메뉴 건너뛰기




Volumn 91, Issue 1, 2011, Pages 31-46

Best practices in heterotrophic high-cell-density microalgal processes: Achievements, potential and possible limitations

Author keywords

Fedbatch process; Heterotrophic growth; High cell density culture; Microalgae; Stirred tank bioreactor; Substrate limitation

Indexed keywords

FED-BATCH PROCESS; HETEROTROPHIC GROWTH; HIGH CELL DENSITY; MICRO-ALGAE; STIRRED TANK BIOREACTORS; SUBSTRATE LIMITATION;

EID: 79959256030     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3311-6     Document Type: Short Survey
Times cited : (233)

References (135)
  • 1
    • 0032891658 scopus 로고    scopus 로고
    • Commercial developments in microalgal biotechnology
    • Apt KE, Behrens PW (1999) Commercial developments in microalgal biotechnology. J Phycol 35(2):215-226 (Pubitemid 29228849)
    • (1999) Journal of Phycology , vol.35 , Issue.2 , pp. 215-226
    • Apt, K.E.1    Behrens, P.W.2
  • 2
    • 0003520693 scopus 로고
    • Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly saturated fatty acids
    • US Patent 5,130,242
    • Barclay WR (1992) Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly saturated fatty acids. US Patent 5,130,242
    • (1992)
    • Barclay, W.R.1
  • 3
    • 0001177042 scopus 로고
    • Heterotrophic production of long-chain omega-3-fatty-acids utilizing algae and algae-like microorganisms
    • Barclay WR, Meager KM, Abril JR (1994) Heterotrophic production of long-chain omega-3-fatty-acids utilizing algae and algae-like microorganisms. J Appl Phycol 6(2):123-129
    • (1994) J Appl Phycol , vol.6 , Issue.2 , pp. 123-129
    • Barclay, W.R.1    Meager, K.M.2    Abril, J.R.3
  • 4
    • 33846502109 scopus 로고    scopus 로고
    • Micro-algae as a source of protein
    • doi:10.1016/j.biotechadv.2006.11.002
    • Becker EW (2007) Micro-algae as a source of protein. Biotechnol Adv 25(2):207-210. doi:10.1016/j.biotechadv.2006.11.002
    • (2007) Biotechnol Adv , vol.25 , Issue.2 , pp. 207-210
    • Becker, E.W.1
  • 5
    • 77951977295 scopus 로고    scopus 로고
    • Photobioreactors and fermentors: The light and dark sides of growing algae
    • Andersen RA (ed) Elsevier, Oxford
    • Behrens PW (2005) Photobioreactors and fermentors: the light and dark sides of growing algae. In: Andersen RA (ed) Algal culturing techniques. Elsevier, Oxford, pp 189-204
    • (2005) Algal Culturing Techniques , pp. 189-204
    • Behrens, P.W.1
  • 6
    • 0001478641 scopus 로고
    • Algal biotechnology products and processes - Matching science and economics
    • Borowitzka MA (1992) Algal biotechnology products and processes - matching science and economics. J Appl Phycol 4 (3):267-279
    • (1992) J Appl Phycol , vol.4 , Issue.3 , pp. 267-279
    • Borowitzka, M.A.1
  • 7
    • 0033034325 scopus 로고    scopus 로고
    • Commercial production of microalgae: Ponds, tanks, tubes and fermenters
    • Borowitzka MA (1999) Commercial production of microalgae: ponds, tanks, tubes and fermenters. J Biotechnol 70(1-3):313-321
    • (1999) J Biotechnol , vol.70 , Issue.1-3 , pp. 313-321
    • Borowitzka, M.A.1
  • 8
    • 56449116079 scopus 로고    scopus 로고
    • Growth inhibition of Monodus subterraneus by free fatty acids
    • doi:10.1002/Bit.21963
    • Bosma R, Miazek K, Willemsen SM, Vermue MH, Wijffels RH (2008) Growth inhibition of Monodus subterraneus by free fatty acids. Biotechnol Bioeng 101(5):1108-1114. doi:10.1002/Bit.21963
    • (2008) Biotechnol Bioeng , vol.101 , Issue.5 , pp. 1108-1114
    • Bosma, R.1    Miazek, K.2    Willemsen, S.M.3    Vermue, M.H.4    Wijffels, R.H.5
  • 9
    • 58849135386 scopus 로고    scopus 로고
    • Flux balance analysis of primary metabolism in Chlamydomonas reinhardtii
    • doi:10.1186/1752-0509-3-4
    • Boyle NR, Morgan JA (2009) Flux balance analysis of primary metabolism in Chlamydomonas reinhardtii. BMC Syst Biol 3:4. doi:10.1186/1752-0509-3-4
    • (2009) BMC Syst Biol , vol.3 , pp. 4
    • Boyle, N.R.1    Morgan, J.A.2
  • 11
    • 72049083209 scopus 로고    scopus 로고
    • Biofuels from microalgae - A review of technologies for production, processing, and extractions of biofuels and co-products
    • doi:10.1016/j.rser.2009.10.009
    • Brennan L, Owende P (2010) Biofuels from microalgae - a review of technologies for production, processing, and extractions of biofuels and co-products. Renewable Sustainable Energy Rev 14(2):557-577. doi:10.1016/j.rser.2009.10.009
    • (2010) Renewable Sustainable Energy Rev , vol.14 , Issue.2 , pp. 557-577
    • Brennan, L.1    Owende, P.2
  • 12
    • 0030855027 scopus 로고    scopus 로고
    • Nutritional properties of microalgae for mariculture
    • DOI 10.1016/S0044-8486(96)01501-3, PII S0044848696015013
    • Brown MR, Jeffrey SW, Volkman JK, Dunstan GA (1997) Nutritional properties of microalgae for mariculture. Aquaculture 151(1-4):315-331 (Pubitemid 27308877)
    • (1997) Aquaculture , vol.151 , Issue.1-4 , pp. 315-331
    • Brown, M.R.1    Jeffrey, S.W.2    Volkman, J.K.3    Dunstan, G.A.4
  • 13
    • 28844438322 scopus 로고    scopus 로고
    • Metabolic relationships between macro- And micronutrients, and the eicosapentaenoic acid and docosahexaenoic acid contents of Pavlova lutheri
    • DOI 10.1016/j.enzmictec.2005.05.014, PII S0141022905002759
    • Carvalho AP, Pontes I, Gaspar H, Malcata FX (2006) Metabolic relationships between macro- and micronutrients, and the eicosapentaenoic acid and docosahexaenoic acid contents of Pavlova lutheri. Enzyme Microb Technol 38(3-4):358-366. doi:10.1016/j.enzmictec.2005.05.014 (Pubitemid 41774503)
    • (2006) Enzyme and Microbial Technology , vol.38 , Issue.3-4 , pp. 358-366
    • Carvalho, A.P.1    Pontes, I.2    Gaspar, H.3    Malcata, F.X.4
  • 14
    • 77349096672 scopus 로고    scopus 로고
    • Flow cytometry sorting of freshwater phytoplankton
    • doi:10.1007/s10811-009-9439-4
    • Cellamare M, Rolland A, Jacquet S (2010) Flow cytometry sorting of freshwater phytoplankton. J Appl Phycol 22(1):87-100. doi:10.1007/s10811-009- 9439-4
    • (2010) J Appl Phycol , vol.22 , Issue.1 , pp. 87-100
    • Cellamare, M.1    Rolland, A.2    Jacquet, S.3
  • 15
    • 0030298327 scopus 로고    scopus 로고
    • High cell density culture of microalgae in heterotrophic growth
    • Chen F (1996) High cell density culture of microalgae in heterotrophic growth. Trends Biotechnol 14(11):421-426
    • (1996) Trends Biotechnol , vol.14 , Issue.11 , pp. 421-426
    • Chen, F.1
  • 16
    • 33646451199 scopus 로고    scopus 로고
    • Growing phototrophic cells without light
    • doi:10.1007/s10529-006-0025-4
    • Chen GQ, Chen F (2006) Growing phototrophic cells without light. Biotechnol Lett 28(9):607-616. doi:10.1007/s10529-006-0025-4
    • (2006) Biotechnol Lett , vol.28 , Issue.9 , pp. 607-616
    • Chen, G.Q.1    Chen, F.2
  • 17
    • 33746257499 scopus 로고    scopus 로고
    • Accumulation of selenium in mixotrophic culture of Spirulina platensis on glucose
    • DOI 10.1016/j.biortech.2005.10.038, PII S0960852405005183
    • Chen TF, Zheng WJ, Wong YS, Yang F, Bai Y (2006) Accumulation of selenium in mixotrophic culture of Spirulina platensis on glucose. Bioresour Technol 97(18):2260-2265 (Pubitemid 44093250)
    • (2006) Bioresource Technology , vol.97 , Issue.18 , pp. 2260-2265
    • Chen, T.1    Zheng, W.2    Wong, Y.-S.3    Yang, F.4    Bai, Y.5
  • 18
    • 53549117437 scopus 로고    scopus 로고
    • Salt-induced alterations in lipid composition of diatom Nitzschia laevis (Bacillariophyceae) under heterotrophic culture condition
    • doi:10.1111/j.1529-8817.2008.00565.x
    • Chen GQ, Jiang Y, Chen F (2008) Salt-induced alterations in lipid composition of diatom Nitzschia laevis (Bacillariophyceae) under heterotrophic culture condition. J Phycol 44(5):1309-1314. doi:10.1111/j.1529-8817.2008.00565. x
    • (2008) J Phycol , vol.44 , Issue.5 , pp. 1309-1314
    • Chen, G.Q.1    Jiang, Y.2    Chen, F.3
  • 19
    • 58149159737 scopus 로고    scopus 로고
    • Study of a two-stage growth of DHA-producing marine algae Schizochytrium limacinum SR21 with shifting dissolved oxygen level
    • doi:10.1007/s00253-008-1740-7
    • Chi ZY, Liu Y, Frear C, Chen SL (2009) Study of a two-stage growth of DHA-producing marine algae Schizochytrium limacinum SR21 with shifting dissolved oxygen level. Appl Microbiol Biotechnol 81(6):1141-1148. doi:10.1007/s00253- 008-1740-7
    • (2009) Appl Microbiol Biotechnol , vol.81 , Issue.6 , pp. 1141-1148
    • Chi, Z.Y.1    Liu, Y.2    Frear, C.3    Chen, S.L.4
  • 20
    • 33947617349 scopus 로고    scopus 로고
    • Biodiesel from microalgae
    • doi:10.1016/j.biotechadv.2007.02.001
    • Chisti Y (2007) Biodiesel from microalgae. Biotechnol Adv 25 (3):294-306. doi:10.1016/j.biotechadv.2007.02.001
    • (2007) Biotechnol Adv , vol.25 , Issue.3 , pp. 294-306
    • Chisti, Y.1
  • 21
    • 67651226120 scopus 로고    scopus 로고
    • Kinetic and stoichiometric relationships of the energy and carbon metabolism in the culture of microalgae
    • Chojnacka K, Marquez-Rocha F-J (2004) Kinetic and stoichiometric relationships of the energy and carbon metabolism in the culture of microalgae. Biotechnology 3(1):21-34
    • (2004) Biotechnology , vol.3 , Issue.1 , pp. 21-34
    • Chojnacka, K.1    Marquez-Rocha, F.-J.2
  • 22
    • 27744591716 scopus 로고    scopus 로고
    • 12 through a symbiotic relationship with bacteria
    • DOI 10.1038/nature04056, PII N04056
    • Croft MT, Lawrence AD, Raux-Deery E, Warren MJ, Smith AG (2005) Algae acquire vitamin B12 through a symbiotic relationship with bacteria. Nature 438(7064):90-93. doi:10.1038/nature04056 (Pubitemid 41599825)
    • (2005) Nature , vol.438 , Issue.7064 , pp. 90-93
    • Croft, M.T.1    Lawrence, A.D.2    Raux-Deery, E.3    Warren, M.J.4    Smith, A.G.5
  • 23
    • 0029803406 scopus 로고    scopus 로고
    • An investigation of the heterotrophic culture of the green alga Tetraselmis
    • Day JG, Tsavalos AJ (1996) An investigation of the heterotrophic culture of the green alga Tetraselmis. J Appl Phycol 8(1):73-77 (Pubitemid 26351632)
    • (1996) Journal of Applied Phycology , vol.8 , Issue.1 , pp. 73-77
    • Day, J.G.1    Tsavalos, A.J.2
  • 24
    • 0038061449 scopus 로고    scopus 로고
    • 13C labelling and desaturase inhibitor experiments
    • DOI 10.1016/S0168-1656(03)00070-1
    • de Swaaf ME, de Rijk TC, van der Meer P, Eggink G, Sijtsma L (2003a) Analysis of docosahexaenoic acid biosynthesis in Crypthecodinium cohnii by C-13 labelling and desaturase inhibitor experiments. J Biotechnol 103(1):21-29. doi:10.1016/S0168-1656(03)00070-1 (Pubitemid 36588887)
    • (2003) Journal of Biotechnology , vol.103 , Issue.1 , pp. 21-29
    • De Swaaf, M.E.1    De Rijk, T.C.2    Van Der, M.P.3    Eggink, G.4    Sijtsma, L.5
  • 25
    • 0242416551 scopus 로고    scopus 로고
    • Fed-batch cultivation of the docosahexaenoic-acid-producing marine alga Crypthecodinium cohnii on ethanol
    • de Swaaf ME, Pronk JT, Sijtsma L (2003b) Fed-batch cultivation of the docosahexaenoic-acid-producing marine alga Crypthecodinium cohnii on ethanol. Appl Microbiol Biotechnol 61(1):40-43. doi:10.1007/s00253-002-1118-1 (Pubitemid 36458051)
    • (2003) Applied Microbiology and Biotechnology , vol.61 , Issue.1 , pp. 40-43
    • De Swaaf, M.E.1    Pronk, J.T.2    Sijtsma, L.3
  • 26
    • 0037457334 scopus 로고    scopus 로고
    • High-cell-density fed-batch cultivation of the docosahexaenoic acid producing marine alga Crypthecodinium cohnii
    • DOI 10.1002/bit.10513
    • de Swaaf ME, Sijtsma L, Pronk JT (2003c) High-cell-density fedbatch cultivation of the docosahexaenoic acid producing marine alga Crypthecodinium cohnii. Biotechnol Bioeng 81(6):666-672. doi:10.1002/Bit.10513 (Pubitemid 36258519)
    • (2003) Biotechnology and Bioengineering , vol.81 , Issue.6 , pp. 666-672
    • De Swaaf, M.E.1    Sijtsma, L.2    Pronk, J.T.3
  • 27
    • 33751436377 scopus 로고    scopus 로고
    • -2 exchange and hydraulics in outdoor open high density microalgal (Chlorella sp.) photobioreactors operated in a Middle and Southern European climate
    • doi:10.1007/s10811-006-9100-4
    • -2 exchange and hydraulics in outdoor open high density microalgal (Chlorella sp.) photobioreactors operated in a Middle and Southern European climate. J Appl Phycol 18(6):811-826. doi:10.1007/s10811-006-9100-4
    • (2006) J Appl Phycol , vol.18 , Issue.6 , pp. 811-826
    • Doucha, J.1    Lívanský, K.2
  • 28
    • 56349094214 scopus 로고    scopus 로고
    • Influence of processing parameters on disintegration of Chlorella cells in various types of homogenizers
    • Doucha J, Lívanský K (2008) Influence of processing parameters on disintegration of Chlorella cells in various types of homogenizers. Appl Microbiol Biotechnol 81(3):431-440
    • (2008) Appl Microbiol Biotechnol , vol.81 , Issue.3 , pp. 431-440
    • Doucha, J.1    Lívanský, K.2
  • 29
    • 84855852917 scopus 로고    scopus 로고
    • Production of high-density Chlorella culture grown in fermenters
    • doi:10.1007/s10811-010-9643-2
    • Doucha J, Lívanský K (2011) Production of high-density Chlorella culture grown in fermenters. J Appl Phycol. doi:10.1007/s10811-010- 9643-2
    • (2011) J Appl Phycol
    • Doucha, J.1    Lívanský, K.2
  • 30
    • 67650710785 scopus 로고    scopus 로고
    • Production of Chlorella biomass enriched by selenium and its use in animal nutrition: A review
    • doi:10.1007/s00253-009-2058-9
    • Doucha J, Lívanský K, Kotrbáček V, Zachleder V (2009) Production of Chlorella biomass enriched by selenium and its use in animal nutrition: a review. Appl Microbiol Biotechnol 83(6):1001-1008. doi:10.1007/s00253-009-2058-9
    • (2009) Appl Microbiol Biotechnol , vol.83 , Issue.6 , pp. 1001-1008
    • Doucha, J.1    Lívanský, K.2    Kotrbáček, V.3    Zachleder, V.4
  • 31
    • 0000351032 scopus 로고
    • Heterotrophy of carbon
    • Stewart WDP (ed) Blackwell, Oxford
    • Droop MR (1974) Heterotrophy of carbon. In: Stewart WDP (ed) Algal physiology and biochemistry. Blackwell, Oxford, pp 530-559
    • (1974) Algal Physiology and Biochemistry , pp. 530-559
    • Droop, M.R.1
  • 32
    • 34047219747 scopus 로고    scopus 로고
    • Vitamins, phytoplankton and bacteria: Symbiosis or scavenging?
    • doi:10.1093/plankt/fbm009
    • Droop MR (2007) Vitamins, phytoplankton and bacteria: symbiosis or scavenging? J Plankton Res 29(2):107-113. doi:10.1093/plankt/fbm009
    • (2007) J Plankton Res , vol.29 , Issue.2 , pp. 107-113
    • Droop, M.R.1
  • 34
    • 0000425055 scopus 로고    scopus 로고
    • Nutrition of microorganisms
    • Egli T (2000) Nutrition of microorganisms. Encyclopedia of Microbiology 3:431-447
    • (2000) Encyclopedia of Microbiology , vol.3 , pp. 431-447
    • Egli, T.1
  • 35
    • 0019504988 scopus 로고
    • Theoretical analysis of media used in the growth of yeasts on methanol
    • Egli T, Fiechter A (1981) Theoretical-analysis of media used in the growth of yeasts on methanol. J Gen Microbiol 123:365-369 (Pubitemid 11126704)
    • (1981) Journal of General Microbiology , vol.123 , Issue.2 , pp. 365-369
    • Egli, T.1    Fiechter, A.2
  • 36
    • 0015963057 scopus 로고
    • Studies on Chlorella regularis heterotrophic fast growing strain. 1. Growth-characteristics and cellular components of Chlorella regularis, heterotrophic fast growing strain
    • Endo H, Nakajima K, Chino R, Shirota M (1974) Studies on Chlorella regularis heterotrophic fast growing strain. 1. Growth-characteristics and cellular components of Chlorella regularis, heterotrophic fast growing strain. Agric Biol Chem 38(1):9-18
    • (1974) Agric Biol Chem , vol.38 , Issue.1 , pp. 9-18
    • Endo, H.1    Nakajima, K.2    Chino, R.3    Shirota, M.4
  • 37
    • 45149095750 scopus 로고    scopus 로고
    • Production of phycocyanin - A pigment with applications in biology, biotechnology, foods and medicine
    • doi:10.1007/s00253-008-1542-y
    • Eriksen NT (2008a) Production of phycocyanin - a pigment with applications in biology, biotechnology, foods and medicine. Appl Microbiol Biotechnol 80(1):1-14. doi:10.1007/s00253-008-1542-y
    • (2008) Appl Microbiol Biotechnol , vol.80 , Issue.1 , pp. 1-14
    • Eriksen, N.T.1
  • 38
    • 49749096338 scopus 로고    scopus 로고
    • The technology of microalgal culturing
    • doi:10.1007/s10529-008-9740-3
    • Eriksen NT (2008b) The technology of microalgal culturing. Biotechnol Lett 30(9):1525-1536. doi:10.1007/s10529-008-9740-3
    • (2008) Biotechnol Lett , vol.30 , Issue.9 , pp. 1525-1536
    • Eriksen, N.T.1
  • 39
    • 0033850128 scopus 로고    scopus 로고
    • Rationalizing elemental ratios in unicellular algae
    • Falkowski PG (2000) Rationalizing elemental ratios in unicellular algae. J Phycol 36(1):3-6
    • (2000) J Phycol , vol.36 , Issue.1 , pp. 3-6
    • Falkowski, P.G.1
  • 40
    • 9644284562 scopus 로고    scopus 로고
    • Enhancement of fatty acid production of Chlorella sp (Chlorophyceae) by addition of glucose and sodium thiosulphate to culture medium
    • doi:10.1016/j.procbio.2004.06.011
    • Feng FY, YangW, Jiang GZ, Xu YN, Kuang TY (2005) Enhancement of fatty acid production of Chlorella sp (Chlorophyceae) by addition of glucose and sodium thiosulphate to culture medium. Process Biochem 40(3-4):1315-1318. doi:10.1016/j.procbio.2004.06.011
    • (2005) Process Biochem , vol.40 , Issue.3-4 , pp. 1315-1318
    • Feng, F.Y.1    Yang, W.2    Jiang, G.Z.3    Xu, Y.N.4    Kuang, T.Y.5
  • 41
    • 43949139914 scopus 로고    scopus 로고
    • Effect of mixed organic substrate on alpha-tocopherol production by Euglena gracilis in photoheterotrophic culture
    • doi:10.1007/s00253-008-1443-0
    • Fujita T, Aoyagi H, Ogbonna JC, Tanaka H (2008) Effect of mixed organic substrate on alpha-tocopherol production by Euglena gracilis in photoheterotrophic culture. Appl Microbiol Biotechnol 79(3):371-378. doi:10.1007/s00253-008-1443-0
    • (2008) Appl Microbiol Biotechnol , vol.79 , Issue.3 , pp. 371-378
    • Fujita, T.1    Aoyagi, H.2    Ogbonna, J.C.3    Tanaka, H.4
  • 42
    • 34548685399 scopus 로고    scopus 로고
    • Lipid accumulation in Schizochytrium G13/2S produced in continuous culture
    • DOI 10.1007/s00253-007-1019-4
    • Ganuza E, Izquierdo MS (2007) Lipid accumulation in Schizochytrium G13/2S produced in continuous culture. Appl Microbiol Biotechnol 76(5):985-990. doi:10.1007/s00253-007-1019-4 (Pubitemid 47415601)
    • (2007) Applied Microbiology and Biotechnology , vol.76 , Issue.5 , pp. 985-990
    • Ganuza, E.1    Izquierdo, M.S.2
  • 43
    • 49749151392 scopus 로고    scopus 로고
    • High-cell-density cultivation of Schizochytrium sp in an ammonium/pH-auxostat fed-batch system
    • doi:10.1007/s10529-008-9723-4
    • Ganuza E, Anderson AJ, Ratledge C (2008) High-cell-density cultivation of Schizochytrium sp in an ammonium/pH-auxostat fed-batch system. Biotechnol Lett 30(9):1559-1564. doi:10.1007/s10529-008-9723-4
    • (2008) Biotechnol Lett , vol.30 , Issue.9 , pp. 1559-1564
    • Ganuza, E.1    Anderson, A.J.2    Ratledge, C.3
  • 44
    • 4444361407 scopus 로고    scopus 로고
    • Mixotrophic growth of the microalga Phaeodactylum tricornutum - Influence of different nitrogen and organic carbon sources on productivity and biomass composition
    • doi:10.1016/j.procbio.2004.01.016
    • Garcia MCC, Miron AS, Sevilla JMF, Grima EM, Camacho FG (2005) Mixotrophic growth of the microalga Phaeodactylum tricornutum - influence of different nitrogen and organic carbon sources on productivity and biomass composition. Process Biochem 40(1):297-305. doi:10.1016/j.procbio.2004.01.016
    • (2005) Process Biochem , vol.40 , Issue.1 , pp. 297-305
    • Garcia, M.C.C.1    Miron, A.S.2    Sevilla, J.M.F.3    Grima, E.M.4    Camacho, F.G.5
  • 45
    • 0000735280 scopus 로고
    • Microalgal feeds for aquaculture
    • Gladue RM, Maxey (1994) Microalgal feeds for aquaculture. J Appl Phycol 6(2):131-141
    • (1994) J Appl Phycol , vol.6 , Issue.2 , pp. 131-141
    • Gladue, R.M.1    Maxey2
  • 46
    • 0009527320 scopus 로고
    • Minor element composition of yeast extract
    • Grant CL, Pramer D (1962) Minor element composition of yeast extract. J Bacteriol 84:869-870
    • (1962) J Bacteriol , vol.84 , pp. 869-870
    • Grant, C.L.1    Pramer, D.2
  • 47
    • 35348921759 scopus 로고    scopus 로고
    • Heterotrophic high-cell-density fed-batch and continuous-flow cultures of Galdieria sulphuraria and production of phycocyanin
    • DOI 10.1007/s00253-007-1150-2
    • Graverholt OS, Eriksen NT (2007) Heterotrophic high-cell-density fed-batch and continuous-flow cultures of Galdieria sulphuraria and production of phycocyanin. Appl Microbiol Biotechnol 77 (1):69-75. doi:10.1007/s00253-007- 1150-2 (Pubitemid 47573327)
    • (2007) Applied Microbiology and Biotechnology , vol.77 , Issue.1 , pp. 69-75
    • Graverholt, O.S.1    Eriksen, N.T.2
  • 48
    • 70350353205 scopus 로고    scopus 로고
    • Lipid productivity as a key characteristic for choosing algal species for biodiesel production
    • doi:10.1007/s10811-008-9392-7
    • Griffiths MJ, Harrison STL (2009) Lipid productivity as a key characteristic for choosing algal species for biodiesel production. J Appl Phycol 21(5):493-507. doi:10.1007/s10811-008-9392-7
    • (2009) J Appl Phycol , vol.21 , Issue.5 , pp. 493-507
    • Griffiths, M.J.1    Harrison, S.T.L.2
  • 50
    • 79958255848 scopus 로고    scopus 로고
    • Microalgae as sources of high added-value compounds - A brief review of recent work
    • doi:10.1002/btpr.575
    • Guedes AC, Amaro HM, Malcata FX (2011) Microalgae as sources of high added-value compounds - a brief review of recent work. Biotechnol Prog. doi:10.1002/btpr.575
    • (2011) Biotechnol Prog
    • Guedes, A.C.1    Amaro, H.M.2    Malcata, F.X.3
  • 51
    • 0034789284 scopus 로고    scopus 로고
    • Production of astaxanthin by Haematococcus pluvialis in a sequential heterotrophic-photoautotrophic culture
    • DOI 10.1023/A:1011921329568
    • Hata N, Ogbonna JC, Hasegawa Y, Taroda H, Tanaka H (2001) Production of astaxanthin by Haematococcus pluvialis in a sequential heterotrophic - photoautotrophic culture. J Appl Phycol 13(5):395-402 (Pubitemid 32972733)
    • (2001) Journal of Applied Phycology , vol.13 , Issue.5 , pp. 395-402
    • Hata, N.1    Ogbonna, J.C.2    Hasegawa, Y.3    Taroda, H.4    Tanaka, H.5
  • 53
    • 65649134815 scopus 로고    scopus 로고
    • Cultivation of microalgae for oil production with a cultivation strategy of urea limitation
    • doi:10.1016/j.biortech.2009.03.019
    • Hsieh C-H, Wu W-T (2009) Cultivation of microalgae for oil production with a cultivation strategy of urea limitation. Bioresour Technol 100:3921-3926. doi:10.1016/j.biortech.2009.03.019
    • (2009) Bioresour Technol , vol.100 , pp. 3921-3926
    • Hsieh, C.-H.1    Wu, W.-T.2
  • 55
    • 0034333380 scopus 로고    scopus 로고
    • Increase in Chlorella strains calorific values when grown in low nitrogen medium
    • Illman AM, Scragg AH, Shales SW (2000) Increase in Chlorella strains calorific values when grown in low nitrogen medium. Enzyme Microb Technol 27(8):631-635
    • (2000) Enzyme Microb Technol , vol.27 , Issue.8 , pp. 631-635
    • Illman, A.M.1    Scragg, A.H.2    Shales, S.W.3
  • 56
    • 24944561909 scopus 로고    scopus 로고
    • Employment of reactive oxygen species to enhance astaxanthin formation in Chlorella zofingiensis in heterotrophic culture
    • doi:10.1016/j.procbio.2005.02.014
    • Ip PF, Chen F (2005a) Employment of reactive oxygen species to enhance astaxanthin formation in Chlorella zofingiensis in heterotrophic culture. Process Biochem 40(11):3491-3496. doi:10.1016/j.procbio.2005.02.014
    • (2005) Process Biochem , vol.40 , Issue.11 , pp. 3491-3496
    • Ip, P.F.1    Chen, F.2
  • 57
    • 7444220106 scopus 로고    scopus 로고
    • Production of astaxanthin by the green microalga Chlorella zofingiensis in the dark
    • doi:10.1016/j.procbio.2004.01.039
    • Ip PF, Chen F (2005b) Production of astaxanthin by the green microalga Chlorella zofingiensis in the dark. Process Biochem 40 (2):733-738. doi:10.1016/j.procbio.2004.01.039
    • (2005) Process Biochem , vol.40 , Issue.2 , pp. 733-738
    • Ip, P.F.1    Chen, F.2
  • 58
    • 34249061497 scopus 로고    scopus 로고
    • Docosahexaenoic acid accumulation in thraustochytrids: Search for the rationale
    • DOI 10.1007/s00227-007-0608-1
    • Jain R, Raghukumar S, Sambaiah K, Kumon Y, Nakahara T (2007) Docosahexaenoic acid accumulation in thraustochytrids: search for the rationale. Mar Biol 151(5):1657-1664. doi:10.1007/s00227-007-0608-1 (Pubitemid 46789073)
    • (2007) Marine Biology , vol.151 , Issue.5 , pp. 1657-1664
    • Jain, R.1    Raghukumar, S.2    Sambaiah, K.3    Kumon, Y.4    Nakahara, T.5
  • 60
    • 0026417572 scopus 로고
    • High density photoautotrophic algal cultures - Design, construction, and operation of a novel photobioreactor system
    • Javanmardian M, Palsson BO (1991) High density photoautotrophic algal cultures - design, construction, and operation of a novel photobioreactor system. Biotechnol Bioeng 38 (10):1182-1189
    • (1991) Biotechnol Bioeng , vol.38 , Issue.10 , pp. 1182-1189
    • Javanmardian, M.1    Palsson, B.O.2
  • 61
    • 0033926893 scopus 로고    scopus 로고
    • Effects of medium glucose concentration and pH on docosahexaenoic acid content of heterotrophic Crypthecodinium cohnii
    • DOI 10.1016/S0032-9592(00)00163-1, PII S0032959200001631
    • Jiang Y, Chen F (2000) Effects of medium glucose concentration and pH on docosahexaenoic acid content of heterotrophic Crypthecodinium cohnii. Process Biochem 35(10):1205-1209 (Pubitemid 30463513)
    • (2000) Process Biochemistry , vol.35 , Issue.10 , pp. 1205-1209
    • Jiang, Y.1    Chen, F.2
  • 62
    • 79959247727 scopus 로고    scopus 로고
    • Production of omega-3 fatty acids in microflora of thraustochytriales using modified media
    • Patent WO 2008/049512 A1
    • Kiy T, Lui M, Zeumer O (2008) Production of omega-3 fatty acids in microflora of thraustochytriales using modified media. Patent WO 2008/049512 A1
    • (2008)
    • Kiy, T.1    Lui, M.2    Zeumer, O.3
  • 63
    • 43549108761 scopus 로고    scopus 로고
    • Phytoplankton stoichiometry
    • doi:10.1007/s11284-008-0470-8
    • Klausmeier CA, Litchman E, Daufresne T, Levin SA (2008) Phytoplankton stoichiometry. Ecol Res 23(3):479-485. doi:10.1007/s11284-008-0470-8
    • (2008) Ecol Res , vol.23 , Issue.3 , pp. 479-485
    • Klausmeier, C.A.1    Litchman, E.2    Daufresne, T.3    Levin, S.A.4
  • 64
    • 0027513039 scopus 로고
    • Enhanced carotenoid biosynthesis by oxidative stress in acetate-induced cyst cells of a green unicellular alga, Haematococcus pluvialis
    • Kobayashi M, Kakizono T, Nagai S (1993) Enhanced carotenoid biosynthesis by oxidative stress in acetate induced cyst cells of a green unicellular alga, Haematococcus pluvialis. Appl Environ Microbiol 59(3):867-873 (Pubitemid 23072368)
    • (1993) Applied and Environmental Microbiology , vol.59 , Issue.3 , pp. 867-873
    • Kobayashi, M.1    Kakizono, T.2    Nagai, S.3
  • 65
    • 77957060555 scopus 로고
    • Eicosapentaenoic acids and methods for their production
    • Patent WO 91/14427
    • Kyle DJ, Gladue RM (1991) Eicosapentaenoic acids and methods for their production. Patent WO 91/14427
    • (1991)
    • Kyle, D.J.1    Gladue, R.M.2
  • 66
    • 62949150241 scopus 로고
    • Docosahexaenoic acid, methods for its production and compounds containing the same
    • Patent WO 91/11918
    • Kyle DJ, Reeb SE, Sicotte VJ (1991) Docosahexaenoic acid, methods for its production and compounds containing the same. Patent WO 91/11918
    • (1991)
    • Kyle, D.J.1    Reeb, S.E.2    Sicotte, V.J.3
  • 67
    • 0031431296 scopus 로고    scopus 로고
    • Commercial production of microalgae in the Asia-Pacific rim
    • Lee YK (1997) Commercial production of microalgae in the Asia-Pacific rim. J Appl Phycol 9(5):403-411
    • (1997) J Appl Phycol , vol.9 , Issue.5 , pp. 403-411
    • Lee, Y.K.1
  • 68
    • 0034817728 scopus 로고    scopus 로고
    • Microalgal mass culture systems and methods: Their limitation and potential
    • Lee YK (2001) Microalgal mass culture systems and methods: their limitation and potential. J Appl Phycol 13(4):307-315
    • (2001) J Appl Phycol , vol.13 , Issue.4 , pp. 307-315
    • Lee, Y.K.1
  • 71
    • 0000649355 scopus 로고
    • Culture and nutrition of some apochlorotic diatoms of genus Nitzschia
    • Lewin J, Lewin RA (1967) Culture and nutrition of some apochlorotic diatoms of genus Nitzschia. J Gen Microbiol 46:361
    • (1967) J Gen Microbiol , vol.46 , pp. 361
    • Lewin, J.1    Lewin, R.A.2
  • 72
    • 67649185849 scopus 로고    scopus 로고
    • Biomass and lipid productivities of Chlorella vulgaris under autotrophic, heterotrophic and mixotrophic growth conditions
    • doi:10.1007/s10529-009-9975-7
    • Liang YN, Sarkany N, Cui Y (2009) Biomass and lipid productivities of Chlorella vulgaris under autotrophic, heterotrophic and mixotrophic growth conditions. Biotechnol Lett 31(7):1043-1049. doi:10.1007/s10529-009-9975-7
    • (2009) Biotechnol Lett , vol.31 , Issue.7 , pp. 1043-1049
    • Liang, Y.N.1    Sarkany, N.2    Cui, Y.3
  • 73
    • 62949164411 scopus 로고    scopus 로고
    • Effects of organic carbon sources on growth, photosyn
    • thesis, and respiration of Phaeodactylum tricornutum. doi:10.1007/s10811-008-9355-z
    • Liu XJ, Duan SS, Li AF, Xu N, Cai ZP, Hu ZX (2009) Effects of organic carbon sources on growth, photosynthesis, and respiration of Phaeodactylum tricornutum. J Appl Phycol 21(2):239-246. doi:10.1007/s10811-008-9355-z
    • (2009) J Appl Phycol , vol.21 , Issue.2 , pp. 239-246
    • Liu, X.J.1    Duan, S.S.2    Li, A.F.3    Xu, N.4    Cai, Z.P.5    Hu, Z.X.6
  • 74
    • 77952900682 scopus 로고    scopus 로고
    • Enhanced lipid production of Chlorella vulgaris by adjustment of cultivation conditions
    • doi:10.1016/j.biortech.2010.03.120
    • Lv JM, Cheng LH, Xu XH, Zhang L, Chen HL (2010) Enhanced lipid production of Chlorella vulgaris by adjustment of cultivation conditions. Bioresour Technol 101(17):6797-6804. doi:10.1016/j.biortech.2010.03.120
    • (2010) Bioresour Technol , vol.101 , Issue.17 , pp. 6797-6804
    • Lv, J.M.1    Cheng, L.H.2    Xu, X.H.3    Zhang, L.4    Chen, H.L.5
  • 75
    • 0033851422 scopus 로고    scopus 로고
    • Effect of nutrient availability on the biochemical and elemental stoichiometry in the freshwater diatom Stephanodiscus minutulus (Bacillariophyceae)
    • Lynn SG, Kilham SS, Kreeger DA, Interlandi SJ (2000) Effect of nutrient availability on the biochemical and elemental stoichiometry in the freshwater diatom Stephanodiscus minutulus (Bacillariophyceae). J Phycol 36(3):510-522
    • (2000) J Phycol , vol.36 , Issue.3 , pp. 510-522
    • Lynn, S.G.1    Kilham, S.S.2    Kreeger, D.A.3    Interlandi, S.J.4
  • 76
    • 79959231804 scopus 로고    scopus 로고
    • Induction of astaxanthin formation in the green microalga Chlorococcum sp by reactive oxygen species (ROS) under mixotrophic conditions of growth
    • Chen F, Jiang Y (eds) Kluwer Academic, Dordrecht
    • Ma RYN, Chen F (2001) Induction of astaxanthin formation in the green microalga Chlorococcum sp by reactive oxygen species (ROS) under mixotrophic conditions of growth. In: Chen F, Jiang Y (eds) Algae and their biotechnological potential. Kluwer Academic, Dordrecht, pp 519-523
    • (2001) Algae and Their Biotechnological Potential , pp. 519-523
    • Ryn, M.1    Chen, F.2
  • 77
    • 0032487112 scopus 로고    scopus 로고
    • Elemental balancing of biomass and medium composition enhances growth capacity in high-density Chlorella vulgaris cultures
    • DOI 10.1002/(SICI)1097-0290(19980905)59:5<605::AID-BIT11>3.0.CO;2-8
    • Mandalam RK, Palsson BO (1998) Elemental balancing of biomass and medium composition enhances growth capacity in high-density Chlorella vulgaris cultures. Biotechnol Bioeng 59 (5):605-611 (Pubitemid 28350462)
    • (1998) Biotechnology and Bioengineering , vol.59 , Issue.5 , pp. 605-611
    • Mandalam, R.K.1    Palsson, B.O.2
  • 78
    • 34547828044 scopus 로고    scopus 로고
    • Study of docosahexaenoic acid production by the heterotrophic microalga Crypthecodinium cohnii CCMP 316 using carob pulp as a promising carbon source
    • DOI 10.1007/s11274-007-9349-z
    • Mendes A, Guerra P, Madeira V, Ruano F, da Silva TL, Reis A (2007) Study of docosahexaenoic acid production by the heterotrophic microalga Crypthecodinium cohnii CCMP 316 using carob pulp as a promising carbon source. World J Microbiol Biotechnol 23 (9):1209-1215. doi:10.1007/s11274-007-9349-z (Pubitemid 47245894)
    • (2007) World Journal of Microbiology and Biotechnology , vol.23 , Issue.9 , pp. 1209-1215
    • Mendes, A.1    Guerra, P.2    Madeira, V.3    Ruano, F.4    Lopes, D.S.T.5    Reis, A.6
  • 79
    • 62949197772 scopus 로고    scopus 로고
    • Crypthecodinium cohnii with emphasis on DHA production: A review
    • doi:10.1007/s10811-008-9351-3
    • Mendes A, Reis A, Vasconcelos R, Guerra P, Lopes da Silva T (2009) Crypthecodinium cohnii with emphasis on DHA production: a review. J Appl Phycol 21:199-214. doi:10.1007/s10811-008-9351-3
    • (2009) J Appl Phycol , vol.21 , pp. 199-214
    • Mendes, A.1    Reis, A.2    Vasconcelos, R.3    Guerra, P.4    Lopes Da Silva, T.5
  • 81
    • 0000401813 scopus 로고
    • Bioenergetic analysis of mixotrophic growth in Chlorella vulgaris and Scenedesmus acutus
    • Ogawa T, Aiba S (1981) Bioenergetic analysis of mixotrophic growth in Chlorella vulgaris and Scenedesmus acutus. Biotechnol Bioeng 23(5):1121-1132
    • (1981) Biotechnol Bioeng , vol.23 , Issue.5 , pp. 1121-1132
    • Ogawa, T.1    Aiba, S.2
  • 82
    • 0031866708 scopus 로고    scopus 로고
    • Heterotrophic cultivation of Euglena gracilis Z for efficient production of alpha-tocopherol
    • DOI 10.1023/A:1008011201437
    • Ogbonna JC, Tomiyama S, Tanaka H (1998) Heterotrophic cultivation of Euglena gracilis Z for efficient production of alphatocopherol. J Appl Phycol 10(1):67-74 (Pubitemid 28324679)
    • (1998) Journal of Applied Phycology , vol.10 , Issue.1 , pp. 67-74
    • Ogbonna, J.C.1    Tomiyama, S.2    Tanaka, H.3
  • 83
    • 79251619733 scopus 로고    scopus 로고
    • Heterotrophic growth and lipid production of Chlorella protothecoides on glycerol
    • doi:10.1007/s00449-010-0474-y
    • O'Grady J, Morgan JA (2011) Heterotrophic growth and lipid production of Chlorella protothecoides on glycerol. Bioprocess Biosyst Eng 34(1):121-125. doi:10.1007/s00449-010-0474-y
    • (2011) Bioprocess Biosyst Eng , vol.34 , Issue.1 , pp. 121-125
    • O'Grady, J.1    Morgan, J.A.2
  • 84
    • 0002594472 scopus 로고
    • Chlorella
    • Borowitzka MA, Borowitzka LJ (eds) Cambridge University Press, Cambridge
    • Oh-Hama T, Miyachi S (1988) Chlorella. In: Borowitzka MA, Borowitzka LJ (eds) Microalgal biotechnology. Cambridge University Press, Cambridge, pp 3-26
    • (1988) Microalgal Biotechnology , pp. 3-26
    • Oh-Hama, T.1    Miyachi, S.2
  • 85
    • 0042066368 scopus 로고    scopus 로고
    • Commercial development of microalgal biotechnology: From the test tube to the marketplace
    • doi:10.1016/S1389-0344(03)00076-5
    • Olaizola M (2003) Commercial development of microalgal biotechnology: from the test tube to the marketplace. Biomol Eng 20 (4-6):459-466. doi:10.1016/S1389-0344(03)00076-5
    • (2003) Biomol Eng , vol.20 , Issue.4-6 , pp. 459-466
    • Olaizola, M.1
  • 86
    • 58549090345 scopus 로고    scopus 로고
    • Genomic insights into marine microalgae
    • doi:10.1146/annurev.genet.42.110807.091417
    • Parker MS, Mock T, Armbrust EV (2008) Genomic insights into marine microalgae. Annu Rev Genet 42:619-645. doi:10.1146/annurev.genet.42.110807. 091417
    • (2008) Annu Rev Genet , vol.42 , pp. 619-645
    • Parker, M.S.1    Mock, T.2    Armbrust, E.V.3
  • 87
    • 78649649684 scopus 로고    scopus 로고
    • Heterotrophic cultures of microalgae: Metabolism and potential products
    • doi:10.1016/j.watres.2010.08.037
    • Perez-Garcia O, Escalante FM, de-Bashan LE, Bashan Y (2011) Heterotrophic cultures of microalgae: metabolism and potential products.Water Res 45(1):11-36. doi:10.1016/j.watres.2010.08.037
    • (2011) Water Res , vol.45 , Issue.1 , pp. 11-36
    • Perez-Garcia, O.1    Escalante, F.M.2    De-Bashan, L.E.3    Bashan, Y.4
  • 88
    • 77957019344 scopus 로고    scopus 로고
    • Strategies for high-level recombinant protein expression in transgenic microalgae: A review
    • doi:10.1016/j.biotechadv.2010.08.006
    • Potvin G, Zhang Z (2010) Strategies for high-level recombinant protein expression in transgenic microalgae: A review. Biotech Adv 28:910-918. doi:10.1016/j.biotechadv.2010.08.006
    • (2010) Biotech Adv , vol.28 , pp. 910-918
    • Potvin, G.1    Zhang, Z.2
  • 89
    • 8644242931 scopus 로고    scopus 로고
    • Valuable products from biotechnology of microalgae
    • DOI 10.1007/s00253-004-1647-x
    • Pulz O, Gross W (2004) Valuable products from biotechnology of microalgae. Appl Microbiol Biotechnol 65(6):635-648. doi:10.1007/s00253-004- 1647-x (Pubitemid 39506544)
    • (2004) Applied Microbiology and Biotechnology , vol.65 , Issue.6 , pp. 635-648
    • Pulz, O.1    Gross, W.2
  • 91
    • 45849103886 scopus 로고    scopus 로고
    • A perspective on the biotechnological potential of microalgae
    • DOI 10.1080/10408410802086783, PII 793345809
    • Raja R, Hemaiswarya S, Kumar NA, Sridhar S, Rengasamy R (2008) A perspective on the biotechnological potential of microalgae. Crit Rev Microbiol 34(2):77-88. doi:10.1080/10408410802086783 (Pubitemid 351878992)
    • (2008) Critical Reviews in Microbiology , vol.34 , Issue.2 , pp. 77-88
    • Raja, R.1    Hemaiswarya, S.2    Kumar, N.A.3    Sridhar, S.4    Rengasamy, R.5
  • 92
    • 84988206314 scopus 로고
    • Production of extracellular polysaccharide by unicellular red alga Porphyridium aerugineum
    • doi:10.1111/j.1529-8817.1972.tb04007.x
    • Ramus J (1972) Production of extracellular polysaccharide by unicellular red alga Porphyridium aerugineum. J Phycol 8 (1):97-111. doi:10.1111/j.1529- 8817.1972.tb04007.x
    • (1972) J Phycol , vol.8 , Issue.1 , pp. 97-111
    • Ramus, J.1
  • 93
    • 0028247924 scopus 로고
    • Effect of nutrient limitation on fatty acid and lipid content of marine microalgae
    • Reitan KI, Rainuzzo JR, Olsen Y (1994) Effect of nutrient limitation on fatty acid and lipid content of marine microalgae. J Phycol 30(6):972-979
    • (1994) J Phycol , vol.30 , Issue.6 , pp. 972-979
    • Reitan, K.I.1    Rainuzzo, J.R.2    Olsen, Y.3
  • 94
    • 0032922829 scopus 로고    scopus 로고
    • High-cell-density cultivation of microorganisms
    • DOI 10.1007/s002530051412
    • Riesenberg D, Guthke R (1999) High-cell-density cultivation of microorganisms. Appl Microbiol Biotechnol 51(4):422-430 (Pubitemid 29210561)
    • (1999) Applied Microbiology and Biotechnology , vol.51 , Issue.4 , pp. 422-430
    • Riesenberg, D.1    Guthke, R.2
  • 95
    • 58149269804 scopus 로고    scopus 로고
    • Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor
    • doi:10.1002/bit.22033
    • Rodolfi L, Chini Zittelli G, Bassi N, Padovani G, Biondi N, Bonini G, Tredici MR (2009) Microalgae for oil: strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor. Biotechnol Bioeng 102(1):100-112. doi:10.1002/bit.22033
    • (2009) Biotechnol Bioeng , vol.102 , Issue.1 , pp. 100-112
    • Rodolfi, L.1    Chini Zittelli, G.2    Bassi, N.3    Padovani, G.4    Biondi, N.5    Bonini, G.6    Tredici, M.R.7
  • 96
    • 53049102292 scopus 로고    scopus 로고
    • A green light for engineered algae: Redirecting metabolism to fuel a biotechnology revolution
    • doi:10.1016/j.copbio.2008.07.008
    • Rosenberg JN, Oyler GA, Wilkinson L, Betenbaugh MJ (2008) A green light for engineered algae: redirecting metabolism to fuel a biotechnology revolution. Curr Opin Biotechnol 19(5):430-436. doi:10.1016/j.copbio.2008.07.008
    • (2008) Curr Opin Biotechnol , vol.19 , Issue.5 , pp. 430-436
    • Rosenberg, J.N.1    Oyler, G.A.2    Wilkinson, L.3    Betenbaugh, M.J.4
  • 97
    • 0002888810 scopus 로고
    • Heterotrophic production of ascorbic-acid by microalgae
    • Running JA, Huss RJ, Olson PT (1994) Heterotrophic production of ascorbic-acid by microalgae. J Appl Phycol 6(2):99-104
    • (1994) J Appl Phycol , vol.6 , Issue.2 , pp. 99-104
    • Running, J.A.1    Huss, R.J.2    Olson, P.T.3
  • 98
    • 0036692602 scopus 로고    scopus 로고
    • Extracellular production of L-ascorbic acid by Chlorella protothecoides, Prototheca species, and mutants of P. moriformis during aerobic culturing at low pH
    • DOI 10.1038/sj.jim.7000275
    • Running JA, Severson DK, Schneider KJ (2002) Extracellular production of L-ascorbic acid by Chlorella protothecoides, Prototheca species, and mutants of P. moriformis during aerobic culturing at low pH. J Ind Microbiol Biotechnol 29(2):93-98. doi:10.1038/sj.jim.7000275 (Pubitemid 34988942)
    • (2002) Journal of Industrial Microbiology and Biotechnology , vol.29 , Issue.2 , pp. 93-98
    • Running, J.A.1    Severson, D.K.2    Schneider, K.J.3
  • 99
    • 12444250064 scopus 로고    scopus 로고
    • Production of intracellular phytochemicals in chlorella under heterotrophic conditions
    • Sansawa H, Endo H (2004) Production of intracellular phytochemicals in Chlorella under heterotrophic conditions. J Biosci Bioeng 98(6):437-444 (Pubitemid 40144031)
    • (2004) Journal of Bioscience and Bioengineering , vol.98 , Issue.6 , pp. 437-444
    • Sansawa, H.1    Endo, H.2
  • 100
    • 17444422502 scopus 로고    scopus 로고
    • Heterotrophic high cell-density fed-batch cultures of the phycocyanin-producing red alga Galdieria sulphuraria
    • DOI 10.1002/bit.20417
    • Schmidt RA, Wiebe MG, Eriksen NT (2005) Heterotrophic high cell-density fed-batch cultures of the phycocyanin-producing red alga Galdieria sulphuraria. Biotechnol Bioeng 90(1):77-84. doi:10.1002/Bit.20417 (Pubitemid 40547041)
    • (2005) Biotechnology and Bioengineering , vol.90 , Issue.1 , pp. 77-84
    • Schmidt, R.A.1    Wiebe, M.G.2    Eriksen, N.T.3
  • 101
    • 0003080240 scopus 로고
    • The production of clonal and axenic cultures of microalgae using fluorescence-activated cell sorting
    • Sensen CW, Heimann K, Melkonian M (1993) The production of clonal and axenic cultures of microalgae using fluorescence-activated cell sorting. Eur J Phycol 28:93-97
    • (1993) Eur J Phycol , vol.28 , pp. 93-97
    • Sensen, C.W.1    Heimann, K.2    Melkonian, M.3
  • 102
    • 77949310059 scopus 로고    scopus 로고
    • Heterotrophic culture of Chlorella protothecoides in various nitrogen sources for lipid production
    • doi:10.1007/s12010-009-8659-z
    • Shen Y, Yuan W, Pei Z, Mao E (2010) Heterotrophic culture of Chlorella protothecoides in various nitrogen sources for lipid production. Appl Biochem Biotechnol 160(6):1674-1684. doi:10.1007/s12010-009-8659-z
    • (2010) Appl Biochem Biotechnol , vol.160 , Issue.6 , pp. 1674-1684
    • Shen, Y.1    Yuan, W.2    Pei, Z.3    Mao, E.4
  • 103
    • 0034255898 scopus 로고    scopus 로고
    • Heterotrophic production of biomass and lutein by Chlorella protothecoides on various nitrogen sources
    • Shi XM, Zhang XW, Chen F (2000) Heterotrophic production of biomass and lutein by Chlorella protothecoides on various nitrogen sources. Enzyme Microb Technol 27(3-5):312-318
    • (2000) Enzyme Microb Technol , vol.27 , Issue.3-5 , pp. 312-318
    • Shi, X.M.1    Zhang, X.W.2    Chen, F.3
  • 104
    • 0036021987 scopus 로고    scopus 로고
    • High-yield production of lutein by the green microalga Chlorella protothecoides in heterotrophic fed-batch culture
    • DOI 10.1021/bp0101987
    • Shi XM, Jiang Y, Chen F (2002) High-yield production of lutein by the green microalga Chlorella protothecoides in heterotrophic fed-batch culture. Biotechnol Prog 18(4):723-727. doi:10.1021/bp0101987 (Pubitemid 34853382)
    • (2002) Biotechnology Progress , vol.18 , Issue.4 , pp. 723-727
    • Shi, X.-M.1    Jiang, Y.2    Chen, F.3
  • 105
    • 33748462327 scopus 로고    scopus 로고
    • Kinetic modeling of lutein production by heterotrophic Chlorella at various pH and temperatures
    • doi:10.1002/mnfr.200600037
    • Shi XM, Wu ZY, Chen F (2006) Kinetic modeling of lutein production by heterotrophic Chlorella at various pH and temperatures. Mol Nutr Food Res 50(8):763-768. doi:10.1002/mnfr.200600037
    • (2006) Mol Nutr Food Res , vol.50 , Issue.8 , pp. 763-768
    • Shi, X.M.1    Wu, Z.Y.2    Chen, F.3
  • 106
    • 27844593257 scopus 로고    scopus 로고
    • Accumulation of phycocyanin in heterotrophic and mixotrophic cultures of the acidophilic red alga Galdieria sulphuraria
    • DOI 10.1016/j.enzmictec.2005.05.010, PII S0141022905002309
    • Sloth JK, Wiebe MG, Eriksen NT (2006) Accumulation of phycocyanin in heterotrophic and mixotrophic cultures of the acidophilic red alga Galdieria sulphuraria. Enzyme Microb Technol 38(1-2):168-175. doi:10.1016/j.enzmictec. 2005.05.010 (Pubitemid 41660533)
    • (2006) Enzyme and Microbial Technology , vol.38 , Issue.1-2 , pp. 168-175
    • Sloth, J.K.1    Wiebe, M.G.2    Eriksen, N.T.3
  • 107
    • 77956747852 scopus 로고    scopus 로고
    • Micro-algae come of age as a platform for recombinant protein production
    • doi:10.1007/s10529-010-0326-5
    • Specht E, Miyake-Stoner S, Mayfield S (2010) Micro-algae come of age as a platform for recombinant protein production. Biotechnol Lett 32(10):1373-1383. doi:10.1007/s10529-010-0326-5
    • (2010) Biotechnol Lett , vol.32 , Issue.10 , pp. 1373-1383
    • Specht, E.1    Miyake-Stoner, S.2    Mayfield, S.3
  • 109
    • 53049094204 scopus 로고    scopus 로고
    • Sugar-based growth, astaxanthin accumulation and carotenogenic transcription of heterotrophic Chlorella zofingiensis (Chlorophyta)
    • doi:10.1016/j.procbio.2008.07.014
    • Sun N, Wang Y, Li YT, Huang JC, Chen F (2008) Sugar-based growth, astaxanthin accumulation and carotenogenic transcription of heterotrophic Chlorella zofingiensis (Chlorophyta). Process Biochem 43(11):1288-1292. doi:10.1016/j.procbio.2008.07.014
    • (2008) Process Biochem , vol.43 , Issue.11 , pp. 1288-1292
    • Sun, N.1    Wang, Y.2    Li, Y.T.3    Huang, J.C.4    Chen, F.5
  • 110
    • 22744451914 scopus 로고    scopus 로고
    • CCAC - Culture Collection of Algae at the University of Cologne: A new collection of axenic algae with emphasis on flagellates
    • doi:10.1127/0029-5035/2004/0079-0077
    • Surek B, Melkonian M (2004) CCAC - Culture Collection of Algae at the University of Cologne: a new collection of axenic algae with emphasis on flagellates. Nova Hedwig 79:77-92. doi:10.1127/0029-5035/2004/0079-0077
    • (2004) Nova Hedwig , vol.79 , pp. 77-92
    • Surek, B.1    Melkonian, M.2
  • 111
    • 0037514592 scopus 로고    scopus 로고
    • Biomass nutrient profiles of three microalgae: Spirulina platensis, Chlorella vulgaris, and Isochrisis galbana
    • Tokusoglu O, Unal MK (2003) Biomass nutrient profiles of three microalgae: Spirulina platensis, Chlorella vulgaris, and Isochrisis galbana. J Food Sci 68(4):1144-1148 (Pubitemid 36632047)
    • (2003) Journal of Food Science , vol.68 , Issue.4 , pp. 1144-1148
    • Tokusoglu, O.1    Unal, M.K.2
  • 112
    • 70350510816 scopus 로고    scopus 로고
    • Breaking the habit. Integrating plasticity into taxonomy
    • Trainor FR (2009) Breaking the habit. Integrating plasticity into taxonomy. Syst Biodivers 7:95-100
    • (2009) Syst Biodivers , vol.7 , pp. 95-100
    • Trainor, F.R.1
  • 114
    • 85063545024 scopus 로고
    • Laboratory techniques for the cultivation of microalgae
    • Richmond A (ed) CRC, Boca Raton, FL
    • Vonshak A (1986) Laboratory techniques for the cultivation of microalgae. In: Richmond A (ed) Handbook of microalgal mass culture. CRC, Boca Raton, FL, pp 117-145
    • (1986) Handbook of Microalgal Mass Culture , pp. 117-145
    • Vonshak, A.1
  • 115
    • 29344469593 scopus 로고    scopus 로고
    • Algal transgenics in the genomic era
    • DOI 10.1111/j.1529-8817.2005.00133.x
    • Walker TL, Collet C, Purton S (2005a) Algal transgenics in the genomic ERA. J Phycol 41(6):1077-1093. doi:10.1111/j.1529-8817.2005.00133.x (Pubitemid 43004983)
    • (2005) Journal of Phycology , vol.41 , Issue.6 , pp. 1077-1093
    • Walker, T.L.1    Collet, C.2    Purton, S.3
  • 116
    • 28244470082 scopus 로고    scopus 로고
    • Microalgae as bioreactors
    • DOI 10.1007/s00299-005-0004-6
    • Walker TL, Purton S, Becker DK, Collet C (2005b) Microalgae as bioreactors. Plant Cell Rep 24(11):629-641. doi:10.1007/s00299-005-0004-6 (Pubitemid 41712695)
    • (2005) Plant Cell Reports , vol.24 , Issue.11 , pp. 629-641
    • Walker, T.L.1    Purton, S.2    Becker, D.K.3    Collet, C.4
  • 117
    • 48349083447 scopus 로고    scopus 로고
    • Growth-associated biosynthesis of astaxanthin in heterotrophic Chlorella zofingiensis (Chlorophyta)
    • doi:10.1007/s11274-008-9692-8
    • Wang Y, Peng J (2008) Growth-associated biosynthesis of astaxanthin in heterotrophic Chlorella zofingiensis (Chlorophyta). World J Microbiol Biotechnol 24(9):1915-1922. doi:10.1007/s11274-008-9692-8
    • (2008) World J Microbiol Biotechnol , vol.24 , Issue.9 , pp. 1915-1922
    • Wang, Y.1    Peng, J.2
  • 118
    • 0037010767 scopus 로고    scopus 로고
    • Perfusion culture of the diatom Nitzschia laevis for ultra-high yield of eicosapentaenoic acid
    • Wen ZY, Chen F (2002) Perfusion culture of the diatom Nitzschia laevis for ultra-high yield of eicosapentaenoic acid. Process Biochem 38(4):523-529
    • (2002) Process Biochem , vol.38 , Issue.4 , pp. 523-529
    • Wen, Z.Y.1    Chen, F.2
  • 119
    • 0037492427 scopus 로고    scopus 로고
    • Heterotrophic production of eicosapentaenoic acid by microalgae
    • doi:10.1016/S0734-9750(03)00051-X
    • Wen ZY, Chen F (2003) Heterotrophic production of eicosapentaenoic acid by microalgae. Biotechnol Adv 21(4):273-294. doi:10.1016/S0734-9750(03)00051-X
    • (2003) Biotechnol Adv , vol.21 , Issue.4 , pp. 273-294
    • Wen, Z.Y.1    Chen, F.2
  • 120
    • 0036661106 scopus 로고    scopus 로고
    • High cell density culture of the diatom Nitzschia laevis for eicosapentaenoic acid production: Fed-batch development
    • DOI 10.1016/S0032-9592(02)00034-1, PII S0032959202000341
    • Wen ZY, Jiang Y, Chen F (2002) High cell density culture of the diatom Nitzschia laevis for eicosapentaenoic acid production: fed-batch development. Process Biochem 37(12):1447-1453 (Pubitemid 35192009)
    • (2002) Process Biochemistry , vol.37 , Issue.12 , pp. 1447-1453
    • Wen, Z.-Y.1    Jiang, Y.2    Chen, F.3
  • 121
    • 58249126028 scopus 로고    scopus 로고
    • Study of increasing lipid production from fresh water microalgae Chlorella vulgaris
    • doi:10.1016/j.jtice.2008.07.007
    • Widjaja A, Chien CC, Ju YH (2009) Study of increasing lipid production from fresh water microalgae Chlorella vulgaris. J Taiwan Inst Chem Eng 40(1):13-20. doi:10.1016/j.jtice.2008.07.007
    • (2009) J Taiwan Inst Chem Eng , vol.40 , Issue.1 , pp. 13-20
    • Widjaja, A.1    Chien, C.C.2    Ju, Y.H.3
  • 122
    • 37349035027 scopus 로고    scopus 로고
    • Potential of sponges and microalgae for marine biotechnology
    • doi:10.1016/j.tibtech.2007.10.002
    • Wijffels RH (2008) Potential of sponges and microalgae for marine biotechnology. Trends Biotechnol 26(1):26-31. doi:10.1016/j.tibtech.2007.10.002
    • (2008) Trends Biotechnol , vol.26 , Issue.1 , pp. 26-31
    • Wijffels, R.H.1
  • 123
    • 77955619699 scopus 로고    scopus 로고
    • An outlook on microalgal biofuels
    • doi:10.1126/science.1189003
    • Wijffels RH, Barbosa MJ (2010) An outlook on microalgal biofuels. Science 329(5993):796-799. doi:10.1126/science.1189003
    • (2010) Science , vol.329 , Issue.5993 , pp. 796-799
    • Wijffels, R.H.1    Barbosa, M.J.2
  • 124
    • 33845804679 scopus 로고    scopus 로고
    • Optimization for high-density cultivation of heterotrophic Chlorella based on a hybrid neural network model
    • doi:10.1111/j.1472-765X.2006.02038.x
    • Wu ZY, Shi XM (2007) Optimization for high-density cultivation of heterotrophic Chlorella based on a hybrid neural network model. Lett Appl Microbiol 44(1):13-18. doi:10.1111/j.1472-765X.2006.02038.x
    • (2007) Lett Appl Microbiol , vol.44 , Issue.1 , pp. 13-18
    • Wu, Z.Y.1    Shi, X.M.2
  • 125
    • 43749103791 scopus 로고    scopus 로고
    • Rheological properties of Chlorella pyrenoidosa culture grown heterotrophically in a fermentor
    • doi:10.1007/s10811-007-9244-x
    • Wu ZY, Shi XM (2008) Rheological properties of Chlorella pyrenoidosa culture grown heterotrophically in a fermentor. J Appl Phycol 20(3):279-282. doi:10.1007/s10811-007-9244-x
    • (2008) J Appl Phycol , vol.20 , Issue.3 , pp. 279-282
    • Wu, Z.Y.1    Shi, X.M.2
  • 126
    • 33646459271 scopus 로고    scopus 로고
    • Production of single cell oils by dinoflagellates
    • Cohen Z, Ratledge C (eds) AOCS, Champaign, IL
    • Wynn JP, Behrens PW, Sundararajan A, Hansen J, Apt K (2005) Production of single cell oils by dinoflagellates. In: Cohen Z, Ratledge C (eds) Single cell oils. AOCS, Champaign, IL
    • (2005) Single Cell Oils
    • Wynn, J.P.1    Behrens, P.W.2    Sundararajan, A.3    Hansen, J.4    Apt, K.5
  • 127
    • 38349193099 scopus 로고    scopus 로고
    • High-density fermentation of microalga Chlorella protothecoides in bioreactor for microbiodiesel production
    • doi:10.1007/s00253-007-1285-1
    • Xiong W, Li XF, Xiang JY, Wu QY (2008) High-density fermentation of microalga Chlorella protothecoides in bioreactor for microbiodiesel production. Appl Microbiol Biotechnol 78(1):29-36. doi:10.1007/s00253-007-1285-1
    • (2008) Appl Microbiol Biotechnol , vol.78 , Issue.1 , pp. 29-36
    • Xiong, W.1    Li, X.F.2    Xiang, J.Y.3    Wu, Q.Y.4
  • 128
    • 74749090955 scopus 로고    scopus 로고
    • Double CO(2) fixation in photosynthesis-fermentation model enhances algal lipid synthesis for biodiesel production
    • doi:10.1016/j.biortech.2009.11.041
    • Xiong W, Gao C, Yan D, Wu C, Wu Q (2010a) Double CO(2) fixation in photosynthesis-fermentation model enhances algal lipid synthesis for biodiesel production. Bioresour Technol 101 (7):2287-2293. doi:10.1016/j.biortech.2009.11. 041
    • (2010) Bioresour Technol , vol.101 , Issue.7 , pp. 2287-2293
    • Xiong, W.1    Gao, C.2    Yan, D.3    Wu, C.4    Wu, Q.5
  • 129
    • 77957733466 scopus 로고    scopus 로고
    • C-13-Tracer and gas chromatography-mass spectrometry analyses reveal metabolic flux distribution in the oleaginous microalga Chlorella protothecoides
    • doi:10.1104/pp.110.158956
    • Xiong W, Liu LX, Wu C, Yang C, Wu QY (2010b) C-13-Tracer and gas chromatography-mass spectrometry analyses reveal metabolic flux distribution in the oleaginous microalga Chlorella protothecoides. Plant Physiol 154(2):1001-1011. doi:10.1104/pp.110.158956
    • (2010) Plant Physiol , vol.154 , Issue.2 , pp. 1001-1011
    • Xiong, W.1    Liu, L.X.2    Wu, C.3    Yang, C.4    Wu, Q.Y.5
  • 130
    • 0025965483 scopus 로고
    • Growth of and omega-3-fatty-acid production by Phaeodactylum tricornutum under different culture conditions
    • Yongmanitchai W, Ward OP (1991) Growth of and omega-3-fatty-acid production by Phaeodactylum tricornutum under different culture conditions. Appl Environ Microbiol 57(2):419-425
    • (1991) Appl Environ Microbiol , vol.57 , Issue.2 , pp. 419-425
    • Yongmanitchai, W.1    Ward, O.P.2
  • 131
    • 0035874988 scopus 로고    scopus 로고
    • Trophic conversion of an obligate photoautotrophic organism through metabolic engineering
    • DOI 10.1126/science.160015
    • Zaslavskaia LA, Lippmeier JC, Shih C, Ehrhardt D, Grossman AR, Apt KE (2001) Trophic conversion of an obligate photoautotrophic organism through metabolic engineering. Science 292(5524):2073-2075. doi:10.1126/science.160015 (Pubitemid 32691572)
    • (2001) Science , vol.292 , Issue.5524 , pp. 2073-2075
    • Zaslavskaia, L.A.1    Lippmeier, J.C.2    Shih, C.3    Ehrhardt, D.4    Grossman, A.R.5    Apt, K.E.6
  • 132
    • 0033230932 scopus 로고    scopus 로고
    • Kinetic models for heterotrophic growth of Chlamydomonas reinhardtii in batch and fed-batch cultures
    • DOI 10.1016/S0032-9592(99)00082-5, PII S0032959299000825
    • Zhang XW, Chen F, Johns MR (1999a) Kinetic models for heterotrophic growth of Chlamydomonas reinhardtii in batch and fed-batch cultures. Process Biochem 35(3-4):385-389 (Pubitemid 29533737)
    • (1999) Process Biochemistry , vol.35 , Issue.3-4 , pp. 385-389
    • Zhang, X.-W.1    Chen, F.2    Johns, M.R.3
  • 133
    • 0032790140 scopus 로고    scopus 로고
    • Kinetic models for astaxanthin production by high cell density mixotrophic culture of the microalga Haematococcus pluvialis
    • DOI 10.1038/sj.jim.2900685
    • Zhang XW, Gong XD, Chen F (1999b) Kinetic models for astaxanthin production by high cell density mixotrophic culture of the microalga Haematococcus pluvialis. J Ind Microbiol Biotechnol 23(1):691-696 (Pubitemid 29397153)
    • (1999) Journal of Industrial Microbiology and Biotechnology , vol.23 , Issue.1 , pp. 691-696
    • Zhang, X.W.1    Gong, X.-D.2    Chen, F.3
  • 134
    • 0033389245 scopus 로고    scopus 로고
    • A kinetic model for lutein production by the green microalga Chlorella protothecoides in heterotrophic culture
    • Zhang XW, Shi XM, Chen F (1999c) A kinetic model for lutein production by the green microalga Chlorella protothecoides in heterotrophic culture. J Ind Microbiol Biotechnol 23(6):503-507
    • (1999) J Ind Microbiol Biotechnol , vol.23 , Issue.6 , pp. 503-507
    • Zhang, X.W.1    Shi, X.M.2    Chen, F.3
  • 135
    • 0033919965 scopus 로고    scopus 로고
    • Production of cell mass and eicosapentaenoic acid (EPA) in ultrahigh cell density cultures of Nannochloropsis sp. (Eustigmatophyceae)
    • DOI 10.1017/S0967026200002699
    • Zou N, Zhang CW, Cohen Z, Richmond A (2000) Production of cell mass and eicosapentaenoic acid (EPA) in ultrahigh cell density cultures of Nannochloropsis sp. (Eustigmatophyceae). Eur J Phycol 35(2):127-133 (Pubitemid 30427932)
    • (2000) European Journal of Phycology , vol.35 , Issue.2 , pp. 127-133
    • Zou, N.1    Zhang, C.2    Cohen, Z.3    Richmond, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.