Biological evaluation of chalcones and analogues as hypolipidemic agents

Archiv der Pharmazie

Volumn 339, Issue 10, 2006, Pages 541-546

  Santos, Lorena ^a   Pedrosa, Rozangela Curi ^a   Correa, Rogério ^b   Cechinel Filho, Valdir ^b   Nunes, Ricardo José ^a   Yunes, Rosendo Augusto ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

Author keywords

Chalcones analogues; Cholesterol; Hypolipidemic activity; Triglycerides

Indexed keywords

1 (2' HYDROXYBENZOYL) 4 PHENYLBUTADIENE; 1 (4'METHOXYBENZOYL) 4 PHENYLBUTADIENE; 1 BENZOYL 4 PHENYLBUTADIENE; 2 (2 METHOXYPHENYLL) 1 PHENYLETHYLENE; 2,3 DIBROMO 3 (4 NITROPHENYL) 1 PHENYLPROPAN 1 ONE; 2,33 DIBROMO 1,3 BIS(4 CHLOROPHENYL) PROPAN 1 ONE; 3',4',4 TRICHLOROCHALCONE; 4' CHLOROCHALCONE; 4',4 DICHLOROCHALCONE; ANTILIPEMIC AGENT; CHALCONE DERIVATIVE; MEVINOLIN; TRIACYLGLYCEROL; TYLOXAPOL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTILIPEMIC AGENTS; CHALCONES; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; DIETARY FATS; DRUG EVALUATION, PRECLINICAL; HYPERLIPIDEMIAS; MALE; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

EID: 33750410684     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200600034     Document Type: Article

References (20)

1. M. J. Chapman, Atherosclerosis 2003, 170, 1-13.
2. C. R. Harper, T. A. Jacobson, Arch. Intern. Med. 1999, 159, 1049-1057.
3. R. Corrêa, M. A. S. Pereira, D. Buffon, V. Cechinel Filho, et al. Arch. Pharm. Pharm. Med. Chem. 2001, 334, 332-334.
4. J. R. Dimmock, D. W. Elias, M. A. Beazely, N. M. Kandepu, Curr. Med. Chem. 1999, 6, 1125-1149.
5. P. Boeck, P. C. Leal, R. A. Yunes, V. C. Cechinel-Filho, et al. Arch. Pharm. Chem. Life Sci. 2005, 338, in press.
6. E. Caio, Ph. D Thesis, Universidade Federal do Rio de Janeiro, 2003.
7. S. Garattini, R. Paoletti, L. Bizzi, I. E. Gross, R. Verta in Drugs Affecting Lipid Metabolism (Eds.: S. Garattini and R. Paoletti) Elsevier, Amsterdam, 1961.
8. P. E. Schurr, J. R. Schultz, T. M. Parkinson, Lipids 1972, 7, 68-74.
9. H. N. Hodis, W. J. Mack, Eur Heart J. 1998, 39, 40-44.
10. K. Ohmori, H. Yamada, A. Yasuda, A. Yamamoto, et al., Eur. J. Pharmacol. 2003, 471, 69-76.
11. S. J. Goldfarb, Lipid. Res. 1978, 25, 1450-1461.
12. J. M. Guider, T. H. Simpson, D. B. Thomas, J. Chem. Soc. 1955, 30, 170-173.
13. C. C. Allain, L. S. Poom, C. G. S. Chan, W. Richmond, P. C. Fu, Clin. Chem. 1974, 20, 470475.
14. M. W. McGowan, J. D. Artiss, D. R. Strandbergh, Clin. Chem. 1983, 29, 538-542.
15. R. C. Pedrosa, C. Meyre-Silva, V. Cechinel-Filho, J. C. Benassi, et al., Phytother. Res. 2002, 16, 765-768.
16. J. Folch, M. Lee, G. H. A. Stanley, J. Biol. Chem. 1957, 226, 497-503.
17. W. T. Friedewald, R. I. Levy, D. S. Fredrickson, Clin. Chem. 1972, 18, 499-502.
18. C. O. Adewunmi, F. O. Ogungbamila, J. O. Oluwadiya, Plant. Med. 1987, 53, 110-112.
19. S. N. López, M. V. Castelli, S. A. Zacchino, J. N. Domingues, et al., Bioorg. Med. Chem. 2001, 9, 1999-2013.
20. S. Iwata, T. Nishino, N. Nagata, Y. Satomi, et al., Biol. Pharm. Bull. 1995, 18, 1710-1713.