메뉴 건너뛰기




Volumn 49, Issue 3, 2001, Pages 243-251

Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia

Author keywords

Docosahexaenoic acid; Eicosapentaenoic acid; Schizophrenia; Treatment

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; KIRUNAL; NEUROLEPTIC AGENT; OMEGA 3 FATTY ACID; PHOSPHOLIPID DERIVATIVE; PLACEBO;

EID: 0035971559     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(00)00083-9     Document Type: Article
Times cited : (296)

References (63)
  • 1
    • 0033055142 scopus 로고    scopus 로고
    • The effects of dietary alpha-linolic acid compared with docosahexaenoic acid on brain, retina, liver and heart in the guinea pig
    • Abedin L., Lien E.L., Vingrys A.J., Sinclair A.J. The effects of dietary alpha-linolic acid compared with docosahexaenoic acid on brain, retina, liver and heart in the guinea pig. Lipids. 34:1999;475-482.
    • (1999) Lipids , vol.34 , pp. 475-482
    • Abedin, L.1    Lien, E.L.2    Vingrys, A.J.3    Sinclair, A.J.4
  • 2
    • 0027238756 scopus 로고
    • Phosopholipase A2 activity in serum of neuroleptic-naïve psychiatric in patients
    • Albers M.A., Meurer H., Märki F., Klotz J. Phosopholipase A2 activity in serum of neuroleptic-naïve psychiatric in patients. Pharmacopsychiatry. 26:1993;94-98.
    • (1993) Pharmacopsychiatry , vol.26 , pp. 94-98
    • Albers, M.A.1    Meurer, H.2    Märki, F.3    Klotz, J.4
  • 4
    • 0027738676 scopus 로고
    • Docosahexaenoic acid (22:6, n-3) but not eicosapentaenoic acid (20:5, n-3) can induce neutrophil-mediated injury of cultured endothelial cells: Involvement of neutrophil elastase
    • Bates E.J., Ferrante A., Harvey D.P., Nandoskar M., Poulos A. Docosahexaenoic acid (22:6, n-3) but not eicosapentaenoic acid (20:5, n-3) can induce neutrophil-mediated injury of cultured endothelial cells: involvement of neutrophil elastase. J. Leukoc. Biol. 54:1993;590-598.
    • (1993) J. Leukoc. Biol. , vol.54 , pp. 590-598
    • Bates, E.J.1    Ferrante, A.2    Harvey, D.P.3    Nandoskar, M.4    Poulos, A.5
  • 6
    • 0031719842 scopus 로고    scopus 로고
    • Adverse effects of the atypical antipsychotics
    • Adverse effects of the atypical antipsychotics. J. Clin. Psychiatry. 59:(12):1998;17-22.
    • (1998) J. Clin. Psychiatry , vol.59 , Issue.12 , pp. 17-22
  • 7
    • 0030870208 scopus 로고    scopus 로고
    • Are fish oils beneficial in the prevention and treatment of coronary artery disease?
    • Connor S.L., Connor W.E. Are fish oils beneficial in the prevention and treatment of coronary artery disease? Am. J. Clin. Nutr. 66:(4):1997;1020S-1031S.
    • (1997) Am. J. Clin. Nutr. , vol.66 , Issue.4
    • Connor, S.L.1    Connor, W.E.2
  • 8
    • 0028172777 scopus 로고
    • The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells
    • De Caterina R., Cybulsky M.I., Clinton S.K., Gimbrone M.A. Jr., Libby P. The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arterioscler. Thromb. 14:1994;1829-1836.
    • (1994) Arterioscler. Thromb. , vol.14 , pp. 1829-1836
    • De Caterina, R.1    Cybulsky, M.I.2    Clinton, S.K.3    Gimbrone M.A., Jr.4    Libby, P.5
  • 9
    • 0029670369 scopus 로고    scopus 로고
    • Alpha-linolenic acid dietary deficiency alters age-related changes of dopaminergic and serotoninergic neurotransmission in the rat frontal cortex
    • Delion S., Chalon S., Guilloteau D., Besnard J.C., Durand G. Alpha-linolenic acid dietary deficiency alters age-related changes of dopaminergic and serotoninergic neurotransmission in the rat frontal cortex. J. Neurochem. 66:1996;1582-1591.
    • (1996) J. Neurochem. , vol.66 , pp. 1582-1591
    • Delion, S.1    Chalon, S.2    Guilloteau, D.3    Besnard, J.C.4    Durand, G.5
  • 10
    • 0026562767 scopus 로고
    • Schizophrenia and rheumatoid arthritis: A review
    • Eaton W.W., Hayward C., Ram R. Schizophrenia and rheumatoid arthritis: a review. Schizophr. Res. 6:1992;181-192.
    • (1992) Schizophr. Res. , vol.6 , pp. 181-192
    • Eaton, W.W.1    Hayward, C.2    Ram, R.3
  • 11
    • 0025774954 scopus 로고
    • Purification and characterisation of phospholipase A2 from human epidermis
    • Finnen M.J., Lovell C.R. Purification and characterisation of phospholipase A2 from human epidermis. Biochem. Soc. Trans. 19:1991;91.
    • (1991) Biochem. Soc. Trans. , vol.19 , pp. 91
    • Finnen, M.J.1    Lovell, C.R.2
  • 12
    • 0032854768 scopus 로고    scopus 로고
    • Changes in levels of phosphorus metabolites in temporal lobes of drug-naïve schizophrenic patients
    • Fukuzako H., Fukuzako T., Hashiguchi T., Kodama S., Takigawa M., Fujimoto T. Changes in levels of phosphorus metabolites in temporal lobes of drug-naïve schizophrenic patients. Am. J. Psychiatry. 156:1999;1205-1208.
    • (1999) Am. J. Psychiatry , vol.156 , pp. 1205-1208
    • Fukuzako, H.1    Fukuzako, T.2    Hashiguchi, T.3    Kodama, S.4    Takigawa, M.5    Fujimoto, T.6
  • 13
    • 0023134151 scopus 로고
    • Increased plasma phospholipase-A2 activity in schizophrenic patients: Reduction after neuroleptic therapy
    • Gattaz W.F., Kollisch M., Thuren T., Virtanen J.A., Kinnunen P.K.J. Increased plasma phospholipase-A2 activity in schizophrenic patients: reduction after neuroleptic therapy. Biol. Psychiatry. 22:1987;421-426.
    • (1987) Biol. Psychiatry , vol.22 , pp. 421-426
    • Gattaz, W.F.1    Kollisch, M.2    Thuren, T.3    Virtanen, J.A.4    Kinnunen, P.K.J.5
  • 15
    • 0029024534 scopus 로고
    • Increased platelet phospholipase A2 activity in schizophrenia
    • Gattaz W.F., Schmitt A., Maras A.M. Increased platelet phospholipase A2 activity in schizophrenia. Schizophr. Res. 16:1995;1-6.
    • (1995) Schizophr. Res. , vol.16 , pp. 1-6
    • Gattaz, W.F.1    Schmitt, A.2    Maras, A.M.3
  • 16
    • 0344849434 scopus 로고    scopus 로고
    • Opposite regulation of prostaglandin H synthase isoforms by eicosapentaenoic and docosahexaenoic acids
    • Gilbert M., Achard F., Dalloz S., Maclouf J., Benistant C., Legarde M. Opposite regulation of prostaglandin H synthase isoforms by eicosapentaenoic and docosahexaenoic acids. Lipids. 34:1999;219.
    • (1999) Lipids , vol.34 , pp. 219
    • Gilbert, M.1    Achard, F.2    Dalloz, S.3    MacLouf, J.4    Benistant, C.5    Legarde, M.6
  • 18
    • 0022220591 scopus 로고
    • Characteristics of phospholipid methylation in human erythrocyte ghosts: Relationship to the psychoses and affective disorders
    • Hitzemann R.J., Mark C., Hirschowitz J., Garver D.L. Characteristics of phospholipid methylation in human erythrocyte ghosts: relationship to the psychoses and affective disorders. Biol. Psychiatry. 20:1985;297-307.
    • (1985) Biol. Psychiatry , vol.20 , pp. 297-307
    • Hitzemann, R.J.1    Mark, C.2    Hirschowitz, J.3    Garver, D.L.4
  • 19
    • 0026091918 scopus 로고
    • Fatty acid levels in the brains of schizophrenics and normal controls
    • Horrobin D.F., Manku M.S., Hillman S., Glen A.I. Fatty acid levels in the brains of schizophrenics and normal controls. Biol. Psychiatry. 30:1991;795-805.
    • (1991) Biol. Psychiatry , vol.30 , pp. 795-805
    • Horrobin, D.F.1    Manku, M.S.2    Hillman, S.3    Glen, A.I.4
  • 20
    • 0032503039 scopus 로고    scopus 로고
    • The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental hypothesis of schizophrenia
    • Horrobin D.F. The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental hypothesis of schizophrenia. Schizophr. Res. 30:1998;193-208.
    • (1998) Schizophr. Res. , vol.30 , pp. 193-208
    • Horrobin, D.F.1
  • 21
    • 84950170984 scopus 로고    scopus 로고
    • Equal antithrombotic and triglyceride-lowering effectiveness of eicosapentaenoic acid-rich and docosahexaenoic acid-rich fish oil supplements
    • Howe P.R., Clifton P.M., James M.J. Equal antithrombotic and triglyceride-lowering effectiveness of eicosapentaenoic acid-rich and docosahexaenoic acid-rich fish oil supplements. Lipids. 34:1999;S307-S308.
    • (1999) Lipids , vol.34
    • Howe, P.R.1    Clifton, P.M.2    James, M.J.3
  • 23
    • 0023606101 scopus 로고
    • The positive and negative syndrome scale (PANSS) for schizophrenia
    • Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 13:1987;261-276.
    • (1987) Schizophr. Bull. , vol.13 , pp. 261-276
    • Kay, S.R.1    Fiszbein, A.2    Opler, L.A.3
  • 25
    • 0029976262 scopus 로고    scopus 로고
    • A role for phospholipid polyunsaturation in modulating membrane protein function
    • Litman B.J., Mitchell D.C. A role for phospholipid polyunsaturation in modulating membrane protein function. Lipids. 31:1996;S193-S197.
    • (1996) Lipids , vol.31
    • Litman, B.J.1    Mitchell, D.C.2
  • 26
    • 0018816735 scopus 로고
    • Role of membrane lipids in receptor mechanisms
    • Loh H.H., Law P.Y. Role of membrane lipids in receptor mechanisms. Ann. Rev. Pharmacol. Toxicol. 20:1980;201-234.
    • (1980) Ann. Rev. Pharmacol. Toxicol. , vol.20 , pp. 201-234
    • Loh, H.H.1    Law, P.Y.2
  • 27
    • 0027978180 scopus 로고
    • Plasma membrane phospholipid and cholesterol distribution of skin fibroblasts from drug-naïve patients at the onset of psychosis
    • Mahadik S.P., Mukherjee S., Correnti E.E., Kelkar H.S., Wakade C.G., Costa R.M., Scheffer R. Plasma membrane phospholipid and cholesterol distribution of skin fibroblasts from drug-naïve patients at the onset of psychosis. Schizophr. Res. 13:1994;239-247.
    • (1994) Schizophr. Res. , vol.13 , pp. 239-247
    • Mahadik, S.P.1    Mukherjee, S.2    Correnti, E.E.3    Kelkar, H.S.4    Wakade, C.G.5    Costa, R.M.6    Scheffer, R.7
  • 28
    • 0021043946 scopus 로고
    • Fatty acids in plasma and red cell membranes
    • Manku M.S., Horrobin D.F., Huang S., Morse N. Fatty acids in plasma and red cell membranes. Lipids. 18:1983;906-908.
    • (1983) Lipids , vol.18 , pp. 906-908
    • Manku, M.S.1    Horrobin, D.F.2    Huang, S.3    Morse, N.4
  • 30
    • 0030027226 scopus 로고    scopus 로고
    • Omega-3 fatty acid supplementation in schizophrenic patients
    • Mellor J., Laugharne J.D.E., Peet M. Omega-3 fatty acid supplementation in schizophrenic patients. Human Psychopharmacol. 11:1996;39-46.
    • (1996) Human Psychopharmacol. , vol.11 , pp. 39-46
    • Mellor, J.1    Laugharne, J.D.E.2    Peet, M.3
  • 31
    • 0026508010 scopus 로고
    • Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans
    • Morrow J.D., Awad J.A., Oates J.A., Roberts L.J. Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J. Invest. Dermatol. 98:1992;812-815.
    • (1992) J. Invest. Dermatol. , vol.98 , pp. 812-815
    • Morrow, J.D.1    Awad, J.A.2    Oates, J.A.3    Roberts, L.J.4
  • 33
    • 0032785350 scopus 로고    scopus 로고
    • Eicosapentaenoic acid inhibits prostaglandin D2 generation by inhibiting cyclo-oxygenase-2 in cultured human mast cells
    • Obata T., Nagakura T., Masaki T., Masaki T., Maekawa K., Yamashita K. Eicosapentaenoic acid inhibits prostaglandin D2 generation by inhibiting cyclo-oxygenase-2 in cultured human mast cells. Clin. Exp. Allergy. 29:1999;1129-1135.
    • (1999) Clin. Exp. Allergy , vol.29 , pp. 1129-1135
    • Obata, T.1    Nagakura, T.2    Masaki, T.3    Masaki, T.4    Maekawa, K.5    Yamashita, K.6
  • 38
    • 0343880529 scopus 로고    scopus 로고
    • M. Peet, I. Glen, & D.F. Horrobin. Carnforth, UK: Marius Press
    • Peet M., Glen I., Horrobin D.F. Phospholipid Spectrum Disorder in Schizophrenia. 1999;Marius Press, Carnforth, UK.
    • (1999) Phospholipid Spectrum Disorder in Schizophrenia
  • 39
    • 0025769846 scopus 로고
    • Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naïve schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy
    • Pettegrew J.W., Keshevan M.S., Panchalingam K., Strychor S., Kaplan T.B., Tretta M.G., Allen M. Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naïve schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. Arch. Gen. Psychiatry. 48:1991;563-568.
    • (1991) Arch. Gen. Psychiatry , vol.48 , pp. 563-568
    • Pettegrew, J.W.1    Keshevan, M.S.2    Panchalingam, K.3    Strychor, S.4    Kaplan, T.B.5    Tretta, M.G.6    Allen, M.7
  • 40
    • 0031934870 scopus 로고    scopus 로고
    • Sustained remission of positive and negative symptoms of schizophrenia following treatment with eicosapentaenoic acid
    • Puri B.K., Richardson A.J. Sustained remission of positive and negative symptoms of schizophrenia following treatment with eicosapentaenoic acid. Arch. Gen. Psychiatry. 55:1998;188-189.
    • (1998) Arch. Gen. Psychiatry , vol.55 , pp. 188-189
    • Puri, B.K.1    Richardson, A.J.2
  • 41
    • 0030947208 scopus 로고    scopus 로고
    • Increased phospholipid breakdown in schizophrenia: Evidence for the involvement of a calcium-independent phospholipase A2
    • Ross B.M., Hudson C., Erlich J., Warsh J.J., Kish S.J. Increased phospholipid breakdown in schizophrenia: evidence for the involvement of a calcium-independent phospholipase A2. Arch. Gen. Psychiatry. 54:1997;487-494.
    • (1997) Arch. Gen. Psychiatry , vol.54 , pp. 487-494
    • Ross, B.M.1    Hudson, C.2    Erlich, J.3    Warsh, J.J.4    Kish, S.J.5
  • 42
    • 0002304878 scopus 로고    scopus 로고
    • Brain and blood phospholipase activity in psychiatric disorders
    • M. Peet, I. Glen, & D.F. Horrobin. Carnforth, UK: Marius Press
    • Ross B.M. Brain and blood phospholipase activity in psychiatric disorders. Peet M., Glen I., Horrobin D.F. Phospholipid Spectrum Disorder in Psychiatry. 1999;23-29 Marius Press, Carnforth, UK.
    • (1999) Phospholipid Spectrum Disorder in Psychiatry , pp. 23-29
    • Ross, B.M.1
  • 43
    • 0019362033 scopus 로고
    • The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: Substrate pellagra
    • Rudin D.O. The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra. Biol. Psychiatry. 16:1981;837-848.
    • (1981) Biol. Psychiatry , vol.16 , pp. 837-848
    • Rudin, D.O.1
  • 45
    • 0343009062 scopus 로고    scopus 로고
    • Lack of niacin skin flush response in unmedicated schizophrenic patients
    • in press
    • Shah S., Vankar K., Ramchand C.N., Peet M. Lack of niacin skin flush response in unmedicated schizophrenic patients. Schizophr. Res. 2000;. in press.
    • (2000) Schizophr. Res
    • Shah, S.1    Vankar, K.2    Ramchand, C.N.3    Peet, M.4
  • 48
    • 0027463583 scopus 로고
    • Mechanism of lipid mobilisation associated with cancer cachexia: Interaction between the polyunsaturated fatty acid, eicosapentaenoic acid and inhibitory guanine nucleotide-regulatory protein
    • Tisdale M.J. Mechanism of lipid mobilisation associated with cancer cachexia: interaction between the polyunsaturated fatty acid, eicosapentaenoic acid and inhibitory guanine nucleotide-regulatory protein. Prostaglandins Leukot. Essent. Fatty Acids. 48:1993;105-109.
    • (1993) Prostaglandins Leukot. Essent. Fatty Acids , vol.48 , pp. 105-109
    • Tisdale, M.J.1
  • 52
    • 0024602813 scopus 로고
    • A double blind trial of essential fatty acid supplementation in patients with tardive dyskinesia
    • Vaddadi K.S., Courtney P., Gilleard C.J., Manku M.S., Horrobin D.F. A double blind trial of essential fatty acid supplementation in patients with tardive dyskinesia. Psychiatry Res. 27:1989;313-323.
    • (1989) Psychiatry Res. , vol.27 , pp. 313-323
    • Vaddadi, K.S.1    Courtney, P.2    Gilleard, C.J.3    Manku, M.S.4    Horrobin, D.F.5
  • 53
    • 0031578857 scopus 로고    scopus 로고
    • The new antipsychotics and their potential for early intervention in schizophrenia
    • Waddington J.L., Scully P.J., O'Callaghan E. The new antipsychotics and their potential for early intervention in schizophrenia. Schizophr. Res. 28:1997;207-222.
    • (1997) Schizophr. Res. , vol.28 , pp. 207-222
    • Waddington, J.L.1    Scully, P.J.2    O'Callaghan, E.3
  • 55
    • 0033135391 scopus 로고    scopus 로고
    • Retinal function as a marker for cell membrane omega-3 fatty acid depletion in schizophrenia: A pilot study
    • Warner R., Laugharne J., Peet M., Brown L., Rogers N. Retinal function as a marker for cell membrane omega-3 fatty acid depletion in schizophrenia: a pilot study. Biol. Psychiatry. 45:1999;1138-1142.
    • (1999) Biol. Psychiatry , vol.45 , pp. 1138-1142
    • Warner, R.1    Laugharne, J.2    Peet, M.3    Brown, L.4    Rogers, N.5
  • 56
    • 0030011660 scopus 로고    scopus 로고
    • Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4-dienoyl-CoA reductase gene expression in rats
    • Willumsen N., Vaagenes H., Lie O., Rustan A.C., Berge R.K. Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4-dienoyl-CoA reductase gene expression in rats. Lipids. 31:1996;579-592.
    • (1996) Lipids , vol.31 , pp. 579-592
    • Willumsen, N.1    Vaagenes, H.2    Lie, O.3    Rustan, A.C.4    Berge, R.K.5
  • 58
    • 0028064589 scopus 로고
    • Red blood cell membrane dynamics in schizophrenia II: Fatty acid composition
    • Yao J.K., van Kammen D.P., Welker J.A. Red blood cell membrane dynamics in schizophrenia II: fatty acid composition. Schizophr. Res. 13:1994;217-226.
    • (1994) Schizophr. Res. , vol.13 , pp. 217-226
    • Yao, J.K.1    Van Kammen, D.P.2    Welker, J.A.3
  • 59
    • 0027978178 scopus 로고
    • Red blood cell membrane dynamics in schizophrenia III. Correlation of fatty acid abnormalities with clinical measures
    • Yao J.K., van Kammen D.P., Welker J.A., Gurklis J. Red blood cell membrane dynamics in schizophrenia III. Correlation of fatty acid abnormalities with clinical measures. Schizophr. Res. 13:1994;227-232.
    • (1994) Schizophr. Res. , vol.13 , pp. 227-232
    • Yao, J.K.1    Van Kammen, D.P.2    Welker, J.A.3    Gurklis, J.4
  • 60
    • 0003072171 scopus 로고    scopus 로고
    • Red blood cell and platelet fatty acid metabolism in schizophrenia
    • M. Peet, I. Glen, & D.F. Horrobin. Carnforth, UK: Marius Press
    • Yao J.K. Red blood cell and platelet fatty acid metabolism in schizophrenia. Peet M., Glen I., Horrobin D.F. Phospholipid Spectrum Disorder in Schizophrenia. 1999;57-74 Marius Press, Carnforth, UK.
    • (1999) Phospholipid Spectrum Disorder in Schizophrenia , pp. 57-74
    • Yao, J.K.1
  • 61
    • 0038737030 scopus 로고    scopus 로고
    • Modification of membrane phospholipids with n-6 and n-3 essential fatty acids regulates the gene expression of prostaglandin endoperoxide synthase isoforms upon agonist stimulation
    • R.A. Riemersma, R. Armstrong, R.W. Kelly, & R. Wilson. Champaign, IL: AOCS Press
    • Yokota K., Tsuruhamim K., Nishimura K., Nagayam T., Jisaka M., Takinami K. Modification of membrane phospholipids with n-6 and n-3 essential fatty acids regulates the gene expression of prostaglandin endoperoxide synthase isoforms upon agonist stimulation. Riemersma R.A., Armstrong R., Kelly R.W., Wilson R. Essential Fatty Acids and Eicosanoids. Invited Papers from the Fourth International Congress. 1998;68-73 AOCS Press, Champaign, IL.
    • (1998) Essential Fatty Acids and Eicosanoids. Invited Papers from the Fourth International Congress , pp. 68-73
    • Yokota, K.1    Tsuruhamim, K.2    Nishimura, K.3    Nagayam, T.4    Jisaka, M.5    Takinami, K.6
  • 62
    • 0031444721 scopus 로고    scopus 로고
    • Is pre-psychotic intervention realistic in schizophrenia and related disorders?
    • Yung A.R., McGorry P.D. Is pre-psychotic intervention realistic in schizophrenia and related disorders? Aust. NZ J. Psychiatry. 31:1997;799-805.
    • (1997) Aust. NZ J. Psychiatry , vol.31 , pp. 799-805
    • Yung, A.R.1    McGorry, P.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.