Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy

Clinical and Experimental Nephrology

Volumn 16, Issue 4, 2012, Pages 549-556

  Omori, Hiroki ^a   Kawada, Noritaka ^a   Inoue, Kazunori ^a   Ueda, Yoshiyasu ^a   Yamamoto, Ryohei ^a   Matsui, Isao ^a   Kaimori, Jyunya ^a   Takabatake, Yoshitsugu ^a   Moriyama, Toshiki ^a   Isaka, Yoshitaka ^a   Rakugi, Hiromi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Febuxostat; Tubulointerstitial injury; Ureteral obstruction

Indexed keywords

3 NITROTYROSINE; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; CYTOKINE; FEBUXOSTAT; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; KIDNEY DISEASE; KIDNEY FIBROSIS; MACROPHAGE; MALE; NEPHRITIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; URETER OBSTRUCTIVE NEPHROPATHY;

ANIMALS; CELL MOVEMENT; CYTOKINES; DISEASE MODELS, ANIMAL; FIBROSIS; KIDNEY; KIDNEY DISEASES; MACROPHAGES; MALE; NEPHRITIS, INTERSTITIAL; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; THIAZOLES; TRANSFORMING GROWTH FACTOR BETA; URETERAL OBSTRUCTION; XANTHINE OXIDASE;

EID: 84865143534     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-012-0609-3     Document Type: Article

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