorf, M.1    Thompson, P.L.2
  • 96
    • 84858865440 scopus 로고    scopus 로고
    • Effect of colchicine compared with placebo on high sensitivity C-reactive protein in patients with acute coronary syndrome or acute stroke: A pilot randomized controlled trial
    • Raju, N. C. et al. Effect of colchicine compared with placebo on high sensitivity C-reactive protein in patients with acute coronary syndrome or acute stroke: A pilot randomized controlled trial. J. Thromb. Thrombolysis 33, 88-94 (2012).
    • (2012) J. Thromb. Thrombolysis , vol.33 , pp. 88-94
    • Raju, N.C.1
  • 97
    • 58149328542 scopus 로고    scopus 로고
    • Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: A randomized, double-blind, placebo-controlled trial
    • Muir, S. W. et al. Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: A randomized, double-blind, placebo-controlled trial. Stroke 39, 3303-3307 (2008).
    • (2008) Stroke , vol.39 , pp. 3303-3307
    • Muir, S.W.1
  • 98
    • 36649035053 scopus 로고    scopus 로고
    • Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions
    • Kanbay, M. et al. Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions. Int. Urol. Nephrol. 39, 1227-1233 (2007).
    • (2007) Int. Urol. Nephrol , vol.39 , pp. 1227-1233
    • Kanbay, M.1
  • 99
    • 44349148871 scopus 로고    scopus 로고
    • Allopurinol improves endothelial function and reduces oxidant-inflammatory enzyme of myeloperoxidase in metabolic syndrome
    • Yiginer, O. et al. Allopurinol improves endothelial function and reduces oxidant-inflammatory enzyme of myeloperoxidase in metabolic syndrome. Clin. Res. Cardiol. 97, 334-340 (2008).
    • (2008) Clin. Res. Cardiol , vol.97 , pp. 334-340
    • Yiginer, O.1


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