Agomelatine and Duloxetine synergistically modulates apoptotic pathway by inhibiting oxidative stress triggered intracellular calcium entry in neuronal PC12 cells: Role of TRPM2 and voltage-gated calcium channels

Journal of Membrane Biology

Volumn 247, Issue 5, 2014, Pages 451-459

  Akpinar, Abdullah ^a   Uǧuz, Abdülhadi Cihangir ^a,b   NazIroǧlu, Mustafa ^a,b  

^a SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b SULEYMAN DEMIREL UNIVERSITY   (Turkey)

Author keywords

Agomelatine; Apoptosis; Calcium signaling; Duloxetine; Oxidative stress; TRPM2 channels

Indexed keywords

ACETAMIDE DERIVATIVE; AGOMELATINE; ANTIDEPRESSANT AGENT; ANTIOXIDANT; CALCIUM; CALCIUM CHANNEL; CASPASE 3; CASPASE 9; DULOXETINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; THIOPHENE DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, RAT;

ANIMAL; APOPTOSIS; DRUG EFFECTS; DRUG POTENTIATION; LIPID PEROXIDATION; METABOLISM; OXIDATIVE STRESS; PC12 CELL LINE; RAT;

ACETAMIDES; ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIOXIDANTS; APOPTOSIS; CALCIUM; CALCIUM CHANNELS; CASPASE 3; CASPASE 9; DRUG SYNERGISM; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; OXIDATIVE STRESS; PC12 CELLS; RATS; THIOPHENES; TRPM CATION CHANNELS;

EID: 84898864361     PISSN: 00222631     EISSN: 14321424     Source Type: Journal    
DOI: 10.1007/s00232-014-9652-1     Document Type: Article

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