메뉴 건너뛰기




Volumn 288, Issue 44, 2013, Pages 32074-32092

Transforming growth factor-β3 (TGF-β3) knock-in ameliorates inflammation DuetoTGF-β1 deficiency while promoting glucose tolerance

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; CODING SEQUENCES; EMBRYONIC LETHALITY; FUNCTIONAL DIVERSITY; GLUCOSE TOLERANCE; METABOLIC PHENOTYPE; TRANSFORMING GROWTH FACTORS; WHITE ADIPOSE TISSUES;

EID: 84887094377     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.480764     Document Type: Article
Times cited : (34)

References (66)
  • 1
    • 0023662289 scopus 로고
    • The TGF-β family of growth and differentiation factors
    • Massagué, J. (1987) The TGF-β family of growth and differentiation factors. Cell 49, 437-438
    • (1987) Cell , vol.49 , pp. 437-438
    • Massagué, J.1
  • 2
    • 0023597604 scopus 로고
    • Some recent advances in the chemistry and biology of transforming growth factor-beta
    • Sporn, M. B., and Roberts., A. B., Wakefield, L. M., and de Crombrugghe, B. (1987) Some recent advances in the chemistry and biology of transforming growth factor-β. J. Cell Biol. 105, 1039-1045 (Pubitemid 18029829)
    • (1987) Journal of Cell Biology , vol.105 , Issue.3 , pp. 1039-1045
    • Sporn, M.B.1    Roberts, A.B.2    Wakefield, L.M.3    De Crombrugghe, B.4
  • 3
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi, Y., and Massagué, J. (2003) Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113, 685-700 (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 4
    • 0029943464 scopus 로고    scopus 로고
    • The crystal structure of TGF-β3 and comparison to TGF-β2: Implications for receptor binding
    • Mittl, P. R., and Priestle., J. P., Cox, D. A., McMaster, G., Cerletti, N, and Grütter, M. G. (1996) The crystal structure of TGF-β3 and comparison to TGF-β2: Implications for receptor binding. Protein Sci. 5, 1261-1271 (Pubitemid 26239434)
    • (1996) Protein Science , vol.5 , Issue.7 , pp. 1261-1271
    • Mittl, P.R.E.1    Priestle, J.P.2    Cox, D.A.3    Mcmaster, G.4    Cerletti, N.5    Grutter, M.G.6
  • 5
    • 0005862522 scopus 로고
    • Identification of another member of the transforming growth factor type β gene family
    • ten Dijke, P., Hansen, P., and Iwata., K. K., Pieler, C., and Foulkes, J. G. (1988) Identification of another member of the transforming growth factor type β gene family. Proc. Natl. Acad. Sci. U.S.A. 85, 4715-4719
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 4715-4719
    • Ten Dijke, P.1    Hansen, P.2    Iwata, K.K.3    Pieler, C.4    Foulkes, J.G.5
  • 6
    • 0028180315 scopus 로고
    • The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms
    • Kingsley, D. M. (1994) The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 8, 133-146
    • (1994) Genes Dev. , vol.8 , pp. 133-146
    • Kingsley, D.M.1
  • 7
    • 0024816337 scopus 로고
    • Human transforming growth factor-β3: Recombinant expression, purification, and biological activities in comparison with transforming growth factors-β1 and -β2
    • Graycar, J. L., and Miller., D. A., Arrick, B. A., Lyons, R. M., and Moses., H. L., Derynck, R. (1989) Human transforming growth factor-β3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-β1 and -β2. Mol. Endocrinol. 3, 1977-1986 (Pubitemid 20036903)
    • (1989) Molecular Endocrinology , vol.3 , Issue.12 , pp. 1977-1986
    • Graycar, J.L.1    Miller, D.A.2    Arrick, B.A.3    Lyons, R.M.4    Moses, H.L.5    Derynck, R.6
  • 8
    • 0026772232 scopus 로고
    • Differential expression of the TGF-β isoforms in embryogenesis suggests specific roles in developing and adult tissues
    • Roberts, A. B., and Sporn, M. B. (1992) Differential expression of the TGF-β isoforms in embryogenesis suggests specific roles in developing and adult tissues. Mol. Reprod. Dev. 32, 91-98
    • (1992) Mol. Reprod. Dev. , vol.32 , pp. 91-98
    • Roberts, A.B.1    Sporn, M.B.2
  • 9
    • 0025977578 scopus 로고
    • Embryonic gene expression patterns of TGF-β1, β2, and β3 suggest different developmental function in vivo
    • Millan, F. A., Denhez, F., Kondaiah, P., and Akhurst, R. J. (1991) Embryonic gene expression patterns of TGF-β1, β2, and β3 suggest different developmental function in vivo. Development 111, 131-143
    • (1991) Development , vol.111 , pp. 131-143
    • Millan, F.A.1    Denhez, F.2    Kondaiah, P.3    Akhurst, R.J.4
  • 10
    • 0026326375 scopus 로고
    • Immunohistochemical localization of TGFβ1, TGFβ2, and TGFβ3 in the mouse embryo: Expression patterns suggest multiple roles during embryonic development
    • Pelton, R. W., Saxena, B., Jones, M., Moses, H. L., and Gold, L. I. (1991) Immunohistochemical localization of TGFβ1, TGFβ2, and TGFβ3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J. Cell Biol. 115, 1091-1105 (Pubitemid 21909956)
    • (1991) Journal of Cell Biology , vol.115 , Issue.4 , pp. 1091-1105
    • Pelton, R.W.1    Saxena, B.2    Jones, M.3    Moses, H.L.4    Gold, L.I.5
  • 11
    • 0029074681 scopus 로고
    • Defective haematopoiesis and vasculogenesis in transforming growth factor β1 knock out mice
    • Dickson, M. C., and Martin., J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., and Akhurst, R. J. (1995) Defective haematopoiesis and vasculogenesis in transforming growth factor β1 knock out mice. Development 121, 1845-1854
    • (1995) Development , vol.121 , pp. 1845-1854
    • Dickson, M.C.1    Martin, J.S.2    Cousins, F.M.3    Kulkarni, A.B.4    Karlsson, S.5    Akhurst, R.J.6
  • 12
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
    • Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., and Diebold., R. J., Yin, M., Allen, R., Sidman, C, and Proetzel, G. (1992) Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 359, 693-699
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3    Pawlowski, S.4    Diebold, R.J.5    Yin, M.6    Allen, R.7    Sidman, C.8    Proetzel, G.9
  • 14
    • 0030609894 scopus 로고    scopus 로고
    • TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes
    • Sanford, L. P., Ormsby, I., Gittenberger-de Groot, A. C, Sariola, H., Friedman, R., and Boivin., G. P., Cardell, E. L., and Doetschman, T. (1997) TGF-β2 knockout mice have multiple developmental defects that are non-overlapping with other TGF-β knockout phenotypes. Development 124, 2659-2670 (Pubitemid 27341765)
    • (1997) Development , vol.124 , Issue.13 , pp. 2659-2670
    • Sanford, L.P.1    Ormsby, I.2    Gittenberger-de Groot, A.C.3    Sariola, H.4    Friedman, R.5    Boivin, G.P.6    Cardell, E.L.7    Doetschman, T.8
  • 16
    • 0028806184 scopus 로고
    • Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction
    • Kaartinen, V., and Voncken., J. W., Shuler, C, Warburton, D., Bu, D., Heisterkamp, N, and Groffen, J. (1995) Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nat Genet. 11, 415-421
    • (1995) Nat Genet. , vol.11 , pp. 415-421
    • Kaartinen, V.1    Voncken, J.W.2    Shuler, C.3    Warburton, D.4    Bu, D.5    Heisterkamp, N.6    Groffen, J.7
  • 17
    • 0028989842 scopus 로고
    • Inhibition of TGF-β3 (but not TGF-β1 or TGF-β2) activity prevents normal mouse embryonic palate fusion
    • Brunet, C. L., and Sharpe., P. M., and Ferguson, M. W. (1995) Inhibition of TGF-β3 (but not TGF-β1 or TGF-β2) activity prevents normal mouse embryonic palate fusion. Int. J. Dev. Biol. 39, 345-355
    • (1995) Int. J. Dev. Biol. , vol.39 , pp. 345-355
    • Brunet, C.L.1    Sharpe, P.M.2    Ferguson, M.W.3
  • 18
    • 36549044418 scopus 로고    scopus 로고
    • Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants
    • DOI 10.1016/j.ydbio.2007.09.034, PII S0012160607013887
    • Yang, L. T., and Kaartinen, V. (2007) Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants. Dev. Biol. 312, 384-395 (Pubitemid 350186159)
    • (2007) Developmental Biology , vol.312 , Issue.1 , pp. 384-395
    • Yang, L.-T.1    Kaartinen, V.2
  • 19
    • 0028986030 scopus 로고
    • Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring
    • Shah, M., Foreman, D., and Ferguson, M. (1995) Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring. J. Cell Sci. 108, 985-1002
    • (1995) J. Cell Sci. , vol.108 , pp. 985-1002
    • Shah, M.1    Foreman, D.2    Ferguson, M.3
  • 20
    • 33645311814 scopus 로고    scopus 로고
    • A "traffic control" role for TGFβ3: Orchestrating dermal and epidermal cell motility during wound healing
    • Bandyopadhyay, B., Fan, J., Guan, S., Li, Y., Chen, M., Woodley, D. T., and Li, W. (2006) A "traffic control" role for TGFβ3: orchestrating dermal and epidermal cell motility during wound healing. J. Cell Biol. 172, 1093-1105
    • (2006) J. Cell Biol. , vol.172 , pp. 1093-1105
    • Bandyopadhyay, B.1    Fan, J.2    Guan, S.3    Li, Y.4    Chen, M.5    Woodley, D.T.6    Li, W.7
  • 21
    • 0036679779 scopus 로고    scopus 로고
    • Development and application of fully functional epitope-tagged forms of transforming growth factor-β
    • γ-18
    • Wolfraim, L. A., and Alkemade., G. M., Alex, B., Sharpe, S., Parks, W. T., and Letterio, J. J. (2002) Development and application of fully functional epitope-tagged forms of transforming growth factor-β. J. Immunol. Methods 266, γ-18
    • (2002) J. Immunol. Methods , vol.266
    • Wolfraim, L.A.1    Alkemade, G.M.2    Alex, B.3    Sharpe, S.4    Parks, W.T.5    Letterio, J.J.6
  • 22
    • 0026068693 scopus 로고
    • Characterization of the Mouse Transforming Growth Factor-β1 Promoter and Activation by the Ha-ras Oncogene
    • Geiser, A., Kim, S., Roberts, A., and Sporn, M. (1991) Characterization of the mouse transforming growth factor-β1 promoter and activation by the Ha-ras oncogene. Mol. Cell. Biol. 11, 84-92 (Pubitemid 21895184)
    • (1991) Molecular and Cellular Biology , vol.11 , Issue.1 , pp. 84-92
    • Geiser, A.G.1    Kim, S.-J.2    Roberts, A.B.3    Sporn, M.B.4
  • 23
    • 0025780879 scopus 로고
    • Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
    • Tybulewicz, V. L., and Crawford., C. E., Jackson, P. K., Bronson, R. T., and Mulligan, R. C. (1991) Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-ablproto-oncogene. Cell 65, 1153-1163 (Pubitemid 121001329)
    • (1991) Cell , vol.65 , Issue.7 , pp. 1153-1163
    • Tybulewicz, V.L.J.1    Crawford, C.E.2    Jackson, P.K.3    Bronson, R.T.4    Mulligan, R.C.5
  • 25
    • 0031804499 scopus 로고    scopus 로고
    • Transforming growth factor-beta expression in mouse lung carcinogenesis
    • Jakowlew, S., Moody, T., You, L., and Mariano, J. (1998) Transforming growth factor-β expression in mouse lung carcinogenesis. Exp. Lung Res. 24, 579-593 (Pubitemid 28308952)
    • (1998) Experimental Lung Research , vol.24 , Issue.4 , pp. 579-593
    • Jakowlew, S.B.1    Moody, T.W.2    You, L.3    Mariano, J.M.4
  • 28
    • 0033821973 scopus 로고    scopus 로고
    • Human mast cell migration in response to members of the transforming growth factor-β family
    • Olsson, N, Piek, E., ten Dijke, P., and Nilsson, G. (2000) Human mast cell migration in response to members of the transforming growth factor-β family. J. Leukocyte Biol. 67, 350-356
    • (2000) J. Leukocyte Biol. , vol.67 , pp. 350-356
    • Olsson, N.1    Piek, E.2    Ten Dijke, P.3    Nilsson, G.4
  • 30
    • 0025215307 scopus 로고
    • Mechanism of activation of latent recombinant growth factor β1 byplasmin
    • Lyons, R., Gentry, L., Purchio, A., and Moses, H. (1990) Mechanism of activation of latent recombinant growth factor β1 byplasmin. J. Cell Biol. 110, 1361-1367
    • (1990) J. Cell Biol. , vol.110 , pp. 1361-1367
    • Lyons, R.1    Gentry, L.2    Purchio, A.3    Moses, H.4
  • 31
    • 0027305971 scopus 로고
    • Thrombospondin causes activation of latent transforming growth factor-β secreted by endothelial cells by a novel mechanism
    • Schultz-Cherry, S., and Murphy-Ullich, J. E. (1993) Thrombospondin causes activation of latent transforming growth factor-β secreted by endothelial cells by a novel mechanism. J. Cell Biol. 122, 923-932 (Pubitemid 23241101)
    • (1993) Journal of Cell Biology , vol.122 , Issue.4 , pp. 923-932
    • Schultz-Cherry, S.1    Murphy-Ullrich, J.E.2
  • 37
    • 0032934979 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 reveals an essential role in transforming growth factor β-mediated signal transduction
    • Datto, M. B., and Frederick., J. P., Pan, L., Borton, A. J., Zhuang, Y., and Wang, X. F. (1999) Targeted disruption of Smad3 reveals an essential role in transforming growth factor β-mediated signal transduction. Mol. Cell. Biol. 19, 2495-2504 (Pubitemid 29144493)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.4 , pp. 2495-2504
    • Datto, M.B.1    Frederick, J.P.2    Pan, L.3    Borton, A.J.4    Zhuang, Y.5    Wang, X.-F.6
  • 38
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
    • Yang, X., and Letterio., J. J., Lechleider, R. J., Chen, L., Hayman, R., Gu, H, Roberts, A.B., and Deng, C (1999) Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBOJ. 18, 1280-1291 (Pubitemid 29110312)
    • (1999) EMBO Journal , vol.18 , Issue.5 , pp. 1280-1291
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3    Chen, L.4    Hayman, R.5    Gu, H.6    Roberts, A.B.7    Deng, C.8
  • 42
    • 0024790411 scopus 로고
    • Complementary DNA cloning of the murine transforming growth factor-β3 (TGFβ3) precursor and the comparative expression of TGFβ3 and TGFβ1 messenger RNA in murine embryos and adult tissues
    • Miller, D. A., Lee, A., Matsui, Y., Chen, E. Y., and Moses., H. L., and Derynck, R. (1989) Complementary DNA cloning of the murine transforming growth factor-β3 (TGFβ3) precursor and the comparative expression of TGFβ3 and TGFβ1 messenger RNA in murine embryos and adult tissues. Mol. Endocrinol. 3, 1926-1934 (Pubitemid 20036897)
    • (1989) Molecular Endocrinology , vol.3 , Issue.12 , pp. 1926-1934
    • Miller, D.A.1    Lee, A.2    Matsui, Y.3    Chen, E.Y.4    Moses, H.L.5    Derynck, R.6
  • 47
    • 77649186285 scopus 로고    scopus 로고
    • The association between transforming growth factor β3 polymorphisms and left ventricular structure in hypertensive subjects
    • Hu, B. C, Li, L., Sun, R. H, Gao, P. J., and Zhu., D. L., Wang, J. G., and Chu, S. L. (2010) The association between transforming growth factor β3 polymorphisms and left ventricular structure in hypertensive subjects. Clin. Chim. Acta 411, 558-562
    • (2010) Clin. Chim. Acta , vol.411 , pp. 558-562
    • Hu, B.C.1    Li, L.2    Sun, R.H.3    Gao, P.J.4    Zhu, D.L.5    Wang, J.G.6    Chu, S.L.7
  • 48
    • 84857854784 scopus 로고    scopus 로고
    • Evidence for transforming growth factor-β3 gene polymorphism in non-syndromic cleft lip and palate patients from Indian sub-continent
    • Saleem, S., Rajendran, R., Moinak, B., Anna, J., and Pramod, B. J. (2012) Evidence for transforming growth factor-β3 gene polymorphism in non-syndromic cleft lip and palate patients from Indian sub-continent. Med. OralPatol. Oral Cir. Bucal. 17, e197-200
    • (2012) Med. OralPatol. Oral Cir. Bucal. , vol.17
    • Saleem, S.1    Rajendran, R.2    Moinak, B.3    Anna, J.4    Pramod, B.J.5
  • 49
    • 33745178891 scopus 로고    scopus 로고
    • Transforming growth factor-β gene polymorphisms in sarcoidosis patients with and without fibrosis
    • DOI 10.1378/chest.129.6.1584
    • Kruit, A., Grutters, J. C, Ruven, H. J., van Moorsel, C. H, Weiskirchen, R., Mengsteab, S., and van den Bosch, J. M. (2006) Transforming growth factor-β gene polymorphisms in sarcoidosis patients with and without fibrosis. Chest 129, 1584-1591 (Pubitemid 43894990)
    • (2006) Chest , vol.129 , Issue.6 , pp. 1584-1591
    • Kruit, A.1    Grutters, J.C.2    Ruven, H.J.T.3    Van Moorsel, C.H.M.4    Weiskirchen, R.5    Mengsteab, S.6    Van Den Bosch, J.M.M.7
  • 51
    • 0033547875 scopus 로고    scopus 로고
    • TGF-β3, but not TGF-β1, protects keratinocytes against 12-O-tetradecanoylphorbol-13-acetate-induced cell death in vitro and in vivo
    • Li, J., Foitzik, K., Calautti, E., Baden, H, Doetschman, T., and Dotto, G. P. (1999) TGF-β3, but not TGF-β1, protects keratinocytes against 12-O-tetradecanoylphorbol-13-acetate-induced cell death in vitro and in vivo. J. Biol. Chem. 274, 4213-4219
    • (1999) J. Biol. Chem. , vol.274 , pp. 4213-4219
    • Li, J.1    Foitzik, K.2    Calautti, E.3    Baden, H.4    Doetschman, T.5    Dotto, G.P.6
  • 52
    • 54349097492 scopus 로고    scopus 로고
    • TGF-β3: A promising growth factor in engineered organogenesis
    • Hao, J., and Varshney., R. R., and Wang, D. A. (2008) TGF-β3: A promising growth factor in engineered organogenesis. Expert Opin. Biol. Ther. 8, 1485-1493
    • (2008) Expert Opin. Biol. Ther. , vol.8 , pp. 1485-1493
    • Hao, J.1    Varshney, R.R.2    Wang, D.A.3
  • 53
    • 33947265169 scopus 로고    scopus 로고
    • Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice
    • DOI 10.1083/jcb.200611044
    • Yang, Z., Mu, Z., Dabovic, B., Jurukovski, V., Yu, D., Sung, J., Xiong, X., and Munger, J. S. (2007) Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice. J. Cell Biol. 176, 787-793 (Pubitemid 46425539)
    • (2007) Journal of Cell Biology , vol.176 , Issue.6 , pp. 787-793
    • Yang, Z.1    Mu, Z.2    Dabovic, B.3    Jurukovski, V.4    Yu, D.5    Sung, J.6    Xiong, X.7    Munger, J.S.8
  • 54
    • 41949090936 scopus 로고    scopus 로고
    • TGFβ1 and TGFβ3 are partially redundant effectors in brain vascular morphogenesis
    • Mu, Z., Yang, Z., Yu, D., Zhao, Z., and Munger, J. S. (2008) TGFβ1 and TGFβ3 are partially redundant effectors in brain vascular morphogenesis. MechDev. 125, 508-516
    • (2008) MechDev. , vol.125 , pp. 508-516
    • Mu, Z.1    Yang, Z.2    Yu, D.3    Zhao, Z.4    Munger, J.S.5
  • 57
    • 55249124839 scopus 로고    scopus 로고
    • + treg population viaTGF-β3
    • + Treg population viaTGF-β3. Eur. J. Immunol. 389, 2488-2498
    • (2008) Eur. J. Immunol. , vol.389 , pp. 2488-2498
    • Shah, S.1    Qiao, L.2
  • 58
    • 0031032181 scopus 로고    scopus 로고
    • Differential effects of transforming growth factors β1, β2, β3 and β5 on chondrogenesis in mouse limb bud mesenchymal cells
    • Chimal-Monroy, J., and Díaz de León, L. (1997) Differential effects of transforming growth factors 01, 02, 03, and 05 on chondrogenesis in mouse limb bud mesenchymal cells. Int. J. Dev. Biol. 41, 91-102 (Pubitemid 27096496)
    • (1997) International Journal of Developmental Biology , vol.41 , Issue.1 , pp. 91-102
    • Chimal-Monroy, J.1    De Leon, L.D.2
  • 59
    • 34249281694 scopus 로고    scopus 로고
    • Inhibition of osteogenic differentiation of human mesenchymal stem cells
    • DOI 10.1111/j.1524-475X.2007.00244.x
    • Moioli, E. K., Hong, L., and Mao, J. J. (2007) Inhibition of osteogenic differentiation of human mesenchymal stem cells. Wound Repair Regen. 15, 413-421 (Pubitemid 46817418)
    • (2007) Wound Repair and Regeneration , vol.15 , Issue.3 , pp. 413-421
    • Moioli, E.K.1    Hong, L.2    Mao, J.J.3
  • 61
    • 0032145238 scopus 로고    scopus 로고
    • Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-β1 gene
    • DOI 10.1016/S8756-3282(98)00078-7, PII S8756328298000787
    • Geiser, A. G., and Zeng., Q. Q., Sato, M., Helvering, L. M., Hirano, T., and Turner, C. H. (1998) Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-β1 gene. Bone 23, 87-93 (Pubitemid 28379868)
    • (1998) Bone , vol.23 , Issue.2 , pp. 87-93
    • Geiser, A.G.1    Zeng, Q.Q.2    Sato, M.3    Helvering, L.M.4    Hirano, T.5    Turner, C.H.6
  • 62
    • 0031000588 scopus 로고    scopus 로고
    • Elevated expression of transforming growth factor-β in adipose tissue from obese mice
    • Samad, F., Yamamoto, K., Pandey, M., and Loskutoff, D. J. (1997) Elevated expression of transforming growth factor-β in adipose tissue from obese mice. Mol. Med. 3, 37-48 (Pubitemid 27142523)
    • (1997) Molecular Medicine , vol.3 , Issue.1 , pp. 37-48
    • Samad, F.1    Yamamoto, K.2    Pandey, M.3    Loskutoff, D.J.4
  • 64
    • 0033583203 scopus 로고    scopus 로고
    • Conformation and self-association of human recombinant transforming growth factor-β3 in aqueous solutions
    • Pellaud, J., Schote, U., Arvinte, T., and Seelig, J. (1999) Conformation and self-association of human recombinant transforming growth factor-β3 in aqueous solutions. J. Biol. Chem. 274, 7699-7704
    • (1999) J. Biol. Chem. , vol.274 , pp. 7699-7704
    • Pellaud, J.1    Schote, U.2    Arvinte, T.3    Seelig, J.4
  • 65
    • 0030789434 scopus 로고    scopus 로고
    • The interaction of the transforming growth factor-βs with heparin/heparan sulfate is isoform-specific
    • DOI 10.1074/jbc.272.29.18000
    • Lyon, M., Rushton, G., and Gallagher, J. (1997) The interaction of the transforming growth factor-βs with heparin/heparan sulfate is isoform-specific. J. Biol. Chem. 272, 18000-18006 (Pubitemid 27306378)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.29 , pp. 18000-18006
    • Lyon, M.1    Rushton, G.2    Gallagher, J.T.3
  • 66
    • 0036177334 scopus 로고    scopus 로고
    • Crystal structure of the human TβR2 ectodomain-TGF-β3 complex
    • DOI 10.1038/nsb766
    • Hart, P. J., Deep, S., Taylor, A. B., Shu, Z., and Hinck., C. S., and Hinck, A. P. (2002) Crystal structure of the human TβR2 ectodomain-TGF-β3 complex. Nat. Struct. Biol. 9, 203-208 (Pubitemid 34171313)
    • (2002) Nature Structural Biology , vol.9 , Issue.3 , pp. 203-208
    • Hart, P.J.1    Deep, S.2    Taylor, A.B.3    Shu, Z.4    Hinck, C.S.5    Hinck, A.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.