Constitutively polarized granules prime KHYG-1 NK cells

International Immunology

Volumn 18, Issue 9, 2006, Pages 1347-1354

  Suck, Garnet ^a,b,e   Branch, Donald R ^c,d   Aravena, Paola ^a   Mathieson, Mark ^c   Helke, Simone ^a   Keating, Armand ^a,b,c  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d CANADIAN BLOOD SERVICES   (Canada)

^e Johns Hopkins Singapore   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

DEMECOLCINE; MITOGEN ACTIVATED PROTEIN KINASE 1; NATURAL KILLER CELL RECEPTOR NKG2D; PROTEIN P44;

ARTICLE; CANCER CELL CULTURE; CELL CONTACT; CELL LINE; CONTROLLED STUDY; DEGRANULATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MICROTUBULE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; POLARIZATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; TARGET CELL; TUMOR CELL DESTRUCTION; TUMOR IMMUNITY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE; CYTOPLASMIC GRANULES; CYTOTOXICITY, IMMUNOLOGIC; DEMECOLCINE; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KILLER CELLS, NATURAL; MICROSCOPY, CONFOCAL; MICROTUBULES; MITOGEN-ACTIVATED PROTEIN KINASE 1; PROTEIN TRANSPORT; RECEPTORS, IMMUNOLOGIC;

EID: 33749026911     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxl071     Document Type: Article

References (20)

1. Orange, J. S. and Ballas, Z. K. 2006. Natural killer cells in human health and disease. Clin. Immunol. 118:1.
2. Vyas, Y. M., Maniar, H. and Dupont, B. 2002. Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses. Immunol. Rev. 189:161.
3. Jiang, K., Zhong, B., Gilvary, D. L. et al. 2000. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nat. Immunol. 1:419.
4. Yagita, M., Huang, C. L., Umehara, H. et al. 2000. A novel natural killer cell line (KHYG-1) from a patient with aggressive natural killer cell leukemia carrying a p53 point mutation. Leukemia 14:922.
5. Suck, G., Branch, D. R., Smyth, M. J. et al. 2005. KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity. Exp. Hematol. 33:1160.
6. Baetz, K., Isaaz, S. and Griffiths, G. M. 1995. Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis, J. Immunol. 154:6122.
7. Wei, S., Gamero, A. M., Liu, J. H. et al. 1998. Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: Identification of perforin and granzyme B mobilization by functional ERK2. J. Exp. Med. 187:1753.
8. Branch, D. R. and Mills, G. B. 1995. pp60c-src expression is induced by activation of normal human T lymphocytes. J. Immunol. 154:3678.
9. Kuhn, J. R. and Poenie, M. 2002. Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing. Immunity 16:111.
10. Bossi, G. and Griffiths, G. M. 2005. CTL secretory lysosomes: Biogenesis and secretion of a harmful organelle. Semin. Immunol. 17:87.
11. Dehmelt, L. and Halpain, S. 2005. The MAP2/Tau family of microtubule-associated proteins. Genome Biol. 6:204.
12. Katz, P., Zaytoun, A. M. and Lee, J. H. Jr. 1982. Mechanisms of human cell-mediated cytotoxicity. III. Dependence of natural killing on microtubule and microfilament integrity. J. Immunol. 129:2816.
13. Trotta, R., Puorro, K. A., Paroli, M. et al. 1998. Dependence of both spontaneous and antibody-dependent, granule exocytosis-mediated NK cell cytotoxicity on extracellular signal-regulated kinases. J. Immunol. 161:6648.
14. Bryceson, Y. T., March, M. E., Barber, D. F., Ljunggren, H. G. and Long, E. O. 2005. Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. J. Exp. Med. 202:1001.
15. Sablina, A. A., Chumakov, P. M., Levine, A. J. and Kopnin, B. P. 2001. p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling. Oncogene 20:899.
16. Matsumoto, G., Nghiem, M. P., Nozaki, N., Schmits, R. and Penninger, J. M. 1998. Cooperation between CD44 and LFA-1/CD11a adhesion receptors in lymphokine-activated killer cell cytotoxicity. J. Immunol. 160:5781.
17. Thompson, M. D., Burnham, W. M. and Cole, D. E. 2005. The G protein-coupled receptors: Pharmacogenetics and disease. Crit. Rev. Clin. Lab. Sci. 42:311.
18. Hanaoka, N., Kawaguchi, T., Horikawa, K., Nagakura, S., Mitsuya, H. and Nakakuma, H. 2006. Immunoselection by natural killer cells of PIGA mutant cells missing stress-inducible ULBP. Blood 107:1184.
19. Hanna, J., Gonen-Gross, T., Fitchett, J. et al. 2004. Novel APC-like properties of human NK cells directly regulate T cell activation. J. Clin. Invest. 114:1612.
20. Forte, P., Lilienfeld, B. G., Baumann, B. C. and Seebach, J. D. 2005. Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D. J. Immunol. 175:5463.