Effect of evodiagenine mediates photocytotoxicity on human breast cancer cells MDA-MB-231 through inhibition of PI3K/AKT/mTOR and activation of p38 pathways

Fitoterapia

Volumn 99, Issue 1, 2014, Pages 292-299

  Xu, Changliang ^a   Wang, Qizhi ^b   Feng, Xu ^b   Bo, Yun ^c  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b INSTITUTE OF BOTANY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Evodiagenine; p38; Photocytotoxicity; PI3K AKT mTOR

Indexed keywords

CYTOTOXIC AGENT; EVODIAGENINE; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NATURAL PRODUCT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOTOSENSITIZING AGENT; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; FUSED HETEROCYCLIC RINGS; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; MDA MB 231 CELL LINE; OXIDATIVE STRESS; PHOTOCYTOTOXICITY; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ULTRAVIOLET RADIATION; WESTERN BLOTTING; CHEMICAL STRUCTURE; DRUG EFFECTS; FEMALE; METABOLISM; PHOSPHORYLATION; PHOTOCHEMOTHERAPY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; MOLECULAR STRUCTURE; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PHOTOCHEMOTHERAPY; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; ULTRAVIOLET RAYS;

EID: 84908449218     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2014.10.010     Document Type: Article

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