Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates

Journal of Medicinal Chemistry

Volumn 57, Issue 20, 2014, Pages 8635-8645

  Moeker, Janina ^a   Mahon, Brian P ^b   Bornaghi, Laurent F ^a   Vullo, Daniela ^c   Supuran, Claudiu T ^c   McKenna, Robert ^b   Poulsen, Sally Ann ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOHYDRATE DERIVATIVE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONIC ANHYDRASE IX INHIBITOR; ISOENZYME; SULFAMATE DERIVATIVE; SULFUR DERIVATIVE; UNCLASSIFIED DRUG; ZINC; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; MOLECULAR LIBRARY; SULFAMIC ACID; SULFONIC ACID DERIVATIVE; TUMOR ANTIGEN; TUMOR MARKER;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYTOSOL; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; HYDROPHILICITY; HYDROPHOBICITY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; SYNTHESIS;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; SMALL MOLECULE LIBRARIES; SULFONIC ACIDS; TUMOR MARKERS, BIOLOGICAL;

EID: 84908383763     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5012935     Document Type: Article

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