FRET-based dual-emission and pH-responsive nanocarriers for enhanced delivery of protein across intestinal epithelial cell barrier

ACS Applied Materials and Interfaces

Volumn 6, Issue 20, 2014, Pages 18275-18289

  Lu, Kun Ying ^a   Lin, Cheng Wei ^b,c   Hsu, Chun Hua ^d   Ho, Yi Cheng ^e   Chuang, Er Yuan ^f   Sung, Hsing Wen ^f   Mi, Fwu Long ^b,c  

^a NATIONAL TAIPEI UNIVERSITY OF TECHNOLOGY   (Taiwan)

^b School of Medicine   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^f NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

chitosan; drug delivery; pH responsive; protein release

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BIOCHEMISTRY; CHITOSAN; DRUG DELIVERY; ENDOTHELIAL CELLS; FORSTER RESONANCE ENERGY TRANSFER; PROTEINS; TARGETED DRUG DELIVERY;

EPITHELIAL BARRIER; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; IMPERMEABLE BARRIERS; INTESTINAL EPITHELIAL CELLS; ORAL ADMINISTRATION; PH-RESPONSIVE; PROTEIN RELEASE; THERAPEUTIC PROTEIN;

CONTROLLED DRUG DELIVERY;

ANGIOGENESIS INHIBITOR; ARGININE; CHITOSAN; DRUG CARRIER; NANOPARTICLE; POLY(GAMMA-GLUTAMIC ACID); POLYGLUTAMIC ACID; PROTEIN; TAURINE;

ANALOGS AND DERIVATIVES; ANGIOGENESIS; CACO 2 CELL LINE; CALORIMETRY; CHEMISTRY; CYTOLOGY; DRUG DELIVERY SYSTEM; EPITHELIUM CELL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; IMPEDANCE; INFRARED SPECTROSCOPY; INTESTINE; METABOLISM; PARTICLE SIZE; PH; PROCEDURES; PROTON NUCLEAR MAGNETIC RESONANCE; STATIC ELECTRICITY; THERMODYNAMICS; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INHIBITORS; ARGININE; CACO-2 CELLS; CALORIMETRY; CHITOSAN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ELECTRIC IMPEDANCE; EPITHELIAL CELLS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINES; NANOPARTICLES; NEOVASCULARIZATION, PHYSIOLOGIC; PARTICLE SIZE; POLYGLUTAMIC ACID; PROTEINS; PROTON MAGNETIC RESONANCE SPECTROSCOPY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STATIC ELECTRICITY; TAURINE; THERMODYNAMICS;

EID: 84908181139     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/am505441p     Document Type: Article

References (44)

1. Carmeliet, P. Angiogenesis in Life, Disease and Medicine Nature 2005, 438, 932-936
2. Bremer, C.; Tung, C. H.; Weissleder, R. In Vivo Molecular Target Assessment of Matrix Metalloproteinase Inhibition Nat. Med. 2001, 7, 743-748
3. Yancopoulos, G. D.; Davis, S.; Gale, N. W.; Rudge, J. S.; Wiegand, S. J.; Holash, J. Vascular-Specific Growth Factors and Blood Vessel Formation Nature 2000, 407, 242-248
4. Skandalis, S. S.; Gialeli, C.; Theocharis, A. D.; Karamanos, N. K. Advantages of Nanomedicine in The Pharmacological Targeting of Hyaluronan-CD44 Interactions and Signaling in Cancer Adv. Cancer Res. 2014, 123, 277-317
5. Yim, H.; Park, S. J.; Bae, Y. H.; Na, K. Biodegradable Cationic Nanoparticles Loaded with An Anticancer Drug for Deep Penetration of Heterogeneous Tumours Biomaterials 2013, 34, 7674-7682
6. Duan, X.; Wang, P.; Men, K.; Gao, X.; Huang, M.; Gou, M.; Chen, L.; Qian, Z.; Wei, Y. Treating Colon Cancer with A Suicide Gene Delivered by Self-assembled Cationic MPEG-PCL Micelles Nanoscale 2012, 4, 2400-2407
7. Deng, Z. J.; Morton, S. W.; Ben-Akiva, E.; Dreaden, E. C.; Shopsowitz, K. E.; Hammond, P. T. Layer-by-Layer Nanoparticles for Systemic Codelivery of An Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment ACS Nano 2013, 7, 9571-9584
8. Kanwar, J. R.; Mahidhara, G.; Kanwar, R. K. Antiangiogenic Therapy using Nanotechnological-Based Delivery System Drug Discovery Today 2011, 16, 188-202
9. El-Dakdouki, M. H.; Xia, J.; Zhu, D. C.; Kavunja, H.; Grieshaber, J.; O'Reilly, S.; McCormick, J. J.; Huang, X. Assessing The In Vivo Efficacy of Doxorubicin Loaded Hyaluronan Nanoparticles ACS Appl. Mater. Interfaces 2014, 6, 697-705
10. Jia, M.; Li, Y.; Yang, X.; Huang, Y.; Wu, H.; Huang, Y.; Lin, J.; Li, Y.; Hou, Z.; Zhang, Q. Methotrexate and Mitomycin C Loaded Pegylated Chitosan Nanoparticles for Targeted Drug Codelivery and Synergistic Anticancer Effect ACS Appl. Mater. Interfaces 2014, 6, 11413-11423
11. Xie, Y.; Qiao, H.; Su, Z.; Chen, M.; Ping, Q.; Sun, M. PEGylated Carboxymethyl Chitosan/Calcium Phosphate Hybrid Anionic Nanoparticles Mediated hTERT siRNA Delivery for Anticancer Therapy Biomaterials 2014, 35, 7978-7991
12. Vivek, R.; Thangam, R.; NipunBabu, V.; Rejeeth, C.; Sivasubramanian, S.; Gunasekaran, P.; Muthuchelian, K.; Kannan, S. Multifunctional HER2-Antibody Conjugated Polymeric Nanocarrier-Based Drug Delivery System for Multi-Drug-Resistant Breast Cancer Therapy ACS Appl. Mater. Interfaces 2014, 6, 6469-6480
13. He, Q.; Shi, J. MSN Anticancer Nanomedicines: Chemotherapy Enhancement, Overcoming of Drug Resistance, and Metastasis Inhibition Adv. Mater. 2014, 26, 391-411
14. Lee, D. Y.; Kim, S. K.; Kim, Y. S.; Son, D. H.; Nam, J. H.; Kim, I. S.; Park, R. W.; Kim, S. Y.; Byun, Y. Suppression of Angiogenesis and Tumor Growth by Orally Active Deoxycholic Acid-Heparin Conjugate J. Controlled Release 2007, 118, 310-317
15. Park, J. W.; Jeon, O. C.; Kim, S. K.; Al-Hilal, T. A.; Jin, S. J.; Moon, H. T.; Yang, V. C.; Kim, S. Y.; Byun, Y. High Antiangiogenic and Low Anticoagulant Efficacy of Orally Active Low Molecular Weight Heparin Derivatives J. Controlled Release 2010, 148, 317-326
16. Benny, O.; Fainaru, O.; Adini, A.; Cassiola, F.; Bazinet, L.; Adini, I.; Pravda, E.; Nahmias, Y.; Koirala, S.; Corfas, G.; D'Amato, R. J.; Folkman, J. An Orally Delivered Small-Molecule Formulation with Antiangiogenic and Anticancer Activity Nat. Biotechnol. 2008, 26, 799-807
17. Satchi-Fainaro, R.; Puder, M.; Davies, J. W.; Tran, H. T.; Sampson, D. A.; Greene, A. K.; Corfas, G.; Folkman, J. Targeting Angiogenesis with A Conjugate of HPMA Copolymer and TNP-470 Nat. Med. 2004, 10, 255-261
18. Lee, A.; Langer, R. Shark Cartilage Contains Inhibitors of Tumor Angiogenesis Science 1983, 221, 1185-1187
19. Boivin, D.; Gendron, S.; Beaulieu, E.; Gingras, D.; Beliveau, R. The Antiangiogenic Agent Neovastat (AE-941) Induces Endothelial Cell Apoptosis Mol. Cancer Ther. 2002, 1, 795-802
20. Beliveau, R.; Gingras, D.; Kruger, E. A.; Lamy, S.; Sirois, P.; Simard, B.; Sirois, M. G.; Tranqui, L.; Baffert, F.; Beaulieu, E.; Dimitriadou, V.; Pepin, M. C.; Courjal, F.; Ricard, I.; Poyet, P.; Falardeau, P.; Figg, W. D.; Dupont, E. The Antiangiogenic Agent Neovastat (AE-941) Inhibits Vascular Endothelial Growth Factor-Mediated Biological Effects Clin. Cancer Res. 2002, 8, 1242-1250
21. Lu, C.; Lee, J. J.; Komaki, R.; Herbst, R. S.; Feng, L.; Evans, W. K.; Choy, H.; Desjardins, P.; Esparaz, B. T.; Truong, M. T.; Saxman, S.; Kelaghan, J.; Bleyer, A.; Fisch, M. J. Chemoradiotherapy with or without AE-941 In Stage III Non-small Cell Lung Cancer: A Randomized Phase III Trial J. Natl. Cancer Inst. 2010, 102, 859-865
22. Chen, J.; Ouyang, J.; Kong, J.; Zhong, W.; Xing, M. M. Photo-Cross-Linked and pH-Sensitive Biodegradable Micelles for Doxorubicin Delivery ACS Appl. Mater. Interfaces 2013, 5, 3108-3117
23. Binauld, S.; Stenzel, M. H. Acid-Degradable Polymers for Drug Delivery: a Decade of Innovation Chem. Commun. 2013, 49, 2082-2102
24. Xia, B.; Wang, X.; He, F.; Cui, Q.; Li, L. Self-Assembly of Conjugated Polymer on Hybrid Nanospheres for Cellular Imaging Applications ACS Appl. Mater. Interfaces 2012, 4, 6332-6337
25. Banerjee, A.; Bhatia, D.; Saminathan, A.; Chakraborty, S.; Kar, S.; Krishnan, Y. Controlled Release of Encapsulated Cargo from A DNA Icosahedron using A Chemical Trigger Angew. Chem., Int. Ed. 2013, 52, 6854-6857
26. Chen, W.; Meng, F.; Cheng, R.; Zhong, Z. pH-Sensitive Degradable Polymersomes for Triggered Release of Anticancer Drugs: A Comparative Study with Micelles J. Controlled Release 2010, 142, 40-46
27. Feng, W.; Nie, W.; He, C.; Zhou, X.; Chen, L.; Qiu, K.; Wang, W.; Yin, Z. Effect of pH-Responsive Alginate/Chitosan Multilayers Coating on Delivery Efficiency, Cellular Uptake and Biodistribution of Mesoporous Silica Nanoparticles Based Nanocarriers ACS Appl. Mater. Interfaces 2014, 6, 8447-8460
28. Wang, S.; Zhang, S.; Liu, J.; Liu, Z.; Su, L.; Wang, H.; Chang, J. pH- and Reduction-Responsive Polymeric Lipid Vesicles for Enhanced Tumor Cellular Internalization and Triggered Drug Release ACS Appl. Mater. Interfaces 2014, 6, 10706-10713
29. Hu, X.; Neoh, K. G.; Shi, Z.; Kang, E. T.; Poh, C.; Wang, W. An In Vitro Assessment of Titanium Functionalized with Polysaccharides Conjugated with Vascular Endothelial Growth Factor for Enhanced Osseointegration and Inhibition of Bacterial Adhesion Biomaterials 2010, 31, 8854-8863
30. Sonaje, K.; Lin, K. J.; Wang, J. J.; Mi, F. L.; Chen, C. T.; Juang, J. H.; Sung, H. W. Self-Assembled pH-Sensitive Nanoparticles: A Platform for Oral Delivery of Protein Drugs Adv. Funct Mater. 2010, 20, 3695-3700
31. Ho, Y. C.; Liao, Z. X.; Panda, N.; Tang, D. W.; Yu, S. H.; Mi, F. L.; Sung, H. W. Self-Organized Nanoparticles Prepared by Guanidine- and Disulfide-Modified Chitosan as A Gene Delivery Carrier J. Mater. Chem. 2011, 21, 16918-16927
32. Sun, L.; Wang, Y.; Jiang, T.; Zheng, X.; Zhang, J.; Sun, J.; Sun, C.; Wang, S. Novel Chitosan-Functionalized Spherical Nanosilica Matrix as An Oral Sustained Drug Delivery System for Poorly Water-Soluble Drug Carvedilol ACS Appl. Mater. Interfaces 2013, 5, 103-113
33. Hsu, L. W.; Ho, Y. C.; Chuang, E. Y.; Chen, C. T.; Juang, J. H.; Su, F. Y.; Hwang, S. M.; Sung, H. W. Effects of pH on Molecular Mechanisms of Chitosan-Integrin Interactions and Resulting Tight-Junction Disruptions Biomaterials 2013, 34, 784-793
34. Yu, S. H.; Tang, D. W.; Hsieh, H. Y.; Wu, W. S.; Lin, B. X.; Chuang, E. Y.; Sung, H. W.; Mi, F. L. Nanoparticle-Induced Tight-Junction Opening for The Transport of An Anti-Angiogenic Sulfated Polysaccharide Across Caco-2 Cell Monolayers Acta. Biomater. 2013, 9, 7449-7459
35. Chuang, E. Y.; Nguyen, G. T.; Su, F. Y.; Lin, K. J.; Chen, C. T.; Mi, F. L.; Yen, T. C.; Juang, J. H.; Sung, H. W. Combination Therapy via Oral Co-Administration of Insulin- and Exendin-4-Loaded Nanoparticles to Treat Type 2 Diabetic Rats Undergoing OGTT Biomaterials 2013, 34, 7994-8001
36. Lee, A.; Langer, R. Shark Cartilage Contains Inhibitors of Tumor Angiogenesis Science 1983, 221, 1185-1187
37. Zhang, X.; Li, J.; Li, W.; Zhang, A. Synthesis and Characterization of Thermo- and pH-Responsive Double-Hydrophilic Diblock Copolypeptides Biomacromolecules 2007, 8, 3557-3567
38. Tang, D. W.; Yu, S. H.; Ho, Y. C.; Mi, F. L.; Kuo, P. L.; Sung, H. W. Heparinized Chitosan/Poly(gamma-glutamic acid) Nanoparticles for Multi-Functional Delivery of Fibroblast Growth Factor and Heparin Biomaterials 2010, 31, 9320-9332
39. Lin, I. C.; Liang, M.; Liu, T. Y.; Ziora, Z. M.; Monteiro, M. J.; Toth, I. Interaction of Densely Polymer-Coated Gold Nanoparticles with Epithelial Caco-2 Monolayers Biomacromolecules 2011, 12, 1339-1348
40. Huang, Y.; Lapitsky, Y. Determining The Colloidal Behavior of Ionically Cross-Linked Polyelectrolytes with Isothermal Titration Calorimetry J. Phys. Chem. B 2013, 117, 9548-9557
41. Chiu, Y. L.; Chen, S. A.; Chen, J. H.; Chen, K. J.; Chen, H. L.; Sung, H. W. A Dual-Emission Forster Resonance Energy Transfer Nanoprobe for Sensing/Imaging pH Changes In The Biological Environment ACS Nano 2010, 4, 7467-7474
42. Pu, H. L.; Chiang, W. L.; Maiti, B.; Liao, Z. X.; Ho, Y. C.; Shim, M. S.; Chuang, E. Y.; Xia, Y.; Sung, H. W. Nanoparticles with Dual Responses to Oxidative Stress and Reduced pH for Drug Release and Anti-Inflammatory Applications ACS Nano 2014, 8, 1213-1221
43. Artursson, P.; Palm, K.; Luthman, K. Caco-2 Monolayers In Experimental and Theoretical Predictions of Drug Transport Adv. Drug Delivery Rev. 2012, 64, 280-289
44. Chen, M. C.; Mi, F. L.; Liao, Z. X.; Hsiao, C. W.; Sonaje, K.; Chung, M. F.; Hsu, L. W.; Sung, H. W. Recent Advances in Chitosan-Based Nanoparticles for Oral Delivery of Macromolecules Adv. Drug Delivery Rev. 2013, 65, 865-879