Discovery and Development of Insect-Resistant Crops Using Genes from Bacillus thuringiensis

Advances in Insect Physiology

Volumn 47, Issue , 2014, Pages 177-247

  Narva, Kenneth E ^a   Storer, Nicholas P ^a   Meade, Thomas ^a  

^a DOW AGROSCIENCES LLC   (United States)

Author keywords

Bacillus thuringiensis; Bt corn; Bt cotton; Bt crops; Bt soybean; Genetically engineered crops; Insect resistant crops

Indexed keywords

EID: 84908367797     PISSN: 00652806     EISSN: 22136800     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800197-4.00004-X     Document Type: Chapter

References (256)

1. Abbas H.K., Zablotowicz R.M., Weaver M.A., Shier W.T., Bruns H.A., Bellaloui N., Accinelli C., Abel C.A. Implications of Bt traits on mycotoxin contamination in maize: overview and recent experimental results in southern United States. J. Agric. Food Chem. 2013, 61:11759-11770.
2. Adang M.J., Staver M.J., Rocheleau T.A., Leighton J., Barker R.F., Thompson D.V. Characterized full-length and truncated plasmid clones of the crystal protein of Bacillus thuringiensis subsp. kurstaki HD-73 and their toxicity to Manduca sexta. Gene 1985, 36:289-300.
3. Adang M., Brody M., Cardineau G., Eagan N., Roush R., Shewmaker C., Jones A., Oakes J., McBride K. The reconstruction and expression of a Bacillus thuringiensis cryIIIA gene in protoplasts and potato plants. Plant Mol. Biol. 1993, 21:1131-1145.
4. Alstad D.N., Andow D.A. Managing the evolution of insect resistance to transgenic plants. Science 1995, 268:1894-1896.
5. Angus T.A. A bacterial toxin paralysing silkworm larvae. Nature 1954, 173:545-546.
6. Arantes O., Lereclus D. Construction of cloning vectors for Bacillus thuringiensis. Gene 1991, 108:115-119.
7. Archer T.L., Patrick C., Schuster G., Cronholm G., Bynum E.D., Morrison W.P. Ear and shank damage by corn borers and corn earworms to four events of Bacillus thuriengiensis transgenic maize. Crop Prot. 2001, 20:139-144.
8. Arrieta G., Espinoza A.M. Characterization of a Bacillus thuringiensis strain collection isolated from diverse Costa Rican natural ecosystems. Rev. Biol. Trop. 2006, 54:13-27.
9. Barfoot P., Brookes G. Key global environmental impacts of genetically modified (GM) crop use 1996-2012. GM Crops Food Biotechnol. Agric. Food Chain 2014, 5:10-21.
10. Barloy F., Delecluse A., Nicolas L., Lecadet M.M. Cloning and expression of the first anaerobic toxin gene from Clostridium bifermentans subsp. malaysia, encoding a new mosquitocidal protein with homologies to Bacillus thuringiensis delta-endotoxins. J. Bacteriol. 1996, 178:3099-3105.
11. Baum J.A., Johnson T.B., Carlton B.C. Bacillus thuringiensis: natural and recombinant bioinsecticide products. Biopesticides: Use and Delivery 1998, 189-209. F.R. Hall, J.J. Menn (Eds.).
12. Baxter S.W., Badenes-Perez F.R., Morrison A., Vogel H., Crickmore N., Kain W., Wang P., Heckel D.G., Jiggins C.D. Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera. Genetics 2011, 189:675-679.
13. Ben-Dov E. Bacillus thuringiensis subsp. israelensis and its Dipteran-specific toxins. Toxins 2014, 6:1222-1243.
14. Bergamasco V.B., Mendes D.R., Fernandes O.A., Desiderio J.A., Lemos M.V. Bacillus thuringiensis Cry1Ia10 and Vip3Aa protein interactions and their toxicity in Spodoptera spp. (Lepidoptera). J. Invertebr. Pathol. 2013, 112:152-158.
15. Berliner E. Ueber die schlaVsucht der Ephestia kuhniella und Bac. thuringiensis n. sp. Z. Angew. Entomol. 1915, 2:21-56.
16. Bernardi O., Sorgatto R.J., Barbosa A.D., Domingues F.A., Dourado P.M., Carvalho R.A., Martinelli S., Head G.P., Omoto C. Low susceptibility of Spodoptera cosmioides, Spodoptera eridania and Spodoptera frugiperda (Lepidoptera: Noctuidae) to genetically-modified soybean expressing Cry1Ac protein. Crop Prot. 2014, 58:33-40.
17. Berry C. The bacterium, Lysinibacillus sphaericus, as an insect pathogen. J. Invertebr. Pathol. 2012, 109:1-10.
18. Betz F.S., Hammond B.G., Fuchs R.L. Safety and advantages of Bacillus thuringiensis-protected plants to control insect pests. Regul. Toxicol. Pharmacol. 2000, 32:156-173.
19. Blanco C.A. Heliothis virescens and Bt cotton in the United States. GM Crops Food Biotechnol. Agric. Food Chain 2012, 3:201-212.
20. Boiteau G., Osborn W.P.L., Drew M.E. Residual activity of lmidacloprid controlling colorado potato beetle (Coleoptera: Chrysomelidae) and three species of potato colonizing aphids (Homoptera: Aphidae). J. Econ. Entomol. 1997, 90:309-319.
21. Bolivar F., Rodriguez R.L., Betlach M.C., Boyer H.W. Construction and characterization of new cloning vehicles I. Ampicillin-resistant derivatives of the plasmid pMB9. Gene 1977, 2:75-93.
22. Bommireddy P.L., Leonard B.R., Temple J., Price P., Emfinger K., Cook D., Hardke J.T. Field performance and seasonal efficacy profiles of transgenic cotton lines expressing Vip3A and VipCot against Helicoverpa zea (Boddie) and heliothis virescens (F.). J. Cotton Sci. 2011, 15:251-259.
23. Boonserm P., Davis P., Ellar D.J., Li J. Crystal structure of the mosquito-larvicidal toxin Cry4Ba and its biological implications. J. Mol. Biol. 2005, 348:363-382.
24. Boonserm P., Mo M., Angsuthanasombat C., Lescar J. Structure of the functional form of the mosquito larvicidal Cry4Aa toxin from Bacillus thuringiensis at a 2.8-angstrom resolution. J. Bacteriol. 2006, 188:3391-3401.
25. Bravo A., Sarabia S., Lopez L., Ontiveros H., Abarca C., Ortiz A., Ortiz M., Lina L., Villalobos F.J., Pena G., Nunez-Valdez M.E., Soberon M., Quintero R. Characterization of cry genes in a Mexican Bacillus thuringiensis strain collection. Appl. Environ. Microbiol. 1998, 64:4965-4972.
26. Brookes G., Barfoot P. Economic impact of GM crops: the global income and production effects 1996-2012. GM Crops Food Biotechnol. Agric. Food Chain 2014, 5:37-47.
27. Buntin G.D. Corn expressing Cry1Ab or Cry1F endotoxin for fall armyworm and corn earworm (Lepidoptera: Noctuidae) management in field corn for grain production. Fla. Entomol. 2008, 91:523-530.
28. Buntin G.D., All J.N., Lee R.D., Wilson D.M. Plant-incorporated Bacillus thuringiensis resistance for control of fall armyworm and corn earworm (Lepidoptera: Noctuidae) in corn. J. Econ. Entomol. 2004, 97:1603-1611.
29. Burkness E.C., Dively G., Patton T., Morey A.C., Hutchison W.D. Novel Vip3A Bacillus thuringiensis (Bt) maize approaches high-dose efficacy against Helicoverpa zea (Lepidoptera: Noctuidae) under field conditions: implications for resistance management. GM Crops 2010, 1:337-343.
30. Butko P. Cytolytic toxin Cyt1A and its mechanism of membrane damage: data and hypotheses. Appl. Environ. Microbiol. 2003, 69:2415-2422.
31. Caccia S., Hernandez-Rodriguez C.S., Mahon R.J., Downes S., James W., Bautsoens N., Van Rie J., Ferre J. Binding site alteration is responsible for field-isolated resistance to Bacillus thuringiensis Cry2A insecticidal proteins in two Helicoverpa species. PLoS One 2010, 5:e9975.
32. Caramori T., Albertini A.M., Galizzi A. In vivo generation of hybrids between two Bacillus thuringiensis insect-toxin-encoding genes. Gene 1991, 98:37-44.
33. Carlton B.C., Gawron-Burke C. Genetic Improvement of Bacillus thuringiensis for Bioinsecticide Development 1993, Marcel Dekker Inc., New York, NY.
34. Carozzi N.B., Kramer V.C., Warren G.W., Evola S., Koziel M.G. Prediction of insecticidal activity of Bacillus thuringiensis strains by polymerase chain reaction product profiles. Appl. Environ. Microbiol. 1991, 57:3057-3061.
35. Carroll J., Li J., Ellar D.J. Proteolytic processing of a coleopteran-specific delta-endotoxin produced by Bacillus thuringiensis var. tenebrionis. Biochem. J. 1989, 261:99-105.
36. Carroll J., Convents D., Van Damme J., Boets A., Van Rie J., Ellar D.J. Intramolecular proteolytic cleavage of Bacillus thuringiensis Cry3A delta-endotoxin may facilitate its coleopteran toxicity. J. Invertebr. Pathol. 1997, 70:41-49.
37. Carroll M.W., Head G., Caprio M.A. When and where a seed mix refuge makes sense for managing insect resistance to Bt plants. Crop Prot. 2012, 38:74-79.
38. Catangui M.A. Transgenic Bacillus thuringiensis corn hybrid performance against univoltine ecotype European corn borer (Lepidoptera: Crambidae) in South Dakota. J. Econ. Entomol. 2003, 96:957-968.
39. GM Crop Database 2012, CERA, Center for Environmental Risk Assessment (CERA), ILSI Research Foundation, Washington D.C. http://cera-gmc.org/index.php?action=gm_crop_database.
40. Chang C., Yu Y.M., Dai S.M., Law S.K., Gill S.S. High-level cryIVD and cytA gene expression in Bacillus thuringiensis does not require the 20-kilodalton protein, and the coexpressed gene products are synergistic in their toxicity to mosquitoes. Appl. Environ. Microbiol. 1993, 59:815-821.
41. Chougule N.P., Li H., Liu S., Linz L.B., Narva K.E., Meade T., Bonning B.C. Retargeting of the Bacillus thuringiensis toxin Cyt2Aa against hemipteran insect pests. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:8465-8470.
42. Cohen S., Dym O., Albeck S., Ben-Dov E., Cahan R., Firer M., Zaritsky A. High-resolution crystal structure of activated Cyt2Ba monomer from Bacillus thuringiensis subsp. israelensis. J. Mol. Biol. 2008, 380:820-827.
43. Cohen S., Albeck S., Ben-Dov E., Cahan R., Firer M., Zaritsky A., Dym O. Cyt1Aa toxin: crystal structure reveals implications for its membrane-perforating function. J. Mol. Biol. 2011, 413:804-814.
44. Contreras E., Schoppmeier M., Real M.D., Rausell C. Sodium solute symporter and cadherin proteins act as Bacillus thuringiensis Cry3Ba toxin functional receptors in Tribolium castaneum. J. Biol. Chem. 2013, 288:18013-18021.
45. Corbin, D.R., Romano, C.P., 2006. Plants transformed to express Cry2A δ-endotoxins. U.S. patent number 7,064,249.
46. Craveiro K.I., Gomes Junior J.E., Silva M.C., Macedo L.L., Lucena W.A., Silva M.S., de Souza Junior J.D., Oliveira G.R., de Magalhaes M.T., Santiago A.D., Grossi-de-Sa M.F. Variant Cry1Ia toxins generated by DNA shuffling are active against sugarcane giant borer. J. Biotechnol. 2010, 145:215-221.
47. Crickmore N., Zeigler D.R., Feitelson J., Schnepf E., Van Rie J., Lereclus D., Baum J., Dean D.H. Revision of the nomenclature for the Bacillus thuringiensis pesticidal crystal proteins. Microbiol. Mol. Biol. Rev. 1998, 62:807-813.
48. Crickmore N., Baum J., Bravo A., Lereclus D., Narva K., Sampson K., Schnepf E., Sun M., Zeigler D.R. Bacillus thuringiensis toxin nomenclature http://www.btnomenclature.info/.
49. Dean D.H., Rajamohan F., Lee M.K., Wu S.J., Chen X.J., Alcantara E., Hussain S.R. Probing the mechanism of action of Bacillus thuringiensis insecticidal proteins by site-directed mutagenesis-a minireview. Gene 1996, 179:111-117.
50. de Barjac H., Bonnefoi A. Essai de classification biochemique et serologique de 24 sourches de Bacillus du type B. thuringiensis. Entomophaga 1962, 7:5-31.
51. de Barjac H., Bonnefoi A. A classification of strains of Bacillus thuringiensis Berliner with a key to their differentiation. J. Invertebr. Pathol. 1968, 11:335-347.
52. de Freitas Bueno R.C.O., de Freitas Bueno A., Moscardi F., Postali Parra J.R., Hoffmann-Campo C.B. Lepidopteran larva consumption of soybean foliage: basis for developing multiple-species economic thresholds for pest management decisions. Pest Manag. Sci. 2011, 67:170-174.
53. de Maagd R.A., Kwa M.S., van der Klei H., Yamamoto T., Schipper B., Vlak J.M., Stiekema W.J., Bosch D. Domain III substitution in Bacillus thuringiensis delta-endotoxin CryIA(b) results in superior toxicity for Spodoptera exigua and altered membrane protein recognition. Appl. Environ. Microbiol. 1996, 62:1537-1543.
54. de Maagd R.A., van der Klei H., Bakker P.L., Stiekema W.J., Bosch D. Different domains of Bacillus thuringiensis delta-endotoxins can bind to insect midgut membrane proteins on ligand blots. Appl. Environ. Microbiol. 1996, 62:2753-2757.
55. de Maagd R.A., Bravo A., Crickmore N. How Bacillus thuringiensis has evolved specific toxins to colonize the insect world. Trends Genet. 2001, 17:193-199.
56. de Maagd R.A., Bravo A., Berry C., Crickmore N., Schnepf H.E. Structure, diversity, and evolution of protein toxins from spore-forming entomopathogenic bacteria. Annu. Rev. Genet. 2003, 37:409-433.
57. DiFonzo C., Cullen E.M. Handy Bt Trait Table 2013, University of Wisconsin. http://labs.russell.wisc.edu/cullenlab/extension/extension-publications/.
58. DiLeo M.V., Bakker M.d., Chu E.Y., Hoekenga O.A. An assessment of the relative influences of genetic background, functional diversity at major regulatory genes, and transgenic constructs on the tomato fruit metabolome. Plant Genome 2014, 7. 10.3835/plantgenome2013.06.0021.
59. Dimock M., Turner J., Lampel J. Endophytic microorganisms for delivery of genetically engineered microbial pesticides in plants. Advanced Engineered Biopesticides 1993, Marcel Dekker Inc., New York, NY. L. Kim (Ed.).
60. Donovan W.P., Rupar M.J., Slaney A.C., Malvar T., Gawron-Burke M.C., Johnson T.B. Characterization of two genes encoding Bacillus thuringiensis insecticidal crystal proteins toxic to Coleoptera species. Appl. Environ. Microbiol. 1992, 58:3921-3927.
61. Downes S., Mahon R. Successes and challenges of managing resistance in Helicoverpa armigera to Bt cotton in Australia. GM Crops Food 2012, 3:228-234.
62. Dulmage H.D. Insecticidal activity of isolates of Bacillus thuringiensis and their potential for pest control. Microbial Control of Pests and Diseases, 1970-1980 1981, 193-222. Academic Press, London. H.D. Burges (Ed.).
63. Eichenseer H., Strohbehn R., Burks J. Frequency and severity of western bean cutworm (Lepidoptera: Noctuidae) ear damage in transgenic corn hybrids expressing different Bacillus thuringiensis cry toxins. J. Econ. Entomol. 2008, 101:555-563.
64. Ellis R.T., Stockhoff B.A., Stamp L., Schnepf H.E., Schwab G.E., Knuth M., Russell J., Cardineau G.A., Narva K.E. Novel Bacillus thuringiensis binary insecticidal crystal proteins active on western corn rootworm, Diabrotica virgifera virgifera LeConte. Appl. Environ. Microbiol. 2002, 68:1137-1145.
65. Estruch J.J., Warren G.W., Mullins M.A., Nye G.J., Craig J.A., Koziel M.G. Vip3A, a novel Bacillus thuringiensis vegetative insecticidal protein with a wide spectrum of activities against lepidopteran insects. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:5389-5394.
66. Fang J., Xu X., Wang P., Zhao J.Z., Shelton A.M., Cheng J., Feng M.G., Shen Z. Characterization of chimeric Bacillus thuringiensis Vip3 toxins. Appl. Environ. Microbiol. 2007, 73:956-961.
67. Fang Y., Li Z., Liu J., Shu C., Wang X., Zhang X., Yu X., Zhao D., Liu G., Hu S., Zhang J., Al-Mssallem I., Yu J. A pangenomic study of Bacillus thuringiensis. J. Genet. Genomics 2011, 38:567-576.
68. FAO Expert Consultation on Genetically modified organisms in crop production and their effects on the environment: methodologies for monitoring and the way ahead. 2005. Food and Agriculture Organization of the United Nations. Rome, Italy. "" "TopOfPage". http://www.fao.org/docrep/008/ae738e/ae738e00.htm#TopOfPage.
69. Farinós G.P., De La Poza M., Hernández-Crespo P., Ortego F., Castañera P. Resistance monitoring of field populations of the corn borers Sesamia nonagrioides and Ostrinia nubilalis after 5 years of Bt maize cultivation in Spain. Entomol. Exp. Appl. 2004, 110:23-30.
70. Farinos G.P., De la Poza M., Ortego F., Castanera P. Susceptibility to the Cry1F toxin of field populations of Sesamia nonagrioides (Lepidoptera: Noctuidae) in Mediterranean maize cultivation regions. J. Econ. Entomol. 2012, 105:214-221.
71. Federici B.A. Insecticidal bacteria: an overwhelming success for invertebrate pathology. J. Invertebr. Pathol. 2005, 89:30-38.
72. Federici B.A., Bauer L.S. Cyt1Aa protein of Bacillus thuringiensis is toxic to the cottonwood leaf beetle, chrysomela scripta, and suppresses high levels of resistance to Cry3Aa. Appl. Environ. Microbiol. 1998, 64:4368-4371.
73. Fedoroff N.V. Burdensome and unnecessary regulation. GM Crops 2011, 2:87-88.
74. Feitelson J.S., Payne J., Kim L. Bacillus thuringiensis: insects and beyond. Nat. Biotechnol. 1992, 10:271-275.
75. Finer J., Dhillon T. Transgenic plant production. Plant Biotechnology and Genetics: Principles, Techniques, and Applications 2007, 245-274. John Wiley & Sons, Inc., Hoboken, NJ. C.N. Stewart (Ed.).
76. Fischhoff D.A., Bowdish K.S., Perlak F.J., Marrone P.G., McCormick S.M., Niedermeyer J.G., Dean D.A., Kusano-Kretzmer K., Mayer E.J., Rochester D.E., Rogers S.G., Fraley R.T. Insect tolerant transgenic tomato plants. Nat. Biotechnol. 1987, 5:807-813.
77. Fox J.L. EPA re-evaluates StarLink license. Nat. Biotechnol. 2001, 19:11.
78. Gaertner F.H., Quick T.C., Thompson M.A. Cell cap: an encapsulation system for insecticidal biotoxin proteins. Advanced Engineered Biopesticides 1993, 73-84. Marcel Dekker Inc., New York, NY. L. Kim (Ed.).
79. Gahan L.J., Gould F., Heckel D.G. Identification of a gene associated with Bt resistance in Heliothis virescens. Science 2001, 293:857-860.
80. Gahan L.J., Pauchet Y., Vogel H., Heckel D.G. An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac toxin. PLoS Genet. 2010, 6:e1001248.
81. Galitsky N., Cody V., Wojtczak A., Ghosh D., Luft J.R., Pangborn W., English L. Structure of the insecticidal bacterial delta-endotoxin Cry3Bb1 of Bacillus thuringiensis. Acta Crystallogr. D Biol. Crystallogr. 2001, 57:1101-1109.
82. Gassmann A.J. Field-evolved resistance to Bt maize by western corn rootworm: predictions from the laboratory and effects in the field. J. Invertebr. Pathol. 2012, 110:287-293.
83. Gassmann A.J., Petzold-Maxwell J.L., Keweshan R.S., Dunbar M.W. Field-evolved resistance to bt maize by Western corn rootworm. PLoS One 2011, 6:e22629.
84. Gassmann A.J., Petzold-Maxwell J.L., Clifton E.H., Dunbar M.W., Hoffmann A.M., Ingber D.A., Keweshan R.S. Field-evolved resistance by western corn rootworm to multiple Bacillus thuringiensis toxins in transgenic maize. Proc. Natl. Acad. Sci. 2014, 111:5141-5146.
85. Ghimire M.N., Huang F., Leonard R., Head G.P., Yang Y. Susceptibility of Cry1Ab-susceptible and -resistant sugarcane borer to transgenic corn plants containing single or pyramided Bacillus thuringiensis genes. Crop Prot. 2011, 30:74-81.
86. Goldberg L.J., Margalit J. A bacterial spore demonstrating rapid larvicidal activity against Anopheles sergentii, Uranotaeniaunguiculata, Culex univittatus, Aedes aegypti, and Culex pipiens. Mosq. News 1977, 37:317-324.
87. Gomez I., Pardo-Lopez L., Munoz-Garay C., Fernandez L.E., Perez C., Sanchez J., Soberon M., Bravo A. Role of receptor interaction in the mode of action of insecticidal Cry and Cyt toxins produced by Bacillus thuringiensis. Peptides 2007, 28:169-173.
88. Gouffon C., Van Vliet A., Van Rie J., Jansens S., Jurat-Fuentes J.L. Binding sites for Bacillus thuringiensis Cry2Ae toxin on heliothine brush border membrane vesicles are not shared with Cry1A, Cry1F, or Vip3A toxin. Appl. Environ. Microbiol. 2011, 77:3182-3188.
89. Gould F. Sustainability of transgenic insecticidal cultivars: integrating pest genetics and ecology. Annu. Rev. Entomol. 1998, 43:701-726.
90. Gould F., Blair N., Reid M., Rennie T.L., Lopez J., Micinski S. Bacillus thuringiensis-toxin resistance management: stable isotope assessment of alternate host use by Helicoverpa zea. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:16581-16586.
91. Griffitts J.S., Haslam S.M., Yang T., Garczynski S.F., Mulloy B., Morris H., Cremer P.S., Dell A., Adang M.J., Aroian R.V. Glycolipids as receptors for Bacillus thuringiensis crystal toxin. Science 2005, 307:922-925.
92. Grochulski P., Masson L., Borisova S., Pusztai-Carey M., Schwartz J.L., Brousseau R., Cygler M. Bacillus thuringiensis CryIA(a) insecticidal toxin: crystal structure and channel formation. J. Mol. Biol. 1995, 254:447-464.
93. Gunning R.V., Dang H.T., Kemp F.C., Nicholson I.C., Moores G.D. New resistance mechanism in Helicoverpa armigera threatens transgenic crops expressing Bacillus thuringiensis Cry1Ac toxin. Appl. Environ. Microbiol. 2005, 71:2558-2563.
94. Guo S., Ye S., Liu Y., Wei L., Xue J., Wu H., Song F., Zhang J., Wu X., Huang D., Rao Z. Crystal structure of Bacillus thuringiensis Cry8Ea1: an insecticidal toxin toxic to underground pests, the larvae of Holotrichia parallela. J. Struct. Biol. 2009, 168:259-266.
95. Gustafson D.I., Head G.P., Caprio M.A. Modeling the impact of alternative hosts on Helicoverpa zea adaptation to bollgard cotton. J. Econ. Entomol. 2006, 99:2116-2124.
96. Hammond B.G., Jez J.M. Impact of food processing on the dietary risk assessment for proteins introduced into biotechnology-derived soybean and corn crops. Food Chem. Toxicol. 2011, 49:711-721.
97. Hammond R.B., Higley L.G., Pedigo L.P., Bledsoe L., Spomer S.M., DeGooyer T.A. Simulated Insect Defoliation on Soybean: Influence of Row Width. J. Econ. Entomol. 2000, 93:1429-1436.
98. Han S., Craig J.A., Putnam C.D., Carozzi N.B., Tainer J.A. Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex. Nat. Struct. Mol. Biol. 1999, 6:932-936.
99. Hannay C.L. Crystalline inclusions in aerobic sporeforming bacteria. Nature 1953, 172:1004.
100. Hansen G., Wright M.S. Recent advances in the transformation of plants. Trends Plant Sci. 1999, 4:226-231.
101. Hardke J.T., Leonard B.R., Huang F., Jackson R.E. Damage and survivorship of fall armyworm (Lepidoptera: Noctuidae) on transgenic field corn expressing Bacillus thuringiensis Cry proteins. Crop Prot. 2011, 30:168-172.
102. He K., Wang Z., Zhou D., Wen L., Song Y., Yao Z. Evaluation of transgenic Bt corn for resistance to the Asian corn borer (Lepidoptera: Pyralidae). J. Econ. Entomol. 2003, 96:935-940.
103. Head G.P., Greenplate J. The design and implementation of insect resistance management programs for Bt crops. GM Crops Food 2012, 3:144-153.
104. Head G., Carroll M., Clark T., Galvan T., Huckaba R.M., Price P., Samuel L., Storer N.P. Efficacy of SmartStax(r) insect-protected corn hybrids against corn rootworm: the value of pyramiding the Cry3Bb1 and Cry34/35Ab1 proteins. Crop Prot. 2014, 57:38-47.
105. Heckel D.G., Gahan L.J., Baxter S.W., Zhao J.Z., Shelton A.M., Gould F., Tabashnik B.E. The diversity of Bt resistance genes in species of Lepidoptera. J. Invertebr. Pathol. 2007, 95:192-197.
106. Hellmich R.L., Siegfried B.D., Sears M.K., Stanley-Horn D.E., Daniels M.J., Mattila H.R., Spencer T., Bidne K.G., Lewis L.C. Monarch larvae sensitivity to Bacillus thuringiensis- purified proteins and pollen. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:11925-11930.
107. Herman R.A., Price W.D. Unintended compositional changes in genetically modified (gm) crops: 20 years of research. J. Agric. Food Chem. 2013, 61:11695-11701.
108. Herman R.A., Scherer P.N., Young D.L., Mihaliak C.A., Meade T., Woodsworth A.T., Stockhoff B.A., Narva K.E. Binary insecticidal crystal protein from Bacillus thuringiensis, strain PS149B1: effects of individual protein components and mixtures in laboratory bioassays. J. Econ. Entomol. 2002, 95:635-639.
109. Herman R.A., Chassy B.M., Parrott W. Compositional assessment of transgenic crops: an idea whose time has passed. Trends Biotechnol. 2009, 27:555-557.
110. Hernandez-Martinez P., Naseri B., Navarro-Cerrillo G., Escriche B., Ferre J., Herrero S. Increase in midgut microbiota load induces an apparent immune priming and increases tolerance to Bacillus thuringiensis. Environ. Microbiol. 2010, 12:2730-2737.
111. Hernandez-Martinez P., Hernandez-Rodriguez C.S., Rie J.V., Escriche B., Ferre J. Insecticidal activity of Vip3Aa, Vip3Ad, Vip3Ae, and Vip3Af from Bacillus thuringiensis against lepidopteran corn pests. J. Invertebr. Pathol. 2013, 113:78-81.
112. Hernandez-Rodriguez C.S., Van Vliet A., Bautsoens N., Van Rie J., Ferre J. Specific binding of Bacillus thuringiensis Cry2A insecticidal proteins to a common site in the midgut of Helicoverpa species. Appl. Environ. Microbiol. 2008, 74:7654-7659.
113. Herrero S., Gechev T., Bakker P.L., Moar W.J., de Maagd R.A. Bacillus thuringiensis Cry1Ca-resistant Spodoptera exigua lacks expression of one of four aminopeptidase N genes. BMC Genomics 2005, 6:96.
114. Herrnstadt C., Gilroy T.E., Sobieski D.A., Bennett B.D., Gaertner F.H. Nucleotide sequence and deduced amino acid sequence of a coleopteran-active delta-endotoxin gene from Bacillus thuringiensis subsp. san diego. Gene 1987, 57:37-46.
115. Hofte H., Whiteley H.R. Insecticidal crystal proteins of Bacillus thuringiensis. Microbiol. Rev. 1989, 53:242-255.
116. Hofte H., Van Rie J., Jansens S., Van Houtven A., Vanderbruggen H., Vaeck M. Monoclonal antibody analysis and insecticidal spectrum of three types of lepidopteran-specific insecticidal crystal proteins of Bacillus thuringiensis. Appl. Environ. Microbiol. 1988, 54:2010-2017.
117. Hui F., Scheib U., Hu Y., Sommer R.J., Aroian R.V., Ghosh P. Structure and glycolipid binding properties of the nematicidal protein Cry5B. Biochemistry 2012, 51:9911-9921.
118. Husz B. Field experiments on the application of Bacillus thuringiensis against the corn borer. Int. Corn Borer Invest. Sci. Rep. 1930, 3:91-98.
119. Ishiwata S. On a type of severe Xacherie (sotto disease). Dainihon Sanshi Kaiho 1901, 114:1-5.
120. Ives A.R., Glaum P.R., Ziebarth N.L., Andow D.A. The evolution of resistance to two-toxin pyramid transgenic crops. Ecol. Appl. 2011, 21:503-515.
121. Jackson R.E., Bradley J.R., Van Duyn J.W., Gould F. Comparative production of Helicoverpa zea (Lepidoptera: Noctuidae) from transgenic cotton expressing either one or two Bacillus thuringiensis proteins with and without insecticide oversprays. J. Econ. Entomol. 2004, 97:1719-1725.
122. James C. Global Status of Commercialize/Biotech Crops: 2013 2013, ISAAA, Ithaca, NY, ISAAA Brief No. 46.
123. Jones G.W., Nielsen-Leroux C., Yang Y., Yuan Z., Dumas V.F., Monnerat R.G., Berry C. A new Cry toxin with a unique two-component dependency from Bacillus sphaericus. FASEB J. 2007, 21:4112-4120.
124. Jung Y.C., Kim S.U., Cote J.C., Lecadet M.M., Chung Y.S., Bok S.H. Characterization of a new Bacillus thuringiensis Subsp. higo strain isolated from rice bran in Korea. J. Invertebr. Pathol. 1998, 71:95-96.
125. Jurat-Fuentes J.L., Gahan L.J., Gould F.L., Heckel D.G., Adang M.J. The HevCaLP protein mediates binding specificity of the Cry1A class of Bacillus thuringiensis toxins in Heliothis virescens. Biochemistry 2004, 43:14299-14305.
126. Kaur S. Molecular approaches towards development of novel Bacillus thuringiensis biopesticides. World J. Microbiol. Biotechnol. 2000, 16:781-793.
127. Keller M., Sneh B., Strizhov N., Prudovsky E., Regev A., Koncz C., Schell J., Zilberstein A. Digestion of delta-endotoxin by gut proteases may explain reduced sensitivity of advanced instar larvae of Spodoptera littoralis to CryIC. Insect Biochem. Mol. Biol. 1996, 26:365-373.
128. Khajuria C., Buschman L.L., Chen M.S., Siegfried B.D., Zhu K.Y. Identification of a novel aminopeptidase P-like gene (OnAPP) possibly involved in Bt toxicity and resistance in a major corn pest (Ostrinia nubilalis). PLoS One 2011, 6:e23983.
129. Koziel M.G., Beland G.L., Bowman C., Carozzi N.B., Crenshaw R., Crossland L., Dawson J., Desai N., Hill M., Kadwell S., Launis K., Lewis K., Maddox D., McPherson K., Meghji M.R., Merlin E., Rhodes R., Warren G.W., Wright M., Evola S.V. Field performance of elite transgenic maize plants expressing an insecticidal protein derived from Bacillus thuringiensis. Nat. Biotechnol. 1993, 11:194-200.
130. Krieg A., Huger A.M., Langenbruch G.A., Schnetter W. Bacillus thuringiensis var. tenebrionis: a new pathotype effective against larvae of Coleoptera. Z. Angew. Entomol. 1983, 96:500-508.
131. Kronstad J.W., Whiteley H.R. Three classes of homologous Bacillus thuringiensis crystal-protein genes. Gene 1986, 43:29-40.
132. Kronstad J.W., Schnepf H.E., Whiteley H.R. Diversity of locations for Bacillus thuringiensis crystal protein genes. J. Bacteriol. 1983, 154:419-428.
133. Kullik S.A., Sears M.K., Schaafsma A.W. Sublethal effects of Cry 1F Bt corn and clothianidin on black cutworm (Lepidoptera: Noctuidae) larval development. J. Econ. Entomol. 2011, 104:484-493.
134. Ladics G.S., Cressman R.F., Herouet-Guicheney C., Herman R.A., Privalle L., Song P., Ward J.M., McClain S. Bioinformatics and the allergy assessment of agricultural biotechnology products: industry practices and recommendations. Regul. Toxicol. Pharmacol. 2011, 60:46-53.
135. Lampel J.S., Canter G.L., Dimock M.B., Kelly J.L., Anderson J.J., Uratani B.B., Foulke J.S., Turner J.T. Integrative cloning, expression, and stability of the cryIA(c) gene from Bacillus thuringiensis subsp. kurstaki in a recombinant strain of Clavibacter xyli subsp. cynodontis. Appl. Environ. Microbiol. 1994, 60:501-508.
136. Lawson E.C., Weiss J.D., Thomas P.E., Kaniewski W.K. NewLeaf Plus(r) Russet Burbank potatoes: replicase-mediated resistance to potato leafroll virus. Mol. Breed. 2001, 7:1-12.
137. Lecadet M.M., Chaufaux J., Ribier J., Lereclus D. Construction of novel Bacillus thuringiensis strains with different insecticidal activities by transduction and transformation. Appl. Environ. Microbiol. 1992, 58:840-849.
138. Lee M.K., Walters F.S., Hart H., Palekar N., Chen J.S. The mode of action of the Bacillus thuringiensis vegetative insecticidal protein Vip3A differs from that of Cry1Ab delta-endotoxin. Appl. Environ. Microbiol. 2003, 69:4648-4657.
139. Lee M.K., Miles P., Chen J.S. Brush border membrane binding properties of Bacillus thuringiensis Vip3A toxin to Heliothis virescens and Helicoverpa zea midguts. Biochem. Biophys. Res. Commun. 2006, 339:1043-1047.
140. Lee H., Park S.Y., Zhang Z.J. An overview of genetic transformation of soybean. A Comprehensive Survey of International Soybean Research - Genetics 2013, 439-506. Physiology, Agronomy and Nitrogen Relationships. InTech. http://www.intechopen.com/books/a-comprehensive-survey-of-international-soybean-research-genetics-physiology-agronomy-and-nitrogen-relationships/an-overview-of-genetic-transformation-of-soybean, J. Board (Ed.).
141. Letowski J., Bravo A., Brousseau R., Masson L. Assessment of cry1 gene contents of Bacillus thuringiensis strains by use of DNA microarrays. Appl. Environ. Microbiol. 2005, 71:5391-5398.
142. Li J.D., Carroll J., Ellar D.J. Crystal structure of insecticidal delta-endotoxin from Bacillus thuringiensis at 2.5 A resolution. Nature 1991, 353:815-821.
143. Li J., Koni P.A., Ellar D.J. Structure of the mosquitocidal delta-endotoxin CytB from Bacillus thuringiensis sp. kyushuensis and implications for membrane pore formation. J. Mol. Biol. 1996, 257:129-152.
144. Li H., Oppert B., Higgins R.A., Huang F., Zhu K.Y., Buschman L.L. Comparative analysis of proteinase activities of Bacillus thuringiensis-resistant and -susceptible Ostrinia nubilalis (Lepidoptera: Crambidae). Insect Biochem. Mol. Biol. 2004, 34:753-762.
145. Li H., Olson M., Lin G., Hey T., Tan S.Y., Narva K.E. Bacillus thuringiensis Cry34Ab1/Cry35Ab1 interactions with western corn rootworm midgut membrane binding sites. PLoS One 2013, 8:e53079.
146. Likitvivatanavong S., Chen J., Bravo A., Soberon M., Gill S.S. Cadherin, alkaline phosphatase, and aminopeptidase N as receptors of Cry11Ba toxin from Bacillus thuringiensis subsp. jegathesan in Aedes aegypti. Appl. Environ. Microbiol. 2011, 77:24-31.
147. Likitvivatanavong S., Chen J., Evans A.M., Bravo A., Soberon M., Gill S.S. Multiple receptors as targets of Cry toxins in mosquitoes. J. Agric. Food Chem. 2011, 59:2829-2838.
148. Liu X.S., Dean D.H. Redesigning Bacillus thuringiensis Cry1Aa toxin into a mosquito toxin. Protein Eng. Des. Sel. 2006, 19:107-111.
149. Luttrell R.G., Jackson R.E. Helicoverpa zea and Bt cotton in the United States. GM Crops Food Biotechnol. Agric. Food Chain 2012, 3:213-227.
150. Ma G., Schmidt O., Keller M. Pre-feeding of a glycolipid binding protein LEC-8 from Caenorhabditis elegans revealed enhanced tolerance to Cry1Ac toxin in Helicoverpa armigera. Results Immunol. 2012, 2:97-103.
151. MacIntosh S.C. Managing the risk of insect resistance to transgenic insect control traits: practical approaches in local environments. Pest Manag. Sci. 2010, 66:100-106.
152. MacIntosh S.C., McPherson S.L., Perlak F.J., Marrone P.G., Fuchs R.L. Purification and characterization of Bacillus thuringiensis var. tenebrionis insecticidal proteins produced in E. coli. Biochem. Biophys. Res. Commun. 1990, 170:665-672.
153. Macrae T.C., Baur M.E., Boethel D.J., Fitzpatrick B.J., Gao A.G., Gamundi J.C., Harrison L.A., Kabuye V.T., Mcpherson R.M., Miklos J.A., Paradise M.S., Toedebusch A.S., Viegas A. Laboratory and field evaluations of transgenic soybean exhibiting high-dose expression of a synthetic Bacillus thuringiensis cry1A gene for control of Lepidoptera. J. Econ. Entomol. 2005, 98:577-587.
154. Marra M.C., Piggott N.E., Goodwin B.K. The impact of corn rootworm protected biotechnology traits in the United States. AgBioForum 2012, 15:217-230.
155. Masson L., Schwab G., Mazza A., Brousseau R., Potvin L., Schwartz J.L. A novel Bacillus thuringiensis (PS149B1) containing a Cry34Ab1/Cry35Ab1 binary toxin specific for the western corn rootworm Diabrotica virgifera virgifera LeConte forms ion channels in lipid membranes. Biochemistry 2004, 43:12349-12357.
156. Mattes O. Parasitare krankheiten der mehimottenlarven und versuche uber ihre verwendbarkeit als biologisches bekamfungsmittel. Ges Naturw Marburg Schrift. 1927, 381.
157. McDougall P. The Cost and Time Involved in the Discovery, Development and Authorisation of a New Plant Biotechnology Derived Trait 2011, A Consultancy Study for CropLife International. http://www.croplife.org/PhillipsMcDougallStudy.
158. McPherson R.M., MacRae T.C. Evaluation of transgenic soybean exhibiting high expression of a synthetic Bacillus thuringiensis cry1A transgene for suppressing lepidopteran population densities and crop injury. J. Econ. Entomol. 2009, 102:1640-1648.
159. Mendelsohn M., Kough J., Vaituzis Z., Matthews K. Are Bt crops safe?. Nat. Biotechnol. 2003, 21:1003-1009.
160. Morin S., Biggs R.W., Sisterson M.S., Shriver L., Ellers-Kirk C., Higginson D., Holley D., Gahan L.J., Heckel D.G., Carriere Y., Dennehy T.J., Brown J.K., Tabashnik B.E. Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:5004-5009.
161. Morse R.J., Yamamoto T., Stroud R.M. Structure of Cry2Aa suggests an unexpected receptor binding epitope. Structure 2001, 9:409-417.
162. Mumm R.H. A look at product development with genetically modified crops: examples from maize. J. Agric. Food Chem. 2013, 61:8254-8259.
163. Naimov S., Weemen-Hendriks M., Dukiandjiev S., de Maagd R.A. Bacillus thuringiensis delta-endotoxin Cry1 hybrid proteins with increased activity against the Colorado potato beetle. Appl. Environ. Microbiol. 2001, 67:5328-5330.
164. Naranjo S.E. Impacts of Bt transgenic cotton on integrated pest management. J. Agric. Food Chem. 2010, 59:5842-5851.
165. Narva K., Siegfried B., Storer N. Transgenic approaches to western corn rootworm control. Yellow Biotechnology II 2013, 135-162. Springer, Berlin. A. Vilcinskas (Ed.).
166. Noguera P.A., Ibarra J.E. Detection of new cry genes of Bacillus thuringiensis by use of a novel PCR primer system. Appl. Environ. Microbiol. 2010, 76:6150-6155.
167. Ochoa-Campuzano C., Real M.D., Martinez-Ramirez A.C., Bravo A., Rausell C. An ADAM metalloprotease is a Cry3Aa Bacillus thuringiensis toxin receptor. Biochem. Biophys. Res. Commun. 2007, 362:437-442.
168. Ohba M., Mizuki E., Uemori A. Parasporin, a new anticancer protein group from Bacillus thuringiensis. Anticancer Res. 2009, 29:427-433.
169. Oliveira G.R., Silva M.C., Lucena W.A., Nakasu E.Y., Firmino A.A., Beneventi M.A., Souza D.S., Gomes J.E., de Souza J.D., Rigden D.J., Ramos H.B., Soccol C.R., Grossi-de-Sa M.F. Improving Cry8Ka toxin activity towards the cotton boll weevil (Anthonomus grandis). BMC Biotechnol. 2011, 11:85.
170. Onstad D.W., Mitchell P.D., Hurley T.M., Lundgren J.G., Porter R.P., Krupke C.H., Spencer J.L., DiFonzo C.D., Baute T.S., Hellmich R.L., Buschman L.L., Hutchison W.D., Tooker J.F. Seeds of change: corn seed mixtures for resistance management and integrated pest management. J. Econ. Entomol. 2011, 104:343-352.
171. Oppert B., Kramer K.J., Beeman R.W., Johnson D., McGaughey W.H. Proteinase-mediated insect resistance to Bacillus thuringiensis toxins. J. Biol. Chem. 1997, 272:23473-23476.
172. Pardo-Lopez L., Munoz-Garay C., Porta H., Rodriguez-Almazan C., Soberon M., Bravo A. Strategies to improve the insecticidal activity of Cry toxins from Bacillus thuringiensis. Peptides 2009, 30:589-595.
173. Pardo-Lopez L., Soberon M., Bravo A. Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection. FEMS Microbiol. Rev. 2013, 37:3-22.
174. Payne, J., Sick, A.J., 1993. Bacillus thuringiensis isolate active against lepidopteran pests, and genes encoding novel lepidopteran-active toxins. U.S. patent number 5,188,960.
175. Payne, J.M., Narva, K.E., Uyeda, K.A., Stalder, C.J., Michaels, T.M., 1995. Bacillus thuringiensis isolate PS201T6 toxin. U.S. patent number 5,436,002.
176. Perez C., Fernandez L.E., Sun J., Folch J.L., Gill S.S., Soberon M., Bravo A. Bacillus thuringiensis subsp. israelensis Cyt1Aa synergizes Cry11Aa toxin by functioning as a membrane-bound receptor. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:18303-18308.
177. Perez C., Munoz-Garay C., Portugal L.C., Sanchez J., Gill S.S., Soberon M., Bravo A. Bacillus thuringiensis ssp. israelensis Cyt1Aa enhances activity of Cry11Aa toxin by facilitating the formation of a pre-pore oligomeric structure. Cell. Microbiol. 2007, 9:2931-2937.
178. Perlak F.J., Fuchs R.L., Dean D.A., McPherson S.L., Fischhoff D.A. Modification of the coding sequence enhances plant expression of insect control protein genes. Proc. Natl. Acad. Sci. U. S. A. 1991, 88:3324-3328.
179. Petolino J., Arnold N. Whiskers-mediated maize transformation. Transgenic Maize 2009, 59-67. Humana Press, Clifton, NJ. M.P. Scott (Ed.).
180. Petzold-Maxwell J.L., Meinke L.J., Gray M.E., Estes R.E., Gassmann A.J. Effect of Bt maize and soil insecticides on yield, injury, and rootworm survival: implications for resistance management. J. Econ. Entomol. 2013, 106:1941-1951.
181. Pigott C.R., Ellar D.J. Role of receptors in Bacillus thuringiensis crystal toxin activity. Microbiol. Mol. Biol. Rev. 2007, 71:255-281.
182. Porcar M., Juarez-Perez V. PCR-based identification of Bacillus thuringiensis pesticidal crystal genes. FEMS Microbiol. Rev. 2003, 26:419-432.
183. Privalle L.S., Chen J., Clapper G., Hunst P., Spiegelhalter F., Zhong C.X. Development of an agricultural biotechnology crop product: testing from discovery to commercialization. J. Agric. Food Chem. 2012, 60:10179-10187.
184. Qiao F., Huang J., Rozelle S., Wilen J. Natural refuge crops, buildup of resistance, and zero-refuge strategy for Bt cotton in China. Sci. China Life Sci. 2010, 53:1227-1238.
185. Radauer C., Bublin M., Wagner S., Mari A., Breiteneder H. Allergens are distributed into few protein families and possess a restricted number of biochemical functions. J. Allergy Clin. Immunol. 2008, 121:847-852. e847.
186. Rahman M.M., Roberts H.L., Schmidt O. The development of the endoparasitoid Venturia canescens in Bt-tolerant, immune induced larvae of the flour moth Ephestia kuehniella. J. Invertebr. Pathol. 2004, 87:129-131.
187. Rajagopal R., Sivakumar S., Agrawal N., Malhotra P., Bhatnagar R.K. Silencing of midgut aminopeptidase N of Spodoptera litura by double-stranded RNA establishes its role as Bacillus thuringiensis toxin receptor. J. Biol. Chem. 2002, 277:46849-46851.
188. Raybould A., Higgins L., Horak M., Layton R., Storer N., De La Fuente J., Herman R. Assessing the ecological risks from the persistence and spread of feral populations of insect-resistant transgenic maize. Transgenic Res. 2012, 21:655-664.
189. Reay-Jones F.P.F., Wiatrak P., Greene J.K. Evaluating the performance of transgenic corn producing Bacillus thuringiensis toxins in South Carolina. J. Agric. Urban Entomol. 2009, 26:77-86.
190. Reed G.L., Jensen A.S., Riebe J., Head G., Duan J.J. Transgenic Bt potato and conventional insecticides for Colorado potato beetle management: comparative efficacy and non-target impacts. Entomol. Exp. Appl. 2001, 100:89-100.
191. Ricroch A.E. Assessment of GE food safety using '-omics' techniques and long-term animal feeding studies. Nat. Biotechnol. 2013, 30:349-354.
192. Ricroch A.E., Berge J.B., Kuntz M. Evaluation of genetically engineered crops using transcriptomic, proteomic and metabolomic profiling techniques. Plant Physiol. 2011, 155:1752-1761.
193. Romeis J., Hellmich R., Candolfi M., Carstens K., De Schrijver A., Gatehouse A., Herman R., Huesing J., McLean M., Raybould A., Shelton A., Waggoner A. Recommendations for the design of laboratory studies on non-target arthropods for risk assessment of genetically engineered plants. Transgenic Res. 2011, 20:1-22.
194. Rosellini D. Selectable markers and reporter genes: a well furnished toolbox for plant science and genetic engineering. Crit. Rev. Plant Sci. 2012, 31:401-453.
195. Roush R.T., Shelton A.M. Assessing the odds: the emergence of resistance to Bt transgenic plants. Nat. Biotechnol. 1997, 15:816-817.
196. Rule D.M., Nolting S.P., Prasifka P.L., Storer N.P., Hopkins B.W., Scherder E.F., Siebert M.W., Hendrix W.H. Efficacy of pyramided Bt proteins Cry1F, Cry1A.105, and Cry2Ab2 expressed in SmartStax corn hybrids against lepidopteran insect pests in the northern United States. J. Econ. Entomol. 2014, 107:403-409.
197. Rupar, M.J., Donovan, W.P., Tan, Y., Annette, S., 2000. Bacillus thuringiensis CryET29 compositions toxic to coleopteran insects and Ctenocephalides spp. U.S. patent number 6,093,69.
198. Saiki R.K., Gelfand D.H., Stoffel S., Scharf S.J., Higuchi R., Horn G.T., Mullis K.B., Erlich H.A. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1988, 239:487-491.
199. Sanahuja G., Banakar R., Twyman R.M., Capell T., Christou P. Bacillus thuringiensis: a century of research, development and commercial applications. Plant Biotechnol. J. 2011, 9:283-300.
200. Schnepf H.E., Whiteley H.R. Cloning and expression of the Bacillus thuringiensis crystal protein gene in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 1981, 78:2893-2897.
201. Schnepf E., Crickmore N., Van Rie J., Lereclus D., Baum J., Feitelson J., Zeigler D.R., Dean D.H. Bacillus thuringiensis and its pesticidal crystal proteins. Microbiol. Mol. Biol. Rev. 1998, 62:775-806.
202. Schnepf H.E., Lee S., Dojillo J., Burmeister P., Fencil K., Morera L., Nygaard L., Narva K.E., Wolt J.D. Characterization of Cry34/Cry35 binary insecticidal proteins from diverse Bacillus thuringiensis strain collections. Appl. Environ. Microbiol. 2005, 71:1765-1774.
203. Sears M.K., Hellmich R.L., Stanley-Horn D.E., Oberhauser K.S., Pleasants J.M., Mattila H.R., Siegfried B.D., Dively G.P. Impact of Bt corn pollen on monarch butterfly populations: a risk assessment. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:11937-11942.
204. Sekar V., Thompson D.V., Maroney M.J., Bookland R.G., Adang M.J. Molecular cloning and characterization of the insecticidal crystal protein gene of Bacillus thuringiensis var. tenebrionis. Proc. Natl. Acad. Sci. U. S. A. 1987, 84:7036-7040.
205. Sena J.A., Hernandez-Rodriguez C.S., Ferre J. Interaction of Bacillus thuringiensis Cry1 and Vip3A proteins with Spodoptera frugiperda midgut binding sites. Appl. Environ. Microbiol. 2009, 75:2236-2237.
206. Shan G. Immunoassays in Agricultural Biotechnology 2011, John Wiley & Sons, Hoboken, NJ.
207. Shelton A.M., Zhao J.-Z., Roush R.T. Economic, ecological, food safety, and social consequences of the deployment of BT transgenic plants. Annu. Rev. Entomol. 2002, 47:845-881.
208. Shelton A.M., Olmstead D.L., Burkness E.C., Hutchison W.D., Dively G., Welty C., Sparks A.N. Multi-state trials of Bt sweet corn varieties for control of the corn earworm (Lepidoptera: Noctuidae). J. Econ. Entomol. 2013, 106:2151-2159.
209. Siebert M.W., Nolting S.P., Hendrix W., Dhavala S., Craig C., Leonard B.R., Stewart S.D., All J., Musser F.R., Buntin G.D., Samuel L. Evaluation of corn hybrids expressing Cry1F, Cry1A.105, Cry2Ab2, Cry34Ab1/Cry35Ab1, and Cry3Bb1 against southern United States insect pests. J. Econ. Entomol. 2012, 105:1825-1834.
210. Siegel J.P. The mammalian safety of Bacillus thuringiensis-based insecticides. J. Invertebr. Pathol. 2001, 77:13-21.
211. Slaney A.C., Robbins H.L., English L. Mode of action of Bacillus thuringiensis toxin CryIIIA: an analysis of toxicity in Leptinotarsa decemlineata (Say) and Diabrotica undecimpunctata howardi Barber. Insect Biochem. Mol. Biol. 1992, 22:9-18.
212. Smith R.H., Hood E.E. Agrobacterium-tumefaciens transformation of monocotyledons. Crop Sci. 1995, 35:301-309.
213. Soberon M., Pardo-Lopez L., Lopez I., Gomez I., Tabashnik B.E., Bravo A. Engineering modified Bt toxins to counter insect resistance. Science 2007, 318:1640-1642.
214. Soberon M., Gill S.S., Bravo A. Signaling versus punching hole: how do Bacillus thuringiensis toxins kill insect midgut cells?. Cell. Mol. Life Sci. 2009, 66:1337-1349.
215. Soberon M., Pardo L., Munoz-Garay C., Sanchez J., Gomez I., Porta H., Bravo A. Pore formation by Cry toxins. Adv. Exp. Med. Biol. 2010, 677:127-142.
216. Soberon M., Lopez-Diaz J.A., Bravo A. Cyt toxins produced by Bacillus thuringiensis: a protein fold conserved in several pathogenic microorganisms. Peptides 2013, 41:87-93.
217. Stemmer W.P. DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:10747-10751.
218. Storer N.P., Kubiszak M.E., Ed King J., Thompson G.D., Santos A.C. Status of resistance to Bt maize in Spodoptera frugiperda: lessons from Puerto Rico. J. Invertebr. Pathol. 2012, 110:294-300.
219. Storer N.P., Thompson G.D., Head G.P. Application of pyramided traits against Lepidoptera in insect resistance management for Bt crops. GM Crops Food Biotechnol. Agric. Food Chain 2012, 3:154-162.
220. Storer N.P., Thompson G.D., Head G.P. Application of pyramided traits against Lepidoptera in insect resistance management for Bt crops. GM Crops Food 2012, 3:154-162.
221. Tabashnik B.E., Gould F. Delaying corn rootworm resistance to Bt corn. J. Econ. Entomol. 2012, 105:767-776.
222. Tabashnik B.E., Cushing N.L., Finson N., Johnson M.W. Field development of resistance to Bacillus thuringiensis in diamondback moth (Lepidoptera: Plutellidae). J. Econ. Entomol. 1990, 83:1671-1676.
223. Tabashnik B.E., Liu Y., Malvar T., Heckel D.G., Masson L., Ferré J. Insect resistance to Bacillus thuringiensis: uniform or diverse?. Philos. Trans. R. Soc. Lond. B Biol. Sci. 1998, 353:1751-1756.
224. Tabashnik B.E., Huang F., Ghimire M.N., Leonard B.R., Siegfried B.D., Rangasamy M., Yang Y., Wu Y., Gahan L.J., Heckel D.G., Bravo A., Soberon M. Efficacy of genetically modified Bt toxins against insects with different genetic mechanisms of resistance. Nat. Biotechnol. 2011, 29:1128-1131.
225. Tabashnik B.E., Morin S., Unnithan G.C., Yelich A.J., Ellers-Kirk C., Harpold V.S., Sisterson M.S., Ellsworth P.C., Dennehy T.J., Antilla L., Liesner L., Whitlow M., Staten R.T., Fabrick J.A., Li X., Carriere Y. Sustained susceptibility of pink bollworm to Bt cotton in the United States. GM Crops Food 2012, 3:194-200.
226. Tabashnik B.E., Brevault T., Carriere Y. Insect resistance to Bt crops: lessons from the first billion acres. Nat. Biotechnol. 2013, 31:510-521.
227. Thomas W.E., Ellar D.J. Bacillus thuringiensis var israelensis crystal delta-endotoxin: effects on insect and mammalian cells in vitro and in vivo. J. Cell Sci. 1983, 60:181-197.
228. Tomasino S.F., Leister R.T., Dimock M.B., Beach R.M., Kelly J.L. Field performance of Clavibacter xyli subsp. cynodontis expressing the insecticidal protein gene cryIA(c) of Bacillus thuringiensis against European corn borer in field corn. Biol. Control 1995, 5:442-448.
229. Biopesticides Registration Action Document-Bacillus thuringiensis (Bt) Plant-Incorporated Protectants 2001, U.S. Environmental Protection Agency, Office of Pesticide Programs, Biopesticides and Pollution Prevention Division, Washington D.C.
230. A set of scientific issues being considered by the environmental protection agency regarding: Bt plant-pesticides risk and benefit assessments: insect resistance management. FIFRA Scientific Advisory Panel Report No. 2000-07a 2001, U.S. Environmental Protection Agency.
231. U.S. Environmental Protection Agency, 2007. White Paper on Tier-Based Testing for the Effects of Proteinaceous Insecticidal Plant-Incorporated Protectants on Non-Target Arthropods for Regulatory Risk Assessments. Washington D.C. http://www.epa.gov/opp00001/biopesticides/pips/non-target-arthropods.pdf.
232. Updated EPA Review of ABSTC's 2010 Corn Insect Resistance Management Compliance Assurance Program 2011, U.S. Environmental Protection Agency, Memo from J. Martinez to M. Mendelsohn, Office of Chemical Safety and Pollution Prevention, Biopesticides and Pollution Prevention Division, Washington D.C.
233. Vachon V., Laprade R., Schwartz J.L. Current models of the mode of action of Bacillus thuringiensis insecticidal crystal proteins: a critical review. J. Invertebr. Pathol. 2012, 111:1-12.
234. Vaeck M., Reynaerts A., Hofte H., Jansens S., De Beuckeleer M., Dean C., Zabeau M., Montagu M.V., Leemans J. Transgenic plants protected from insect attack. Nature 1987, 328:33-37.
235. van Frankenhuyzen K. Insecticidal activity of Bacillus thuringiensis crystal proteins. J. Invertebr. Pathol. 2009, 101:1-16.
236. van Frankenhuyzen K. Cross-order and cross-phylum activity of Bacillus thuringiensis pesticidal proteins. J. Invertebr. Pathol. 2013, 114:76-85.
237. Vaughn T., Cavato T., Brar G., Coombe T., DeGooyer T., Ford S., Groth M., Howe A., Johnson S., Kolacz K., Pilcher C., Purcell J., Romano C., English L., Pershing J. A method of controlling corn rootworm feeding using a Bacillus thuringiensis protein expressed in transgenic maize. Crop Sci. 2005, 45:931-938.
238. Vidal-Quist J.C., Castanera P., Gonzalez-Cabrera J. Diversity of Bacillus thuringiensis strains isolated from citrus orchards in spain and evaluation of their insecticidal activity against Ceratitis capitata. J. Microbiol. Biotechnol. 2009, 19:749-759.
239. Von Tersch M.A., Slatin S.L., Kulesza C.A., English L.H. Membrane-permeabilizing activities of Bacillus thuringiensis coleopteran-active toxin CryIIIB2 and CryIIIB2 domain I peptide. Appl. Environ. Microbiol. 1994, 60:3711-3717.
240. Wabiko H., Raymond K.C., Bulla L.A. Bacillus thuringiensis entomocidal protoxin gene sequence and gene product analysis. DNA 1986, 5:305-314.
241. Walker K.A., Hellmich R.L., Lewis L.C. Late-Instar European Corn Borer (Lepidoptera: Crambidae) tunneling and survival in transgenic corn hybrids. J. Econ. Entomol. 2000, 93:1276-1285.
242. Walters F.S., Stacy C.M., Lee M.K., Palekar N., Chen J.S. An engineered chymotrypsin/cathepsin G site in domain I renders Bacillus thuringiensis Cry3A active against Western corn rootworm larvae. Appl. Environ. Microbiol. 2008, 74:367-374.
243. Walters F.S., deFontes C.M., Hart H., Warren G.W., Chen J.S. Lepidopteran-active variable-region sequence imparts coleopteran activity in eCry3.1Ab, an engineered Bacillus thuringiensis hybrid insecticidal protein. Appl. Environ. Microbiol. 2010, 76:3082-3088.
244. Warren G.W. Vegetative insecticidal proteins: novel proteins for control of corn pests. Advances in Insect Control, the Role of Transgenic Plants 1997, 109-121. Taylors & Francis Ltd., London. N.B. Carozzi, M. Koziel (Eds.).
245. Wasano N., Ohba M. Assignment of delta-endotoxin genes of the four lepidoptera-specific Bacillus thuringiensis strains that produce spherical parasporal inclusions. Curr. Microbiol. 1998, 37:408-411.
246. Widner W.R., Whiteley H.R. Two highly related insecticidal crystal proteins of Bacillus thuringiensis subsp. kurstaki possess different host range specificities. J. Bacteriol. 1989, 171:965-974.
247. Wu F. Mycotoxin reduction in Bt corn: potential economic, health, and regulatory impacts. Transgenic Res. 2006, 15:277-289.
248. Wu D., Johnson J.J., Federici B.A. Synergism of mosquitocidal toxicity between CytA and CryIVD proteins using inclusions produced from cloned genes of Bacillus thuringiensis. Mol. Microbiol. 1994, 13:965-972.
249. Wu S.J., Koller C.N., Miller D.L., Bauer L.S., Dean D.H. Enhanced toxicity of Bacillus thuringiensis Cry3A delta-endotoxin in coleopterans by mutagenesis in a receptor binding loop. FEBS Lett. 2000, 473:227-232.
250. Xu X., Yu L., Wu Y. Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thuringiensis in Helicoverpa armigera. Appl. Environ. Microbiol. 2005, 71:948-954.
251. Yang Y., Zhu Y.C., Ottea J., Husseneder C., Leonard B.R., Abel C., Luttrell R., Huang F. Down regulation of a gene for cadherin, but not alkaline phosphatase, associated with Cry1Ab resistance in the sugarcane borer Diatraea saccharalis. PLoS One 2011, 6:e25783.
252. Ye W., Zhu L., Liu Y., Crickmore N., Peng D., Ruan L., Sun M. Mining new crystal protein genes from Bacillus thuringiensis on the basis of mixed plasmid-enriched genome sequencing and a computational pipeline. Appl. Environ. Microbiol. 2012, 78:4795-4801.
253. Zhang J., Hodgman T.C., Krieger L., Schnetter W., Schairer H.U. Cloning and analysis of the first cry gene from Bacillus popilliae. J. Bacteriol. 1997, 179:4336-4341.
254. Zhang X., Candas M., Griko N.B., Rose-Young L., Bulla L.A. Cytotoxicity of Bacillus thuringiensis Cry1Ab toxin depends on specific binding of the toxin to the cadherin receptor BT-R1 expressed in insect cells. Cell Death Differ. 2005, 12:1407-1416.
255. Zhang X., Candas M., Griko N.B., Taussig R., Bulla L.A. A mechanism of cell death involving an adenylyl cyclase/PKA signaling pathway is induced by the Cry1Ab toxin of Bacillus thuringiensis. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:9897-9902.
256. Zhang S., Cheng H., Gao Y., Wang G., Liang G., Wu K. Mutation of an aminopeptidase N gene is associated with Helicoverpa armigera resistance to Bacillus thuringiensis Cry1Ac toxin. Insect Biochem. Mol. Biol. 2009, 39:421-429.