The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop

International Journal of Biochemistry and Cell Biology

Volumn 57, Issue , 2014, Pages 84-95

  Xiao, Peng ^a,b   Wang, Xiao ^a,b   Wang, Hong Mei ^a,b   Fu, Xiao Lei ^a,b   Cui, Fu Ai ^a   Yu, Xiao ^a,b   Wen, Shi Shuai ^a,b   Bi, Wen Xiang ^a   Sun, Jin Peng ^a,b,c  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Provincial School Key Laboratory for Protein Science of Chronic Degenerative Diseases   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Enzyme catalysis; Insulin signaling; Phosphatase; PTP1B; Second sphere residue

Indexed keywords

INSULIN; INSULIN RECEPTOR; PHOSPHATE; PHOSPHOPEPTIDE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; SECOND SPHERE RESIDUE; THR263 ENZYME; UNCLASSIFIED DRUG; PTPN1 PROTEIN, HUMAN;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROLYSIS; HYDROPHOBICITY; NONHUMAN; NUCLEOPHILICITY; PH; SIGNAL TRANSDUCTION; STEADY STATE; WILD TYPE; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC TRANSFECTION; HEPG2 CELL LINE; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; CATALYSIS; CATALYTIC DOMAIN; HEP G2 CELLS; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 84908265082     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.10.004     Document Type: Article

References (40)

1. A. Alonso, N. Bottini, S. Bruckner, S. Rahmouni, S. Williams, and S.P. Schoenberger Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH J Biol Chem 279 2004 4922 4928
2. D. Barford, A.J. Flint, and N.K. Tonks Crystal structure of human protein tyrosine phosphatase 1B Science 263 1994 1397 1404
3. D. Barford, A.K. Das, and M.P. Egloff The structure and mechanism of protein phosphatases: insights into catalysis and regulation Annu Rev Biophys Biomol Struct 27 1998 133 164
4. A.J. Barr, E. Ugochukwu, W.H. Lee, O.N. King, P. Filippakopoulos, and I. Alfano Large-scale structural analysis of the classical human protein tyrosine phosphatome Cell 136 2009 352 363
5. D.S. Black, A. Marie-Cardine, B. Schraven, and J.B. Bliska The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophages Cell Microbiol 2 2000 401 414
6. I.G. Boutselis, X. Yu, Z.Y. Zhang, and R.F. Borch Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug J Med Chem 50 2007 856 864
7. M. Chen, J.P. Sun, J. Liu, and X. Yu Research progress of several protein tyrosine phosphatases in diabetes Sheng Li Xue Bao 62 2010 179 189
8. M. Elchebly, P. Payette, E. Michaliszyn, W. Cromlish, S. Collins, and A.L. Loy Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene Science 283 1999 1544 1548
9. P. Emsley, and K. Cowtan Coot: model-building tools for molecular graphics Acta Crystallogr D: Biol Crystallogr 60 2004 2126 2132
10. S. Galic, C. Hauser, B.B. Kahn, F.G. Haj, B.G. Neel, and N.K. Tonks Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP Mol Cell Biol 25 2005 819 829
11. K.L. Guan, and J.E. Dixon Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia Science 249 1990 553 556
12. R.J. Gum, L.L. Gaede, S.L. Koterski, M. Heindel, J.E. Clampit, and B.A. Zinker Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice Diabetes 52 2003 21 28
13. Z. Jia, D. Barford, A.J. Flint, and N.K. Tonks Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B Science 268 1995 1754 1758
14. T.O. Johnson, J. Ermolieff, and M.R. Jirousek Protein tyrosine phosphatase 1B inhibitors for diabetes Nat Rev Drug Discov 1 2002 696 709
15. R. Li, D.D. Xie, J.H. Dong, H. Li, K.S. Li, and J. Su Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase J Neurochem 128 2014 315 329
16. W.A. Lim, and T. Pawson Phosphotyrosine signaling: evolving a new cellular communication system Cell 142 2010 661 667
17. S. Liu, L.F. Zeng, L. Wu, X. Yu, T. Xue, and A.M. Gunawan Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors J Am Chem Soc 130 2008 17075 17084
18. J. Liu, M. Chen, R. Li, F. Yang, X. Shi, and L. Zhu Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W PLOS ONE 7 2012 e43631
19. D.L. Lohse, J.M. Denu, N. Santoro, and J.E. Dixon Roles of aspartic acid-181 and serine-222 in intermediate formation and hydrolysis of the mammalian protein-tyrosine-phosphatase PTP1 Biochemistry 36 1997 4568 4575
20. A.J. McCoy, R.W. Grosse-Kunstleve, P.D. Adams, M.D. Winn, L.C. Storoni, and R.J. Read Phaser crystallographic software J Appl Crystallogr 40 2007 658 674
21. T. Mustelin, T. Vang, and N. Bottini Protein tyrosine phosphatases and the immune response Nat Rev Immunol 5 2005 43 57
22. Z. Otwinowski, D. Borek, W. Majewski, and W. Minor Multiparametric scaling of diffraction intensities Acta Crystallogr A 59 2003 228 234
23. C. Pan, H.D. Liu, Z. Gong, X. Yu, X.B. Hou, and D.D. Xie Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site Sci Rep 3 2013 2333
24. A.K. Pedersen, X.L. Guo, K.B. Moller, G.H. Peters, H.S. Andersen, and J.S. Kastrup Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis Biochem J 378 2004 421 433
25. C.A. Schneider, W.S. Rasband, and K.W. Eliceiri NIH Image to ImageJ: 25 years of image analysis Nat Methods 9 2012 671 675
26. R.A. Seifert, S.A. Coats, A. Oganesian, M.B. Wright, M. Dishmon, and C.J. Booth PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein Exp Cell Res 287 2003 374 386
27. J.P. Sun, A.A. Fedorov, S.Y. Lee, X.L. Guo, K. Shen, and D.S. Lawrence Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor J Biol Chem 278 2003 12406 12414
28. J.P. Sun, L. Wu, A.A. Fedorov, S.C. Almo, and Z.Y. Zhang Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor J Biol Chem 278 2003 33392 33399
29. J.P. Sun, W.Q. Wang, H. Yang, S. Liu, F. Liang, and A.A. Fedorov Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion Biochemistry 44 2005 12009 12021
30. W.Q. Wang, J.P. Sun, and Z.Y. Zhang An overview of the protein tyrosine phosphatase superfamily Curr Top Med Chem 3 2003 739 748
31. W.Q. Wang, J. Bembenek, K.R. Gee, H. Yu, H. Charbonneau, and Z.Y. Zhang Kinetic and mechanistic studies of a cell cycle protein phosphatase Cdc14 J Biol Chem 279 2004 30459 30468
32. H.M. Wang, Y.F. Xu, S.L. Ning, D.X. Yang, Y. Li, and Y.J. Du The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes Cell Res 24 2014 1067 1090
33. X. Yu, J.P. Sun, Y. He, X. Guo, S. Liu, and B. Zhou Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases Proc Natl Acad Sci U S A 104 2007 19767 19772
34. Z.Y. Zhang Kinetic and mechanistic characterization of a mammalian protein-tyrosine phosphatase, PTP1 J Biol Chem 270 1995 11199 11204
35. Z.Y. Zhang Mechanistic studies on protein tyrosine phosphatases Prog Nucleic Acid Res Mol Biol 73 2003 171 220
36. Z.Y. Zhang, Y. Wang, and J.E. Dixon Dissecting the catalytic mechanism of protein-tyrosine phosphatases Proc Natl Acad Sci U S A 91 1994 1624 1627
37. Z.Y. Zhang, Y. Wang, L. Wu, E.B. Fauman, J.A. Stuckey, and H.L. Schubert The Cys(X)5Arg catalytic motif in phosphoester hydrolysis Biochemistry 33 1994 15266 15270
38. Z.Y. Zhang, W.P. Malachowski, R.L. Van Etten, and J.E. Dixon Nature of the rate-determining steps of the reaction catalyzed by the Yersinia protein-tyrosine phosphatase J Biol Chem 269 1994 8140 8145
39. Z.Y. Zhang, B.A. Palfey, L. Wu, and Y. Zhao Catalytic function of the conserved hydroxyl group in the protein tyrosine phosphatase signature motif Biochemistry 34 1995 16389 16396
40. Y. Zhao, L. Wu, S.J. Noh, K.L. Guan, and Z.Y. Zhang Altering the nucleophile specificity of a protein-tyrosine phosphatase-catalyzed reaction. Probing the function of the invariant glutamine residues J Biol Chem 273 1998 5484 5492