Do CD4+Foxp3+ Treg cells correlate with transplant outcomes: A systematic review on recipients of solid organ transplantation

Cellular Immunology

Volumn 270, Issue 1, 2011, Pages 5-12

  Shan, Juan ^a   Guo, Yinjia ^a   Luo, Lei ^a   Lu, Jun ^a   Li, Chengwen ^a   Zhang, Chuntao ^a   Huang, Yuchuan ^a   Feng, Li ^a   Wu, Wenqiao ^a   Long, Dan ^a   Li, Shengfu ^a   Li, Youping ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b Chinese Evidence Based Medicine Centre   (China)

Author keywords

Foxp3; Graft function; Graft survival rate; Immune marker; Regulatory T cells; Solid organ transplantation; Systematic review; Transplant tolerance; Tregs counts; Tregs function

Indexed keywords

AZATHIOPRINE; BASILIXIMAB; CALCINEURIN INHIBITOR; CD4 ANTIGEN; CYCLOSPORIN; GLUCOCORTICOID; LYMPHOCYTE ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY; TRANSCRIPTION FACTOR FOXP3;

ACUTE GRAFT REJECTION; ALLOGRAFT; BIOPSY; CARDIAC GRAFT REJECTION; CD4 LYMPHOCYTE COUNT; CELL FUNCTION; CHRONIC GRAFT REJECTION; COCHRANE LIBRARY; DIAGNOSTIC VALUE; EMBASE; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMAN; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LUNG TRANSPLANTATION; MEDLINE; NONHUMAN; ORGAN TRANSPLANTATION; OUTCOME ASSESSMENT; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; RISK; SOLID ORGAN TRANSPLANTATION; SURVIVAL RATE; SYSTEMATIC REVIEW; T LYMPHOCYTE; TREATMENT OUTCOME; TREG CELL; URINALYSIS;

CD4 LYMPHOCYTE COUNT; CLINICAL TRIALS AS TOPIC; FORKHEAD TRANSCRIPTION FACTORS; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; MALE; ORGAN TRANSPLANTATION; PREDICTIVE VALUE OF TESTS; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION IMMUNOLOGY; TREATMENT OUTCOME;

EID: 79959852905     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2011.05.006     Document Type: Review

References (33)

1. Velthuis J.H.L., Mol W.M., Weimar W., et al. CD4+ CD25bright+ regulatory T cells can mediate donor nonreactivity in long-term immunosuppressed kidney allograft patients. American Journal of Transplantation 2006, 6(12):2955-2964.
2. Baan C.C., Velthuis J.H.L., van Gurp E.A.F.J., et al. Functional CD25bright+ alloresponsive T cells in fully immunosuppressed renal allograft recipients. Clinical 2007, 21:63-71.
3. Elthuis J.H.L., Hesselink D.A., Hendrikx T.K., et al. Kinetic analysis reveals potency of CD4+ CD25bright+ regulatory T-cells in kidney transplant patients. Transplant Immunology 2007, 18:159-165.
4. Hendrikx T.K., Van Gurp E.A.F.J., Sewgobind V.D.K.D., et al. Generation of donor-specific regulatory t-cell function in kidney transplant patients. Transplantation 2009, 87(3):376-383.
5. Wang Z., Fu X.Y., Shi B.Y., et al. Antigen-specific suppression by induced CD4+CD25 high regulatory T cells in kidney recipients. Proceedings 2009, 41:1574-1576.
6. Yoshizawa A., Ito A., Li Y., et al. The roles of CD25+CD4+ regulatory T cells in operational tolerance after living donor liver transplantation. Proceedings 2005, 37:37-39.
7. Lee M.K. Promotion of allograft survival by CD4+CD25+ regulatory T cells: evidence for in vivo inhibition of effector cell proliferation. J. Immunol. 2004, 172:6539-6544.
8. Bestard O., Cruzado J.M., Mestre M., et al. Achieving donor-specific hyporesponsiveness is associated with Foxp3+ regulatory T cell recruitment in human renal allograft infiltrates. J. Immunol. 2007, 179:4901-4909.
9. Martin L., de la Vega M.F., Bocrie O., et al. Detection of Foxp3+ cells on biopsies of kidney transplants with early acute rejection. Proceedings 2007, 39:2586-2588.
10. Veronese F., Rotman S., Smith R.N., et al. Pathological and clinical correlates of Foxp3+ cells in renal allografts during acute rejection. Am. J. Transplant 2007, 7:914-922.
11. Bunnag S., Allanach K., Jhangri G.S., et al. FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes. American Journal of Transplantation 2008, 8(7):1423-1433.
12. Muthukumar T., Dadhania D., Ding R., et al. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. New England Journal of Medicine 2005, 353:2342-2351.
13. Demirkiran A., Kok A., Kwekkeboom J., et al. Low circulating regulatory T-cell levels after acute rejection in liver transplantation. Liver 2006, 12:277-284.
14. Dijke I.E., Korevaar S.S., Caliskan K., et al. Inadequate immune regulatory function of CD4+CD25bright+Foxp3+ T cells in heart transplant patients who experience acute cellular rejection. Transplantation 2009, 87(8):1191-1200.
15. Karczewski M., Karczewski J., Kostrzewa A., et al. The role of Foxp3+ regulatory T cells in kidney transplantation. Transplant. Proc. 2009, 41(5):1527-1529.
16. Kreijveld E., Koenen H.J.P.M., van Cranenbroek B., et al. Immunological monitoring of renal transplant recipients to predict acute allograft rejection following the discontinuation of tacrolimus. PLoS ONE 2008, 3(7):e2711.
17. Pons J.A., Revilla-Nuin B., Baroja-Mazo A., et al. FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal. Transplantation 2008, 86(10):1370-1378.
18. Sakamoto R., Asonuma K., Ramirez M.E.Z., et al. Forkhead box P3 (FOXP3) mRNA expression immediately after living-donor liver transplant. Experimental and Clinical 2009, 7:8-12.
19. Cécile Taflin, Dominique Nochy, Gary Hill, et al. Regulatory T cells in kidney allograft infiltrates correlate with initial inflammation and graft function. Transplantation 2010, 89:194-199.
20. Dijke I.E., Velthuis J.H.L., Caliskan K., et al. Transplantation 2007, 83(11):1477-1484.
21. Dijke I.E., Caliskan K., Korevaar S.S., et al. FOXP3 mRNA expression analysis in the peripheral blood and allograft of heart transplant patients. Transplant Immunology 2008, 18:250-254.
22. Stenard F., Nguyen C., Cox K., et al. Decreases in circulating CD4+CD25hiFoxp3+ cells and increases in intragraft Foxp3+ cells accompany allograft rejection in pediatric liver allograft recipients. Pediatric 2009, 13:70-80.
23. Braudeau C., Racape M., Giral M., et al. Variation in numbers of CD4+CD25highFoxp3+ T cells with normal immuno-regulatory properties in long-term graft outcome. Transplant International 2007, 20:845-855.
24. Li Y., Zhao X., Cheng D., et al. The presence of Foxp3 expressing T cells within grafts of tolerant human liver transplant recipients. Transplantation 2008, 86:1837-1843.
25. Alvarez C.M., Opelz G., Garcia L.F., et al. Expression of regulatory t-cell-related molecule genes and clinical outcome in kidney transplant recipients. Transplantation 2009, 87(6):857-863.
26. Ashton-Chess J., Dugast E., Colvin R.B., et al. Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients. Journal of the American Society of Nephrology 2009, 20:1113-1122.
27. Iwase H., Kobayashi T., Kodera Y., et al. Clinical significance of regulatory T-cell-related gene expression in peripheral blood after renal transplantation. Transplantation 2011, 91(2):191-198.
28. Bhorade S.M., Chen H., Molinero L. Decreased percentage of CD4+Foxp3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome. Transplantation 2010, 90(5):540-546.
29. Gregson A.L., Hoji A., Palchevskiy V., et al. Protection against bronchiolitis obliterans syndrome is associated with allograft CCR7+CD45RA2- T regulatory cells. PLoS ONE 2010, 5(6):e11354.
30. Martinez-Llordella M., Puig-Pey I., Orlando G., et al. Multiparameter immune profiling of operational tolerance in liver transplantation. American Journal of Transplantation 2007, 7(2):309-319.
31. Huang Y.C., Shan J., Zhang C.T., et al. Peripheral blood T regulatory cell counts may not predict transplant rejection. BMC Immunology 2010, 11:40.
32. Wan Y., Flavell R. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007, 445:766-770.
33. Fan Zhigang, Spencer Joel A., Yan Lu., et al. In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response. Nature Medicine 2010, 16:718-722.