Assembly of TβRI:TβRII:TGFβ ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent

Journal of Molecular Biology

Volumn 354, Issue 5, 2005, Pages 1052-1068

  Zúñiga, Jorge E ^a   Groppe, Jay C ^a   Cui, Yumin ^a,c   Hinck, Cynthia S ^a   Contreras Shannon, Verónica ^a   Pakhomova, Olga N ^a   Yang, Junhua ^a   Tang, Yuping ^a   Mendoza, Valentín ^b   López Casillas, Fernando ^b   Sun, LuZhe ^a   Hinck, Andrew P ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

^c Hutchinson Medipharma Ltd   (China)

Author keywords

NMR; TGF beta; TGF beta type I receptor; TGF beta type II receptor; T RI, T RII cooperative assembly

Indexed keywords

CYTOKINE RECEPTOR ANTAGONIST; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; ACTIVIN RECEPTOR 1; ISOPROTEIN; LIGAND; LUCIFERASE; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; SMAD2 PROTEIN; SMAD2 PROTEIN, HUMAN; TBETAR I KINASE; TBETAR II KINASE; TBETAR-I KINASE; TBETAR-II KINASE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ASSAY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CATTLE; CELL DIVISION; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ESCHERICHIA COLI; FEMALE; GENETIC VARIABILITY; GENETICS; IN VITRO STUDY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT; MOUSE; NUCLEAR MAGNETIC RESONANCE; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALIA;

ACTIVIN RECEPTORS, TYPE I; AMINO ACID SEQUENCE; ANIMALS; CATTLE; CELL DIVISION; ENDOTHELIUM, VASCULAR; ESCHERICHIA COLI; FEMALE; GENES, REPORTER; HUMANS; LIGANDS; LUCIFERASES; MICE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VARIATION (GENETICS);

EID: 28144447981     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.10.014     Document Type: Article

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