AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats

Journal of Hypertension

Volumn 30, Issue 4, 2012, Pages 725-733

  Ford, Rebecca J ^a   Teschke, Susan R ^a   Reid, E Benjamin ^a   Durham, Kristina K ^a   Kroetsch, Jeffrey T ^a   Rush, James W E ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

AMP activated protein kinase; SHR; vasomotor function; WKY

Indexed keywords

5 AMINOIMIDAZOLE 4 CARBOXYAMIDE 1 BETA DEXTRO RIBOFURANOSIDE; ANTIHYPERTENSIVE AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AORTA; ARTERY CATHETER; ARTERY DILATATION; ARTERY RESISTANCE; ARTICLE; BIOCHEMISTRY; BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; CAROTID ARTERY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART HEMODYNAMICS; HEART RATE; HYPERTENSION; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ARTERY; MESENTERY BLOOD VESSEL; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; VASOMOTOR REFLEX; WISTAR KYOTO RAT;

EID: 84858702507     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32835050ca     Document Type: Article

References (32)

1. Jin X, Townley R, Shapiro L. Structural insight into AMPK regulation: ADP comes into play. Structure 2007; 15:1285-1295. (Pubitemid 47539159)
2. Foley J, Adams G, Meyer R. Utility of AICAr for metabolic studies is diminished by systemic effects in situ. Am J Physiol 1989; 257 (3 Pt 1):C488-C494.
3. Bosselaar M, Smits P, van Loon LJC, Tack CJ. Intravenous AICAR during hyperinsulinemia induces systemic hemodynamic changes but has no local metabolic effect. J Clin Pharmacol 2010; 51:1893-1900.
4. Goirand F, Solar M, Athea Y, Viollet B, Mateo P, Fortin D, et al. Activation of AMP kinase {alpha}1 subunit induces aortic vasorelaxation in mice. J Physiol 2007; 581 (Pt 3):1163-1171. (Pubitemid 46887985)
5. Ford RJ, Rush JWE. Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent. Heart Circ Physiol 2011; 300:H64-H75.
6. Rubin LJ, Magliola L, Feng X, Jones AW, Hale CC. Metabolic activation of AMP kinase in vascular smooth muscle. J Appl Physiol 2005; 98:296-306. (Pubitemid 40041260)
7. Bradley EA, Eringa EC, Stehouwer CDA, Korstjens I, van Nieuw Amerongen GP, Musters R, et al. Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusion. Arterioscler Thromb Vasc Biol 2010; 30:1137-1142.
8. Bosselaar M, Boon H, van Loon LJC, van den Broek PHH, Smits P, Tack CJ. Intra-arterial AICA-riboside administration induces NO-dependent vasodilation in vivo in human skeletal muscle. Endocrinol Metab 2009; 297:E759-E766.
9. Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S. Endotheliumdependent contractions and endothelial dysfunction in human hypertension. Br J Pharmacol 2009; 157:527-536.
10. Feletou M, Vanhoutte P. Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol 2006; 291:H985-H1002. (Pubitemid 44343640)
11. Chen Z, Mitchelhill K, Michell B, Stapleton D, Rodriguez-Crespo I, Witters L, et al. AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett 1999; 443:285-289. (Pubitemid 29080812)
12. Davis BJ, Xie Z, Viollet B, Zou MH. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 2006; 55:496-505. (Pubitemid 43343281)
13. MorrowV, Foufelle F, Connell J, Petrie J,Gould G, Salt I. Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. J Biol Chem 2003; 278:31629-31639. (Pubitemid 37048341)
14. Chen Z, Peng IC, Sun W, Su MI, Hsu PH, Fu Y, et al. AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res 2009; 104:496-505.
15. Chen Z, Peng IC, Cui X, Li YS, Chien S, Shyy JYJ. Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci 2010; 107:10268-10273.
16. Ford RJ, Graham DA, Denniss SG, Quadrilatero J, Rush JWE. Glutathione depletion in vivo enhances contraction and attenuates endothelium-dependent relaxation of isolated rat aorta. Free Radic Biol Med 2006; 40:670-678. (Pubitemid 43170819)
17. Buhl ES, Jessen N, Pold R, Ledet T, Flyvbjerg A, Pedersen SB, et al. Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome. Diabetes 2002; 51:2199-2206. (Pubitemid 34729025)
18. Nielsen H, Thom SM, Hughes AD, Martin GN, Mulvany MJ, Sever PS. Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels. Br J Pharmacol 1989; 97:829-834. (Pubitemid 19168717)
19. Mulvany MJ, Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 1977; 41:19-26. (Pubitemid 8132079)
20. Falloon BJ, Stephens N, Tulip JR, Heagerty AM. Comparison of small artery sensitivity and morphology in pressurized and wire-mounted preparations. Am J Physiol 1995; 268 (2 Pt 2):H670-H678.
21. Hardie D. Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 2003; 546:113-120. (Pubitemid 36782291)
22. Suter M, Riek U, Tuerk R, Schlattner U, Wallimann T, Neumann D. Dissecting the role of 50-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem 2006; 281: 32207-32216. (Pubitemid 46036775)
23. Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J 2007; 403:139-148. (Pubitemid 46569875)
24. Ishimitsu T, Honda T, Ohno E, Furukata S, Sudo Y, Nakano N, et al. Year-long antihypertensive therapy with candesartan completely prevents development of cardiovascular organ injuries in spontaneously hypertensive rats. Int Heart J 2010; 51:359-364.
25. Bagnost T, Ma L, da Silva RF, Rezakhaniha R, Houdayer C, Stergiopulos N, et al. Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension. Cardiovasc Res 2010; 87:569-577.
26. Huang P, Huang Z, Mashimo H, Bloch K, Moskowitz M, Bevan J, Fishman M. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995; 377:239-242.
27. Fryer LGD. The antidiabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 2002; 277:25226-25232.
28. Pershadsingh HA, Szollosi J, Benson S, Hyun WC, Feuerstein BG, Kurtz TW. Effects of ciglitazone on blood pressure and intracellular calcium metabolism. Hypertension 1993; 21:1020-1023. (Pubitemid 23166960)
29. Verma S, Bhanot S, Arikawa E, Yao L, McNeill JH. Direct vasodepressor effects of pioglitazone in spontaneously hypertensive rats. Pharmacology 1998; 56:7-16. (Pubitemid 28022423)
30. Bhalla RC, Toth KF, Tan E, Bhatty RA, Mathias E, Sharma RV. Vascular effects ofmetformin. Possiblemechanismsfor its antihypertensive action in the spontaneously hypertensive rat. Am J Hypertens 1996; 9:570-576. (Pubitemid 26228080)
31. Wang S, Liang B, Viollet B, Zou MH. Inhibition of the AMP-activated protein kinase-{alpha}2 accentuates agonist-induced vascular smooth muscle contraction and high blood pressure in mice. Hypertension 2011; 57:1010-1017.
32. Dolinsky VW, Morton JS, Oka T, Robillard-Frayne I, Bagdan M, Lopaschuk GD, et al. Calorie restriction prevents hypertension and cardiac hypertrophy in the spontaneously hypertensive rat. Hypertension 2010; 56:412-421.