Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 43, 2014, Pages 15556-15561

  Shibata, Shigeru ^a,b,c   Arroyo, Juan Pablo ^a   Castañeda Bueno, María ^a   Puthumana, Jeremy ^a   Zhang, Junhui ^a   Uchida, Shunya ^b   Stone, Kathryn L ^a   Lam, TuKiet T ^a   Lifton, Richard P ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Distal tubule; Hypertension; PHAII; Posttranslational modification; Renin angiotensin aldosterone system

Indexed keywords

ANGIOTENSIN II; CULLIN; CULLIN 3; PROTEIN KINASE C; PROTEIN KINASE WNK4; SODIUM CHLORIDE COTRANSPORTER; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; CARRIER PROTEIN; KLHL3 PROTEIN, HUMAN; PHOSPHOSERINE; PRKWNK4 PROTEIN, MOUSE; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; WNK4 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPERKALEMIA; HYPERTENSION; MISSENSE MUTATION; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REDUCTION; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CELL LINE; CHEMISTRY; KIDNEY; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION;

AMINO ACID SEQUENCE; ANGIOTENSIN II; ANIMALS; CARRIER PROTEINS; CELL LINE; HUMANS; KIDNEY; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTEOLYSIS; SIGNAL TRANSDUCTION;

EID: 84908431198     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1418342111     Document Type: Article

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