Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

Molecular Brain

Volumn 5, Issue 1, 2012, Pages

  Belrose, Jillian C ^a,b   Xie, Yu Feng ^b   Gierszewski, Lynn J ^b   MacDonald, John F ^a,b   Jackson, Michael F ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Aging; Glutathione; Oxidative stress; Primary hippocampal culture; Pyramidal neuron; TRPM2

Indexed keywords

BUTHIONINE SULFOXIMINE; GLUTATHIONE; THIOL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; ACETYLCYSTEINE; ADENOSINE DIPHOSPHATE RIBOSE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; THIOL DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; HIPPOCAMPUS; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; VOLTAGE CLAMP; ANIMAL; CELL STRAIN HEK293; CHANNEL GATING; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; TIME;

ACETYLCYSTEINE; ADENOSINE DIPHOSPHATE RIBOSE; ANIMALS; CELL AGING; CELLS, CULTURED; GENE EXPRESSION REGULATION; GLUTATHIONE; HEK293 CELLS; HOMEOSTASIS; HUMANS; ION CHANNEL GATING; MICE; NEURONS; PYRAMIDAL CELLS; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SULFHYDRYL COMPOUNDS; TIME FACTORS; TRPM CATION CHANNELS;

EID: 84859392620     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/1756-6606-5-11     Document Type: Article

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