메뉴 건너뛰기




Volumn 11, Issue 10, 2014, Pages 10016-10035

In vitro and in vivo effects of free and chalcones-loaded nanoemulsions: Insights and challenges in targeted cancer Chemotherapies

Author keywords

Chalcones; Chemotherapy; Leukemia; Nanoemulsion; Nanomedicine

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; CATALASE; CHALCONE DERIVATIVE; CHOLESTEROL; CREATININE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; PROTEIN; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; UREA; ANTINEOPLASTIC AGENT; EMULSION; NANOPARTICLE;

EID: 84908341765     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph111010016     Document Type: Article
Times cited : (15)

References (63)
  • 1
    • 84863772728 scopus 로고    scopus 로고
    • Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the children's oncology group
    • 1. Hunger, S.P.; Lu, X.; Devidas, M.; Camitta, B.M.; Gaynon, P.S.; Winick, N.J.; Reaman, G.H.; Carroll, W.L. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the children's oncology group. J. Clin. Oncol. 2012, 30, 1663–1669.
    • (2012) J. Clin. Oncol , vol.30 , pp. 1663-1669
    • Hunger, S.P.1    Lu, X.2    Devidas, M.3    Camitta, B.M.4    Gaynon, P.S.5    Winick, N.J.6    Reaman, G.H.7    Carroll, W.L.8
  • 2
    • 80054044276 scopus 로고    scopus 로고
    • Adult Primary Care after Childhood Acute Lymphoblastic Leukemia
    • 2. Diller, L. Adult Primary Care after Childhood Acute Lymphoblastic Leukemia. N. Eng. J. Med. 2011, 365, 1417–1424.
    • (2011) N. Eng. J. Med , vol.365 , pp. 1417-1424
    • Diller, L.1
  • 6
    • 58149392264 scopus 로고    scopus 로고
    • Bone Mineral Density in Young Adult Survivors of Acute Lymphoblastic Leukemia
    • 6. Thomas, I.H.; Donohue, J.E.; Ness, K.K.; Dengel, D.R.; Baker, K.S.; Gurney, J.G. Bone Mineral Density in Young Adult Survivors of Acute Lymphoblastic Leukemia. Cancer 2008, 113, 3248–3256.
    • (2008) Cancer , vol.113 , pp. 3248-3256
    • Thomas, I.H.1    Donohue, J.E.2    Ness, K.K.3    Dengel, D.R.4    Baker, K.S.5    Gurney, J.G.6
  • 7
    • 0037440152 scopus 로고    scopus 로고
    • Toward optimal central nervous system-directed treatment in childhood acute lymphoblastic leukemia
    • 7. Pui, C.H. Toward optimal central nervous system-directed treatment in childhood acute lymphoblastic leukemia. J. Clin. Oncol. 2003, 21, 179–181.
    • (2003) J. Clin. Oncol , vol.21 , pp. 179-181
    • Pui, C.H.1
  • 8
    • 79952095577 scopus 로고    scopus 로고
    • Modern therapy of acute lymphoblastic leukemia
    • 8. Bassan, R.; Hoelzer, D. Modern therapy of acute lymphoblastic leukemia. J. Clin. Oncol. 2011, 29, 532–543.
    • (2011) J. Clin. Oncol , vol.29 , pp. 532-543
    • Bassan, R.1    Hoelzer, D.2
  • 9
    • 33947225700 scopus 로고    scopus 로고
    • The present and future of nanotechnology in human health care
    • 9. Sahoo, S.K.; Parveen, S.; Panda, J.J. The present and future of nanotechnology in human health care. Nanomedicine 2007, 3, 20–31.
    • (2007) Nanomedicine , vol.3 , pp. 20-31
    • Sahoo, S.K.1    Parveen, S.2    Panda, J.J.3
  • 10
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • 10. Kreuter, J. Nanoparticulate systems for brain delivery of drugs. Adv. Drug Deliv. Rev. 2001, 47, 65–81.
    • (2001) Adv. Drug Deliv. Rev , vol.47 , pp. 65-81
    • Kreuter, J.1
  • 11
    • 34547913813 scopus 로고    scopus 로고
    • Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles
    • 11. Wong, H.L.; Bendayan, R.; Rauth, A.M.; Li, Y.; Wu, X.Y. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv. Drug Deliv. Rev. 2007, 59, 491–504.
    • (2007) Adv. Drug Deliv. Rev , vol.59 , pp. 491-504
    • Wong, H.L.1    Bendayan, R.2    Rauth, A.M.3    Li, Y.4    Wu, X.Y.5
  • 12
    • 84896699451 scopus 로고    scopus 로고
    • Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
    • 12. Bertrand, N.; Wu, J.; Xu, X.; Kamaly, N.; Farokhzad, O.C. Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology. Adv. Drug Deliv. Rev. 2014, 66, 2–25.
    • (2014) Adv. Drug Deliv. Rev , vol.66 , pp. 2-25
    • Bertrand, N.1    Wu, J.2    Xu, X.3    Kamaly, N.4    Farokhzad, O.C.5
  • 13
    • 84901980504 scopus 로고    scopus 로고
    • Nanoemulsions in Translational Research-Opportunities and Challenges in Targeted Cancer Therapy
    • 13. Ganta, S.; Talekar, M.; Singh, A.; Coleman, T.P.; Amiji, M.M. Nanoemulsions in Translational Research-Opportunities and Challenges in Targeted Cancer Therapy. AAPS PharmSciTech 2014, 15, 694–708.
    • (2014) AAPS Pharmscitech , vol.15 , pp. 694-708
    • Ganta, S.1    Talekar, M.2    Singh, A.3    Coleman, T.P.4    Amiji, M.M.5
  • 14
    • 78651379634 scopus 로고    scopus 로고
    • Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism
    • 14. Gao, F.; Zhang, Z.; Bu, H.; Huang, Y.; Gao, Z.; Shen, J.; Zhao, C.; Li, Y. Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism. J. Control. Release 2011, 149, 168–174.
    • (2011) J. Control. Release , vol.149 , pp. 168-174
    • Gao, F.1    Zhang, Z.2    Bu, H.3    Huang, Y.4    Gao, Z.5    Shen, J.6    Zhao, C.7    Li, Y.8
  • 15
    • 78449251490 scopus 로고    scopus 로고
    • Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death
    • 15. Winter, E.; Chiaradia, L.D.; de Cordova, C.A.; Nunes, R.J.; Yunes, R.A.; Creczynski-Pasa, T.B. Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death. Bioorg. Med. Chem. 2010, 18, 8026–8034.
    • (2010) Bioorg. Med. Chem , vol.18 , pp. 8026-8034
    • Winter, E.1    Chiaradia, L.D.2    De Cordova, C.A.3    Nunes, R.J.4    Yunes, R.A.5    Creczynski-Pasa, T.B.6
  • 16
    • 84897940926 scopus 로고    scopus 로고
    • Involvement of extrinsic and intrinsic apoptotic pathways together with endoplasmic reticulum stress in cell death induced by naphthylchalcones in a leukemic cell line: Advantages of multi-target action
    • 16. Winter, E.; Chiaradia, L.D.; Silva, A.H.; Nunes, R.J.; Yunes, R.A.; Creczynski-Pasa, T.B. Involvement of extrinsic and intrinsic apoptotic pathways together with endoplasmic reticulum stress in cell death induced by naphthylchalcones in a leukemic cell line: Advantages of multi-target action. Toxicol. In Vitro 2014, 28, 769–777.
    • (2014) Toxicol. In Vitro , vol.28 , pp. 769-777
    • Winter, E.1    Chiaradia, L.D.2    Silva, A.H.3    Nunes, R.J.4    Yunes, R.A.5    Creczynski-Pasa, T.B.6
  • 17
    • 38549094205 scopus 로고    scopus 로고
    • Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: Quantitative structure—activity relationships
    • 17. Chiaradia, L.D.; Santos, R.; Vitor, C.E.; Vieira, A.A.; Leal, P.C.; Nunes, R.J.; Calixto, J.B.; Yunes, R.A. Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: Quantitative structure—activity relationships. Bioorg. Med. Chem. 2008, 16, 658–667.
    • (2008) Bioorg. Med. Chem , vol.16 , pp. 658-667
    • Chiaradia, L.D.1    Santos, R.2    Vitor, C.E.3    Vieira, A.A.4    Leal, P.C.5    Nunes, R.J.6    Calixto, J.B.7    Yunes, R.A.8
  • 18
    • 27644440555 scopus 로고    scopus 로고
    • Solid lipid nanoparticles containing tamoxifen characterization and in vitro antitumoral activity
    • 18. Fontana, G.; Maniscalco, L.; Schillaci, D.; Cavallaro, G.; Giammona, G. Solid lipid nanoparticles containing tamoxifen characterization and in vitro antitumoral activity. Drug Deliv. 2005, 12, 385–392.
    • (2005) Drug Deliv , vol.12 , pp. 385-392
    • Fontana, G.1    Maniscalco, L.2    Schillaci, D.3    Cavallaro, G.4    Giammona, G.5
  • 19
    • 0002121327 scopus 로고
    • Stochastic Problems in Physics and Astronomy
    • 19. Chandrasekhar, S. Stochastic Problems in Physics and Astronomy. Rev. Modern Physics 1943, 15, 1–89.
    • (1943) Rev. Modern Physics , vol.15 , pp. 1-89
    • Chandrasekhar, S.1
  • 20
    • 84870438557 scopus 로고    scopus 로고
    • Available online, accessed on 15 July 2014
    • ICH Expert Working Group. Validation of Analytical Procedures: Text and Methodology Q2(R1). Available online: http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q2_R1/Step4/Q2_R1__Guideline.pdf (accessed on 15 July 2014).
    • Validation of Analytical Procedures: Text and Methodology Q2(R1)
  • 21
    • 4344588895 scopus 로고    scopus 로고
    • Microdialysis for evaluating the entrapment and release of a lipophilic drug from nanoparticles
    • 21. Michalowski, C.B.; Guterres, S.S.; Dalla Costa, T. Microdialysis for evaluating the entrapment and release of a lipophilic drug from nanoparticles. J. Pharm. Biomed. Anal. 2004, 35, 1093–1100.
    • (2004) J. Pharm. Biomed. Anal , vol.35 , pp. 1093-1100
    • Michalowski, C.B.1    Guterres, S.S.2    Dalla Costa, T.3
  • 22
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • 22. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55–63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 23
    • 6444244281 scopus 로고    scopus 로고
    • Refining procedures for the administration of substances
    • Report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement. British Veterinary Association Animal Welfare Foundation/Fund for the Replacement of Animals in Medical Experiments/Royal Society for the Prevention of Cruelty to Animals/Universities Federation for Animal Welfare
    • 23. Morton, D.B.; Jennings, M.; Buckwell, A.; Ewbank, R.; Godfrey, C.; Holgate, B.; Inglis, I.; James, R.; Page, C.; Sharman, I.; et al. Refining procedures for the administration of substances. Report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement. British Veterinary Association Animal Welfare Foundation/Fund for the Replacement of Animals in Medical Experiments/Royal Society for the Prevention of Cruelty to Animals/Universities Federation for Animal Welfare. Lab. Anim. 2001, 35, 1–41.
    • (2001) Lab. Anim , vol.35 , pp. 1-41
    • Morton, D.B.1    Jennings, M.2    Buckwell, A.3    Ewbank, R.4    Godfrey, C.5    Holgate, B.6    Inglis, I.7    James, R.8    Page, C.9    Sharman, I.10
  • 25
    • 0021027358 scopus 로고
    • Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay
    • 25. Cathcart, R.; Schwiers, E.; Ames, B.N. Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal. Biochem. 1983, 134, 111–116.
    • (1983) Anal. Biochem , vol.134 , pp. 111-116
    • Cathcart, R.1    Schwiers, E.2    Ames, B.N.3
  • 26
    • 0021288821 scopus 로고
    • Assays of glutathione peroxidase
    • 26. Flohe, L.; Gunzler, W.A. Assays of glutathione peroxidase. Methods Enzymol. 1984, 105, 114–121.
    • (1984) Methods Enzymol , vol.105 , pp. 114-121
    • Flohe, L.1    Gunzler, W.A.2
  • 27
    • 0021318441 scopus 로고
    • Catalase in vitro
    • 27. Aebi, H. Catalase in vitro. Methods Enzymol. 1984, 105, 121–126.
    • (1984) Methods Enzymol , vol.105 , pp. 121-126
    • Aebi, H.1
  • 28
    • 0016808562 scopus 로고
    • Purification and characterization of the flavoenzyme glutathione reductase from rat liver
    • 28. Carlberg, I.; Mannervik, B. Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J. Biol. Chem. 1975, 250, 5475–5480.
    • (1975) J. Biol. Chem , vol.250 , pp. 5475-5480
    • Carlberg, I.1    Mannervik, B.2
  • 29
    • 0017105696 scopus 로고
    • Mechanism for the several activities of the glutathione S-transferases
    • 29. Keen, J.H.; Habig, W.H.; Jakoby, W.B. Mechanism for the several activities of the glutathione S-transferases. J. Biol. Chem. 1976, 251, 6183–6188.
    • (1976) J. Biol. Chem , vol.251 , pp. 6183-6188
    • Keen, J.H.1    Habig, W.H.2    Jakoby, W.B.3
  • 30
    • 0021288836 scopus 로고
    • Comparative studies on different methods of malonaldehyde determination
    • 30. Bird, R.P.; Draper, H.H. Comparative studies on different methods of malonaldehyde determination. Methods Enzymol. 1984, 105, 299–305.
    • (1984) Methods Enzymol , vol.105 , pp. 299-305
    • Bird, R.P.1    Draper, H.H.2
  • 31
    • 73649194769 scopus 로고
    • Improved method for the determination of blood glutathione
    • 31. Beutler, E.; Duron, O.; Kelly, B.M. Improved method for the determination of blood glutathione. J. Lab. Clin. Med. 1963, 61, 882–888.
    • (1963) J. Lab. Clin. Med , vol.61 , pp. 882-888
    • Beutler, E.1    Duron, O.2    Kelly, B.M.3
  • 32
    • 0026687704 scopus 로고
    • Haematological and hepatotoxic effects of silken styles of corn in albino rats
    • 32. Garg, D.K.; Goyal, R.N. Haematological and hepatotoxic effects of silken styles of corn in albino rats. J. Appl. Toxicol. 1992, 12, 359–363.
    • (1992) J. Appl. Toxicol , vol.12 , pp. 359-363
    • Garg, D.K.1    Goyal, R.N.2
  • 33
    • 24944447847 scopus 로고    scopus 로고
    • Role of diallyl tetrasulfide in ameliorating the cadmium induced biochemical changes in rats
    • 33. Pari, L.; Murugavel, P. Role of diallyl tetrasulfide in ameliorating the cadmium induced biochemical changes in rats. Environ. Toxicol. Pharmacol. 2005, 20, 493–500.
    • (2005) Environ. Toxicol. Pharmacol , vol.20 , pp. 493-500
    • Pari, L.1    Murugavel, P.2
  • 34
    • 0037133126 scopus 로고    scopus 로고
    • Targeting to macrophages: Role of physicochemical properties of particulate carriers—liposomes and microspheres—on the phagocytosis by macrophages
    • 34. Ahsan, F.; Rivas, I.P.; Khan, M.A.; Torres Suárez, A.I. Targeting to macrophages: Role of physicochemical properties of particulate carriers—liposomes and microspheres—on the phagocytosis by macrophages. J. Control. Rel. 2002, 79, 29–40.
    • (2002) J. Control. Rel , vol.79 , pp. 29-40
    • Ahsan, F.1    Rivas, I.P.2    Khan, M.A.3    Torres Suárez, A.I.4
  • 35
    • 4344604026 scopus 로고    scopus 로고
    • Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods
    • 35. Galindo-Rodriguez, S.; Allemann, E.; Fessi, H.; Doelker, E. Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods. Pharm. Res. 2004, 21, 1428–1439.
    • (2004) Pharm. Res. , vol.21 , pp. 1428-1439
    • Galindo-Rodriguez, S.1    Allemann, E.2    Fessi, H.3    Doelker, E.4
  • 37
    • 24644519939 scopus 로고    scopus 로고
    • Engineering of nanoemulsions for drug delivery
    • 37. Sarker, D.K. Engineering of nanoemulsions for drug delivery. Curr. Drug Deliv. 2005, 2, 297–310.
    • (2005) Curr. Drug Deliv , vol.2 , pp. 297-310
    • Sarker, D.K.1
  • 38
    • 42649130036 scopus 로고    scopus 로고
    • Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes
    • 38. Xiang, G.; Wu, J.; Lu, Y.; Liu, Z.; Lee, R.J. Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes. Int. J. Pharm. 2008, 356, 29–36.
    • (2008) Int. J. Pharm , vol.356 , pp. 29-36
    • Xiang, G.1    Wu, J.2    Lu, Y.3    Liu, Z.4    Lee, R.J.5
  • 39
    • 35548933654 scopus 로고    scopus 로고
    • Role of formulation composition in folate receptor-targeted liposomal doxorubicin delivery to acute myelogenous leukemia cells.
    • 39. Lu, Y.; Wu, J.; Wu, J.; Gonit, M.; Yang, X.; Lee, A.; Xiang, G.; Li, H.; Liu, S.; Marcucci, G.; et al. Role of formulation composition in folate receptor-targeted liposomal doxorubicin delivery to acute myelogenous leukemia cells. Mol. Pharm. 2007, 4, 707–712.
    • (2007) Mol. Pharm , vol.4 , pp. 707-712
    • Lu, Y.1    Wu, J.2    Wu, J.3    Gonit, M.4    Yang, X.5    Lee, A.6    Xiang, G.7    Li, H.8    Liu, S.9    Marcucci, G.10
  • 40
    • 33947362046 scopus 로고    scopus 로고
    • The folate receptor: What does it promise in tissue-targeted therapeutics?
    • 40. Salazar, M.D.; Ratnam, M. The folate receptor: What does it promise in tissue-targeted therapeutics? Cancer Metastasis Rev. 2007, 26, 141–152.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 141-152
    • Salazar, M.D.1    Ratnam, M.2
  • 41
    • 84904617546 scopus 로고    scopus 로고
    • Targeted nanoparticles for pediatric leukemia therapy
    • 41. Basha, R.; Sabnis, N.; Heym, K.; Bowman, W.P.; Lacko, A.G. Targeted nanoparticles for pediatric leukemia therapy. Front. Oncol. 2014, 4, doi:10.3389/fonc.2014.00101.
    • (2014) Front. Oncol , pp. 4
    • Basha, R.1    Sabnis, N.2    Heym, K.3    Bowman, W.P.4    Lacko, A.G.5
  • 45
    • 84878650588 scopus 로고    scopus 로고
    • Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: A novel application in pediatric nanomedicine
    • 45. Krishnan, V.; Xu, X.; Barwe, S.P.; Yang, X.; Czymmek, K.; Waldman, S.A.; Mason, R.W.; Jia, X.; Rajasekaran, A.K. Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: A novel application in pediatric nanomedicine. Mol. Pharm. 2013, 10, 2199–2210.
    • (2013) Mol. Pharm , vol.10 , pp. 2199-2210
    • Krishnan, V.1    Xu, X.2    Barwe, S.P.3    Yang, X.4    Czymmek, K.5    Waldman, S.A.6    Mason, R.W.7    Jia, X.8    Rajasekaran, A.K.9
  • 46
    • 19444365656 scopus 로고    scopus 로고
    • Tamoxifen citrate loaded amphiphilic β-cyclodextrin nanoparticles: In vitro characterization and cytotoxicity
    • 46. Memisoglu-Bilensoy, E.; Vural, I.; Bochot, A.; Renoir, J.M.; Duchene, D.; Hıncal, A.A. Tamoxifen citrate loaded amphiphilic β-cyclodextrin nanoparticles: In vitro characterization and cytotoxicity. J. Control. Rel. 2005, 104, 489–496.
    • (2005) J. Control. Rel , vol.104 , pp. 489-496
    • Memisoglu-Bilensoy, E.1    Vural, I.2    Bochot, A.3    Renoir, J.M.4    Duchene, D.5    Hıncal, A.A.6
  • 49
    • 84864310354 scopus 로고    scopus 로고
    • Paclitaxel loaded PEGylated gleceryl monooleate based nanoparticulate carriers in chemotherapy
    • 49. Jain, V.; Swarnakar, N.K.; Mishra, P.R.; Verma, A.; Kaul, A.; Mishra, A.K.; Jain, N.K. Paclitaxel loaded PEGylated gleceryl monooleate based nanoparticulate carriers in chemotherapy. Biomaterials 2012, 33, 7206–7220.
    • (2012) Biomaterials , vol.33 , pp. 7206-7220
    • Jain, V.1    Swarnakar, N.K.2    Mishra, P.R.3    Verma, A.4    Kaul, A.5    Mishra, A.K.6    Jain, N.K.7
  • 50
    • 84862668236 scopus 로고    scopus 로고
    • Transport of drugs across the blood–brain barrier by nanoparticles
    • 50. Wohlfart, S.; Gelperina, S.; Kreuter, J. Transport of drugs across the blood–brain barrier by nanoparticles. J. Control. Rel. 2012, 161, 264–273.
    • (2012) J. Control. Rel , vol.161 , pp. 264-273
    • Wohlfart, S.1    Gelperina, S.2    Kreuter, J.3
  • 51
    • 41449091856 scopus 로고    scopus 로고
    • Potential of solid lipid nanoparticles in brain targeting
    • 51. Kaur, I.P.; Bhandari, R.; Bhandari, S.; Kakkar, V. Potential of solid lipid nanoparticles in brain targeting. J. Control. Rel. 2008, 127, 97–109.
    • (2008) J. Control. Rel , vol.127 , pp. 97-109
    • Kaur, I.P.1    Bhandari, R.2    Bhandari, S.3    Kakkar, V.4
  • 52
    • 34250771840 scopus 로고    scopus 로고
    • Central nervous system disease in acute lymphoblastic leukemia: Prophylaxis and treatment
    • 52. Pui, C.H. Central nervous system disease in acute lymphoblastic leukemia: Prophylaxis and treatment. Hemat. Am. Soc. Hematol. Educ. Program. 2006, 1, 142–146.
    • (2006) Hemat. Am. Soc. Hematol. Educ. Program , vol.1 , pp. 142-146
    • Pui, C.H.1
  • 53
    • 80054771643 scopus 로고    scopus 로고
    • Lipoprotein-inspired nanoparticles for cancer theranostics
    • 53. Ng, K.K.; Lovell, J.F.; Zheng, G. Lipoprotein-inspired nanoparticles for cancer theranostics. Acc. Chem. Res. 2011, 44, 1105–1113.
    • (2011) Acc. Chem. Res , vol.44 , pp. 1105-1113
    • Ng, K.K.1    Lovell, J.F.2    Zheng, G.3
  • 54
    • 0037390497 scopus 로고    scopus 로고
    • Structural characterisation of nucleoside loaded low density lipoprotein as a main criterion for the applicability as drug delivery system
    • 54. Hammel, M.; Laggner, P.; Prassl, R. Structural characterisation of nucleoside loaded low density lipoprotein as a main criterion for the applicability as drug delivery system. Chem. Phys. Lipids 2003, 123, 193–207.
    • (2003) Chem. Phys. Lipids , vol.123 , pp. 193-207
    • Hammel, M.1    Laggner, P.2    Prassl, R.3
  • 55
    • 0018181378 scopus 로고
    • Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells
    • 55. Ho, Y.K.; Smith, R.G.; Brown, M.S.; Goldstein, J.L. Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells. Blood 1978, 52, 1099–1114.
    • (1978) Blood , vol.52 , pp. 1099-1114
    • Ho, Y.K.1    Smith, R.G.2    Brown, M.S.3    Goldstein, J.L.4
  • 56
    • 52949130918 scopus 로고    scopus 로고
    • Delivery of daunorubicin to cancer cells with decreased toxicity by association with a lipidic nanoemulsion that binds to LDL receptors
    • 56. Teixeira, R.S.; Valduga, C.J.; Benvenutti, L.A.; Schreier, S.; Maranhao, R.C. Delivery of daunorubicin to cancer cells with decreased toxicity by association with a lipidic nanoemulsion that binds to LDL receptors. J. Pharm. Pharmacol. 2008, 60, 1287–1295.
    • (2008) J. Pharm. Pharmacol , vol.60 , pp. 1287-1295
    • Teixeira, R.S.1    Valduga, C.J.2    Benvenutti, L.A.3    Schreier, S.4    Maranhao, R.C.5
  • 58
    • 33751272720 scopus 로고    scopus 로고
    • Pharmacokinetics and tumor uptake of a derivatized form of paclitaxel associated to a cholesterol-rich nanoemulsion (LDE) in patients with gynecologic cancers
    • 58. Dias, M.L.; Carvalho, J.P.; Rodrigues, D.G.; Graziani, S.R.; Maranhao, R.C. Pharmacokinetics and tumor uptake of a derivatized form of paclitaxel associated to a cholesterol-rich nanoemulsion (LDE) in patients with gynecologic cancers. Cancer Chemother. Pharmacol. 2007, 59, 105–111.
    • (2007) Cancer Chemother. Pharmacol , vol.59 , pp. 105-111
    • Dias, M.L.1    Carvalho, J.P.2    Rodrigues, D.G.3    Graziani, S.R.4    Maranhao, R.C.5
  • 59
    • 79952117339 scopus 로고    scopus 로고
    • Modification of composition of a nanoemulsion with different cholesteryl ester molecular species: Effects on stability, peroxidation, and cell uptake
    • 59. Almeida, C.P.; Vital, C.G.; Contente, T.C.; Maria, D.A.; Maranhao, R.C. Modification of composition of a nanoemulsion with different cholesteryl ester molecular species: Effects on stability, peroxidation, and cell uptake. Int. J. Nanomedicine 2010, 5, 679–686.
    • (2010) Int. J. Nanomedicine , vol.5 , pp. 679-686
    • Almeida, C.P.1    Vital, C.G.2    Contente, T.C.3    Maria, D.A.4    Maranhao, R.C.5
  • 60
    • 0029782318 scopus 로고    scopus 로고
    • Receptor-mediated uptake of low-density lipoprotein by B16 melanoma cells in vitro and in vivo in mice
    • 60. Versluis, A.J.; van Geel, P.J.; Oppelaar, H.; van Berkel, T.J.; Bijsterbosch, M.K. Receptor-mediated uptake of low-density lipoprotein by B16 melanoma cells in vitro and in vivo in mice. Br. J. Cancer 1996, 74, 525–532.
    • (1996) Br. J. Cancer , vol.74 , pp. 525-532
    • Versluis, A.J.1    Van Geel, P.J.2    Oppelaar, H.3    Van Berkel, T.J.4    Bijsterbosch, M.K.5
  • 61
    • 84862691394 scopus 로고    scopus 로고
    • Altering the immune response with lipid-based nanoparticles
    • 61. Landesman-Milo, D.; Peer, D. Altering the immune response with lipid-based nanoparticles. J. Control. Rel. 2012, 161, 600–608.
    • (2012) J. Control. Rel , vol.161 , pp. 600-608
    • Landesman-Milo, D.1    Peer, D.2
  • 63
    • 54349110612 scopus 로고    scopus 로고
    • Liver function in oncology: Biochemistry and beyond
    • 63. Field, K.M.; Dow, C.; Michael, M. Part I: Liver function in oncology: Biochemistry and beyond. Lancet Oncol. 2008, 9, 1092–1101.
    • (2008) Lancet Oncol , vol.9 , pp. 1092-1101
    • Field, K.M.1    Dow, C.2    Michael, M.3    Part, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.