Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 21, 2014, Pages 6146-6155

  Yang, Wei ^a   Li, Lixuan ^a,b   Ji, Xun ^a   Wu, Xiaowei ^a   Su, Mingbo ^a   Sheng, Li ^a   Zang, Yi ^a   Li, Jia ^a,b   Liu, Hong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

HDACs; HDACs inhibitor; Hydroxamic acid; Thieno 2,3 d pyrimidines

Indexed keywords

4 ANILINOTHIENO[2,3 D]PYRIMIDINEDERIVATIVE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; HYDROXAMIC ACID DERIVATIVE; N1 (4 ((2 FLUORO 2 IODOPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N8 HYDROXYOCTANEDIAMIDE; N1 (4 ((2,4 DIFLUOROPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N8 HYDROXYOCTANEDIAMIDE; N1 (4 ((3 CHLORO 2 FLUOROPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N8 HYDROXYOCTANEDIAMIDE; N1 (4 ((3 CHLOROPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N8 HYDROXYOCTANEDIAMIDE; N1 (4 ((3,4 DIMETHYLPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N7 HYDROXYHEPTANEDIAMIDE; N1 (4 ((3,4 DIMETHYLPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N8 HYDROXYOCTANEDIAMIDE; N1 (4 ((4 (DIETHYLAMINO) 3 FLUOROPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N8 HYDROXYOCTANEDIAMIDE; N1 (4 ((4 (DIETHYLAMINO)PHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N8 HYDROXYOCTANEDIAMIDE; N1 (4 ((4 BROMO 2 FLUOROPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N8 HYDROXYOCTANEDIAMIDE; N1 (4 ((4 CHLORO 2 FLUOROPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N8 HYDROXYOCTANEDIAMIDE; N1 (4 ((4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N6 HYDROXYADIPAMIDE; N1 (4 ((4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N7 HYDROXYHEPTANEDIAMIDE; N1 (4 ((4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N8 HYDROXYOCTANEDIAMIDE; N1 (4 ((4 CHLORO 3 FLUOROPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N6 HYDROXYADIPAMIDE; N1 (4 ((4 CHLORO 3 FLUOROPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N7 HYDROXYHEPTANEDIAMIDE; N1 (4 ((4 CHLORO 3 FLUOROPHENYL)AMINO)THIENO[2,3 D]PYRIMIDIN 6 YL) N8 HYDROXYOCTANEDIAMIDE; N1 HYDROXY N7 (4 (4 TOLYLAMINO)THIENO[2,3 D]PYRIMIDIN 6 YL)HEPTANEDIAMIDE; N1 HYDROXY N7 (4 (PHENYLAMINO)THIENO[2,3 D]PYRIMIDIN 6 YL)HEPTANEDIAMIDE; N1 HYDROXY N8 (4 (4 TOLYLAMINO)THIENO[2,3 D]PYRIMIDIN 6 YL)OCTANEDIAMIDE; N1 HYDROXY N8 (4 (PHENYLAMINO)THIENO[2,3 D]PYRIMIDIN 6 YL)OCTANEDIAMIDE; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT; ANTINEOPLASTIC AGENT; HISTONE DEACETYLASE; HYDROXAMIC ACID; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HCT116 CELL LINE; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; RMPI8226 CELL LINE; UPREGULATION; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; METABOLISM; NEOPLASMS; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MOLECULAR DOCKING SIMULATION; NEOPLASMS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908461603     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.08.030     Document Type: Article

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