Synergistic effects of homocysteine, S-adenosylhomocysteine and adenosine on apoptosis in BV-2 murine microglial cells

BioFactors

Volumn 34, Issue 2, 2008, Pages 81-95

  Lin, Hung Chi ^a   Yang, Chih Min ^a   Liu, Cheng Ling ^a   Hu, Miao Lin ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Adenosine; Apoptosis; Homocysteine; S adenosylhomocysteine; Synergy

Indexed keywords

5 METHYLDEOXYCYTIDINE; ADENOSINE; ALPHA TOCOPHEROL; BIOLOGICAL MARKER; CASPASE 3; CASPASE 9; CELL DNA; CYTOCHROME C; DICHLORODIHYDROFLUORESCEIN DIACETATE; HOMOCYSTEINE; LIPOCORTIN 5; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; S ADENOSYLHOMOCYSTEINE;

AMINO ACID METABOLISM; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DNA METHYLATION; ENZYME ACTIVITY; IMMUNOBLOTTING; MICROGLIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ADENOSINE; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE; CELL SURVIVAL; DRUG SYNERGISM; HOMOCYSTEINE; METHYLATION; MICE; MICROGLIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; S-ADENOSYLHOMOCYSTEINE;

MURINAE;

EID: 69449101923     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520340201     Document Type: Article

References (39)

1. R.E. Bellas, E.O. Harrington, K.L. Sheahan, J. Newton, C. Marcus and S. Rounds, FAK blunts adenosine-homocysteineinduced endothelial cell apoptosis: requirement for PI 3-kinase, American Journal of Physiology Lung Cellular and Molecular Physiology 282 (2002), L1135-1142,
2. S. Bergmann, V. Shatrov, F. Ratter, S. Schiemann, K. Schulze-Osthoff and V. Lehmann, Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-κB in L929 cells, Journal of Immunology 153 (1994), 1736-1743.
3. T. Chavarria, F. Sanchez-Jimenez, A.R. Quesada and M.A. Mdina, Homocysteine inhibits the proliferation and invasive potential of HT-1080 human fibrosarcoma cells, Biochemical and Biophysical Research Communications 301 (2003), 540-544.
4. C.A. Cooney, C.K. Wise and L.A. Poirier, An improved sample preparation method for the quantitative HPLC determination 5-methyldeoxycytidine in animal tissue DNA, The Journal of Liquid Chromatography & Related Technologies 20 (1997), 1279-1293.
5. D. Dawicki, D. Chatterjee, J. Wyche and S. Rounds, Extracellular ATP and adenosine cause apoptosis of pulmonary artery endothelial cells, The American Journal of Physiology 273 (1997), L485-L494. (Pubitemid 127751589)
6. S.F. De, Cabo, M.J. Hazen, M.L. Molero and J. Ferńandez-piqueras, S-adenosyl-L-homocysteine: a non-cytotoxic hypomethylating agent, Experientia 50 (1994), 658-689.
7. B.P. Ennedy, T. Bottiglieri, A. Hansen and E. Maslish, Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferase and cognitive function, Journal of Neural Transmission 111 (2004), 547-567.
8. K. Eto, T. Asada, K. Arima, T. Makifuchi and H. Kimura, Brain hydrogen sulfite is severely decreased in Alzheimer's disease, Biochemical and Biophysical Research Communications 293 (2002), 1485-1488.
9. J.D. Finkelstein and J.J. Martin, Homocysteine, The International Journal of Biochemistry & Cell Biology 32 (2000), 385-389.
10. M. Frantseva, J.L. Perez-Velazquez, A. Tonkikh, Y. Adamchik and P.L. Carlen, Neurotrauma/neurodegeneration and mitochondrial dysfunction, Progress in Brain Research 137 (2002), 171-176.
11. B.B. Fredholm, A.P. IJzerman, K.A. Jacobson, K.N. Klotz and J. Linden, International Union of Pharmacology, XXV, Nomenclature and classification of adenosine receptors, Pharmacology Review 53 (2001), 527-552.
12. W. Fu, N.P. Dudman, M.A. Perry, K. Young and X.I.Wang, Interrelations between plasma homocysteine and intracellular S-adenosylhomocysteine, Biochemical and Biophysical Research Communications 271 (2000), 47-53.
13. R.C. Gupta, Nonrandom binging of the carcinogenN-hydroxy-2-Acetylamino- fluorene to repetitive sequences of rat liver DNA in vivo, Proceedings of the National Academy of Sciences of the United States of America 81 (1984), 6943-6947.
14. B. Halliwell and J.M.C. Gutteridge, Free Radicals in Biology and Medicine, Oxford University Press Inc, New York, 2007
15. D.R. Hoffman, D.W. Marion, W.E. Cornatzer and J.A. Duerre, S-adenosylmethionine and S-adenosylhomocysteine metabolism in isolated liver, Journal of Biological Chemistry 255 (1980), 10822-10827
16. B. Hultberg, A. Andersson and A. Isaksson, Hypomethylation as a cause of homocysteine-induced cell damage in human cell lines, Toxicology 147 (2000), 69-75.
17. S.J. James, S. Melnyk, M. Pogribny, I.P. Pogribny and M.A. Caudill, Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology, Journal of Nutrition 132 (2002), 2361S-2366S.
18. C.M. Knudson, K.S. Tung, W.G. Tourtellotte, G.A. Brown and S.J. Korsmeyer, Bax-deficient mice with lymphoid hyperplasia and male germ cell death, Science 270 (1995), 96-99.
19. N.M. Kredich and M.S. Hershifield, S-adenosylhomocysteine toxicity in normal and adenosine kinase-deficient lymphoblasts of human origin, Proceedings of the National Academy of Sciences of the United States of America 76 (1979), 2450-2454.
20. M.E. Lee and H.Wang, Homocysteine and hypomethylation: A novel link to vascular disease, Trends in Cardiovascular Medicine 9 (1999), 49-54. (Pubitemid 29142580)
21. P.Y. Lin, T.H. Yang, H.C Lin and M.L. Hu, Synergistic effects of S-adenosylhomocysteine and homocysteine on DNA damage in a murine microglial cell line, Clinica Chimica Acta 379 (2007), 139-144.
22. J.W. Miller, Homocysteine, folate deficiency, and Parkinson's disease, Nutrition Reviews 60 (2002), 410-413. (Pubitemid 36026501)
23. H. Mochizuki, K. Goto, H. Mori and Y. Mizuno, Histochemical detection of apoptosis in Parkinson's disease. Journal of Neurological, Science 137 (1996), 120-123.
24. M. Naoi and W. Maruyama, Cell death of dopamine neurons in aging and Parkinson's disease, Mechanisms of Ageing and Development 111 (1999), 175-188.
25. A.J. Olszewski and K.S. McCully, Homocysteine metabolism and the oxidative modification of proteins and lipids, Free Radical Biology & Medicine 14 (1992), 683-693. (Pubitemid 23172577)
26. V. Ralevic and G. Burnstock, Receptors for purines and pyrimidines, Pharmacological Reviews 50 (1998), 413-492.
27. F. Ratter,M. Germer, T. Fischbach, K. Schulze-Ostboff, M.E. Peter,W. Droge and V. Lehmann, S-adenosylhomocysteine as a physiological modulator of Apo-1-mediated apoptosis, International Immunology 8 (1996), 1139-1147.
28. P. Sacerdote, S. Denis-Donini, P. Paglia, F. Granucci, A.E. Panerai and P. Ricciardi-Castagnoli, Cloned microglial cells but not macrophages synthesize beta-endorphin in response to CRH activation, Glia 9 (1993), 305-310.
29. S.T. Smiley, M. Reers, C. Hartshorn-Mottoal, M. Lin, A. Chen, T.W. Smith, G.D. Steele, D. Glenn and B. Chen, Intracellular heterogeneity in mitochondrial membrane potential revealed by a J-aggregate-forming lipophilic cation JC-1, Proceedings of the National Academy of Sciences of the United States of America 88 (1991), 3671-3675.
30. J.H. Su, A.J. Anderson, B.J. Cummings and C.W. Cotman, Immunohisto-chemical evidence for apoptosis cell death in Alzheimer's disease, Neuroreporter 5 (1994), 2529-2533.
31. A.Y. Sun and Y.M. Chen, Extracellular ATP-induced apoptosis in PC12 cells, Advances in Experimental Medicine and Biology 446 (1998), 73-83. (Pubitemid 128701731)
32. N. Tyagi, A.V. Ovechkin, D. Lominadze, K.S. Monshal and S.C. Tyagi, Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia, Journal of Cellular Biochemistry 98 (2006), 1150-1162. (Pubitemid 44131429)
33. S.E. Vollset, H. Refsum, A. Tverdal, O. Nygard, J.E. Nordrehaug, G.S. Tell and P.M. Ueland, Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study, The American Journal of Clinical Nutrition 74 (2001), 130-136. (Pubitemid 32574920)
34. C.K.Wise, C.A. Conney, S.F. Ali and L.A. Poirier, Measuring S-adenosylmethionine in whole blood, red blood cells and cultured cells using a fast preparation method and high-performance liquid chromatography, The Journal of Chromatography B 696 (1997), 145-152.
35. T.S. Yang, N.C. Yang and M.L. Hu, S-adenosylhomocysteine enhances Hydrogen peroxide-induced DNA damage by inhibition of DNA repair, Nutrition and Cancer 47 (2003), 70-75. (Pubitemid 38250438)
36. J. Yang, X. Liu, K. Bhalla, C.N. Kim, A.M. Ibrado, J. Cai, T.I. Peng, D.P. Jones and X. Wang, Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science 275 (1997), 1129-1132. (Pubitemid 27097312)
37. P. Yi, S. Melnyk, M. Pogribna, I.P. Pogribny, J. Hinet and S.J. James, Increase in plasma homocysteine associated with parallel increase in plasma S-adenosylhomocystsine and DNA hypomethylation, Journal of Biological Chemistry 275 (2000), 29318-29323.
38. Z. Zhao, T. Kapoian, M. Shepard and E.A. Lianos, Adenosine-induced apoptosis in glomerular mesangial cells, Kidney International 61 (2002), 1276-1285. (Pubitemid 34304488)
39. B.T. Zhu, On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis, Histology and Histopathology 17 (2002), 1283-1291.