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Volumn 162, Issue 1, 2015, Pages 74-86

The effects of rapamycin on regulatory T cells: Its potential time-dependent role in inducing transplant tolerance

Author keywords

Rapamycin; Regulatory T cells; Systematic review; Time dependent effects; Tolerance induction; Transplantation

Indexed keywords

ALEMTUZUMAB; AZATHIOPRINE; CALCINEURIN INHIBITOR; CYCLOSPORIN A; EVEROLIMUS; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY; IMMUNOSUPPRESSIVE AGENT;

EID: 84908432145     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2014.07.006     Document Type: Review
Times cited : (31)

References (73)
  • 1
    • 79959852905 scopus 로고    scopus 로고
    • Do CD4+Foxp3+ Treg cells correlate with transplant outcomes: a systematic review on recipients of solid organ transplantation
    • Shan J., Guo Y., Luo L., Lu J., Li C., Zhang C., et al. Do CD4+Foxp3+ Treg cells correlate with transplant outcomes: a systematic review on recipients of solid organ transplantation. Cell Immunol 2011, 270:5-12.
    • (2011) Cell Immunol , vol.270 , pp. 5-12
    • Shan, J.1    Guo, Y.2    Luo, L.3    Lu, J.4    Li, C.5    Zhang, C.6
  • 2
    • 84864278784 scopus 로고    scopus 로고
    • In vitro effects of cyclosporine A and tacrolimus on regulatory T-cell proliferation and function
    • Miroux C., Morales O., Ghazal K., Othman S.B., de Launoit Y., Pancré V., et al. In vitro effects of cyclosporine A and tacrolimus on regulatory T-cell proliferation and function. Transplantation 2012, 94(2):123-131.
    • (2012) Transplantation , vol.94 , Issue.2 , pp. 123-131
    • Miroux, C.1    Morales, O.2    Ghazal, K.3    Othman, S.B.4    de Launoit, Y.5    Pancré, V.6
  • 3
    • 0035886032 scopus 로고    scopus 로고
    • Rapamycin: clinical results and future opportunities
    • Kahan B.D., Camardo J.S. Rapamycin: clinical results and future opportunities. Transplantation 2001, 72:1181-1193.
    • (2001) Transplantation , vol.72 , pp. 1181-1193
    • Kahan, B.D.1    Camardo, J.S.2
  • 4
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia M., Stabilini A., Roncarolo M.G. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005, 105:4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 5
    • 34250156673 scopus 로고    scopus 로고
    • Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells
    • Gao W., Lu Y., El Essawy B., Oukka M., Kuchroo V.K., Strom T.B. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant 2007, 7(7):1722-1732.
    • (2007) Am J Transplant , vol.7 , Issue.7 , pp. 1722-1732
    • Gao, W.1    Lu, Y.2    El Essawy, B.3    Oukka, M.4    Kuchroo, V.K.5    Strom, T.B.6
  • 6
    • 79952750887 scopus 로고    scopus 로고
    • Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice
    • Wang Y., Camir G., Lin Y., Froicu M., Deng S., Shlomchik W.D. Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice. J Immunol 2011, 186:2809-2818.
    • (2011) J Immunol , vol.186 , pp. 2809-2818
    • Wang, Y.1    Camir, G.2    Lin, Y.3    Froicu, M.4    Deng, S.5    Shlomchik, W.D.6
  • 7
    • 77749324907 scopus 로고    scopus 로고
    • Rapamycin and tacrolimus differentially modulate acute graft-versus-host disease in rats after liver transplantation
    • Xu G., Wang L., Chen W., Xue F., Bai X., Liang L. Rapamycin and tacrolimus differentially modulate acute graft-versus-host disease in rats after liver transplantation. Liver Transplant 2010, 16(3):357-363.
    • (2010) Liver Transplant , vol.16 , Issue.3 , pp. 357-363
    • Xu, G.1    Wang, L.2    Chen, W.3    Xue, F.4    Bai, X.5    Liang, L.6
  • 8
    • 77953674618 scopus 로고    scopus 로고
    • Rapamycin promotes the expansion of CD4+Foxp3+ regulatory T cells after liver transplantation
    • Lu L., Qian X.F., Rao J.H., Wang X.H., Zheng S.G., Zhang F. Rapamycin promotes the expansion of CD4+Foxp3+ regulatory T cells after liver transplantation. Transplant Proc 2010, 42:1755-1757.
    • (2010) Transplant Proc , vol.42 , pp. 1755-1757
    • Lu, L.1    Qian, X.F.2    Rao, J.H.3    Wang, X.H.4    Zheng, S.G.5    Zhang, F.6
  • 9
    • 84862934566 scopus 로고    scopus 로고
    • Rapamycin combined with donor immature dendritic cells promotes liver allograft survival in association with CD4+CD25+Foxp3+ regulatory T cell expansion
    • Wang G.Y., Yang Y., Li H., Zhang J., Li M.R., Zhang Q. Rapamycin combined with donor immature dendritic cells promotes liver allograft survival in association with CD4+CD25+Foxp3+ regulatory T cell expansion. Hepatol Res 2012, 42:192-202.
    • (2012) Hepatol Res , vol.42 , pp. 192-202
    • Wang, G.Y.1    Yang, Y.2    Li, H.3    Zhang, J.4    Li, M.R.5    Zhang, Q.6
  • 10
    • 33845915103 scopus 로고    scopus 로고
    • Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin
    • Strauss L., Whiteside T.L., Knights A., Bergmann C., Knuth A., Zippelius A. Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin. J Immunol 2007, 178:320-329.
    • (2007) J Immunol , vol.178 , pp. 320-329
    • Strauss, L.1    Whiteside, T.L.2    Knights, A.3    Bergmann, C.4    Knuth, A.5    Zippelius, A.6
  • 11
    • 67650105331 scopus 로고    scopus 로고
    • Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin
    • Strauss L., Czystowska M., Szajnik M., Mandapathil M., Whiteside T.L. Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin. PLos ONE 2009, 4(6):e5994.
    • (2009) PLos ONE , vol.4 , Issue.6 , pp. e5994
    • Strauss, L.1    Czystowska, M.2    Szajnik, M.3    Mandapathil, M.4    Whiteside, T.L.5
  • 12
    • 77951295311 scopus 로고    scopus 로고
    • Impact of immunosuppressants on the therapeutic efficacy of in vitro-expanded CD4+CD25+Foxp3+ regulatory T cells in allotransplantation
    • Lim D.G., Koo S.K., Park Y.H., Kim Y., Kim H.M., Park C.S. Impact of immunosuppressants on the therapeutic efficacy of in vitro-expanded CD4+CD25+Foxp3+ regulatory T cells in allotransplantation. Transplantation 2010, 89:928-936.
    • (2010) Transplantation , vol.89 , pp. 928-936
    • Lim, D.G.1    Koo, S.K.2    Park, Y.H.3    Kim, Y.4    Kim, H.M.5    Park, C.S.6
  • 13
    • 79954633673 scopus 로고    scopus 로고
    • Adoptive transfer of CD4+CD25+ regulatory cells combined with low-dose sirolimus and anti-thymocyte globulin delays acute rejection of renal allografts in Cynomolgus monkeys
    • Ma A., Qi S., Song L., Hu Y., Dun H., Massicotte E. Adoptive transfer of CD4+CD25+ regulatory cells combined with low-dose sirolimus and anti-thymocyte globulin delays acute rejection of renal allografts in Cynomolgus monkeys. Int Immunopharmacol 2011, 11(5):618-629.
    • (2011) Int Immunopharmacol , vol.11 , Issue.5 , pp. 618-629
    • Ma, A.1    Qi, S.2    Song, L.3    Hu, Y.4    Dun, H.5    Massicotte, E.6
  • 14
    • 63649085948 scopus 로고    scopus 로고
    • Combined therapy of CD4+CD25+ regulatory T cells with low-dose sirolimus, but not calcineurin inhibitors, preserves suppressive function of regulatory T cells and prolongs allograft survival in mice
    • Ma A., Qi S., Wang Z., Massicotte E., Dupuis M., Daloze P. Combined therapy of CD4+CD25+ regulatory T cells with low-dose sirolimus, but not calcineurin inhibitors, preserves suppressive function of regulatory T cells and prolongs allograft survival in mice. Int Immunopharmacol 2009, 9:553-563.
    • (2009) Int Immunopharmacol , vol.9 , pp. 553-563
    • Ma, A.1    Qi, S.2    Wang, Z.3    Massicotte, E.4    Dupuis, M.5    Daloze, P.6
  • 15
    • 34047130792 scopus 로고    scopus 로고
    • Rapamycin enriches for CD4+CD25+CD27+ Foxp3+ regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple sclerosis
    • Keever-Taylor C.A., Browning M.B., Johnson B.D., Truitt R.L., Bredeson C.N., Behn B. Rapamycin enriches for CD4+CD25+CD27+ Foxp3+ regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple sclerosis. Cytotherapy 2007, 9(2):144-157.
    • (2007) Cytotherapy , vol.9 , Issue.2 , pp. 144-157
    • Keever-Taylor, C.A.1    Browning, M.B.2    Johnson, B.D.3    Truitt, R.L.4    Bredeson, C.N.5    Behn, B.6
  • 16
    • 44449100271 scopus 로고    scopus 로고
    • Cutting edge: Foxp3-mediated induction of Pim-2 allows human T regulatory cells to preferentially expand in rapamycin
    • Basu S., Golovina T., Mikheeva T., June C.H., Riley J.L. Cutting edge: Foxp3-mediated induction of Pim-2 allows human T regulatory cells to preferentially expand in rapamycin. J Immunol 2008, 180:5794-5798.
    • (2008) J Immunol , vol.180 , pp. 5794-5798
    • Basu, S.1    Golovina, T.2    Mikheeva, T.3    June, C.H.4    Riley, J.L.5
  • 17
    • 77958545416 scopus 로고    scopus 로고
    • Number of peripheral blood regulatory T cells and lymphocyte activation at 3 months after conversion to mtor inhibitor therapy
    • San Segundo D., Fernández-Fresnedo G., Gago M., Beares I., Ruiz-Criado J., González M. Number of peripheral blood regulatory T cells and lymphocyte activation at 3 months after conversion to mtor inhibitor therapy. Transplant Proc 2010, 42(8):2871-2873.
    • (2010) Transplant Proc , vol.42 , Issue.8 , pp. 2871-2873
    • San Segundo, D.1    Fernández-Fresnedo, G.2    Gago, M.3    Beares, I.4    Ruiz-Criado, J.5    González, M.6
  • 18
    • 36049021889 scopus 로고    scopus 로고
    • The influence of immuosuppressive therapy on the development of CD4+CD25+T cells after renal transplantation
    • Korczak-Kowalska G., Wierzbicki P., Bocian K., Klosowska D., Niemczyk M., Wyzgal J., et al. The influence of immuosuppressive therapy on the development of CD4+CD25+T cells after renal transplantation. Transplant Proc 2007, 39(9):2721-2723.
    • (2007) Transplant Proc , vol.39 , Issue.9 , pp. 2721-2723
    • Korczak-Kowalska, G.1    Wierzbicki, P.2    Bocian, K.3    Klosowska, D.4    Niemczyk, M.5    Wyzgal, J.6
  • 20
    • 37349080895 scopus 로고    scopus 로고
    • Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal transplant patients given alemtuzumab induction from chronic allograft injury
    • Ruggenenti P., Perico N., Gotti E., Cravedi P., D'Agati V., Gagliardini E., et al. Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal transplant patients given alemtuzumab induction from chronic allograft injury. Transplantation 2007, 84(8):956-964.
    • (2007) Transplantation , vol.84 , Issue.8 , pp. 956-964
    • Ruggenenti, P.1    Perico, N.2    Gotti, E.3    Cravedi, P.4    D'Agati, V.5    Gagliardini, E.6
  • 22
    • 79960139581 scopus 로고    scopus 로고
    • The effect of the different immunosuppression therapy on CD4(+)Foxp3(+) Treg cells in kidney recipients
    • Mo C.B., Song W.L., Wang Z.P., Zheng J.M., Fu Y.X., Feng G., et al. The effect of the different immunosuppression therapy on CD4(+)Foxp3(+) Treg cells in kidney recipients. Zhonghua wai ke za zhi [Chinese J Surg] 2009, 47(22):1741-1743.
    • (2009) Zhonghua wai ke za zhi [Chinese J Surg] , vol.47 , Issue.22 , pp. 1741-1743
    • Mo, C.B.1    Song, W.L.2    Wang, Z.P.3    Zheng, J.M.4    Fu, Y.X.5    Feng, G.6
  • 24
    • 79953800720 scopus 로고    scopus 로고
    • Costimulatory blockade with mTor inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation
    • Bestard O., Cassis L., Cruzado J.M., Torras J., Franquesa M., Gil-Vernet S., et al. Costimulatory blockade with mTor inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation. Transpl Int 2011, 24(5):451-460.
    • (2011) Transpl Int , vol.24 , Issue.5 , pp. 451-460
    • Bestard, O.1    Cassis, L.2    Cruzado, J.M.3    Torras, J.4    Franquesa, M.5    Gil-Vernet, S.6
  • 25
    • 80051556040 scopus 로고    scopus 로고
    • Monitoring of CD4+CD25highIL-7R (alpha) high-activated T cells in kidney transplant recipients
    • Vallotton L., Hadaya K., Venetz J.P., Buehler L.H., Ciuffreda D., Nseir G., et al. Monitoring of CD4+CD25highIL-7R (alpha) high-activated T cells in kidney transplant recipients. Clin J Am Soc Nephrol 2011, 6(8):2025-2033.
    • (2011) Clin J Am Soc Nephrol , vol.6 , Issue.8 , pp. 2025-2033
    • Vallotton, L.1    Hadaya, K.2    Venetz, J.P.3    Buehler, L.H.4    Ciuffreda, D.5    Nseir, G.6
  • 26
    • 84873287283 scopus 로고    scopus 로고
    • Comparison of regulatory T cells and FoxP3-positive T-cell subsets in the peripheral blood of renal transplant recipients with sirolimus versus cyclosporine: a preliminary study
    • Zhao T., Yang C., Qiu Y., Xue Y., Zhao Z., Song D., et al. Comparison of regulatory T cells and FoxP3-positive T-cell subsets in the peripheral blood of renal transplant recipients with sirolimus versus cyclosporine: a preliminary study. Transplant Proc 2013, 45(1):148-152.
    • (2013) Transplant Proc , vol.45 , Issue.1 , pp. 148-152
    • Zhao, T.1    Yang, C.2    Qiu, Y.3    Xue, Y.4    Zhao, Z.5    Song, D.6
  • 27
    • 84859240217 scopus 로고    scopus 로고
    • Cyclosporin but not everolimus inhibits chemokine receptor expression on CD4+ T cell subsets circulating in the peripheral blood of renal transplant recipients
    • Hoerning A., Kohler S., Jun C., Lu J., Fu J., Tebbe B., et al. Cyclosporin but not everolimus inhibits chemokine receptor expression on CD4+ T cell subsets circulating in the peripheral blood of renal transplant recipients. Clin Exp Immunol 2012, 168(2):251-259.
    • (2012) Clin Exp Immunol , vol.168 , Issue.2 , pp. 251-259
    • Hoerning, A.1    Kohler, S.2    Jun, C.3    Lu, J.4    Fu, J.5    Tebbe, B.6
  • 28
    • 61349091633 scopus 로고    scopus 로고
    • Immunoregulatory profiles in liver transplant recipients on different immunosuppressive agents
    • Levitsky J., Miller J., Wang E., Rosen A., Flaa C., Abecassis M., et al. Immunoregulatory profiles in liver transplant recipients on different immunosuppressive agents. Hum Immunol 2009, 70(3):146-150.
    • (2009) Hum Immunol , vol.70 , Issue.3 , pp. 146-150
    • Levitsky, J.1    Miller, J.2    Wang, E.3    Rosen, A.4    Flaa, C.5    Abecassis, M.6
  • 29
    • 77956464307 scopus 로고    scopus 로고
    • Influence of immunosuppressive drugs on the development of CD4(+)CD25(high) Foxp3(+) T cells in liver transplant recipients
    • Chu Z., Zhang J., Zhao Y., Ji Q., Zhong J., Zhang C., et al. Influence of immunosuppressive drugs on the development of CD4(+)CD25(high) Foxp3(+) T cells in liver transplant recipients. Transplant Proc 2010, 42(7):2599-2601.
    • (2010) Transplant Proc , vol.42 , Issue.7 , pp. 2599-2601
    • Chu, Z.1    Zhang, J.2    Zhao, Y.3    Ji, Q.4    Zhong, J.5    Zhang, C.6
  • 30
    • 84870570002 scopus 로고    scopus 로고
    • Differing effects of rapamycin or calcineurin inhibitor on T-regulatory cells in pediatric liver and kidney transplant recipients
    • Akimova T., Kamath B.M., Goebel J.W., Meyers K.E., Rand E.B., Hawkins A., et al. Differing effects of rapamycin or calcineurin inhibitor on T-regulatory cells in pediatric liver and kidney transplant recipients. Am J Transplant 2012, 12(12):3449-3461.
    • (2012) Am J Transplant , vol.12 , Issue.12 , pp. 3449-3461
    • Akimova, T.1    Kamath, B.M.2    Goebel, J.W.3    Meyers, K.E.4    Rand, E.B.5    Hawkins, A.6
  • 31
    • 84863295985 scopus 로고    scopus 로고
    • Successful resolution of inflammation and increased regulatory T cells in sirolimus-treated post-transplant allograft hepatitis
    • Ekong U.D., Mathew J., Melin-Aldana H., Wang D., Alonso E.M. Successful resolution of inflammation and increased regulatory T cells in sirolimus-treated post-transplant allograft hepatitis. Pediatr Transplant 2012, 16(2):165-175.
    • (2012) Pediatr Transplant , vol.16 , Issue.2 , pp. 165-175
    • Ekong, U.D.1    Mathew, J.2    Melin-Aldana, H.3    Wang, D.4    Alonso, E.M.5
  • 32
    • 75149182766 scopus 로고    scopus 로고
    • Increased frequency of regulatory T Cells and selection of highly potent CD62L+ cells during treatment of human lung transplant recipients with rapamycin
    • Lange C.M., Tran T.Y.V., Farnik H., Jungblut S., Born T., Wagner T.O., et al. Increased frequency of regulatory T Cells and selection of highly potent CD62L+ cells during treatment of human lung transplant recipients with rapamycin. Transpl Int 2010, 23(3):266-276.
    • (2010) Transpl Int , vol.23 , Issue.3 , pp. 266-276
    • Lange, C.M.1    Tran, T.Y.V.2    Farnik, H.3    Jungblut, S.4    Born, T.5    Wagner, T.O.6
  • 33
    • 2442637772 scopus 로고    scopus 로고
    • Shevach IL-2 Is critically required for the in vitro activation of CD4+CD25+T cell suppressor function
    • Thornton A.M., Donovan E.E., Piccirillo C.A., Ethan M. Shevach IL-2 Is critically required for the in vitro activation of CD4+CD25+T cell suppressor function. J Immunol 2004, 172:6519-6523.
    • (2004) J Immunol , vol.172 , pp. 6519-6523
    • Thornton, A.M.1    Donovan, E.E.2    Piccirillo, C.A.3    Ethan, M.4
  • 34
    • 0026503434 scopus 로고
    • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A
    • Fruman D.A., Klee C.B., Bierer B.E., Burakoff S.J. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci USA 1992, 89(9):3686-3690.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.9 , pp. 3686-3690
    • Fruman, D.A.1    Klee, C.B.2    Bierer, B.E.3    Burakoff, S.J.4
  • 35
    • 79959852905 scopus 로고    scopus 로고
    • Do CD4+Foxp3+ Treg cells correlate with transplant outcomes: a systematic review on recipients of solid organ transplantation?
    • Shan J., Guo Y., Luo L., Lu J., Li C., Zhang C. Do CD4+Foxp3+ Treg cells correlate with transplant outcomes: a systematic review on recipients of solid organ transplantation?. Cell Immunol 2011, 270:5-12.
    • (2011) Cell Immunol , vol.270 , pp. 5-12
    • Shan, J.1    Guo, Y.2    Luo, L.3    Lu, J.4    Li, C.5    Zhang, C.6
  • 36
    • 77955395369 scopus 로고    scopus 로고
    • A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model
    • D'Addio F., Yuan X., Habicht A., Williams J., Ruzek M., Iacomini J. A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model. Transplantation 2010, 90:260-269.
    • (2010) Transplantation , vol.90 , pp. 260-269
    • D'Addio, F.1    Yuan, X.2    Habicht, A.3    Williams, J.4    Ruzek, M.5    Iacomini, J.6
  • 37
    • 79954762251 scopus 로고    scopus 로고
    • Generation of adaptive regulatory T cells by alloantigen is required for some but not all transplant tolerance protocols
    • Kim J.I., O'Connor M.R., Duff P.E., Zhao G., Lee K.M., liades P.E. Generation of adaptive regulatory T cells by alloantigen is required for some but not all transplant tolerance protocols. Transplantation 2011, 91:707-713.
    • (2011) Transplantation , vol.91 , pp. 707-713
    • Kim, J.I.1    O'Connor, M.R.2    Duff, P.E.3    Zhao, G.4    Lee, K.M.5    liades, P.E.6
  • 38
    • 41749112206 scopus 로고    scopus 로고
    • Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation
    • Liu Y., Chen Y., Liu F.Q., Lamb J.R., Tam P.K. Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation. Transpl Int 2008, 21(5):483-494.
    • (2008) Transpl Int , vol.21 , Issue.5 , pp. 483-494
    • Liu, Y.1    Chen, Y.2    Liu, F.Q.3    Lamb, J.R.4    Tam, P.K.5
  • 39
    • 63649085948 scopus 로고    scopus 로고
    • Combined therapy of CD4+CD25+ regulatory T cells with low-dose sirolimus, but not calcineurin inhibitors, preserves suppressive function of regulatory T cells and prolongs allograft survival in mice
    • Ma A., Qi S., Wang Z., Massicotte E., Dupuis M., Daloze P. Combined therapy of CD4+CD25+ regulatory T cells with low-dose sirolimus, but not calcineurin inhibitors, preserves suppressive function of regulatory T cells and prolongs allograft survival in mice. Int Immunopharmacol 2009, 9(5):553-563.
    • (2009) Int Immunopharmacol , vol.9 , Issue.5 , pp. 553-563
    • Ma, A.1    Qi, S.2    Wang, Z.3    Massicotte, E.4    Dupuis, M.5    Daloze, P.6
  • 40
    • 78049512513 scopus 로고    scopus 로고
    • Combined administration of a mutant TGF-beta1/Fc and rapamycin promotes induction of regulatory T cells and islet allograft tolerance
    • Zhang W., Zhang D., Shen M., Liu Y., Tian Y., Thomson A.W. Combined administration of a mutant TGF-beta1/Fc and rapamycin promotes induction of regulatory T cells and islet allograft tolerance. J Immunol 2010, 185:4750-4759.
    • (2010) J Immunol , vol.185 , pp. 4750-4759
    • Zhang, W.1    Zhang, D.2    Shen, M.3    Liu, Y.4    Tian, Y.5    Thomson, A.W.6
  • 41
    • 77955909935 scopus 로고    scopus 로고
    • Anti-CD154 mAB and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation
    • Muller Y.D., Mai G., Morel P., Serre-Beinier V., Gonelle-Gispert C., Yung G.P. Anti-CD154 mAB and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation. PLoS ONE 2010, 5(4):e10352.
    • (2010) PLoS ONE , vol.5 , Issue.4 , pp. e10352
    • Muller, Y.D.1    Mai, G.2    Morel, P.3    Serre-Beinier, V.4    Gonelle-Gispert, C.5    Yung, G.P.6
  • 42
    • 83055173312 scopus 로고    scopus 로고
    • Rapamycin combined with anti-CD45RB mAB and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation
    • Gagliani N., Gregori S., Jofra T., Valle A., Stabilini A., Rothstein D.M. Rapamycin combined with anti-CD45RB mAB and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation. PLoS ONE 2011, 6(12):e28434.
    • (2011) PLoS ONE , vol.6 , Issue.12 , pp. e28434
    • Gagliani, N.1    Gregori, S.2    Jofra, T.3    Valle, A.4    Stabilini, A.5    Rothstein, D.M.6
  • 43
    • 84864463754 scopus 로고    scopus 로고
    • Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo
    • Hester J., Schiopu A., Nadig S.N., Wood K.J. Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo. Am J Transplant 2013, 12(8):2008-2016.
    • (2013) Am J Transplant , vol.12 , Issue.8 , pp. 2008-2016
    • Hester, J.1    Schiopu, A.2    Nadig, S.N.3    Wood, K.J.4
  • 44
    • 38049177784 scopus 로고    scopus 로고
    • Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
    • Zeiser R., Dennis B., Leveson-Gower D.B., Kambham N., Beilhack A., Loh J. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood 2008, 111:453-462.
    • (2008) Blood , vol.111 , pp. 453-462
    • Zeiser, R.1    Dennis, B.2    Leveson-Gower, D.B.3    Kambham, N.4    Beilhack, A.5    Loh, J.6
  • 45
    • 53149092106 scopus 로고    scopus 로고
    • CD28 costimulation is essential for human T regulatory expansion and function
    • Golovina T.N., Mikheeva T., Suhoski M.M., Aqui N.A., Tai V.C., Shan X. CD28 costimulation is essential for human T regulatory expansion and function. J Immunol 2008, 181:2855-2868.
    • (2008) J Immunol , vol.181 , pp. 2855-2868
    • Golovina, T.N.1    Mikheeva, T.2    Suhoski, M.M.3    Aqui, N.A.4    Tai, V.C.5    Shan, X.6
  • 46
    • 36048954800 scopus 로고    scopus 로고
    • Effect of immunosuppressants on the expansion and function of naturally occurring regulatory T cells
    • Lim D.G., Joe I.-Y., Park Y.-H., Chang S.H., Wee Y.M., Han D.J. Effect of immunosuppressants on the expansion and function of naturally occurring regulatory T cells. Transpl Immunol 2007, 18:94-100.
    • (2007) Transpl Immunol , vol.18 , pp. 94-100
    • Lim, D.G.1    Joe, I.-Y.2    Park, Y.-H.3    Chang, S.H.4    Wee, Y.M.5    Han, D.J.6
  • 47
    • 33845379986 scopus 로고    scopus 로고
    • Rapamycin promotes expansion of functional CD4 +CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
    • Battaglia M., Stabilini A., Migliavacca B., Horejs-Hoeck J., Kaupper T., Roncarolo M.G. Rapamycin promotes expansion of functional CD4 +CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol 2006, 177:8338-8347.
    • (2006) J Immunol , vol.177 , pp. 8338-8347
    • Battaglia, M.1    Stabilini, A.2    Migliavacca, B.3    Horejs-Hoeck, J.4    Kaupper, T.5    Roncarolo, M.G.6
  • 48
    • 49349095817 scopus 로고    scopus 로고
    • Clinical-grade preparation of human natural regulatory T-cells encoding the thymidine kinase suicide gene as a safety gene
    • Guillot-Delost M., Cheraï M., Hamel Y., Rosenzwajg M., et al. Clinical-grade preparation of human natural regulatory T-cells encoding the thymidine kinase suicide gene as a safety gene. J Gene Med 2008, 10:834-846.
    • (2008) J Gene Med , vol.10 , pp. 834-846
    • Guillot-Delost, M.1    Cheraï, M.2    Hamel, Y.3    Rosenzwajg, M.4
  • 50
    • 79251589897 scopus 로고    scopus 로고
    • Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human t regulatory cells
    • Golovina T.N., Mikheeva T., Brusko T.M., Blazar B.R., Bluestone J.A., Riley J.L. Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human t regulatory cells. PLoS ONE 2011, 6(1):e15868.
    • (2011) PLoS ONE , vol.6 , Issue.1 , pp. e15868
    • Golovina, T.N.1    Mikheeva, T.2    Brusko, T.M.3    Blazar, B.R.4    Bluestone, J.A.5    Riley, J.L.6
  • 51
    • 31544482746 scopus 로고    scopus 로고
    • Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+subset of human CD4+CD25+ regulatory T cells
    • Coenen J.J.A., Koenen H.J.P.M., van Rijssen E., Hilbrands L.B., Joosten I. Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+subset of human CD4+CD25+ regulatory T cells. Blood 2006, 107:1018-1023.
    • (2006) Blood , vol.107 , pp. 1018-1023
    • Coenen, J.J.A.1    Koenen, H.J.P.M.2    van Rijssen, E.3    Hilbrands, L.B.4    Joosten, I.5
  • 52
    • 78650188983 scopus 로고    scopus 로고
    • An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
    • Procaccini C., De Rosa V., Galgani M., et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 2010, 33:929-941.
    • (2010) Immunity , vol.33 , pp. 929-941
    • Procaccini, C.1    De Rosa, V.2    Galgani, M.3
  • 53
    • 40049087686 scopus 로고    scopus 로고
    • STAT5-signaling cytokines regulate the expression of FOXP3 in CD41CD251 regulatory T cells and CD4+CD25+ effector T cells
    • Passerini L., Allan S.E., Battaglia M., Di Nunzio S., Alstad A.N., Levings M.K. STAT5-signaling cytokines regulate the expression of FOXP3 in CD41CD251 regulatory T cells and CD4+CD25+ effector T cells. Int Immunol 2008, 20(3):421-431.
    • (2008) Int Immunol , vol.20 , Issue.3 , pp. 421-431
    • Passerini, L.1    Allan, S.E.2    Battaglia, M.3    Di Nunzio, S.4    Alstad, A.N.5    Levings, M.K.6
  • 54
    • 84859810622 scopus 로고    scopus 로고
    • Ex-vivo expanded baboon CD4+ CD25 Hi Treg cells suppress baboon anti-pig T and B cell immune response
    • Singh A.K., Seavey C.N., Horvath K.A., Mohiuddin M.M. Ex-vivo expanded baboon CD4+ CD25 Hi Treg cells suppress baboon anti-pig T and B cell immune response. Xenotransplantation 2012, 19(2):102-111.
    • (2012) Xenotransplantation , vol.19 , Issue.2 , pp. 102-111
    • Singh, A.K.1    Seavey, C.N.2    Horvath, K.A.3    Mohiuddin, M.M.4
  • 55
    • 84861813492 scopus 로고    scopus 로고
    • Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus
    • Singh K., Kozyr N., Stempora L., Kirk A.D., Larsen C.P., Blazar B.R., et al. Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus. Am J Transplant 2012, 12(6):1441-1457.
    • (2012) Am J Transplant , vol.12 , Issue.6 , pp. 1441-1457
    • Singh, K.1    Kozyr, N.2    Stempora, L.3    Kirk, A.D.4    Larsen, C.P.5    Blazar, B.R.6
  • 56
    • 35748956420 scopus 로고    scopus 로고
    • Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
    • Kopf H., de la Rosa G.M., Howard O.M., Chen X. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. Int Immunopharmacol 2007, 7(13):1819-1824.
    • (2007) Int Immunopharmacol , vol.7 , Issue.13 , pp. 1819-1824
    • Kopf, H.1    de la Rosa, G.M.2    Howard, O.M.3    Chen, X.4
  • 58
    • 41149113441 scopus 로고    scopus 로고
    • The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+cells
    • Haxhinasto S., Mathis D., Benoist C. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+cells. J Exp Med 2008, 205(3):565-574.
    • (2008) J Exp Med , vol.205 , Issue.3 , pp. 565-574
    • Haxhinasto, S.1    Mathis, D.2    Benoist, C.3
  • 59
    • 79952931627 scopus 로고    scopus 로고
    • Integrated T-cell receptor and costimulatory signals determine TGF-b-dependent differentiation and maintenance of Foxp31 regulatory T cells
    • Gabryšová L., Christensen J.R., Wu X., Kissenpfennig A., Malissen B., O'Garra A. Integrated T-cell receptor and costimulatory signals determine TGF-b-dependent differentiation and maintenance of Foxp31 regulatory T cells. Eur J Immunol 2011, 41:1242-1248.
    • (2011) Eur J Immunol , vol.41 , pp. 1242-1248
    • Gabryšová, L.1    Christensen, J.R.2    Wu, X.3    Kissenpfennig, A.4    Malissen, B.5    O'Garra, A.6
  • 60
    • 77952711172 scopus 로고    scopus 로고
    • Conversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma
    • Kim B.-S., Kim I.-B, Park Y.-J, Kim Y.S., Kim Y.J., Chang W.S. Conversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma. Proc Natl Acad Sci USA 2010, 107(19):8743-8747.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.19 , pp. 8743-8747
    • Kim, B.-S.1    Kim, I.-B.2    Park, Y.-J.3    Kim, Y.S.4    Kim, Y.J.5    Chang, W.S.6
  • 61
    • 77953807734 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 (TGF-β1) and rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3+ Tregs
    • Kawamoto K., Pahuja A., Hering B.J., Bansal-Pakala P. Transforming growth factor beta 1 (TGF-β1) and rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3+ Tregs. Transpl Immunol 2010, 23:28-33.
    • (2010) Transpl Immunol , vol.23 , pp. 28-33
    • Kawamoto, K.1    Pahuja, A.2    Hering, B.J.3    Bansal-Pakala, P.4
  • 62
    • 77649217359 scopus 로고    scopus 로고
    • Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ Tregs
    • Bocian K., Borysowski J., Wierzbicki P. Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ Tregs. Nephrol Dial Transplant 2010, 25:710-717.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 710-717
    • Bocian, K.1    Borysowski, J.2    Wierzbicki, P.3
  • 63
    • 42249109013 scopus 로고    scopus 로고
    • Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+T Cells
    • Alice Long S., Buckner J.H. Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+T Cells. J Autoimmun 2008, 30(4):293-302.
    • (2008) J Autoimmun , vol.30 , Issue.4 , pp. 293-302
    • Alice Long, S.1    Buckner, J.H.2
  • 64
    • 84866168094 scopus 로고    scopus 로고
    • Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses
    • Procaccini C., De Rosa V., Galgani M., Carbone F., Cassano S., Greco D., et al. Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses. J Immunol 2012, 189(September (6)):2941-2953.
    • (2012) J Immunol , vol.189 , Issue.SEPTEMBER 6 , pp. 2941-2953
    • Procaccini, C.1    De Rosa, V.2    Galgani, M.3    Carbone, F.4    Cassano, S.5    Greco, D.6
  • 65
    • 79956097598 scopus 로고    scopus 로고
    • Expansion of CD4+CD25+ regulatory T cells from cord blood CD4+ cells using the common (-chain cytokines (IL-2 and IL-15) and rapamycin
    • Asanuma S., Tanaka J., Sugita J. Expansion of CD4+CD25+ regulatory T cells from cord blood CD4+ cells using the common (-chain cytokines (IL-2 and IL-15) and rapamycin. Ann Hematol 2010, 90(6):617-624.
    • (2010) Ann Hematol , vol.90 , Issue.6 , pp. 617-624
    • Asanuma, S.1    Tanaka, J.2    Sugita, J.3
  • 66
    • 79954629524 scopus 로고    scopus 로고
    • Generation of human regulatory T cells de novo with suppressive function prevent xenogeneic graft versus host disease
    • Qian X., Wang K., Wang X., Zheng S.G., Lu L. Generation of human regulatory T cells de novo with suppressive function prevent xenogeneic graft versus host disease. Int Immunopharmacol 2011, 11(5):630-637.
    • (2011) Int Immunopharmacol , vol.11 , Issue.5 , pp. 630-637
    • Qian, X.1    Wang, K.2    Wang, X.3    Zheng, S.G.4    Lu, L.5
  • 67
    • 60649092158 scopus 로고    scopus 로고
    • Rapamycin promotes the enrichment of CD4+CD25HiFoxP3+T regulatory cells from naïve CD4+ T cells of baboon that suppress anti porcine xenogenic response in vitro
    • Singh A.K., Horvath K.A., Muhammad M. Rapamycin promotes the enrichment of CD4+CD25HiFoxP3+T regulatory cells from naïve CD4+ T cells of baboon that suppress anti porcine xenogenic response in vitro. Transplant Proc 2009, 41(1):418-421.
    • (2009) Transplant Proc , vol.41 , Issue.1 , pp. 418-421
    • Singh, A.K.1    Horvath, K.A.2    Muhammad, M.3
  • 69
    • 84881192927 scopus 로고    scopus 로고
    • MTORC1 couples immune signals and metabolic programming to establish T (reg)-cell function
    • Zeng H., Yang K., Cloer C., Neale G., Vogel P., Chi H. mTORC1 couples immune signals and metabolic programming to establish T (reg)-cell function. Nature 2013, 499(7459):485-490.
    • (2013) Nature , vol.499 , Issue.7459 , pp. 485-490
    • Zeng, H.1    Yang, K.2    Cloer, C.3    Neale, G.4    Vogel, P.5    Chi, H.6
  • 70
    • 84890040690 scopus 로고    scopus 로고
    • TSC1 regulates the balance between effector and regulatory T cells
    • Park Y., Jin H.S., Lopez J., Elly C., Kim G., Murai M., et al. TSC1 regulates the balance between effector and regulatory T cells. J Clin Invest 2013, 123(12):5165-5178.
    • (2013) J Clin Invest , vol.123 , Issue.12 , pp. 5165-5178
    • Park, Y.1    Jin, H.S.2    Lopez, J.3    Elly, C.4    Kim, G.5    Murai, M.6
  • 71
    • 0037944120 scopus 로고    scopus 로고
    • Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
    • Mizuki M.J., Schwable C., Steur C., Choudhary C., Agrawal S., Sargin B. Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood 2003, 101:3164-3173.
    • (2003) Blood , vol.101 , pp. 3164-3173
    • Mizuki, M.J.1    Schwable, C.2    Steur, C.3    Choudhary, C.4    Agrawal, S.5    Sargin, B.6
  • 72
    • 77958151145 scopus 로고    scopus 로고
    • The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells
    • Liu G., Yang K., Burns S., Shrestha S., Chi H. The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells. Nat Immunol 2010, 11(11):1047-1057.
    • (2010) Nat Immunol , vol.11 , Issue.11 , pp. 1047-1057
    • Liu, G.1    Yang, K.2    Burns, S.3    Shrestha, S.4    Chi, H.5
  • 73
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • Delgoffe G.M., Pollizzi K.N., Waickman A.T., Heikamp E., Meyers D.J., Horton M.R. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol 2011, 12(4):295-303.
    • (2011) Nat Immunol , vol.12 , Issue.4 , pp. 295-303
    • Delgoffe, G.M.1    Pollizzi, K.N.2    Waickman, A.T.3    Heikamp, E.4    Meyers, D.J.5    Horton, M.R.6


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