Combined therapy of CD4+CD25+ regulatory T cells with low-dose sirolimus, but not calcineurin inhibitors, preserves suppressive function of regulatory T cells and prolongs allograft survival in mice

International Immunopharmacology

Volumn 9, Issue 5, 2009, Pages 553-563

  Ma, Anlun ^a   Qi, Shijie ^a   Wang, Ziying ^a   Massicotte, Eric ^b   Dupuis, Martine ^b   Daloze, Pierre ^a   Chen, Huifang ^a  

^a NOTRE DAME HOSPITAL   (Canada)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Allograft; Cyclosporine A; Regulatory T cells; Sirolimus; Tacrolimus; Transplantation

Indexed keywords

CALCINEURIN INHIBITOR; CD4 ANTIGEN; CYCLOSPORIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; PADGEM PROTEIN; RAPAMYCIN; THYMOCYTE ANTIBODY; TRANSCRIPTION FACTOR FOXP3; TACROLIMUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELL SURVIVAL; CELL THERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; EFFECTOR CELL; GRAFT SURVIVAL; HEART TRANSPLANTATION; IN VITRO STUDY; LOW DRUG DOSE; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SPLEEN; ADOPTIVE IMMUNOTHERAPY; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CBA MOUSE; CELL CULTURE; DRUG EFFECTS; GRAFT REJECTION; IMMUNOLOGY; METABOLISM; MULTIMODALITY CANCER THERAPY; PATHOLOGY; TRANSPLANTATION TOLERANCE;

ANIMALS; ANTIGENS, CD4; CELL PROLIFERATION; CELLS, CULTURED; COMBINED MODALITY THERAPY; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOTHERAPY, ADOPTIVE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; SIROLIMUS; T-LYMPHOCYTES, REGULATORY; TACROLIMUS; TRANSPLANTATION TOLERANCE;

EID: 63649085948     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.01.033     Document Type: Article

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