Design, synthesis, and biological evaluation of novel carbohydrate-based sulfamates as carbonic anhydrase inhibitors

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1481-1489

  Lopez, Marie ^a   Trajkovic, Jonathan ^a   Bornaghi, Laurent F ^a   Innocenti, Alessio ^b   Vullo, Daniela ^b   Supuran, Claudiu T ^b   Poulsen, Sally Ann ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,2',3,3',4',6 HEPTA O ACETYL 6' SULFAMOYL BETA MALTOSE; 1,2,3,4 TETRA O ACETYL 6 SULFAMOYL BETA DEXTRO GALACTOPYRANOSE; 1,2,3,4 TETRA O ACETYL 6 SULFAMOYL BETA DEXTRO GLUCOPYRANOSE; 1,2,3,4 TETRA O ACETYL 6 SULFAMOYL BETA DEXTRO MANNOPYRANOSE; 1,2,3,4 TETRA O BUTYRYL 6 SULFAMOYL BETA DEXTRO GLUCOPYRANOSE; 1,2,3,4 TETRA O PROPIONYL 6 SULFAMOYL BETA DEXTRO GLUCOPYRANOSE; 6 SULFAMOYL ALPHA,BETA DEXTRO GALACTOPYRANOSE; 6 SULFAMOYL ALPHA,BETA DEXTRO GLUCOPYRANOSE; 6 SULFAMOYL ALPHA,BETA DEXTRO MANNOPYRANOSE; 6' SULFAMOYL ALPHA,BETA MALTOSE; CARBOHYDRATE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; METHYL 2,3,4 TRI O ACETYL 6 SULFAMOYL ALPHA DEXTRO GLUCOPYRANOSE; METHYL 6 SULFAMOYL ALPHA DEXTRO GLUCOPYRANOSE; SULFAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; STEREOCHEMISTRY;

ANTINEOPLASTIC AGENTS; CARBONIC ANHYDRASE INHIBITORS; DISACCHARIDES; DRUG DESIGN; FRUCTOSE; HUMANS; ISOENZYMES; MOLECULAR CONFORMATION; MONOSACCHARIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; SULFONIC ACIDS;

EID: 79952268421     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101525j     Document Type: Article

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