A signaling network stimulated by β2 integrin promotes the polarization of lytic granules in cytotoxic cells

Science Signaling

Volumn 7, Issue 346, 2014, Pages ra96-

  Zhang, Minggang ^a   March, Michael E ^a,c   Lane, William S ^b   Long, Eric O ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b HARVARD UNIVERSITY   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD18 ANTIGEN; FOCAL ADHESION KINASE 2; IMMUNOGLOBULIN G1; INTEGRIN LINKED KINASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2; JANUS KINASE 1; JANUS KINASE 3; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PAXILLIN; PHOSPHATIDYLINOSITOL 3 KINASE; INTEGRIN-LINKED KINASE; ORGANIC COMPOUND; PARD6A PROTEIN, HUMAN; PKH67; PROTEIN CDC42; PROTEIN SERINE THREONINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA;

ARTICLE; BIOINFORMATICS; CELL MEDIATED CYTOTOXICITY; CELL MIGRATION; CELL POLARITY; CELL SURFACE; CONJUGATION; CONTROLLED STUDY; DEGRANULATION; FOCAL ADHESION; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOLOGICAL SYNAPSE; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MICROTUBULE ORGANIZING CENTER; NATURAL KILLER CELL; POLARIZATION; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; PROTEOMICS; SIGNAL TRANSDUCTION; TARGET CELL; WESTERN BLOTTING; ANALYSIS OF VARIANCE; CELL GRANULE; CONFOCAL MICROSCOPY; CYTOTOXIC T LYMPHOCYTE; GENE SILENCING; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PROCEDURES; REAL TIME POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANALYSIS OF VARIANCE; ANTIGENS, CD18; BLOTTING, WESTERN; CDC42 GTP-BINDING PROTEIN; CELL POLARITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOPLASMIC GRANULES; FOCAL ADHESION KINASE 2; GENE KNOCKDOWN TECHNIQUES; HUMANS; KILLER CELLS, NATURAL; MICROSCOPY, CONFOCAL; MICROTUBULE-ORGANIZING CENTER; ORGANIC CHEMICALS; PAXILLIN; PROTEIN-SERINE-THREONINE KINASES; PROTEOMICS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC; TANDEM MASS SPECTROMETRY;

EID: 84908455770     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005629     Document Type: Article

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