Identification of the high affinity binding site in transforming growth factor-β involved in complex formation with α 2-macroglobulin: Implications regarding the molecular mechanisms of complex formation between α2-macroglobulin and growth factors, cytokines, and hormones

Journal of Biological Chemistry

Volumn 276, Issue 49, 2001, Pages 46212-46218

  Liu, Qianjin ^a   Ling, Thai Yen ^b   Shieh, Huey Sheng ^c   Johnson, Frank E ^a   Huang, Jung San ^a,b   Huang, Shuan Shian ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ELECTROPHORESIS; GELS; HYDROPHOBICITY;

AFFINITY INTERACTION;

HORMONES;

ALANINE; ALPHA 2 MACROGLOBULIN; CYTOKINE; GROWTH FACTOR; HORMONE; NERVE GROWTH FACTOR; PENTACOSACTIDE; PEPTIDE; TANSFORMING GROWTH FACTOR BETA1 W52A; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ISOFORM; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TRYPTOPHAN; UNCLASSIFIED DRUG; RADIOACTIVE IODINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; HIGH AFFINITY BINDING SITE; HYDROPHOBICITY; MOLECULAR MECHANICS; PLASMA CLEARANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN INTERACTION; SEQUENCE HOMOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING;

ALPHA-MACROGLOBULINS; AMINO ACID SEQUENCE; BINDING SITES; CYTOKINES; HORMONES; IODINE RADIOISOTOPES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTOR; PROTEIN BINDING; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFORMING GROWTH FACTOR BETA; TRYPTOPHAN;

EID: 0035824641     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105177200     Document Type: Article

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