Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia

Neuroscience

Volumn 281, Issue , 2014, Pages 251-257

  Fu, B ^a   Zhang, J ^a   Zhang, X ^a,b,c   Zhang, C ^a   Li, Y ^a   Zhang, Y ^a   He, T ^a   Li, P ^a   Zhu, X ^a   Zhao, Y ^a   Wang, X ^b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Hebei Collaborative Innovation Center for Cardio cerebrovascular Disease   (China)

^c Hebei Key Laboratory for Neurology   (China)

Author keywords

Alpha lipoic acid; Ischemic stroke; Oxidative stress; Peroxisome proliferator activated receptor co activator 1 ; Silent mating type information regulation 2 homolog 1

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SIRTUIN 1; SUPEROXIDE DISMUTASE; THIOCTIC ACID; ANTIOXIDANT; PPARGC1A PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN WATER; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CEREBRAL ARTERY DISEASE; DISEASE MODEL; METABOLISM;

ANIMALS; ANTIOXIDANTS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; SIRTUIN 1; SUPEROXIDE DISMUTASE; THIOCTIC ACID; UP-REGULATION;

EID: 84908375148     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.09.058     Document Type: Article

References (33)

1. Bederson J.B., Pitts L.H., Germano S.M., Nishimura M.C., Davis R.L., Bartkowski H.M. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 1986, 17(6):1304-1308.
2. Cantó C., Auwerx J. Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab 2009, 20(7):325-331.
3. Cantó C., Auwerx J. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol 2009, 20(2):98-105.
4. Ceulemans A.G., Zgavc T., Kooijman R., Hachimi-Idrissi S., Sarre S., Michotte Y. The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia. J Neuroinflamm 2010, 7:74.
5. Chen L., Wang L., Zhang X., Cui L., Xing Y., Dong L., Liu Z., Li Y., Zhang X., Wang C., Bai X., Zhang J., Zhang L., Zhao X. The protection by Octreotide against experimental ischemic stroke: Up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-κB expression. Brain Res 2012, 1475:80-87.
6. Chen W., Kang C., Wang S., Lee H.M. α-lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase. Diabetologia 2012, 55(6):1824-1835.
7. Cosar E., Sahin F.K., Köken G., Toy H., Basarali K., Büyükbas S. The protective effect of alpha-lipoic acid in experimental ovarian ischaemia-reperfusion injury. Aust N Z J Obstet Gynaecol 2007, 47(6):499-503.
8. Crack P.J., Taylor J.M. Reactive oxygen species and the modulation of stroke. Free Radic Biol Med 2005, 38(11):1433-1444.
9. Gursoy-Ozdemir Y., Can A., Dalkara T. Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia. Stroke 2004, 35:1449-1453.
10. Hall E.D., Vaishnav R.A., Mustafa A.G. Antioxidant therapies for traumatic brain injury. Neurotherapeutics 2010, 7(1):51-61.
11. Hattori I., Takagi Y., Nakamura H., Nozaki K., Bai J., Kondo N., Sugino T., Nishimura M., Hashimoto N., Yodoi J. Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in mice. Antioxid Redox Signal 2004, 6(1):81-87.
12. Ji H., Zhang X., Du Y., Liu H., Li S., Li L. Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain. Brain Res Bull 2012, 87(1):50-59.
13. Jiang T., Yin F., Yao J., Brinton R.D., Cadenas E. Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC-1α transcriptional pathway. Aging Cell 2013, 12(6):1021-1031.
14. Li L., Zhang X., Cui L., Wang L., Liu H., Ji H., Du Y. Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice. Brain Res 2013, 1497:32-39.
15. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20(1):84-91.
16. Mitsui Y., Schmelzer J.D., Zollman P.J., Mitsui M., Tritschler H.J., Low P.A. Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. J Neurol Sci 1999, 163(1):11-16.
17. Nemoto S., Fergusson M.M., Finkel T. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem 2005, 280(16):16456-16460.
18. Niizuma K., Endo H., Chan P.H. Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival. J Neurochem 2009, 109(suppl. 1):133-138.
19. Ozbal S., Ergur B.U., Erbil G., Tekmen I., Bagriyanik A., Cavdar Z. The effects of α-lipoic acid against testicular ischemia-reperfusion injury in rats. Scientific World J 2012, 2012:489248.
20. Packer L., Tritschler H.J., Wessel K. Neuroprotection by the metabolic antioxidant α-lipoic acid. Free Radic Biol Med 1997, 22(1-2):359-378.
21. Panigrahi M., Sadguna Y., Shivakumar B.R., Kolluri S.V., Roy S., Packer L., Ravindranath V. Alpha-lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res 1996, 717(1-2):184-188.
22. Puigserver P., Spiegelman B.M. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 2003, 24(1):78-90.
23. Raval A.P., Lin H.W., Dave K.R., Defazio R.A., Della Morte D., Kim E.J., Perez-Pinzon M.A. Resveratrol and ischemic preconditioning in the brain. Curr Med Chem 2008, 15(15):1545-1551.
24. Rodgers J.T., Lerin C., Gerhart-Hines Z., Puigserver P. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett 2008, 582(1):46-53.
25. Shaafi S., Afrooz M.R., Hajipour B., Dadadshi A., Hosseinian M.M., Khodadadi A. Anti-oxidative effect of lipoic acid in spinal cord ischemia/reperfusion. Med Princ Pract 2011, 20(1):19-22.
26. Slemmer J.E., Shacka J.J., Sweeney M.I., Weber J.T. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem 2008, 15:404-414.
27. St-Pierre J., Drori S., Uldry M., Silvaggi J.M., Rhee J., Jäger S., Handschin C., Zheng K., Lin J., Yang W., Simon D.K., Bachoo R., Spiegelman B.M. Suppression of reactive oxygen species and neuro-degeneration by the PGC-1 transcriptional co-activators. Cell 2006, 127(2):397-408.
28. Wareski P., Vaarmann A., Choubey V., Safiulina D., Liiv J., Kuum M., Kaasik A. PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem 2009, 284(32):21379-21385.
29. Warner D.S., Sheng H., Batinic-Haberle I. Oxidants, antioxidants and the ischemic brain. J Exp Biol 2004, 207(Pt 18):3221-3231.
30. Yang C., Zhang X., Fan H., Liu Y. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res 2009, 1282:133-141.
31. Ye Q., Ye L., Xu X., Huang B., Zhang X., Zhu Y., Chen X. Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway. BMC Complement Altern Med 2012, 12:82.
32. Zhang J., Fu B., Zhang X., Chen L., Zhang L., Zhao X., Bai X., Zhu C., Cui L., Wang L. Neuroprotective effect of bicyclol in rat ischemic stroke: Down-regulates TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulates claudin-5 expression. Brain Res 2013, 1528:80-88.
33. Zhu H., Wang Z., Zhu X., Wu X., Li E., Xu Y. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke. Neuropharmacology 2010, 59(1-2):70-76.