Identification and characterization of a novel splicing variant of vesicular monoamine transporter 1

Journal of Molecular Endocrinology

Volumn 35, Issue 3, 2005, Pages 489-501

  Essand, M ^a   Vikman, S ^a   Grawe J ^a   Gedda, L ^a   Hellberg, C ^b   Oberg, K ^c   Totterman, T H ^a   Giandomenico, Valeria ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NUCLEOTIDE; SEROTONIN; VESICULAR MONOAMINE TRANSPORTER 1;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; EXON; GASTROINTESTINAL TRACT; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; NEUROSECRETORY CELL; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TUMOR CELL;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CARCINOID TUMOR; CELL LINE; CELL LINE, TUMOR; DNA, COMPLEMENTARY; ENDOPLASMIC RETICULUM; ENTEROCHROMAFFIN CELLS; EXONS; GASTROINTESTINAL NEOPLASMS; HUMANS; RECOMBINANT PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; SECRETORY VESICLES; SEROTONIN; TRANSFECTION; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 29744459528     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.01875     Document Type: Article

References (30)

1. Arvan P & Castle D 1998 Sorting and storage during secretory granule biogenesis: looking backward and looking forward. Biochemistry Journal 332 (Pt 3) 593-610.
2. Eiden LE, Schafer MK, Weihe E & Schutz B 2004 The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine. Pflugers Archives 447 636-640.
3. Erickson JD & Varoqui H 2000 Molecular analysis of vesicular amine transporter function and targeting to secretory organelles. FASEB Journal 14 2450-2458.
4. Erickson JD, Eiden LE & Hoffman BJ 1992 Expression cloning of a reserpine-sensitive vesicular monoamine transporter. PNAS 89 10993-10997.
5. Erickson JD, Schafer MK, Bonner TI, Eiden LE & Weihe E 1996 Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. PNAS 93 5166-5171.
6. Gilham D, Alam M, Gao W, Vance DE & Lehner R 2005 Triacylglycerol hydrolase is localized to the endoplasmic reticulum by an unusual retrieval sequence where It participates in VLDL assembly without utilizing VLDL lipids as substrates. Molecular Biology of Cell 16 984-996.
7. Jakobsen AM, Andersson P, Saglik G, Andersson E, Kolby L, Erickson JD, Forssell-Aronsson E, Wangberg B, Ahlman H & Nilsson O 2001 Differential expression of vesicular monoamine transporter (VMAT) 1 and 2 in gastrointestinal endocrine tumours. Journal of Pathology 195 463-472.
8. Kim T, Tao-Cheng JH, Eiden LE & Loh YP 2001 Chromogranin A, an 'on/off' switch controlling dense-core secretory granule biogenesis. Cell 106 499-509.
9. Kirschbaum-Slager N, Lopes GM, Galante PA, Riggins GJ & de Souza SJ 2004 Splicing factors are differentially expressed in tumors. Genetics and Molecular Research 3 512-520.
10. Kolby L, Bernhardt P, Levin-Jakobsen AM, Johanson V, Wangberg B, Ahlman H, Forssell-Aronsson E & Nilsson O 2003 Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters. British Journal of Cancer 89 1383-1388.
11. Krantz DE, Waites C, Oorschot V, Liu Y, Wilson RI, Tan PK, Klumperman J & Edwards RH 2000 A phosphorylation site regulates sorting of the vesicular acetylcholine transporter to dense core vesicles. Journal of Cell Biologv 149 379-396.
12. Liu Y & Edwards RH 1997 Differential localization of vesicular acetylcholine and monoamine transporters in PC12 cells but not CHO cells. Journal of Cell Biology 139 907-916.
13. + toxicity encodes a vesicular amine transporter. Cell 70 539-551.
14. Liu Y, Schweitzer ES, Nirenberg MJ, Pickel VM, Evans CJ & Edwards RH 1994 Preferential localization of a vesicularmonoamine transporter to dense core vesicles in PC12 cells. Journal of Cell Biology 127 1419-1433.
15. Liu Y, Krantz DE, Waites C & Edwards RH 1999 Membrane trafficking of neurotransmitter transporters in the regulation of synaptic transmission. Trends in Cell Biology 9 356-363.
16. Livak KJ & Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) method. Methods 25 402-408.
17. Nilsson O, Jakobsen AM, Kolby L, Bernhardt P, Forssell-Aronsson E & Ahlman H 2004 Importance of vesicle proteins in the diagnosis and treatment of neuroendocrine tumors. Annals of New York Academy of Sciences 1014 280-283.
18. Oberg K 2002 Carcinoid tumors: molecular genetics, tumor biology, and update of diagnosis and treatment. Current Opinion in Oncology 14 38-45.
19. Oberg K 2003 Diagnosis and treatment of carcinoid tumors. Expert Reviews in Anticancer Therapy 3 863-877.
20. Oberg K, Astrup L, Eriksson B, Falkmer SE, Falkmer UG, Gustafsen J, Haglund C, Knigge U, Vatn MH & Vä limäki M 2004a Guidelines for the management of gastroenteropancreatic neuroendocrine tumors (including bronchopulmonary and thymic neoplasms). II. Specific NE tumour types. Acta Oncologica 43 626-636.
21. Oberg K, Kvols L, Caplin M, Delle Fave G, De Herder W, Rindi G, Ruszniewski P, Woltering EA & Wiedenmann B 2004b Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system. Annals of Oncology 15 966-973.
22. Parsons SM 2000 Transport mechanisms in acetylcholine and monoamine storage. FASEB Journal 14 2423-2434.
23. Schafermeyer A, Gratzl M, Rad R, Dossumbekova A, Sachs G & Prinz C 2004 Isolation and receptor profiling of ileal enterochromaffin cells. Acta Physiologica Scandinavica 182 53-62.
24. Stornaiuolo M, Lotti LV, Borgese N, Torrisi MR, Mottola G, Martire G & Bonatti S 2003 KDEL and KKXX retrieval signals appended to the same reporter protein determine different trafficking between endoplasmic reticulum, intermediate compartment, and Golgi complex. Molecular Biology of Cell 14 889-902.
25. van Herpen RE, Oude Ophuis RJ, Wijers M, Bennink MB, van de Loo FA, Fransen J, Wieringa B & Wansink DG 2005 Divergent mitochondrial and endoplasmic reticulum association of DMPK splice isoforms depends on unique sequence arrangements in tail anchors. Molecular and Cellular Biology 25 1402-1414.
26. Varoqui H & Erickson JD 1998a The cytoplasmic tail of the vesicular acetylcholine transporter contains a synaptic vesicle targeting signal. Journal of Biological Chemistry 273 9094-9098.
27. Varoqui H & Erickson JD 1998b Dissociation of the vesicular acetylcholine transporter domains important for high-affinity transport recognition, binding of vesamicol and targeting to synaptic vesicles. Journal of Physiology, Paris 92 141-144.
28. Vikman S, Essand M, Cunningham J, de la Torre M, Öberg K, Tötterman TH & Giandomenico V 2005 Gene expression in midgut carcinoid tumors: potential targets for immunotherapy. Acta Oncologica 44 32-40.
29. Wrzeszczynski KO & Rost B 2004 Annotating proteins from endoplasmic reticulum and Golgi apparatus in eukaryotic proteomes. Cellular and Molecular Life Science 61 1341-1353.
30. Yao J, Erickson JD & Hersh LB 2004 Protein kinase A affects trafficking of the vesicular monoamine transporters in PC12 cells. Traffic 5 1006-1016.