Pharmacokinetics and tumor uptake of a derivatized form of paclitaxel associated to a cholesterol-rich nanoemulsion (LDE) in patients with gynecologic cancers

Cancer Chemotherapy and Pharmacology

Volumn 59, Issue 1, 2007, Pages 105-111

  Dias, Maria L N ^a   Carvalho, Jesus P ^a   Rodrigues, Debora G ^a   Graziani, Silvia R ^a   Maranhão, Raul C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cancer chemotherapy; Drug targeting; Emulsions; Low density lipoprotein (LDL) receptors; Paclitaxel

Indexed keywords

CHOLESTEROL; CHOLESTEROL OLEATE; CREMOPHOR; PACLITAXEL; PACLITAXEL OLEATE; UNCLASSIFIED DRUG;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CANCER MODEL; CANCER PATIENT; CANCER TISSUE; CLINICAL ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DERIVATIZATION; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STABILITY; DRUG TUMOR LEVEL; EMULSION; ENDOMETRIUM CANCER; FEMALE; GYNECOLOGIC CANCER; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; MELANOMA; OVARY CANCER; PRIORITY JOURNAL; RADIOACTIVITY; UTERINE CERVIX CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; CHOLESTEROL; EMULSIONS; ENDOMETRIAL NEOPLASMS; EXCIPIENTS; FEMALE; GENITAL NEOPLASMS, FEMALE; HALF-LIFE; HUMANS; MIDDLE AGED; OVARIAN NEOPLASMS; PACLITAXEL; TRIGLYCERIDES; UTERINE CERVICAL NEOPLASMS;

EID: 33751272720     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-006-0252-3     Document Type: Article

References (21)

1. Ades A, Carvalho JP, Graziani SR, Amancio RF, Souen JS, Pinotti JA, Maranhão RC (2001) Uptake of a cholesterol-rich emulsion by neoplastic ovarian tissues. Gynecol Oncol 82:84-87
2. Azevedo CHM, Carvalho JP, Valduga CJ, Maranhão RC (2005) Plasma kinetics and uptake by the tumor of cholesterol-rich microemulsion (LDE) associated to etoposide oleate in patients with ovarian carcinoma. Gynecol Oncol 97:178-182
3. Folch J, Lees M, Stanley HS (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509
4. Friedewald WT, Levy RI, Fredricson DS (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultra centrifuge. Clin Chem 18:499-502
5. Ginsburg GS, Small DM, Atkinson D (1982) Microemulsions of phospholipids and cholesterol esters. Protein-free models of low density lipoprotein. J Biol Chem 57:8216-8277
6. Goble S, Bear HD (2003) Emerging role of taxanes in adjuvant and neoadjuvant therapy for breast cancer: the potential and the questions. Surg Clin North Am 83:943-971
7. Graziani SR, Igreja FAF, Hegg R, Meneghetti C, Brandizzi LI, Barboza R, Amâncio RF, Pinotti JA, Maranhão RC (2002) Uptake of a cholesterol-rich emulsion by breast cancer. Gynecol Oncol 85:493-497
8. Ho YK, Smith RG, Brown MS, Goldstein JL (1978) Low density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells. Blood 52:1099-1114
9. Lincoln S, Blessing JA, Lee RB, Rocereto T (2003) Activity of paclitaxel as second-line chemotherapy in endometrial carcinoma: a gynecologic oncology group study. Gynecol Oncol 88:277-281
10. Maranhão RC, Garicochea B, Silva EL, Llacer PD, Pileggi FJ, Chamone DA (1992) Increased plasma removal of microemulsions resembling the lipid phase of low-density lipoproteins (LDL) in patients with acute myeloid leukemia: a possible new strategy for the treatment of the disease. Braz J Med Biol Res 25(10):1003-1007
11. Maranhão RC, Cesar TB, Pedroso MTB, Hirata MH, Mesquita CH (1993) Metabolic behavior in rats of a nonprotein microemulsion resembling LDL. Lipids 28:691-696
12. Maranhão RC, Garicochea B, Silva EL, Dorlhiac-Llacer P, Cadena SMS, Coelho IJC, Meneghetti JC, Pileggi FJC, Chamone DAF (1994) Plasma kinetics and biodistribution of a lipid emulsion resembling low-density lipoprotein in patients with acute leukemia. Cancer Res 54:4660-4666
13. Maranhão RC, Graziani SR, Yamaguchi N, Melo RF, Latrilha MC, Rodrigues DG, Couto RD, Schreier S, Buzaid AC (2002) Association of carmustine with a lipid emulsion: in vitro, in vivo and preliminary studies in cancer patients. Cancer Chemother Pharmacol 49:487-498
14. Matthews CME (1957) The theory of tracer experiments with 1331 I-labeled plasma proteins. Phys Med Biol 2:36-44
15. Rao GG, Rogers P, Drake RD, Nguyen P, Coleman RL (2005) Phase I clinical trial of weekly paclitaxel, weekly carboplatin, and concurrent radiotherapy for primary cervical cancer. Gynecol Oncol 96:168-172
16. Rodrigues DG, Maria DA, Fernandes DC, Valduga CJ, Couto RD, Ibañez COM, Maranhão RC (2005) Improvement of paclitaxel therapeutic index by derivatization and association to a cholesterol-rich microemulsion: in vitro and in vivo studies. Cancer Chemother Pharmacol 55:565-576
17. Seidman AD, Hochhauser D, Gollub M, Edelman B, Yao TJ, Hudis CA, Francis P, Fennelly D, Gilewski TA, Moynahan ME, Currie V, Baselga J, Tong W, O'Donaghue M, Salvaggio R, Auguste L, Spriggs D, Norton L (1996) Ninety-six-hour paclitaxel infusion after progression during short taxane exposure: a Phase II pharmacokinetic and pharmacodynamic study in metastatic breast cancer. J Clin Oncol 4:1877-1884
18. Sowby FS (1984) (ed) Radiation protection. Part I. Limits for intakes of radionuclides by workers. Pergamon Press, Oxford
19. ten Tije AJ, Verweij J, Loos WJ, Sparreboom A (2003) Pharmacological effects of formulation vehicles: implication for cancer chemotherapy. Clin Pharmacokinet 42(7):665-685
20. Valduga CJ, Fernandes DC, Lo Prete AC, Azevedo CHM, Rodrigues DG, Maranhão RC (2003) Use of a cholesterol-rich microemulsion that binds to low-density lipoprotein receptors as vehicle for etoposide. J Pharm Pharmacol 55:1615-1622
21. Woo HL, Swenerton KD, Hoskins PJ (1996) Taxol is active in platinum-resistant endometrial adenocarcinoma. Am J Clin Oncol 19:290-291