Control of electrolyte balance through ubiquitination

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 19, 2013, Pages 7535-7536

  Herrera, Marcela ^a   Coffman, Thomas M ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; PROTEIN KINASE WNK1; PROTEIN KINASE WNK4; RENAL OUTER MEDULLARY POTASSIUM CHANNEL; SODIUM; SODIUM CHLORIDE COTRANSPORTER; THIAZIDE DIURETIC AGENT; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

BLOOD PRESSURE; DRUG EFFICACY; ELECTROLYTE BALANCE; HOMEOSTASIS; HUMAN; HYPERTENSION; IMMUNOPRECIPITATION; LOSS OF FUNCTION MUTATION; MASS SPECTROMETRY; NOTE; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOHYPOALDOSTERONISM; UBIQUITINATION;

ANIMALS; CARRIER PROTEINS; CULLIN PROTEINS; GENE EXPRESSION REGULATION; HUMANS; PROTEIN-SERINE-THREONINE KINASES; UBIQUITINATION;

EID: 84877357207     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1305242110     Document Type: Note

References (9)

1. Lifton RP, Gharavi AG, Geller DS (2001) Molecular mechanisms of human hypertension. Cell 104(4): 545-556.
2. Boyden LM, et al. (2012) Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. Nature 482(7383): 98-102.
3. Wilson FH, et al. (2001) Human hypertension caused by mutations in WNK kinases. Science 293(5532): 1107-1112.
4. Shibata S, Zhang J, Puthumana J, Stone KL, Liffton RP (2013) Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc Natl Acad Sci USA 110: 7838-7843.
5. Kahle KT, Ring AM, Lifton RP (2008) Molecular physiology of the WNK kinases. Annu Rev Physiol 70: 329-355.
6. McCormick JA, Ellison DH (2011) The WNKs: Atypical protein kinases with pleiotropic actions. Physiol Rev 91(1): 177-219.
7. Anonymous; ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid- Lowering Treatment to Prevent Heart Attack Trial (2002) Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 288(23): 2981-2997.
8. Lalioti MD, et al. (2006) Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet 38(10):1124- 1132.
9. Prag S, Adams JC (2003) Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals. BMC Bioinformatics 4:42.