Microalgae as versatile cellular factories for valued products

Algal Research

Volumn 6, Issue PA, 2014, Pages 52-63

  Koller, Martin ^a,b   Muhr, Alexander ^c,d   Braunegg, Gerhart ^b  

^a UNIVERSITY OF GRAZ   (Austria)

^b ARENA Arbeitsgemeinschaft für Ressourcenschonende and Nachhaltige Technologien   (Austria)

^c GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^d POLYMER COMPETENCE CENTER LEOBEN GMBH   (Austria)

Author keywords

Cyanobacteria; Green energy carriers; Lipids; Microalgae; Pigments; PUFAs

Indexed keywords

EID: 84908381864     PISSN: 22119264     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.algal.2014.09.002     Document Type: Review

References (129)

1. Abed R.M.M., Dobretsov S., Sudesh K. Applications of cyanobacteria in biotechnology. J. Appl. Microbiol. 2009, 106:1-12.
2. Amaro H.M., Guedes A., Malcata F.X. Advances and perspectives in using microalgae to produce biodiesel. Appl. Energy 2011, 88:3402-3410.
3. Antal T.K., Osipov V., Matorin D.N., Rubin A.B. Membrane potential is involved in regulation of photosynthetic reactions in the marine diatom Thalassiosira weissflogii. J. Photochem. Photobiol. B Biol. 2011, 102(2):169-173.
4. Arad S.M., Yaron A. Natural pigments from red microalgae for use in foods and cosmetics. Trends Food Sci. Technol. 1992, 3:92-97.
5. Ashby R.D., Nunez A., Solaiman D.K.Y., Foglia T.A. Sophorolipid biosynthesis from a biodiesel co-product stream. J. Am. Oil Chem. Soc. 2005, 82:625-630.
6. Ahmad A., Munir B., Abrar M., Bashir S., Adnan M., et al. Perspective of β-Glucan as Functional Ingredient for Food Industry. J. Nutr. Food Sci. 2012, 2(133). 10.4172/2155-9600.1000133.
7. Balaji S., Gopi K., Muthuvelan B. A review on production of poly β hydroxybutyrates from cyanobacteria for the production of bio plastics. Algal Res. 2013, 2(3):278-285.
8. Balaji S., Kalaivani T., Rajasekaran C., Shalini M., Siva R., Singh R.K., Akthar M.A. Arthrospira (Spirulina) species as bioadsorbents for lead, chromium, and cadmium-a comparative study. Clean Soil Air Water 2014, 10.1002/clen.201300478.
9. Banerjee A., Sharma R., Chisti Y., Banerjee U.C. Botryococcus braunii: a renewable source of hydrocarbons and other chemicals. Crit. Rev. Biotechnol. 2002, 22:245-279.
10. Baynes W.J., Dominiczak H.M. Medical Biochemistry 2005, Elsevier Mosby Ltd., Philadelphia. 2nd ed.
11. Becker E.W. Micro-algae as a source of protein. Biotechnol. Adv. 2007, 25:207-210.
12. Beer L.L., Boyd E.S., Peters J.W., Posewitz M.C. Engineering algae for biohydrogen and biofuel production. Curr. Opin. Biotechnol. 2009, 20:264-271.
13. Belarbi E.H., Molina E., Chisti Y. A process for high yield and scaleable recovery of high purity eicosapentaenoic acid esters from microalgae and fish oil. Process Biochem. 2000, 35(9):951-969.
14. Ben-Amotz A. Industrial production of microalgal cell-mass and secondary products - major industrial species - Dunaliella. Handbook of Microalgal Culture 2004, 273-280. Blackwell Publishing Ltd., Oxford. A. Richmond (Ed.).
15. Ben-Amotz A., Avron M. On the factors which determine massive β-carotene accumulation in the halotolerant alga Dunaliella bardawil. Plant Physiol. 1983, 72:593-597.
16. Ben-Amotz A., Edelstein S., Avron M. Use of the β-carotene rich alga Dunaliella bardawil as a source of retinol. Br. Poult. Sci. 1986, 27:613-619.
17. Bhati R., Samantaray S., Sharma L., Mallick N. Poly-β-hydroxybutyrate accumulation in cyanobacteria under photoautotrophy. Biotechnol. J. 2010, 5:1181-1185.
18. Bindu M.S., Sobha V. Pigment composition in seaweeds of Kerala and their potential application in immunodiagnostics. XIX Kerala Science Congress 2007, Kerala State Council for Science, Kannur.
19. Bohutskyi P., Bouwer E. Biogas production from algae and cyanobacteria through anaerobic digestion: a review, analysis, and research needs. Advanced Biofuels and Bioproducts 2013, 873-975. Springer, New York.
20. Borowitzka M.A., Borowitzka L.J., Kessly D. Effects of salinity increase on carotenoid accumulation in the green alga Dunaliella salina. J. Appl. Phycol. 1990, 2:111-119.
21. Brányiková I., Maršálková B., Doucha J., Brányik T., Bišová K., Zachleder V., Vítová M. Microalgae - novel highly efficient starch producers. Biotechnol. Bioeng. 2011, 108:766-776.
22. Brennan L., Owende P. Biofuels from microalgae - a review of technologies for production, processing, and extractions of biofuels and co-products. Renew. Sust. Energ. Rev. 2010, 14:557-577.
23. Budiyono B., Kusworo T.D. Biogas production from cassava starch effluent using microalgae as biostabilisator. Int. J. Sci. Eng. 2011, 2:4-8.
24. Bumbak F., Cook S., Zachleder V., Hauser S., Kovar K. Best practices in heterotrophic high-cell-density microalgal processes: achievements, potential and possible limitations. Appl. Microbiol. Biotechnol. 2011, 91:31-46.
25. Carlson A.S., Van Beilen J.B., Moeller R., Clayton D. Micro- and Macroalgae: Utility for Industrial Applications 2007, CPL Press, Newbury.
26. Chader S., Hacene H., Agathos S.N. Study of hydrogen production by three strains of Chlorella isolated from the soil in the Algerian Sahara. Int. J. Hydrog. Energy 2009, 34:4941-4946.
27. Chen L., Liu T., Zhang W., Chen X., Wang J. Biodiesel production from algae oil high in free fatty acids by two-step catalytic conversion. Bioresour. Technol. 2012, 111:208-214.
28. Chen C.Y., Yeh K.L., Aisyah R., Lee D.J., Chang J.S. Cultivation, photobioreactor design and harvesting of microalgae for biodiesel production: a critical review. Bioresour. Technol. 2011, 102:71-81.
29. Chini Zittelli G., Lavista F., Bastianini A., Rodolfi L., Vincenzini M., Tredici M.R. Production of eicosapentaenoic acid by Nannochloropsis sp. cultures in outdoor tubular photobioreactors. J. Biotechnol. 1999, 70:299-312.
30. Chisti Y. Biodiesel from microalgae. Biotechnol. Adv. 2007, 25:294-306.
31. Chisti Y. Biodiesel from microalgae beats bioethanol. Trends Biotechnol. 2008, 26(3):126-131.
32. Chochois V., Dauvillée D., Beyly A., Tolleter D., Cuiné S., Timpano H., Ball S., Cournac L., Peltier G. Hydrogen production in Chlamydomonas: photosystem II-dependent and-independent pathways differ in their requirement for starch metabolism. Plant Physiol. 2009, 151:631-640.
33. Chue K.T., Ten L.N., Oh Y.K., Woo S.G., Lee M., Yoo S.A. Carotinoid compositions of five microalga species. Chem. Nat. Compd. 2012, 48:141-142.
34. Collet P., Hélias A., Lardon L., Ras M., Goy R.A., Steyer J.P. Life-cycle assessment of microalgae culture coupled to biogas production. Bioresour. Technol. 2011, 102:207-214.
35. da Silva Gervásio Paulo, Mack Matthias, Contiero Jonas Glycerol: a promising and abundant carbon source for industrial microbiology. Biotechnol. Adv. 2009, 27(1):30-39.
36. Díaz G.D., Li Q., Dashwood R.H. Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Res. 2003, 63:1254-1261.
37. Durmaz Y. Vitamin E (α-tocopherol) production by the marine microalgae Nannochloropsis oculata (Eustigmatophyceae) in nitrogen limitation. Aquaculture 2007, 272:717-722.
38. Dyerberg J., Bang H.O. Dietary fat and thrombosis. Lancet 1978, 1:152.
39. Fan Y.Y., Chapkin R.S. Importance of dietary γ-linolenic acid in human health and nutrition. J. Nutr. 1998, 128:1411-1414.
40. Forján Lozano E., Garbayo Nores I., Casal Bejarano C., Vílchez Lobato C. Enhancement of carotenoid production in Nannochloropsis by phosphate and sulphur limitation. Communicating Current Research and Educational Topics and Trends in Applied Microbiology 2007, vol. 1:356-364. Formatex, Badajoz.
41. Granado-Lorencio F., Herrero-Barbudo C., Acién-Fernández G., Molina-Grima E., Fernández-Sevilla J.M., Pérez-Sacristán B., Blanco-Navarro I. In vitro bioaccesibility of lutein and zeaxanthin from the microalgae Scenedesmus almeriensis. Food Chem. 2009, 114:747-752.
42. Gupta M., Kumar N. Scope and opportunities of using glycerol as an energy source. Renew. Sust. Energ. Rev. 2012, 16(7):4551-4556.
43. Haas M.J., McAloon A.J., Yee W.C., Foglia T.A. A process model to estimate biodiesel production costs. Bioresour. Technol. 2006, 97(4):671-678.
44. Hannon M., Gimpel J., Tran M., Rasala B., Mayfield S. Biofuels from algae: challenges and potential. Biofuels 2010, 1:763-784.
45. Hosikian A., Lim S., Halim R., Danquah M.K. Chlorophyll extraction from microalgae: a review on the process engineering aspects. Int. J. Chem. Eng. 2010, 11 pages. Article ID 391632. 10.1155/2010/391632.
46. John R.P., Anisha G.S., Nampoothiri K.M., Pandey A. Micro and macroalgal biomass: a renewable source for bioethanol. Bioresour. Technol. 2011, 102:186-193.
47. Judé S., Roger S., Martel E., Besson P., Richard S., Bougnoux P., Champeroux P., Le Guennec J.Y. Dietary long-chain omega-3 fatty acids of marine origin: a comparison of their protective effects on coronary heart disease and breast cancers. Prog. Biophys. Mol. Biol. 2006, 90:299-325.
48. Kapdan I.K., Kargi F. Bio-hydrogen production from waste materials. Enzym. Microb. Technol. 2006, 38:569-582.
49. Karmali R.A. Historical perspective and potential use of n-3 fatty acids in therapy of cancer cachexia. Nutrition 1996, 12(1):S2-S4.
50. Kato T., Kolenic N., Pardini R.S. Docosahexaenoic acid (DHA), a primary tumor suppressive omega-3 fatty acid, inhibits growth of colorectal cancer independent of p53 mutational status. Nutr. Cancer 2007, 58:178-187.
51. Kelley D.S., Siegel D., Fedor D.M., Adkins Y., Mackey B.E. DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men. J. Nutr. 2009, 139:495-501.
52. Khosravi-Darani K., Mokhtari Z.-B., Amai T., Tanaka K. Microbial production of poly(hydroxybutyrate) from C-1 carbon sources. Appl. Microbiol. Biotechnol. 2013, 97:1407-1424.
53. Khummongkol D., Canterford G.S., Fryer C. Accumulation of heavy metals in unicellular algae. Biotechnol. Bioeng. 1982, 24:2643-2660.
54. Koller M., Salerno A., Tuffner P., Koinigg M., Böchzelt H., Schober S., Pieber S., Schnitzer H., Mittelbach M., Braunegg G. Characteristics and potential of micro algal cultivation strategies: a review. J. Clean. Prod. 2012, 37:377-388.
55. Koller M., Gasser I., Schmid F., Berg G. Linking ecology with economy: insights into polyhydroxyalkanoate-producing microorganisms. Eng. Life Sci. 2011, 11:222-237.
56. Kurano N., Ikemoto H., Miyashita H., Hasegawa T., Hata H., Miyachi S. Fixation and utilization of carbon dioxide by microalgal photosynthesis. Energy Convers. Manag. 1995, 36(6):689-692.
57. Lee Y.K. Commercial production of microalgae in the Asia-Pacific rim. J. Appl. Phycol. 1997, 9:403-411.
58. Lee D.H. Algal biodiesel economy and competition among bio-fuels. Bioresour. Technol. 2011, 102(1):43-49.
59. Levin D.B., Pitt L., Love M. Biohydrogen production: prospects and limitations to practical application. Int. J. Hydrog. Energy 2004, 29:173-185.
60. Libra J.A., Ro K.S., Kammann C., Funke A., Berge N.D., Neubauer Y., Emmerich K.H. Hydrothermal carbonization of biomass residuals: a comparative review of the chemistry, processes and applications of wet and dry pyrolysis. Biofuels 2011, 2(1):71-106.
61. Lorenz R.T., Cysewski G.R. Commercial potential for Haematococcus microalgae as a natural source of astaxanthin. Trends Biotechnol. 2000, 18:160-167.
62. Lubián L.M., Montero O., Moreno-Garrido I., Huertas I.E., Sobrino C., González-del Valle M., Parés G. Nannochloropsis (Eustigmatophyceae) as source of commercially valuable pigments. J. Appl. Phycol. 2000, 12:249-255.
63. Malone J.P. Autistogenesis: a systems theory with evolutionary perspective. Autism Society's 42nd National Conference on Autism Spectrum Disorders 2011, Asa, Orlando.
64. Mann G., Schlegel M., Schumann R., Sakalauskas A. Biogas-conditioning with microalgae. Agron. Res. 2009, 7:33-38.
65. 2 extraction of γ-linolenic acid and other lipids from Arthrospira (Spirulina) maxima: comparison with organic solvent extraction. Food Chem. 2006, 99:57-63.
66. Milledge J.J. Microalgae-commercial potential for fuel, food and feed. Food Sci. Technol. 2012, 26:28-30.
67. Molina Grima E., Belarbi E.H., Acién Fernández F.G., Robles Medina A., Chisti Y. Recovery of microalgal biomass and metabolites: process options and economics. Biotechnol. Adv. 2003, 20(7):491-515.
68. Montgomery R.M., Nachtigall H.B. Oral administration of chlorophyll fractions for body deodorization. Postgrad. Med. 1950, 8:401.
69. Moon M., Kim C.W., Park W.K., Yoo G., Choi Y.E., Yang J.W. Mixotrophic growth with acetate or volatile fatty acids maximizes growth and lipid production in Chlamydomonas reinhardtii. Algal Res. 2013, 2(4):352-357.
70. Mori K., Ooi T., Hiraoka M., Oka N., Hamada H., Tamura M., Kusumi T. Fucoxanthin and its metabolites in edible brown algae cultivated in deep seawater. Mar. Drugs 2004, 2(2):63-72.
71. Mussgnug J.H., Klassen V., Schlüter A., Kruse O. Microalgae as substrates for fermentative biogas production in a combined biorefinery concept. J. Biotechnol. 2010, 150:51-56.
72. Hydrocolloid Applications: Gum Technology in the Food and Other Industries 1997, Springer. A. Nussinovitch (Ed.).
73. Ogut G.C., Konakli B., Calicioglu O., Erguder T.H., Kaymak B., Demirer G.N. Biogas generation from microalgal biomass and the effect of pretreatment. J. Selcuk Univ. Nat. Appl. Sci. 2013, 872-881.
74. Olaizola M. Commercial development of microalgal biotechnology: from the test tube to the marketplace. Biomol. Eng. 2003, 20:459-466.
75. Olaizola M. Commercial production of astaxanthin from Haematococcus pluvialis using 25,000-liter outdoor photobioreactors. J. Appl. Phycol. 2000, 12:499-506.
76. Online resource 1. http://www.ubic-consulting.com/template/fs/documents/Nutraceuticals/The-World-Beta-Glucan-Ingredient-Market.pdf.
77. Online resource 2. http://www.cnchemicals.com/Report/ReportMin_1908.html.
78. Online resource 3. http://www.cnchemicals.com/Report/ReportMin_1908.html.
79. Online resource 4. http://www.efsa.europa.eu/en/efsajournal/pub/2078.html.
80. Online resource 5. http://www.efsa.europa.eu/en/efsajournal/pub/2078.html.
81. Oren A. A hundred years of Dunaliella research: 1905-2005. Saline Syst. 2005, 1:1-14.
82. Papanikolaou P., Ruiz-Sanchez P., Pariset B., Blanchard F., Fick M. High production of 1,3-propanediol from industrial glycerol by a newly isolated Clostridium butyricum strain. J. Biotechnol. 2000, 77:191-208.
83. Pasquet V., Chérouvrier J.R., Farhat F., Thiéry V., Piot J.-M., Bérard J.B., Kaas R., Serive B., Patrice T., Cadoret J.-P., Picot L. Study on the microalgal pigments extraction process: performance of microwave assisted extraction. Process Biochem. 2011, 46:59-67.
84. Parmar A., Singh N.K., Pandey A., Gnansounou E., Madamwar D. Cyanobacteria and microalgae: a positive prospect for biofuels. Bioresour. Technol. 2011, 102:10163-10172.
85. Parmar A., Singh N.K., Kaushal A., Sonawala S., Madamwar D. Purification, characterization and comparison of phycoerythrins from three different marine cyanobacterial cultures. Bioresour. Technol. 2011, 102:1795-1802.
86. Passos F., Ferrer I. Microalgae conversion to biogas: thermal pretreatment contribution on net energy production. Environ. Sci. Technol. 2014, 48(12):7171-7178.
87. Peet M., Brind J., Ramchand C.N., Shah S., Vankar G.K. Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. Schizophr. Res. 2001, 49:243-251.
88. Pittman J.K., Dean A.P., Osundeko O. The potential of sustainable algal biofuel production using wastewater resources. Bioresour. Technol. 2011, 102(1):17-25.
89. Plaza M., Cifuentes A., Ibáñez E. In the search of new functional food ingredients from algae. Trends Food Sci. Technol. 2008, 19(1):31-39.
90. Ponton J.W. Biofuels: thermodynamic sense and nonsense. J. Clean. Prod. 2009, 17:896-899.
91. Pulz O. Photobioreactors: production systems for phototrophic microorganisms. Appl. Microbiol. Biotechnol. 2001, 57:287-293.
92. Pulz O., Gross W. Valuable products from biotechnology of microalgae. Appl. Microbiol. Biotechnol. 2004, 65:635-648.
93. Pyle D.J., Garcia R.A., Wen Z. Producing docosahexaenoic acid (DHA)-rich algae from biodiesel-derived crude glycerol: effects of impurities on DHA production and algal biomass composition. J. Agric. Food Chem. 2008, 56:3933-3939.
94. Rao A.R., Dayananda C., Sarada R., Shamala T.R., Ravishankar G.A. Effect of salinity on growth of green alga Botryococcus braunii and its constituents. Bioresour. Technol. 2007, 98:560-564.
95. Rodolfi L., Chini Zittelli G., Bassi N., Padovani G., Biondi N., Bonini G., Tredici M.R. Microalgae for oil: strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor. Biotechnol. Bioeng. 2009, 102:100-112.
96. Rose D.P., Connolly J.M. Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol. Ther. 1999, 83:217-244.
97. Rosenberg J.N., Oyler G.A., Wilkinson L., Betenbaugh M.J. A green light for engineered algae: redirecting metabolism to fuel a biotechnology revolution. Curr. Opin. Biotechnol. 2008, 19:430-436.
98. Santos A.M., Lamers P.P., Janssen M., Wijffels R.H. Biomass and lipid productivity of Neochloris oleoabundans under alkaline-saline conditions. Algal Res. 2013, 2(3):204-211.
99. Sapci Z., Morken J. The effect of algae species on biodiesel and biogas production observed by using a data model combines algae cultivation with an anaerobic digestion (ACAD) and a biodiesel process. Energy Convers. Manag. 2014, 79:519-524.
100. Serrano A., Siles J.A., Chica A.F., Martin M. Improvement of mesophilic anaerobic co-digestion of agri-food waste by addition of glycerol. J. Environ. Manag. 2014, 140:76-82.
101. Singh S., Kate B.N., Banerjee U.C. Bioactive compounds from cyanobacteria and microalgae: an overview. Crit. Rev. Biotechnol. 2005, 25:73-95.
102. Spolaore P., Joannis-Cassan C., Duran E., Isambert A. Commercial applications of microalgae. J. Biosci. Bioeng. 2006, 101:87-96.
103. Sun A., Davis R., Starbuck M., Ben-Amotz A., Pate R., Pienkos P.T. Comparative cost analysis of algal oil production for biofuels. Energy 2011, 36(8):5169-5179.
104. Tang H., Chen M., Simon Ng K.Y., Salley S.O. Continuous microalgae cultivation in a photobioreactor. Biotechnol. Bioeng. 2012, 109:2468-2474.
105. Trappe T.A., Fluckey J.D., White F., Lambert C.P., Evans W.J. Skeletal muscle PGF2α and PGE2 in response to eccentric resistance exercise: influence of ibuprofen and acetaminophen. J. Clin. Endocrinol. Metab. 2001, 86:5067-5070.
106. Trappmann J., Hawk S.N. The effects of n-3 fatty acids and bexarotene on breast cancer cell progression. J. Cancer Ther. 2011, 2:710-714.
107. Tredici M.R. Mass production of microalgae: photobioreactors. Handbook of Microalgal Culture: Biotechnology and Applied Phycology 1 2004, 178-214. Blackwell Publishing Ltd., Oxford. A. Richmond (Ed.).
108. Tredici M.R. Photobiology of microalgae mass cultures: understanding the tools for the next green revolution. Biofuels 2010, 1:143-162.
109. Tseng C.K. The past, present and future of phycology in China. Hydrobiologia 2004, 512:11-20.
110. Van Harmelen T., Oonk H. Microalgae Biofixation Processes: Applications and Potential Contributions to Greenhouse Gas Mitigation Options 2006, TNO Built Environment and Geosciences, Apeldoorn.
111. Velea S., Dragos N., Serban S., Ilie L., Stalpeanus D., Nicoara A., Stefan E. Biological sequestration of carbon dioxide from thermal power plant emissions, by absorption in microalgal culture media. Rom. Biotechnol. Lett. 2009, 14:4485-4500.
112. 2 bio-mitigation using microalgae. Appl. Microbiol. Biotechnol. 2008, 79:707-718.
113. Wijffels R.H. Potential of sponges and microalgae for marine biotechnology. Trends Biotechnol. 2008, 26:26-31.
114. Wijffels R.H., Barbosa M.J. An outlook on microalgal biofuels. Science 2010, 329(5993):796-799.
115. Wijffels R.H., Kruse O., Hellingwerf K.J. Potential of industrial biotechnology with cyanobacteria and eukaryotic microalgae. Curr. Opin. Biotechnol. 2013, 24:405-413.
116. Woertz I., Feffer A., Lundquist T., Nelson Y. Algae grown on dairy and municipal wastewater for simultaneous nutrient removal and lipid production for biofuel feedstock. J. Environ. Eng. 2009, 135(11):1115-1122.
117. Wu Z., Shi X. Optimization for high-density cultivation of heterotrophic Chlorella based on a hybrid neural network model. Lett. Appl. Microbiol. 2007, 44:13-18.
118. Yaakob Z., Zainal A., Mohamad M., Takriff M.S., Mustafa M.M. Overview: high-values molecules from microalgae. Jordan International Energy Conference 2011, JEA, Amman.
119. Yang F., Hanna M.A., Sun R. Value-added uses for crude glycerol-a byproduct of biodiesel production. Biotechnol. Biofuels 2012, 5:13.
120. Yoshida K., Ishii H., Ishihara Y., Saito H., Yoshishiro O. Bioremediation potential of formaldehyde by the marine microalga Nannochloropsis oculata ST-3 strain. Appl. Biochem. Biotechnol. 2009, 15:321-328.
121. 2-producing Chlamydomonas reinhardtii (green alga). Planta 2002, 214:552-561.
122. Cardozo K.H., Guaratini T., Barros M.P., Falcão V.R., Tonon A.P., Lopes N.P., Campos S., Torres M.A., Souza A.O., Colepicolo P., Pinto E. Metabolites from algae with economical impact. Comparative Biochem. and Physiol. Part C: Toxicol. & Pharmacol. 2007, 146(1):60-78.
123. Sharma L., Mallick N. Accumulation of poly-β-hydroxybutyrate in Nostoc muscorum: regulation by pH, light-dark cycles. N and P status and carbon sources. Bioresour. Technol. 2005, 96(11):1304-1310.
124. De Philippis R., Sili C., Vincenzini M. Glycogen and poly-β-hydroxybutyrate synthesis in Spirulina maxima. J. of Gen. Microbiol. 1992, 138(8):1623-1628.
125. Jau M.H., Yew S.P., Toh P.S., Chong A.S., Chu W.L., Phang S.M., Sudesh K. Biosynthesis and mobilization of poly (3-hydroxybutyrate)[P (3HB)] by Spirulina platensis. International journal of biological macromolecules 2005, 36(3):144-151.
126. Nishioka M., Nakai K., Miyake M., Asada Y., Taya M. Production of poly-β-hydroxybutyrate by thermophilic cyanobacterium, Synechococcus sp. MA19, under phosphate-limited conditions. Biotechnol. Lett. 2001, 23(14):1095-1099.
127. Panda B., Mallick N. Enhanced poly-β-hydroxybutyrate accumulation in a unicellular cyanobacterium, Synechocystis sp. PCC 6803. Letters in applied microbiology 2007, 44(2):194-198.
128. Hermann-Krauss C., Koller M., Muhr A., Fasl H., Stelzer F., Braunegg G. Archaeal production of polyhydroxyalkanoate (PHA) co-and terpolyesters from biodiesel industry-derived by-products 2013, Archaea.
129. Jo Q., Jung Choy E., Won Park D., Véron B. Sterol dynamics of heterotrophic Tetraselmis suecica and its nutritional implication in the bivalve aquaculture. Aquaculture Research 2004, 35(4):371-377.