Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: A novel application in pediatric nanomedicine

Molecular Pharmaceutics

Volumn 10, Issue 6, 2013, Pages 2199-2210

  Krishnan, Vinu ^a,b,c   Xu, Xian ^a,c   Barwe, Sonali P ^b   Yang, Xiaowei ^a,c   Czymmek, Kirk ^c   Waldman, Scott A ^d   Mason, Robert W ^b,c   Jia, Xinqiao ^a,c   Rajasekaran, Ayyappan K ^a,b,c  

^a DUPONT COMPANY   (United States)

^b NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^c UNIVERSITY OF DELAWARE   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

acute lymphoblastic leukemia; dexamethasone; drug delivery; nanomedicine; preclinical model

Indexed keywords

ACETAL; COPOLYMER; DEXAMETHASONE; FLUORESCENT DYE; GLUCOCORTICOID; MACROGOL; NANOPARTICLE; POLYCAPROLACTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CANCER SURVIVAL; CELL DEATH; CHILDHOOD CANCER; CHILDHOOD LEUKEMIA; CONTROLLED STUDY; CYTOTOXICITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG RELEASE; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LEUKEMIA CELL; LIVER; MOUSE; NANOENCAPSULATION; NANOMEDICINE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SPLEEN; SURFACE PROPERTY; VALIDATION PROCESS;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DEXAMETHASONE; FEMALE; HUMANS; LEUKEMIA; LIVER; MICE; MICE, INBRED BALB C; NANOMEDICINE; NANOPARTICLES; PHOSPHORYLATION; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; SPLEEN;

EID: 84878650588     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300350e     Document Type: Article

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