Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: Involvement of TRPM2 and TRPV1 channels

Neuroscience

Volumn 284, Issue , 2015, Pages 225-233

  Övey, I S ^a   Naziroglu M ^a,b  

^a SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b SULEYMAN DEMIREL UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Hippocampus; Homocysteine; Oxidative stress; TRPM2 and TRPV1 channels

Indexed keywords

BUTHIONINE SULFOXIMINE; CASPASE 3; CASPASE 9; GLUTATHIONE; HOMOCYSTEINE; N METHYL DEXTRO ASPARTIC ACID; REACTIVE OXYGEN METABOLITE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; VANILLOID RECEPTOR 1; VOLTAGE GATED CALCIUM CHANNEL; ANTIMETABOLITE; CALCIUM; CAPSAICIN; HYDROGEN PEROXIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, MOUSE; TRPV1 PROTEIN, MOUSE; VANILLOID RECEPTOR;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; HIPPOCAMPUS; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; UPREGULATION; AGING; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOSOL; DRUG EFFECTS; METABOLISM; NERVE CELL; PHYSIOLOGY;

AGING; ANIMALS; ANTIMETABOLITES; APOPTOSIS; BUTHIONINE SULFOXIMINE; CALCIUM; CAPSAICIN; CELLS, CULTURED; CYTOSOL; GLUTATHIONE; HIPPOCAMPUS; HOMOCYSTEINE; HYDROGEN PEROXIDE; MALE; MICE, INBRED C57BL; NEURONS; OXIDATIVE STRESS; TRPM CATION CHANNELS; TRPV CATION CHANNELS;

EID: 84908376973     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.09.078     Document Type: Article

References (39)

1. Akpinar A., Uğuz A.C., Naziroğlu M. Agomelatine and duloxetine synergistic all modulates apoptotic pathway by inhibiting oxidative stress triggered intracellular calcium entry in neuronal PC12 cells: role of TRPM2 and voltage-gated calcium channels. J Membr Biol 2014, 247:451-459.
2. Argun M., Tök L., Uğuz A.C., Celik O., Tök O.Y., Naziroğlu M. Melatonin and amfenac modulate calcium entry, apoptosis, and oxidative stress in ARPE-19 cell culture exposed to blue light irradiation (405nm). Eye (Lond) 2014, 28:752-760.
3. Ataie A., Sabetkasaei M., Haghparast A., Moghaddam A.H., Kazeminejad B. Neuroprotective effects of the polyphenolic antioxidant agent, Curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat. Pharmacol Biochem Behav 2010, 96:378-385.
4. Baydas G., Kutlu S., Naziroglu M., Canpolat S., Sandal S., Ozcan M., Kelestimur H. Inhibitory effects of melatonin on neural lipid peroxidation induced by intracerebroventricularly administered homocysteine. J Pineal Res 2003, 34:36-39.
5. Bejarano I., Redondo P.C., Espino J., Rosado J.A., Paredes S.D., Barriga C., Reiter R.J., Pariente J.A., Rodríguez A.B. Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells. J Pineal Res 2009, 46:392-400.
6. Belrose J.C., Xie Y.F., Gierszewski L.J., MacDonald J.F., Jackson M.F. Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons. Mol Brain 2012, 9(5):11.
7. Cankurtaran M., Yesil Y., Kuyumcu M.E., Oztürk Z.A., Yavuz B.B., Halil M., Ulger Z., Cankurtaran E.S., Arioğul S. Altered levels of homocysteine and serum natural antioxidants links oxidative damage to Alzheimer's disease. J Alzheimers Dis 2013, 33:1051-1058.
8. Chuang H.H., Lin S. Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification. Proc Natl Acad Sci U S A 2009, 106:20097-20102.
9. Espino J., Bejarano I., Paredes S.D., Barriga C., Rodríguez A.B., Pariente J.A. Protective effect of melatonin against human leukocyte apoptosis induced by intracellular calcium overload: relation with its antioxidant actions. J Pineal Res 2011, 51:195-206.
10. Espino J., Bejarano I., Redondo P.C., Rosado J.A., Barriga C., Reiter R.J., Pariente J.A., Rodríguez A.B. Melatonin reduces apoptosis induced by calcium signaling in human leukocytes: evidence for the involvement of mitochondria and Bax activation. J Membr Biol 2010, 233:105-118.
11. Fatmi W., Kechrid Z., Naziroğlu M., Flores-Arce M. Selenium supplementation modulates zinc levels and antioxidant values in blood and tissues of diabetic rats fed zinc-deficient diet. Biol Trace Elem Res 2013, 152:243-250.
12. Finkelstein J.D. Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine. Clin Chem Lab Med 2007, 45(12):1694-1699. [Review].
13. Ghazizadeh V., Naziroğlu M. Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats. Metab Brain Dis 2014, 29:787-799.
14. Hirashima Y., Seshimo S., Fujiki Y., Okabe M., Nishiyama K., Matsumoto M., Kanouchi H., Oka T. Homocysteine and copper induce cellular apoptosis via caspase activation and nuclear translocation of apoptosis-inducing factor in neuronal cell line SH-SY5Y. Neurosci Res 2010, 67:300-306.
15. Jin Y., Brennan L. Effects of homocysteine on metabolic pathways in cultured astrocytes. Neurochem Int 2008, 52:1410-1415.
16. Kamat P.K., Kalani A., Tyagi S.C., Tyagi N. Hydrogen sulfide epigenetically attenuates homocysteine-Induced mitochondrial toxicity mediated through NMDA receptor in mouse brain endothelial (bEnd3) cells. J Cell Physiol 2014, [Epub ahead of print]. 10.1002/jcp.24722.
17. Kumar V.S., Gopalakrishnan A., Naziroğlu M., Rajanikant G.K. Calcium ion-the key player in cerebral ischemia. Curr Med Chem 2014, 21:2065-2075.
18. Lee M., Cho T., Jantaratnotai N., Wang Y.T., McGeer E., McGeer P.L. Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. FASEB J 2010, 24:2533-2545.
19. Lin H.C., Yang C.M., Liu C.L., Hu M.L. Synergistic effects of homocysteine, S-adenosylhomocysteine and adenosine on apoptosis in BV-2 murine microglial cells. Biofactors 2008, 34:81-95.
20. Lorrio S., Gómez-Rangel V., Negredo P., Egea J., Leon R., Romero A., Dal-Cim T., Villarroya M., Rodriguez-Franco M.I., Conde S., Arce M.P., Roda J.M., García A.G., Lópe M.G. Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia. Neuropharmacology 2013, 67:403-411.
21. Naziroğlu M. Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy. Neurochem Res 2009, 34:2181-2191.
22. Naziroğlu M. Molecular role of catalase on oxidative stress-induced Ca(2+) signaling and TRP cation channel activation in nervous system. J Recept Signal Transduct Res 2012, 32:134-141.
23. Naziroğlu M., Dikici D.M., Dursun S. Role of oxidative stress and Ca(2+) signaling on molecular pathways of neuropathic pain in diabetes: focus on TRP channels. Neurochem Res 2012, 37:2065-2075.
24. Naziroğlu M., Çelik Ö., Özgül C., Doğan S., Bal R., Gümral N., Rodríguez A.B., Pariente J.A. Melatonin modulates wireless devices (2.45GHz)-induced brain and dorsal root ganglion injury through TRPM2 and voltage gated calcium channels in rat. Physiol Behav 2012, 105:683-692.
25. 2+ influx in dorsal root ganglion neurons of mice: role of TRPV1 channels. Neuroscience 2013, 242:151-160.
26. Naziroğlu M., Lückhoff A. Effects of antioxidants on calcium influx through TRPM2 channels in transfected cells activated by hydrogen peroxide. J Neurol Sci 2008, 270:152-158.
27. Naziroğlu M., Lückhoff A. A calcium influx pathway regulated separately by oxidative stress and ADP-Ribose in TRPM2 channels: single channel events. Neurochem Res 2008, 33:1256-1262.
28. Naziroğlu M., Özgül C., Çiğ B., Doğan S., Uğuz A.C. Glutathione modulates Ca(2+) influx and oxidative toxicity through TRPM2 channel in rat dorsal root ganglion neurons. J Membr Biol 2011, 242:109-118.
29. Naziroğlu M., Senol N., Ghazizadeh V., Yürüker V. Neuroprotection induced by N-acetylcysteine and selenium against traumatic brain injury-induced apoptosis and calcium entry in hippocampus of rat. Cell Mol Neurobiol 2014, 34:895-903.
30. Naziroğlu M. New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose. Neurochem Res 2007, 32:1990-2001.
31. Naziroğlu M. TRPM2 cation channels, oxidative stress and neurological diseases: where are we now?. Neurochem Res 2011, 36:355-366.
32. 2+ influx in rat dorsal root ganglion. Physiol Behav 2012, 106:122-128.
33. Perraud A.L., Fleig A., Dunn C.A., Bagley L.A., Launay P., Schmitz C., Stokes A.J., Zhu Q., Bessman M.J., Penner R., Kinet J.P., Scharenberg A.M. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by nudix motif homology. Nature 2001, 411:595-599.
34. Ribas V., García-Ruiz C., Fernández-Checa J.C. Glutathione and mitochondria. Front Pharmacol 2014, 5:151.
35. Smeyne M., Smeyne R.J. Glutathione metabolism and Parkinson's disease. Free Radic Biol Med 2013, 62:13-25.
36. Stipanuk M.H. Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 2004, 24:539-577.
37. Tjiattas L., Ortiz D.O., Dhivant S., Mitton K., Rogers E., Shea T.B. Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation. Aging Cell 2004, 3:71-76.
38. Tök L., Naziroğlu M., Uğuz A.C., Tök O. Elevated hydrostatic pressures induce apoptosis and oxidative stress through mitochondrial. J Recept Signal Transduct Res 2014, [Epub ahead of print].
39. Uğuz A.C., Naziroğlu M. Effects of selenium on calcium signaling and apoptosis in rat dorsal root ganglion neurons induced by oxidative stress. Neurochem Res 2012, 37:1631-1638.