Annona muricata leaves induce G1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells

Journal of Ethnopharmacology

Volumn 156, Issue , 2014, Pages 277-289

  Zorofchian Moghadamtousi, Soheil ^a   Karimian, Hamed ^b   Rouhollahi, Elham ^b   Paydar, Mohammadjavad ^b   Fadaeinasab, Mehran ^b   Abdul Kadir, Habsah ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Annona muricata; Apoptosis; Colon cancer; Invasion; Migration; Mitochondria

Indexed keywords

ACETIC ACID ETHYL ESTER; ANNONA MURICATA EXTRACT; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; FLUOROURACIL; LACTATE DEHYDROGENASE; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; CASPASE; PLANT EXTRACT;

ANNONA MURICATA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE S PHASE; CELL DEATH; CELL INVASION; CELL MEMBRANE PERMEABILITY; CELL MIGRATION; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HCT116 CELL LINE; HT 29 CELL LINE; HUMAN; IC50; IMMUNOFLUORESCENCE; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MTT ASSAY; NONHUMAN; OXIDATIVE STRESS; PLANT LEAF; PROTEIN EXPRESSION; UPREGULATION; ANNONA; CHEMISTRY; COLONIC NEOPLASMS; DRUG EFFECTS; METABOLISM; TUMOR CELL LINE;

ANNONA; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; CYTOCHROMES C; DOWN-REGULATION; G1 PHASE CELL CYCLE CHECKPOINTS; HCT116 CELLS; HT29 CELLS; HUMANS; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PLANT EXTRACTS; PLANT LEAVES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; UP-REGULATION;

EID: 84908457155     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.08.011     Document Type: Article

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