Cutting edge: Functional role for proline-rich tyrosine kinase 2 in NK cell-mediated natural cytotoxicity

Journal of Immunology

Volumn 164, Issue 5, 2000, Pages 2272-2276

  Gismondi, Angela ^a   Jacobelli, Jordan ^a   Mainiero, Fabrizio ^a   Paolini, Rossella ^a   Piccoli, Mario ^a   Frati, Luigi ^a,b   Santoni, Angela ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Mediterranean Institute of Neuroscience   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; FOCAL ADHESION KINASE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; PROLINE DERIVATIVE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOUSE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VACCINIA VIRUS; VIRUS RECOMBINANT;

EID: 0034162592     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.5.2272     Document Type: Article

References (24)

1. 2+-induced regulation of ion channel and MAP kinase functions. Nature 376:737.
2. Avraham, S., R. London, Y. Fu, S. Ota, D. Hiregowdara, J. Li, S. Jiang, L. M. Pasztor, R. A. White, J.E. Groopman, and H. Avraham. 1995. Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J. Biol. Chem. 270:27742.
3. cas. J. Biol. Chem. 272:228.
4. Salgia, R., S. Avraham, E. Pisick, J.-L. Lee, S. Raja, E. A. Greenfield, M. Sattle, H. Avraham, and J. D. Griffin. 1996. The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells. J. Biol. Chem. 271:31222.
5. Ganju, R. K., W. C. Hatch, H. Avraham, M. A. Ona, B. Druker, S. Avraham, and J. I. Groopman. 1997. RAFTK, a novel member of the focal adhesion kinase family is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes. J. Exp. Med. 185:1055.
6. 1 integrin fibronectin receptor cross-linking and association with paxillin in human natural killer cells. J. Immunol. 159:4729.
7. Okazaki, H., J. Zhang, M. M. Hamawy, and R. P. Siraganian. 1997. Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in Fc∈RI signaling. J. Biol. Chem. 272:12443.
8. Dikic, I., I. Dikic, and J. Schlessinger. 1998. Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling. J. Biol. Chem. 273: 14301.
9. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47:187.
10. Leibson, P. J. 1997. Signal transduction during natural killer cell activation: inside the mind of a killer. Immunity 6:655.
11. Brumbaugh, K. M., B. A. Binstadt, D. D. Billadeau, R. A. Schoon, C. J. Dick, R. M. Ten, and P. J. Leibson. 1997. Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity. J. Exp. Med. 186:1965.
12. Billadeau, D. D., K. M. Brumbaugh, C. J. Dick, R. A. Schoon, X. R. Bustelo, and P. J. Leibson. 1998. The Vav-Racl pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing. J. Exp. Med. 188:549.
13. Galandrini, R., G. Palmieri, M. Piccoli, L. Frati, and A. Santoni. 1999. Role for the Rac1 exchange factor Vav in the signaling pathways leading to NK cell cytotoxicity. J. Immunol. 162:3148.
14. Milella, M., A. Gismondi, P. Roncaioli, L. Bisogno, G. Palmieri, L. Frati, M. G. Cifone, and A. Santoni. 1997. CD16 cross-linking induces both secretory and extracellular signal-regulated kinase (ERK)-dependent cytosolic phospholipase A2 (PLA2) activity in human natural killer cells: involvement of Erk, but not PLA2, in CD16-triggered granule exocytosis. J. Immunol. 158:3148.
15. Trotta, R., K. A. Puorro, M. Paroli, L. Azzoni, B. Abebe, L. C. Eisenlohr, and B. Perussia. 1998. Dependence of both spontaneous and antibody-dependent, granule exocytosis-mediated NK cell cytotoxicity on extracellular signal-regulated kinases. J. Immunol. 152:6648.
16. Wei, S., A. M. Gamero, J. Hong Liu, A. A. Daulton, N. I. Valkov, J. A. Trapani, A. C. Larner, M. J. Weber, and J. Y. Djeu. 1998. Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (Erk2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2. J. Exp. Med. 187:1753.
17. Jevremovic, D., D. D. Billadeau, R. A. Schoon, C. J. Dick, B. J. Irwin, W. Zhang, L. E. Samelson, R. T. Abraham, and P. J. Leibson. 1999. A role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. J. Immunol. 162:2453.
18. Bonnema, J. D., L. M. Karnitz, R. A. Schoon, R. T. Abraham, P. J. Leibson. 1994. Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. J. Exp. Med. 180:1427.
19. Mainiero, F., A. Gismondi, A. Soriani, M. Cippitelli, G. Palmieri, J. Jacobelli, M. Piccoli, L. Frati, and A. Santoni. 1998. Integrin-mediated Ras-extracellular regulated kinase (Erk) signaling regulates interferon γ production in human natural killer cells. J. Exp. Med. 188:1267.
20. Earl, P. L., N. Cooper, and B. N. Moss. 1991. Expression of proteins in mammalian cells using vaccinia viral vectors. In Current Protocols in Molecular Biology. F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl, eds. Green Publishing and Wiley-Interscience, New York, pp. 16.16-16.18.
21. 5β1 fibronectin receptors enhances natural killer cell cytotoxic activity. J. Immunol. 115:5314.
22. Helander, T. S., O. Carpen, O. Turunen, P. E. Kovanen, A. Vaheri, and T. Timonen. 1996. ICAM-2 redistributed by ezrin as a target for killer cells. Nature 382:265.
23. Timonen, T., M. Patarroyo, and C. G. Gahmberg. 1988. CD11a-c/CD18 and GP84 (LB-2) adhesion molecules on human large granular lymphocytes and their participation in natural killing. J. Immunol. 141:1041.
24. ras activation is associated with Shc and p36 tyrosine phosphorylation and their binding with Grb2 in human natural killer cells. J. Exp. Med. 183:179.