Biological Activity Differences between TGF-β1 and TGF-β3 Correlate with Differences in the Rigidity and Arrangement of Their Component Monomers

Biochemistry

Volumn 53, Issue 36, 2014, Pages 5737-5749

  Huang, Tao ^a,c   Schor, Seth L ^b   Hinck, Andrew P ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c SIBS Novo Nordisk Translational Research Centre for PreDiabetes   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; CELL CULTURE; DISSOCIATION; MONOMERS; NUCLEAR MAGNETIC RESONANCE; PROTEINS; RATE CONSTANTS; SURFACE PLASMON RESONANCE;

CONFORMATIONAL PREFERENCES; DERMAL FIBROBLASTS; DISSOCIATION RATE CONSTANT; HOMODIMER INTERFACE; INTERFACIAL REGION; INTRINSIC DIFFERENCES; SIGNALING PROTEINS; SIGNALING RECEPTOR;

CONFORMATIONS;

AMIDE; CHIMERIC PROTEIN; MONOMER; MUTANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL MIGRATION; CIRCULAR DICHROISM; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION RATE CONSTANT; HETERONUCLEAR SINGLE QUANTUM COHERENCE; LIGAND BINDING; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; RIGIDITY; SKIN FIBROBLAST; SURFACE PLASMON RESONANCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; HAMSTER; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; SEQUENCE HOMOLOGY;

MUS;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3;

EID: 84908320955     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500647d     Document Type: Article

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